PD-L1 and IFN-γ modulate Non-Small Cell Lung Cancer (NSCLC) cell plasticity associated to immune checkpoint inhibitor (ICI)-mediated hyperprogressive disease (HPD)

Background Non-Small Cell Lung Cancer (NSCLC) is the leading cause of cancer death worldwide. Although immune checkpoint inhibitors (ICIs) have shown remarkable clinical efficacy, they can also induce a paradoxical cancer acceleration, known as hyperprogressive disease (HPD), whose causative mechani...

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Bibliographic Details
Published in:	Journal of translational medicine Vol. 23; no. 1; pp. 2 - 20
Main Authors:	Angelicola, Stefania, Giunchi, Francesca, Ruzzi, Francesca, Frascino, Mariateresa, Pitzalis, Mary, Scalambra, Laura, Semprini, Maria Sofia, Pittino, Olga Maria, Cappello, Chiara, Siracusa, Irene, Chillico, Ilaria Candida, Di Noia, Martina, Turato, Cristian, De Siervi, Silvia, Lescai, Francesco, Ciavattini, Teresa, Lopatriello, Giulia, Bertoli, Luca, De Jonge, Hugo, Iamele, Luisa, Altimari, Annalisa, Gruppioni, Elisa, Ardizzoni, Andrea, Rossato, Marzia, Gelsomino, Francesco, Lollini, Pier-Luigi, Palladini, Arianna
Format:	Journal Article
Language:	English
Published:	London BioMed Central 02.01.2025 BMC
Subjects:	Animals B7-H1 Antigen - metabolism Biomedical and Life Sciences Biomedicine Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Cell Plasticity - drug effects Cell Proliferation - drug effects Disease Progression Humans Hyperprogressive disease IFN-γ Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use Immune checkpoint inhibitors Interferon-gamma - metabolism Interferon-gamma - pharmacology Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Medicine/Public Health Mice Network Medicines Non-Small Cell Lung Cancer PD-L1 Tumor plasticity PD-L1 Hyperprogressive disease IFN-γ Non-Small Cell Lung Cancer Tumor plasticity Immune checkpoint inhibitors
ISSN:	1479-5876, 1479-5876
Online Access:	Get full text
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