Fusobacterium nucleatum adhesin FadA binds vascular endothelial cadherin and alters endothelial integrity
Summary Fusobacterium nucleatum is a Gram‐negative oral anaerobe, capable of systemic dissemination causing infections and abscesses, often in mixed‐species, at different body sites. We have shown previously that F. nucleatum adheres to and invades host epithelial and endothelial cells via a novel F...
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| Veröffentlicht in: | Molecular microbiology Jg. 82; H. 6; S. 1468 - 1480 |
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| Hauptverfasser: | , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Oxford, UK
Blackwell Publishing Ltd
01.12.2011
Blackwell |
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| ISSN: | 0950-382X, 1365-2958, 1365-2958 |
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| Abstract | Summary
Fusobacterium nucleatum is a Gram‐negative oral anaerobe, capable of systemic dissemination causing infections and abscesses, often in mixed‐species, at different body sites. We have shown previously that F. nucleatum adheres to and invades host epithelial and endothelial cells via a novel FadA adhesin. In this study, vascular endothelial (VE)‐cadherin, a member of the cadherin family and a cell–cell junction molecule, was identified as the endothelial receptor for FadA, required for F. nucleatum binding to the cells. FadA colocalized with VE‐cadherin on endothelial cells, causing relocation of VE‐cadherin away from the cell–cell junctions. As a result, the endothelial permeability was increased, allowing the bacteria to cross the endothelium through loosened junctions. This crossing mechanism may explain why the organism is able to disseminate systemically to colonize in different body sites and even overcome the placental and blood–brain barriers. Co‐incubation of F. nucleatum and Escherichia coli enhanced penetration of the endothelial cells by the latter in the transwell assays, suggesting F. nucleatum may serve as an ‘enabler’ for other microorganisms to spread systemically. This may explain why F. nucleatum is often found in mixed infections. This study reveals a possible novel dissemination mechanism utilized by pathogens. |
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| AbstractList | Fusobacterium nucleatum is a Gram-negative oral anaerobe, capable of systemic dissemination causing infections and abscesses, often in mixed-species, at different body sites. We have shown previously that F. nucleatum adheres to and invades host epithelial and endothelial cells via a novel FadA adhesin. In this study, vascular endothelial (VE)-cadherin, a member of the cadherin family and a cell-cell junction molecule, was identified as the endothelial receptor for FadA, required for F. nucleatum binding to the cells. FadA colocalized with VE-cadherin on endothelial cells, causing relocation of VE-cadherin away from the cell-cell junctions. As a result, the endothelial permeability was increased, allowing the bacteria to cross the endothelium through loosened junctions. This crossing mechanism may explain why the organism is able to disseminate systemically to colonize in different body sites and even overcome the placental and blood-brain barriers. Co-incubation of F. nucleatum and Escherichia coli enhanced penetration of the endothelial cells by the latter in the transwell assays, suggesting F. nucleatum may serve as an 'enabler' for other microorganisms to spread systemically. This may explain why F. nucleatum is often found in mixed infections. This study reveals a possible novel dissemination mechanism utilized by pathogens.Fusobacterium nucleatum is a Gram-negative oral anaerobe, capable of systemic dissemination causing infections and abscesses, often in mixed-species, at different body sites. We have shown previously that F. nucleatum adheres to and invades host epithelial and endothelial cells via a novel FadA adhesin. In this study, vascular endothelial (VE)-cadherin, a member of the cadherin family and a cell-cell junction molecule, was identified as the endothelial receptor for FadA, required for F. nucleatum binding to the cells. FadA colocalized with VE-cadherin on endothelial cells, causing relocation of VE-cadherin away from the cell-cell junctions. As a result, the endothelial permeability was increased, allowing the bacteria to cross the endothelium through loosened junctions. This crossing mechanism may explain why the organism is able to disseminate systemically to colonize in different body sites and even overcome the placental and blood-brain barriers. Co-incubation of F. nucleatum and Escherichia coli enhanced penetration of the endothelial cells by the latter in the transwell assays, suggesting F. nucleatum may serve as an 'enabler' for other microorganisms to spread systemically. This may explain why F. nucleatum is often found in mixed infections. This study reveals a possible novel dissemination mechanism utilized by pathogens. Fusobacterium nucleatum is a Gram-negative oral anaerobe, capable of systemic dissemination causing infections and abscesses, often in mixed-species, at different body sites. We have shown previously that F. nucleatum adheres to and invades host epithelial and endothelial cells via a novel FadA adhesin. In this study, vascular endothelial (VE)-cadherin, a member of the cadherin family and a cell-cell junction molecule, was identified as the endothelial receptor for FadA, required for F. nucleatum binding to the cells. FadA colocalized with VE-cadherin on endothelial cells, causing relocation of VE-cadherin away from the cell-cell junctions. As a result, the endothelial permeability was increased, allowing the bacteria to cross the endothelium through loosened junctions. This crossing mechanism may explain why the organism is able to disseminate systemically to colonize in different body sites and even overcome the placental and blood-brain barriers. Co-incubation of F. nucleatum and Escherichia coli enhanced penetration of the endothelial cells by the latter in the transwell assays, suggesting F. nucleatum may serve as an 'enabler' for other microorganisms to spread systemically. This may explain why F. nucleatum is often found in mixed infections. This study reveals a possible novel dissemination mechanism utilized by pathogens. Fusobacterium nucleatum is a gram-negative oral anaerobe, capable of systemic dissemination causing infections and abscesses, often in mixed-species, at different body sites. We have shown previously that F. nucleatum adheres to and invades host epithelial and endothelial cells via a novel FadA adhesin. In this study, vascular endothelial (VE)-cadherin, a member of the cadherin family and a cell-cell junction molecule, was identified as the endothelial receptor for FadA, required for F. nucleatum binding to the cells. FadA co-localized with VE-cadherin on endothelial cells, causing relocation of VE-cadherin away from the cell-cell junctions. As a result, the endothelial permeability was increased, allowing the bacteria to cross the endothelium through loosened junctions. This crossing mechanism may explain why the organism is able to disseminate systemically to colonize in different body sites and even overcome the placental and blood-brain barriers. Co-incubation of F. nucleatum and E. coli enhanced penetration of the endothelial cells by the latter in the transwell assays, suggesting F. nucleatum may serve as an “enabler” for other microorganisms to spread systemically. This may explain why F. nucleatum is often found in mixed infections. This study reveals a possible novel dissemination mechanism utilized by pathogens. Fusobacterium nucleatum is a Gram‐negative oral anaerobe, capable of systemic dissemination causing infections and abscesses, often in mixed‐species, at different body sites. We have shown previously that F. nucleatum adheres to and invades host epithelial and endothelial cells via a novel FadA adhesin. In this study, vascular endothelial (VE)‐cadherin, a member of the cadherin family and a cell–cell junction molecule, was identified as the endothelial receptor for FadA, required for F. nucleatum binding to the cells. FadA colocalized with VE‐cadherin on endothelial cells, causing relocation of VE‐cadherin away from the cell–cell junctions. As a result, the endothelial permeability was increased, allowing the bacteria to cross the endothelium through loosened junctions. This crossing mechanism may explain why the organism is able to disseminate systemically to colonize in different body sites and even overcome the placental and blood–brain barriers. Co‐incubation of F. nucleatum and Escherichia coli enhanced penetration of the endothelial cells by the latter in the transwell assays, suggesting F. nucleatum may serve as an ‘enabler’ for other microorganisms to spread systemically. This may explain why F. nucleatum is often found in mixed infections. This study reveals a possible novel dissemination mechanism utilized by pathogens. Fusobacterium nucleatum is a Gram-negative oral anaerobe, capable of systemic dissemination causing infections and abscesses, often in mixed-species, at different body sites. We have shown previously that F. nucleatum adheres to and invades host epithelial and endothelial cells via a novel FadA adhesin. In this study, vascular endothelial (VE)-cadherin, a member of the cadherin family and a cell-cell junction molecule, was identified as the endothelial receptor for FadA, required for F. nucleatum binding to the cells. FadA colocalized with VE-cadherin on endothelial cells, causing relocation of VE-cadherin away from the cell-cell junctions. As a result, the endothelial permeability was increased, allowing the bacteria to cross the endothelium through loosened junctions. This crossing mechanism may explain why the organism is able to disseminate systemically to colonize in different body sites and even overcome the placental and blood-brain barriers. Co-incubation of F. nucleatum and Escherichia coli enhanced penetration of the endothelial cells by the latter in the transwell assays, suggesting F. nucleatum may serve as an 'enabler' for other microorganisms to spread systemically. This may explain why F. nucleatum is often found in mixed infections. This study reveals a possible novel dissemination mechanism utilized by pathogens. [PUBLICATION ABSTRACT] Summary Fusobacterium nucleatum is a Gram‐negative oral anaerobe, capable of systemic dissemination causing infections and abscesses, often in mixed‐species, at different body sites. We have shown previously that F. nucleatum adheres to and invades host epithelial and endothelial cells via a novel FadA adhesin. In this study, vascular endothelial (VE)‐cadherin, a member of the cadherin family and a cell–cell junction molecule, was identified as the endothelial receptor for FadA, required for F. nucleatum binding to the cells. FadA colocalized with VE‐cadherin on endothelial cells, causing relocation of VE‐cadherin away from the cell–cell junctions. As a result, the endothelial permeability was increased, allowing the bacteria to cross the endothelium through loosened junctions. This crossing mechanism may explain why the organism is able to disseminate systemically to colonize in different body sites and even overcome the placental and blood–brain barriers. Co‐incubation of F. nucleatum and Escherichia coli enhanced penetration of the endothelial cells by the latter in the transwell assays, suggesting F. nucleatum may serve as an ‘enabler’ for other microorganisms to spread systemically. This may explain why F. nucleatum is often found in mixed infections. This study reveals a possible novel dissemination mechanism utilized by pathogens. |
| Author | Nithianantham, Stanley Wang, Xiaowei Témoin, Stéphanie Lee, David Shoham, Menachem Fardini, Yann Han, Yiping W. |
| AuthorAffiliation | 4 Department of Reproductive Biology, Case Western Reserve University, Cleveland, Ohio 44106, U.S.A 2 Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, U.S.A 3 Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, U.S.A 1 Department of Periodontics, Case Western Reserve University, Cleveland, Ohio 44106, U.S.A |
| AuthorAffiliation_xml | – name: 3 Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, U.S.A – name: 4 Department of Reproductive Biology, Case Western Reserve University, Cleveland, Ohio 44106, U.S.A – name: 1 Department of Periodontics, Case Western Reserve University, Cleveland, Ohio 44106, U.S.A – name: 2 Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, U.S.A |
| Author_xml | – sequence: 1 givenname: Yann surname: Fardini fullname: Fardini, Yann – sequence: 2 givenname: Xiaowei surname: Wang fullname: Wang, Xiaowei – sequence: 3 givenname: Stéphanie surname: Témoin fullname: Témoin, Stéphanie – sequence: 4 givenname: Stanley surname: Nithianantham fullname: Nithianantham, Stanley – sequence: 5 givenname: David surname: Lee fullname: Lee, David – sequence: 6 givenname: Menachem surname: Shoham fullname: Shoham, Menachem – sequence: 7 givenname: Yiping W. surname: Han fullname: Han, Yiping W. |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25273888$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/22040113$$D View this record in MEDLINE/PubMed |
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| Keywords | Bacteria Adhesin Fusobacterium nucleatum Cadherin Cell adhesion molecule Bacteroidaceae |
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Fusobacterium nucleatum is a Gram‐negative oral anaerobe, capable of systemic dissemination causing infections and abscesses, often in mixed‐species,... Fusobacterium nucleatum is a Gram‐negative oral anaerobe, capable of systemic dissemination causing infections and abscesses, often in mixed‐species, at... Fusobacterium nucleatum is a Gram-negative oral anaerobe, capable of systemic dissemination causing infections and abscesses, often in mixed-species, at... Fusobacterium nucleatum is a gram-negative oral anaerobe, capable of systemic dissemination causing infections and abscesses, often in mixed-species, at... |
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| SubjectTerms | Adhesins, Bacterial - chemistry Adhesins, Bacterial - genetics Adhesins, Bacterial - metabolism Amino Acid Motifs Antigens, CD - genetics Antigens, CD - metabolism Bacteria Binding sites Biological and medical sciences Blood-Brain Barrier - metabolism Blood-Brain Barrier - microbiology Cadherins - genetics Cadherins - metabolism Cell adhesion & migration Cells E coli Endothelial Cells - metabolism Endothelial Cells - microbiology Escherichia coli Fundamental and applied biological sciences. Psychology Fusobacterium Infections - metabolism Fusobacterium Infections - microbiology Fusobacterium nucleatum Fusobacterium nucleatum - chemistry Fusobacterium nucleatum - genetics Fusobacterium nucleatum - metabolism Gram-negative bacteria Humans Microbiology Microorganisms Protein Binding Relocation |
| Title | Fusobacterium nucleatum adhesin FadA binds vascular endothelial cadherin and alters endothelial integrity |
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