MAPK signaling regulates c-MYC for melanoma cell adaptation to asparagine restriction

Amino acid restriction is among promising potential cancer treatment strategies. However, cancer cells employ a multitude of mechanisms to mount resistance to amino acid restriction, which impede the latter’s clinical development. Here we show that MAPK signaling activation in asparagine-restricted...

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Vydáno v:	EMBO reports Ročník 22; číslo 3; s. e51436 - n/a
Hlavní autoři:	Pathria, Gaurav, Verma, Sachin, Yin, Jun, Scott, David A, Ronai, Ze’ev A
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 03.03.2021 Springer Nature B.V John Wiley and Sons Inc
Témata:	Acid resistance Adaptation Amino acids Asparagine ATF4 Cancer Cell activation Cell growth Cell Line, Tumor Cell Proliferation c‐MYC Degradation EMBO03 EMBO21 Glycogen Synthase Kinase 3 Humans MAP kinase MAPK Mechanistic Target of Rapamycin Complex 1 - genetics Mechanistic Target of Rapamycin Complex 1 - metabolism Melanoma Melanoma - genetics mTORC1 Myc protein Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Signal Transduction Signaling melanoma MAPK c-MYC mTORC1 ATF4
ISSN:	1469-221X, 1469-3178, 1469-3178
On-line přístup:	Získat plný text
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