Polygenic Hyperlipidemias and Coronary Artery Disease Risk

Hyperlipidemia is a highly heritable risk factor for coronary artery disease (CAD). While monogenic familial hypercholesterolemia associates with severely increased CAD risk, it remains less clear to what extent a high polygenic load of a large number of LDL (low-density lipoprotein) cholesterol (LD...

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Bibliographic Details
Published in:	Circulation. Genomic and precision medicine Vol. 13; no. 2; p. e002725
Main Authors:	Ripatti, Pietari, Rämö, Joel T, Mars, Nina J, Fu, Yu, Lin, Jake, Söderlund, Sanni, Benner, Christian, Surakka, Ida, Kiiskinen, Tuomo, Havulinna, Aki S, Palta, Priit, Freimer, Nelson B, Widén, Elisabeth, Salomaa, Veikko, Tukiainen, Taru, Pirinen, Matti, Palotie, Aarno, Taskinen, Marja-Riitta, Ripatti, Samuli
Format:	Journal Article
Language:	English
Published:	United States 01.04.2020
Subjects:	Cholesterol, LDL - blood Cohort Studies Coronary Artery Disease - blood Coronary Artery Disease - epidemiology Coronary Artery Disease - etiology Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Hyperlipidemias - complications Hyperlipidemias - genetics Male Middle Aged Multifactorial Inheritance Polymorphism, Single Nucleotide Prognosis Risk Factors Triglycerides - blood coronary artery disease hypertriglyceridemia risk factors humans hypercholesterolemia
ISSN:	2574-8300, 2574-8300
Online Access:	Get more information
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