Self-Assembled Gels for Biomedical Applications

Natural and synthetic gel‐like materials have featured heavily in the development of biomaterials for wound healing and other tissue‐engineering purposes. More recently, molecular gels have been designed and tailored for the same purpose. When mixed with, or conjugated to therapeutic drugs or bioact...

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Veröffentlicht in:	Chemistry, an Asian journal Jg. 6; H. 1; S. 30 - 42
Hauptverfasser:	Truong, Warren Ty, Su, Yingying, Meijer, Joris T., Thordarson, Pall, Braet, Filip
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Weinheim WILEY-VCH Verlag 03.01.2011 WILEY‐VCH Verlag Wiley Subscription Services, Inc
Schlagworte:	Amino Acid Sequence Biocompatible Materials - chemistry biomaterials Biomedical materials Chemistry Chemistry, Pharmaceutical gels Gels - chemistry medicinal chemistry Models, Biological Molecular Sequence Data self-assembly sol-gel processes Tissue Engineering Wound Healing
ISSN:	1861-4728, 1861-471X, 1861-471X
Online-Zugang:	Volltext
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Abstract	Natural and synthetic gel‐like materials have featured heavily in the development of biomaterials for wound healing and other tissue‐engineering purposes. More recently, molecular gels have been designed and tailored for the same purpose. When mixed with, or conjugated to therapeutic drugs or bioactive molecules, these materials hold great promise for treating/curing life‐threatening and degenerative diseases, such as cancer, osteoarthritis, and neural injuries. This focus review explores the latest advances in this field and concentrates on self‐assembled gels formed under aqueous conditions (i.e., self‐assembled hydrogels), and critically compares their performance within different biomedical applications, including three‐dimensional cell‐culture studies, drug delivery, and tissue engineering. Although stability and toxicity issues still need to be addressed in more detail, it is clear from the work reviewed here that self‐assembled gels have a bright future as novel biomaterials. Self‐assembled medicine! Emerging medical applications of self‐assembled gels (see picture) based on interactions between these materials with cells and tissues, such as drug delivery, 3D cell cultures, and tissue engineering, are discussed.
AbstractList	Natural and synthetic gel-like materials have featured heavily in the development of biomaterials for wound healing and other tissue-engineering purposes. More recently, molecular gels have been designed and tailored for the same purpose. When mixed with, or conjugated to therapeutic drugs or bioactive molecules, these materials hold great promise for treating/curing life-threatening and degenerative diseases, such as cancer, osteoarthritis, and neural injuries. This focus review explores the latest advances in this field and concentrates on self-assembled gels formed under aqueous conditions (i.e., self-assembled hydrogels), and critically compares their performance within different biomedical applications, including three-dimensional cell-culture studies, drug delivery, and tissue engineering. Although stability and toxicity issues still need to be addressed in more detail, it is clear from the work reviewed here that self-assembled gels have a bright future as novel biomaterials. [PUBLICATION ABSTRACT] Natural and synthetic gel-like materials have featured heavily in the development of biomaterials for wound healing and other tissue-engineering purposes. More recently, molecular gels have been designed and tailored for the same purpose. When mixed with, or conjugated to therapeutic drugs or bioactive molecules, these materials hold great promise for treating/curing life-threatening and degenerative diseases, such as cancer, osteoarthritis, and neural injuries. This focus review explores the latest advances in this field and concentrates on self-assembled gels formed under aqueous conditions (i.e., self-assembled hydrogels), and critically compares their performance within different biomedical applications, including three-dimensional cell-culture studies, drug delivery, and tissue engineering. Although stability and toxicity issues still need to be addressed in more detail, it is clear from the work reviewed here that self-assembled gels have a bright future as novel biomaterials.Natural and synthetic gel-like materials have featured heavily in the development of biomaterials for wound healing and other tissue-engineering purposes. More recently, molecular gels have been designed and tailored for the same purpose. When mixed with, or conjugated to therapeutic drugs or bioactive molecules, these materials hold great promise for treating/curing life-threatening and degenerative diseases, such as cancer, osteoarthritis, and neural injuries. This focus review explores the latest advances in this field and concentrates on self-assembled gels formed under aqueous conditions (i.e., self-assembled hydrogels), and critically compares their performance within different biomedical applications, including three-dimensional cell-culture studies, drug delivery, and tissue engineering. Although stability and toxicity issues still need to be addressed in more detail, it is clear from the work reviewed here that self-assembled gels have a bright future as novel biomaterials. Natural and synthetic gel‐like materials have featured heavily in the development of biomaterials for wound healing and other tissue‐engineering purposes. More recently, molecular gels have been designed and tailored for the same purpose. When mixed with, or conjugated to therapeutic drugs or bioactive molecules, these materials hold great promise for treating/curing life‐threatening and degenerative diseases, such as cancer, osteoarthritis, and neural injuries. This focus review explores the latest advances in this field and concentrates on self‐assembled gels formed under aqueous conditions (i.e., self‐assembled hydrogels), and critically compares their performance within different biomedical applications, including three‐dimensional cell‐culture studies, drug delivery, and tissue engineering. Although stability and toxicity issues still need to be addressed in more detail, it is clear from the work reviewed here that self‐assembled gels have a bright future as novel biomaterials. magnified image Natural and synthetic gel‐like materials have featured heavily in the development of biomaterials for wound healing and other tissue‐engineering purposes. More recently, molecular gels have been designed and tailored for the same purpose. When mixed with, or conjugated to therapeutic drugs or bioactive molecules, these materials hold great promise for treating/curing life‐threatening and degenerative diseases, such as cancer, osteoarthritis, and neural injuries. This focus review explores the latest advances in this field and concentrates on self‐assembled gels formed under aqueous conditions (i.e., self‐assembled hydrogels), and critically compares their performance within different biomedical applications, including three‐dimensional cell‐culture studies, drug delivery, and tissue engineering. Although stability and toxicity issues still need to be addressed in more detail, it is clear from the work reviewed here that self‐assembled gels have a bright future as novel biomaterials. Self‐assembled medicine! Emerging medical applications of self‐assembled gels (see picture) based on interactions between these materials with cells and tissues, such as drug delivery, 3D cell cultures, and tissue engineering, are discussed. Natural and synthetic gel-like materials have featured heavily in the development of biomaterials for wound healing and other tissue-engineering purposes. More recently, molecular gels have been designed and tailored for the same purpose. When mixed with, or conjugated to therapeutic drugs or bioactive molecules, these materials hold great promise for treating/curing life-threatening and degenerative diseases, such as cancer, osteoarthritis, and neural injuries. This focus review explores the latest advances in this field and concentrates on self-assembled gels formed under aqueous conditions (i.e., self-assembled hydrogels), and critically compares their performance within different biomedical applications, including three-dimensional cell-culture studies, drug delivery, and tissue engineering. Although stability and toxicity issues still need to be addressed in more detail, it is clear from the work reviewed here that self-assembled gels have a bright future as novel biomaterials.
Author	Su, Yingying Braet, Filip Truong, Warren Ty Thordarson, Pall Meijer, Joris T.
Author_xml	– sequence: 1 givenname: Warren Ty surname: Truong fullname: Truong, Warren Ty organization: School of Chemistry, The University of New South Wales, NSW 2052 (Australia) – sequence: 2 givenname: Yingying surname: Su fullname: Su, Yingying organization: Australian Key Centre for Microscopy and Microanalysis, The University to Sydney, NSW 2006 (Australia), Fax: (+61) 2-9351-7682 – sequence: 3 givenname: Joris T. surname: Meijer fullname: Meijer, Joris T. organization: School of Chemistry, The University of New South Wales, NSW 2052 (Australia) – sequence: 4 givenname: Pall surname: Thordarson fullname: Thordarson, Pall organization: School of Chemistry, The University of New South Wales, NSW 2052 (Australia) – sequence: 5 givenname: Filip surname: Braet fullname: Braet, Filip organization: Australian Key Centre for Microscopy and Microanalysis, The University to Sydney, NSW 2006 (Australia), Fax: (+61) 2-9351-7682
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/21077096$$D View this record in MEDLINE/PubMed
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Snippet	Natural and synthetic gel‐like materials have featured heavily in the development of biomaterials for wound healing and other tissue‐engineering purposes. More... Natural and synthetic gel-like materials have featured heavily in the development of biomaterials for wound healing and other tissue-engineering purposes. More...
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SubjectTerms	Amino Acid Sequence Biocompatible Materials - chemistry biomaterials Biomedical materials Chemistry Chemistry, Pharmaceutical gels Gels - chemistry medicinal chemistry Models, Biological Molecular Sequence Data self-assembly sol-gel processes Tissue Engineering Wound Healing
Title	Self-Assembled Gels for Biomedical Applications
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