Natural killer cell number and phenotype in bovine peripheral blood is influenced by age
Natural killer (NK) cells are critical to the innate defence against intracellular infection. High NK cell frequencies have been detected in human neonates, which may compensate for the relative immaturity of the specific immune response. Additionally, phenotypic subsets of NK cells have been identi...
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| Vydané v: | Veterinary immunology and immunopathology Ročník 132; číslo 2; s. 101 - 108 |
|---|---|
| Hlavní autori: | , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
Netherlands
Elsevier B.V
15.12.2009
Amsterdam: Elsevier |
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| ISSN: | 0165-2427, 1873-2534, 1873-2534 |
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| Abstract | Natural killer (NK) cells are critical to the innate defence against intracellular infection. High NK cell frequencies have been detected in human neonates, which may compensate for the relative immaturity of the specific immune response. Additionally, phenotypic subsets of NK cells have been identified in humans with different functional properties. In this study, we examined the age distribution and phenotype of NK populations in bovine peripheral blood, including neonatal animals. We found that the NK cell populations defined by the phenotypes CD3
−CD2
+ and NKp46
+ largely overlapped, so that the majority of NK cells in bovine peripheral blood were CD3
−CD2
+NKp46
+. The remainder of the NK-like cells comprised two minor populations, CD3
−CD2
+NKp46
− and CD3
−CD2
−NKp46
+; the relative proportions of these varied with age. The lowest frequency of NK cells was recorded in 1-day-old calves, with the highest frequency in day 0 calves. The phenotypic characteristics of CD3
−CD2
+ and NKp46
+ NK populations were similar; both populations expressed CD45RO, CD45RB, CD11b, CC84, CD8αα and CD8αβ and did not express CD21, WC1, CD14 or γδ TCR. Age-related phenotypic differences were apparent. The phenotypic characteristics of three NK subpopulations were described; a significantly greater proportion of the CD3
−CD2
−NKp46
+ population expressed CD8α compared to CD3
−CD2
+NKp46
+ cells. Furthermore, a significantly greater proportion of the CD3
−CD2
+NKp46
− population expressed CD8 compared to total CD3
−CD2
+ cells. Adult cattle had a significantly higher proportion of perforin
+ cells compared to calves aged ≤6 weeks. In this age group, the majority of perforin
+ cells expressed NKp46, while in adults the majority of perforin
+ cells were NKp46
−. However, the proportion of NKp46
+ and CD3
−CD2
+ cells that expressed perforin was not significantly different in any age group tested. |
|---|---|
| AbstractList | Natural killer (NK) cells are critical to the innate defence against intracellular infection. High NK cell frequencies have been detected in human neonates, which may compensate for the relative immaturity of the specific immune response. Additionally, phenotypic subsets of NK cells have been identified in humans with different functional properties. In this study, we examined the age distribution and phenotype of NK populations in bovine peripheral blood, including neonatal animals. We found that the NK cell populations defined by the phenotypes CD3(-)CD2(+) and NKp46(+) largely overlapped, so that the majority of NK cells in bovine peripheral blood were CD3(-)CD2(+)NKp46(+). The remainder of the NK-like cells comprised two minor populations, CD3(-)CD2(+)NKp46(-) and CD3(-)CD2(-)NKp46(+); the relative proportions of these varied with age. The lowest frequency of NK cells was recorded in 1-day-old calves, with the highest frequency in day 0 calves. The phenotypic characteristics of CD3(-)CD2(+) and NKp46(+) NK populations were similar; both populations expressed CD45RO, CD45RB, CD11b, CC84, CD8alphaalpha and CD8alphabeta and did not express CD21, WC1, CD14 or gammadelta TCR. Age-related phenotypic differences were apparent. The phenotypic characteristics of three NK subpopulations were described; a significantly greater proportion of the CD3(-)CD2(-)NKp46(+) population expressed CD8alpha compared to CD3(-)CD2(+)NKp46(+) cells. Furthermore, a significantly greater proportion of the CD3(-)CD2(+)NKp46(-) population expressed CD8 compared to total CD3(-)CD2(+) cells. Adult cattle had a significantly higher proportion of perforin(+) cells compared to calves aged </=6 weeks. In this age group, the majority of perforin(+) cells expressed NKp46, while in adults the majority of perforin(+) cells were NKp46(-). However, the proportion of NKp46(+) and CD3(-)CD2(+) cells that expressed perforin was not significantly different in any age group tested.Natural killer (NK) cells are critical to the innate defence against intracellular infection. High NK cell frequencies have been detected in human neonates, which may compensate for the relative immaturity of the specific immune response. Additionally, phenotypic subsets of NK cells have been identified in humans with different functional properties. In this study, we examined the age distribution and phenotype of NK populations in bovine peripheral blood, including neonatal animals. We found that the NK cell populations defined by the phenotypes CD3(-)CD2(+) and NKp46(+) largely overlapped, so that the majority of NK cells in bovine peripheral blood were CD3(-)CD2(+)NKp46(+). The remainder of the NK-like cells comprised two minor populations, CD3(-)CD2(+)NKp46(-) and CD3(-)CD2(-)NKp46(+); the relative proportions of these varied with age. The lowest frequency of NK cells was recorded in 1-day-old calves, with the highest frequency in day 0 calves. The phenotypic characteristics of CD3(-)CD2(+) and NKp46(+) NK populations were similar; both populations expressed CD45RO, CD45RB, CD11b, CC84, CD8alphaalpha and CD8alphabeta and did not express CD21, WC1, CD14 or gammadelta TCR. Age-related phenotypic differences were apparent. The phenotypic characteristics of three NK subpopulations were described; a significantly greater proportion of the CD3(-)CD2(-)NKp46(+) population expressed CD8alpha compared to CD3(-)CD2(+)NKp46(+) cells. Furthermore, a significantly greater proportion of the CD3(-)CD2(+)NKp46(-) population expressed CD8 compared to total CD3(-)CD2(+) cells. Adult cattle had a significantly higher proportion of perforin(+) cells compared to calves aged </=6 weeks. In this age group, the majority of perforin(+) cells expressed NKp46, while in adults the majority of perforin(+) cells were NKp46(-). However, the proportion of NKp46(+) and CD3(-)CD2(+) cells that expressed perforin was not significantly different in any age group tested. Natural killer (NK) cells are critical to the innate defence against intracellular infection. High NK cell frequencies have been detected in human neonates, which may compensate for the relative immaturity of the specific immune response. Additionally, phenotypic subsets of NK cells have been identified in humans with different functional properties. In this study, we examined the age distribution and phenotype of NK populations in bovine peripheral blood, including neonatal animals. We found that the NK cell populations defined by the phenotypes CD3 −CD2 + and NKp46 + largely overlapped, so that the majority of NK cells in bovine peripheral blood were CD3 −CD2 +NKp46 +. The remainder of the NK-like cells comprised two minor populations, CD3 −CD2 +NKp46 − and CD3 −CD2 −NKp46 +; the relative proportions of these varied with age. The lowest frequency of NK cells was recorded in 1-day-old calves, with the highest frequency in day 0 calves. The phenotypic characteristics of CD3 −CD2 + and NKp46 + NK populations were similar; both populations expressed CD45RO, CD45RB, CD11b, CC84, CD8αα and CD8αβ and did not express CD21, WC1, CD14 or γδ TCR. Age-related phenotypic differences were apparent. The phenotypic characteristics of three NK subpopulations were described; a significantly greater proportion of the CD3 −CD2 −NKp46 + population expressed CD8α compared to CD3 −CD2 +NKp46 + cells. Furthermore, a significantly greater proportion of the CD3 −CD2 +NKp46 − population expressed CD8 compared to total CD3 −CD2 + cells. Adult cattle had a significantly higher proportion of perforin + cells compared to calves aged ≤6 weeks. In this age group, the majority of perforin + cells expressed NKp46, while in adults the majority of perforin + cells were NKp46 −. However, the proportion of NKp46 + and CD3 −CD2 + cells that expressed perforin was not significantly different in any age group tested. Natural killer (NK) cells are critical to the innate defence against intracellular infection. High NK cell frequencies have been detected in human neonates, which may compensate for the relative immaturity of the specific immune response. Additionally, phenotypic subsets of NK cells have been identified in humans with different functional properties. In this study, we examined the age distribution and phenotype of NK populations in bovine peripheral blood, including neonatal animals. We found that the NK cell populations defined by the phenotypes CD3⁻CD2⁺ and NKp46⁺ largely overlapped, so that the majority of NK cells in bovine peripheral blood were CD3⁻CD2⁺NKp46⁺. The remainder of the NK-like cells comprised two minor populations, CD3⁻CD2⁺NKp46⁻ and CD3⁻CD2⁻NKp46⁺; the relative proportions of these varied with age. The lowest frequency of NK cells was recorded in 1-day-old calves, with the highest frequency in day 0 calves. The phenotypic characteristics of CD3⁻CD2⁺ and NKp46⁺ NK populations were similar; both populations expressed CD45RO, CD45RB, CD11b, CC84, CD8αα and CD8αβ and did not express CD21, WC1, CD14 or γδ TCR. Age-related phenotypic differences were apparent. The phenotypic characteristics of three NK subpopulations were described; a significantly greater proportion of the CD3⁻CD2⁻NKp46⁺ population expressed CD8α compared to CD3⁻CD2⁺NKp46⁺ cells. Furthermore, a significantly greater proportion of the CD3⁻CD2⁺NKp46⁻ population expressed CD8 compared to total CD3⁻CD2⁺ cells. Adult cattle had a significantly higher proportion of perforin⁺ cells compared to calves aged ≤6 weeks. In this age group, the majority of perforin⁺ cells expressed NKp46, while in adults the majority of perforin⁺ cells were NKp46⁻. However, the proportion of NKp46⁺ and CD3⁻CD2⁺ cells that expressed perforin was not significantly different in any age group tested. Natural killer (NK) cells are critical to the innate defence against intracellular infection. High NK cell frequencies have been detected in human neonates, which may compensate for the relative immaturity of the specific immune response. Additionally, phenotypic subsets of NK cells have been identified in humans with different functional properties. In this study, we examined the age distribution and phenotype of NK populations in bovine peripheral blood, including neonatal animals. We found that the NK cell populations defined by the phenotypes CD3(-)CD2(+) and NKp46(+) largely overlapped, so that the majority of NK cells in bovine peripheral blood were CD3(-)CD2(+)NKp46(+). The remainder of the NK-like cells comprised two minor populations, CD3(-)CD2(+)NKp46(-) and CD3(-)CD2(-)NKp46(+); the relative proportions of these varied with age. The lowest frequency of NK cells was recorded in 1-day-old calves, with the highest frequency in day 0 calves. The phenotypic characteristics of CD3(-)CD2(+) and NKp46(+) NK populations were similar; both populations expressed CD45RO, CD45RB, CD11b, CC84, CD8alphaalpha and CD8alphabeta and did not express CD21, WC1, CD14 or gammadelta TCR. Age-related phenotypic differences were apparent. The phenotypic characteristics of three NK subpopulations were described; a significantly greater proportion of the CD3(-)CD2(-)NKp46(+) population expressed CD8alpha compared to CD3(-)CD2(+)NKp46(+) cells. Furthermore, a significantly greater proportion of the CD3(-)CD2(+)NKp46(-) population expressed CD8 compared to total CD3(-)CD2(+) cells. Adult cattle had a significantly higher proportion of perforin(+) cells compared to calves aged </=6 weeks. In this age group, the majority of perforin(+) cells expressed NKp46, while in adults the majority of perforin(+) cells were NKp46(-). However, the proportion of NKp46(+) and CD3(-)CD2(+) cells that expressed perforin was not significantly different in any age group tested. Natural killer (NK) cells are critical to the innate defence against intracellular infection. High NK cell frequencies have been detected in human neonates, which may compensate for the relative immaturity of the specific immune response. Additionally, phenotypic subsets of NK cells have been identified in humans with different functional properties. In this study, we examined the age distribution and phenotype of NK populations in bovine peripheral blood, including neonatal animals. We found that the NK cell populations defined by the phenotypes CD3 super(-)CD2 super(+) and NKp46 super(+) largely overlapped, so that the majority of NK cells in bovine peripheral blood were CD3 super(-)CD2 super(+)NKp46 super(+). The remainder of the NK-like cells comprised two minor populations, CD3 super(-)CD2 super(+)NKp46 super(-) and CD3 super(-)CD2 super(-)NKp46 super(+); the relative proportions of these varied with age. The lowest frequency of NK cells was recorded in 1-day-old calves, with the highest frequency in day 0 calves. The phenotypic characteristics of CD3 super(-)CD2 super(+) and NKp46 super(+) NK populations were similar; both populations expressed CD45RO, CD45RB, CD11b, CC84, CD8 alpha alpha and CD8 alpha beta and did not express CD21, WC1, CD14 or gamma delta TCR. Age-related phenotypic differences were apparent. The phenotypic characteristics of three NK subpopulations were described; a significantly greater proportion of the CD3 super(-)CD2 super(-)NKp46 super(+) population expressed CD8 alpha compared to CD3 super(-)CD2 super(+)NKp46 super(+) cells. Furthermore, a significantly greater proportion of the CD3 super(-)CD2 super(+)NKp46 super(-) population expressed CD8 compared to total CD3 super(-)CD2 super(+) cells. Adult cattle had a significantly higher proportion of perforin super(+) cells compared to calves aged approximately equal to 6 weeks. In this age group, the majority of perforin super(+) cells expressed NKp46, while in adults the majority of perforin super(+) cells were NKp46 super(-). However, the proportion of NKp46 super(+) and CD3 super(-)CD2 super(+) cells that expressed perforin was not significantly different in any age group tested. |
| Author | Storset, Anne K. Graham, Elizabeth M. Howard, Chris J. Hope, Jayne C. Boysen, Preben Thom, Michelle L. Sopp, Paul |
| Author_xml | – sequence: 1 givenname: Elizabeth M. surname: Graham fullname: Graham, Elizabeth M. organization: Institute for Animal Health, Compton, Newbury, Berkshire, RG20 7NN, United Kingdom – sequence: 2 givenname: Michelle L. surname: Thom fullname: Thom, Michelle L. organization: Institute for Animal Health, Compton, Newbury, Berkshire, RG20 7NN, United Kingdom – sequence: 3 givenname: Chris J. surname: Howard fullname: Howard, Chris J. organization: Institute for Animal Health, Compton, Newbury, Berkshire, RG20 7NN, United Kingdom – sequence: 4 givenname: Preben surname: Boysen fullname: Boysen, Preben organization: Norwegian School of Veterinary Science, Oslo, Norway – sequence: 5 givenname: Anne K. surname: Storset fullname: Storset, Anne K. organization: Norwegian School of Veterinary Science, Oslo, Norway – sequence: 6 givenname: Paul surname: Sopp fullname: Sopp, Paul organization: Institute for Animal Health, Compton, Newbury, Berkshire, RG20 7NN, United Kingdom – sequence: 7 givenname: Jayne C. surname: Hope fullname: Hope, Jayne C. email: jayne.hope@bbsrc.ac.uk organization: Institute for Animal Health, Compton, Newbury, Berkshire, RG20 7NN, United Kingdom |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19525013$$D View this record in MEDLINE/PubMed |
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| Keywords | Natural killer cell Phenotype NKp46 Perforin |
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| SubjectTerms | Aging Aging - immunology animal age Animals Animals, Newborn blood blood sampling cattle Cattle - blood Cattle - immunology cattle diseases CD2 Antigens CD2 Antigens - blood CD3 Complex CD3 Complex - blood gene expression Humans immunity immunology Immunophenotyping Infant, Newborn infectious diseases Killer Cells, Natural Killer Cells, Natural - immunology Lymphocyte Count Lymphocyte Subsets Lymphocyte Subsets - immunology Natural Cytotoxicity Triggering Receptor 1 Natural Cytotoxicity Triggering Receptor 1 - blood Natural killer cell natural killer cells neonates NKp46 Perforin Perforin - blood Phenotype Species Specificity |
| Title | Natural killer cell number and phenotype in bovine peripheral blood is influenced by age |
| URI | https://dx.doi.org/10.1016/j.vetimm.2009.05.002 https://www.ncbi.nlm.nih.gov/pubmed/19525013 https://www.proquest.com/docview/21060917 https://www.proquest.com/docview/46504585 https://www.proquest.com/docview/734157584 |
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