IL-7Rα on CD4+ T cells is required for their survival and the pathogenesis of experimental autoimmune encephalomyelitis

Background The IL-7 receptor alpha (IL-7Rα) binds both IL-7 and thymic stromal lymphopoietin (TSLP). IL-7Rα is essential for the development and survival of naive CD4 + T cells and their differentiation to effector/memory CD4 + T cells. Mice lacking IL-7Rα have severe lymphopenia and are resistant t...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of neuroinflammation Vol. 21; no. 1; pp. 253 - 15
Main Authors:	Azizi, Gholamreza, Van den Broek, Bram, Ishikawa, Larissa Lumi Watanabe, Naziri, Hamed, Yazdani, Reza, Zhang, Guang-Xian, Ciric, Bogoljub, Rostami, Abdolmohamad
Format:	Journal Article
Language:	English
Published:	London BioMed Central 08.10.2024 BMC
Subjects:	Animals Biomedical and Life Sciences Biomedicine CD4+ T cell CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Survival - drug effects Cell Survival - physiology Cytokines - metabolism Encephalomyelitis, Autoimmune, Experimental - chemically induced Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology Experimental autoimmune encephalomyelitis IL-7 receptor alpha Immunology Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Multiple sclerosis Myelin-Oligodendrocyte Glycoprotein - immunology Myelin-Oligodendrocyte Glycoprotein - toxicity Neurobiology Neurology Neurosciences Peptide Fragments - immunology Peptide Fragments - metabolism Peptide Fragments - toxicity Receptors, Interleukin-7 - genetics Receptors, Interleukin-7 - metabolism Experimental autoimmune encephalomyelitis Multiple sclerosis CD4 IL-7 receptor alpha T cell CD4+ T cell
ISSN:	1742-2094, 1742-2094
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!