Saliva in the diagnosis of diseases

Saliva is secreted from the salivary glands and has multiple functions, including mouth cleaning and protection, antibacterial effects and digestion. With the rapid advancement in salivaomics, saliva is well recognized as a pool of biological markers. Saliva, as a non-invasive and safe source, could...

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Bibliographic Details
Published in:International journal of oral science Vol. 8; no. 3; pp. 133 - 137
Main Authors: Zhang, Chen-Zi, Cheng, Xing-Qun, Li, Ji-Yao, Zhang, Ping, Yi, Ping, Xu, Xin, Zhou, Xue-Dong
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 01.09.2016
Springer Nature B.V
State Key Laboratory of 0ral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China%The Clinical Laboratory of West China Hospital of Stomatology, Sichuan University, Chengdu, China
Nature Publishing Group
Subjects:
Biomarkers
Dental Caries
Dentistry
Humans
Medicine
Mouth Diseases - diagnosis
Oral and Maxillofacial Surgery
Orthopedics
Review
Saliva - chemistry
Surgical Orthopedics
saliva
diagnosis
precision medicine
oral diseases
systemic diseases
ISSN:1674-2818, 2049-3169, 2049-3169
Online Access:Get full text
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Summary:Saliva is secreted from the salivary glands and has multiple functions, including mouth cleaning and protection, antibacterial effects and digestion. With the rapid advancement in salivaomics, saliva is well recognized as a pool of biological markers. Saliva, as a non-invasive and safe source, could be a substitute for blood in the diagnosis and prognosis of diseases. This review summarizes the latest advancements in saliva-related studies and addresses the potential value of saliva in the early diagnosis of oral diseases, such as dental caries and periodontal disease, as well as cancer, diabetes and other systemic disorders. Saliva biomarkers range from changes in the biochemical indices of DNA, RNA and proteins to the diversification of microbiota structures. This study integrates data reported in the recent literature and discusses the clinical significance and prospects for the application of saliva in the early diagnosis of diseases, translational medicine and precision medicine.
Bibliography:51-1707/R
Saliva is secreted from the salivary glands and has multiple functions, including mouth cleaning and protection, antibacterial effects and digestion. With the rapid advancement in salivaomics, saliva is well recognized as a pool of biological markers. Saliva, as a non-invasive and safe source, could be a substitute for blood in the diagnosis and prognosis of diseases. This review summarizes the latest advancements in saliva-related studies and addresses the potential value of saliva in the early diagnosis of oral diseases, such as dental caries and periodontal disease, as well as cancer, diabetes and other systemic disorders. Saliva biomarkers range from changes in the biochemical indices of DNA, RNA and proteins to the diversification of microbiota structures. This study integrates data reported in the recent literature and discusses the clinical significance and prospects for the application of saliva in the early diagnosis of diseases, translational medicine and precision medicine.
diagnosis; oral diseases; precision medicine; saliva; systemic diseases
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ISSN:1674-2818
2049-3169
2049-3169
DOI:10.1038/ijos.2016.38