MiR-155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of Apaf-1 expression

MicroRNA-155 (miR-155) overexpression is often found in malignancies including lung cancer. The objective of this study is to verify the hypothesis, based on the results of bioinformatics analysis, that miR-155 modulates cellular apoptosis and DNA damage through the regulation of Apaf-1 and is thus...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Cancer gene therapy Ročník 19; číslo 11; s. 773 - 778
Hlavní autoři:	Zang, Y-S, Zhong, Y-F, Fang, Z, Li, B, An, J
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Nature Publishing Group US 01.11.2012 Nature Publishing Group
Témata:	631/337/384/331 631/67/1059/99 631/67/68 692/699/67/1612 Antineoplastic Agents - pharmacology Apaf-1 protein Apoptosis Apoptotic Protease-Activating Factor 1 - genetics Apoptotic Protease-Activating Factor 1 - metabolism Bioinformatics Biomedical and Life Sciences Biomedicine Care and treatment Caspase 9 - genetics Caspase 9 - metabolism Cell Line, Tumor Cellular signal transduction Cisplatin Cisplatin - pharmacology Comet Assay Control Deoxyribonucleic acid DNA DNA Damage Drug Resistance, Neoplasm - drug effects Gene Expression Gene Expression Regulation, Neoplastic Gene Silencing Gene Therapy Health aspects Humans Lung cancer Lung Neoplasms - metabolism Lung Neoplasms - pathology MicroRNAs - genetics MicroRNAs - metabolism miRNA mRNA original-article Physiological aspects RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism siRNA Transfection lung cancer apoptosis Apaf-1 cisplatin miR-155 DNA damage
ISSN:	0929-1903, 1476-5500, 1476-5500
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!