Salivary Therapeutic Drug Monitoring of Antimicrobial Therapy: Feasible or Futile?

Personalised drug dosing through therapeutic drug monitoring (TDM) is important to maximise efficacy and to minimise toxicity. Hurdles preventing broad implementation of TDM in routine care include the need of sophisticated equipment and highly trained staff, high costs and lack of timely results. S...

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Vydáno v:Clinical pharmacokinetics Ročník 63; číslo 3; s. 269 - 278
Hlavní autoři: Davies Forsman, Lina, Kim, Hannah Yejin, Nguyen, Thi Anh, Alffenaar, Jan-Willem C.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Cham Springer International Publishing 01.03.2024
Springer Nature B.V
Témata:
Anti-Infective Agents
Antibiotics
Chromatography
Current Opinion
Drug dosages
Drug Monitoring - methods
Humans
Internal Medicine
Laboratories
Medicine
Medicine & Public Health
Patients
Pharmacokinetics
Pharmacology/Toxicology
Pharmacotherapy
Plasma
Point of care testing
Proteins
Therapeutic drug monitoring
Toxicity
ISSN:0312-5963, 1179-1926, 1179-1926
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Shrnutí:Personalised drug dosing through therapeutic drug monitoring (TDM) is important to maximise efficacy and to minimise toxicity. Hurdles preventing broad implementation of TDM in routine care include the need of sophisticated equipment and highly trained staff, high costs and lack of timely results. Salivary TDM is a non-invasive, patient-friendly alternative to blood sampling, which has the potential to overcome barriers with traditional TDM. A mobile UV spectrophotometer may provide a simple solution for analysing drug concentrations in saliva samples. Salivary TDM utilising point-of-care tests can support personalised dosing in various settings including low-resource as well as remote settings. In this opinion paper, we describe how hurdles of implementing traditional TDM may be mitigated by salivary TDM with new strategies for patient-friendly point-of-care testing.
Bibliografie:ObjectType-Article-1
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ISSN:0312-5963
1179-1926
1179-1926
DOI:10.1007/s40262-024-01346-7