The thickness and volume of LLETZ specimens can predict the relative risk of pregnancy-related morbidity
Please cite this paper as: Khalid S, Dimitriou E, Conroy R, Paraskevaidis E, Kyrgiou M, Harrity C, Arbyn M, Prendiville W. The thickness and volume of LLETZ specimens can predict the relative risk of pregnancy‐related morbidity. BJOG 2012;119:685–691. Objective The aim of this study was to determin...
Gespeichert in:
| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology Jg. 119; H. 6; S. 685 - 691 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
Oxford, UK
Blackwell Publishing Ltd
01.05.2012
Blackwell Wiley Subscription Services, Inc |
| Schlagworte: | |
| ISSN: | 1470-0328, 1471-0528, 1471-0528 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Please cite this paper as: Khalid S, Dimitriou E, Conroy R, Paraskevaidis E, Kyrgiou M, Harrity C, Arbyn M, Prendiville W. The thickness and volume of LLETZ specimens can predict the relative risk of pregnancy‐related morbidity. BJOG 2012;119:685–691.
Objective The aim of this study was to determine if the individual physical characteristics of the extirpated transformation zone after large loop excision of the transformation zone (LLETZ) might predict the relative risk of adverse obstetric outcome, specifically preterm labour (PTL).
Design A retrospective observational study.
Setting University teaching hospital in Dublin (Coombe Women & Infants University Hospital, CWIUH).
Population Women who had LLETZ treatment for cervical intraepithelial neoplasia (CIN) in the colposcopy service between 1999 and 2002, and who subsequently had a pregnancy at the CWIUH.
Methods Case records and histology reports for eligible women were examined. Age, parity, smoking history, pregnancy complications and CIN grade were recorded. Exclusion criteria were age >42 years, previous treatment for CIN, previous premature labour or twin pregnancies. The Student’s t‐test, Mann–Whitney U‐test, analysis of variants (ANOVA) and logistic regression were employed to analyse the data.
Main outcome measures Gestational age at birth, PTL (i.e. <37 weeks of gestation) and miscarriage rate (<24 weeks of gestation).
Results Out of 1808 women who underwent LLETZ treatment, a total of 353 women were identified who subsequently had a pregnancy at the CWIUH, with 321 being eligible for inclusion in the study. Of these, 76.3% delivered at term, 9.1% delivered at <37 weeks of gestation and 14.6% miscarried at <24 weeks of gestation. There was a three‐fold increase in the risk of PTL if the excision volume exceeded 6 cm3 (RR = 3.00; 95% CI 1.45–5.92), or when the thickness of the excised tissue was greater than 12 mm (RR = 2.98; 95% CI 1.27–7.01). The time interval between LLETZ and pregnancy did not appear to have an effect on PTL rates. We found no association between the grade of CIN and the risk of PTL.
Conclusions This study reveals that the thickness and the total volume of the excised transformation zone are associated with an increased risk of PTL. Excisions thicker than 1.2 cm and larger than 6 cm3 carry a three times greater risk for PTL. |
|---|---|
| AbstractList | Please cite this paper as:
Khalid S, Dimitriou E, Conroy R, Paraskevaidis E, Kyrgiou M, Harrity C, Arbyn M, Prendiville W. The thickness and volume of LLETZ specimens can predict the relative risk of pregnancy‐related morbidity. BJOG 2012;119:685–691.
Objective
The aim of this study was to determine if the individual physical characteristics of the extirpated transformation zone after large loop excision of the transformation zone (LLETZ) might predict the relative risk of adverse obstetric outcome, specifically preterm labour (PTL).
Design
A retrospective observational study.
Setting
University teaching hospital in Dublin (Coombe Women & Infants University Hospital, CWIUH).
Population
Women who had LLETZ treatment for cervical intraepithelial neoplasia (CIN) in the colposcopy service between 1999 and 2002, and who subsequently had a pregnancy at the CWIUH.
Methods
Case records and histology reports for eligible women were examined. Age, parity, smoking history, pregnancy complications and CIN grade were recorded. Exclusion criteria were age >42 years, previous treatment for CIN, previous premature labour or twin pregnancies. The Student’s
t
‐test, Mann–Whitney
U
‐test, analysis of variants (ANOVA) and logistic regression were employed to analyse the data.
Main outcome measures
Gestational age at birth, PTL (i.e. <37 weeks of gestation) and miscarriage rate (<24 weeks of gestation).
Results
Out of 1808 women who underwent LLETZ treatment, a total of 353 women were identified who subsequently had a pregnancy at the CWIUH, with 321 being eligible for inclusion in the study. Of these, 76.3% delivered at term, 9.1% delivered at <37 weeks of gestation and 14.6% miscarried at <24 weeks of gestation. There was a three‐fold increase in the risk of PTL if the excision volume exceeded 6 cm
3
(RR = 3.00; 95% CI 1.45–5.92), or when the thickness of the excised tissue was greater than 12 mm (RR = 2.98; 95% CI 1.27–7.01). The time interval between LLETZ and pregnancy did not appear to have an effect on PTL rates. We found no association between the grade of CIN and the risk of PTL.
Conclusions
This study reveals that the thickness and the total volume of the excised transformation zone are associated with an increased risk of PTL. Excisions thicker than 1.2 cm and larger than 6 cm
3
carry a three times greater risk for PTL. The aim of this study was to determine if the individual physical characteristics of the extirpated transformation zone after large loop excision of the transformation zone (LLETZ) might predict the relative risk of adverse obstetric outcome, specifically preterm labour (PTL). A retrospective observational study. University teaching hospital in Dublin (Coombe Women & Infants University Hospital, CWIUH). Women who had LLETZ treatment for cervical intraepithelial neoplasia (CIN) in the colposcopy service between 1999 and 2002, and who subsequently had a pregnancy at the CWIUH. Case records and histology reports for eligible women were examined. Age, parity, smoking history, pregnancy complications and CIN grade were recorded. Exclusion criteria were age >42 years, previous treatment for CIN, previous premature labour or twin pregnancies. The Student's t-test, Mann-Whitney U-test, analysis of variants (ANOVA) and logistic regression were employed to analyse the data. Gestational age at birth, PTL (i.e. <37 weeks of gestation) and miscarriage rate (<24 weeks of gestation). Out of 1808 women who underwent LLETZ treatment, a total of 353 women were identified who subsequently had a pregnancy at the CWIUH, with 321 being eligible for inclusion in the study. Of these, 76.3% delivered at term, 9.1% delivered at <37 weeks of gestation and 14.6% miscarried at <24 weeks of gestation. There was a three-fold increase in the risk of PTL if the excision volume exceeded 6 cm(3) (RR = 3.00; 95% CI 1.45-5.92), or when the thickness of the excised tissue was greater than 12 mm (RR = 2.98; 95% CI 1.27-7.01). The time interval between LLETZ and pregnancy did not appear to have an effect on PTL rates. We found no association between the grade of CIN and the risk of PTL. This study reveals that the thickness and the total volume of the excised transformation zone are associated with an increased risk of PTL. Excisions thicker than 1.2 cm and larger than 6 cm(3) carry a three times greater risk for PTL. Please cite this paper as: Khalid S, Dimitriou E, Conroy R, Paraskevaidis E, Kyrgiou M, Harrity C, Arbyn M, Prendiville W. The thickness and volume of LLETZ specimens can predict the relative risk of pregnancy‐related morbidity. BJOG 2012;119:685–691. Objective The aim of this study was to determine if the individual physical characteristics of the extirpated transformation zone after large loop excision of the transformation zone (LLETZ) might predict the relative risk of adverse obstetric outcome, specifically preterm labour (PTL). Design A retrospective observational study. Setting University teaching hospital in Dublin (Coombe Women & Infants University Hospital, CWIUH). Population Women who had LLETZ treatment for cervical intraepithelial neoplasia (CIN) in the colposcopy service between 1999 and 2002, and who subsequently had a pregnancy at the CWIUH. Methods Case records and histology reports for eligible women were examined. Age, parity, smoking history, pregnancy complications and CIN grade were recorded. Exclusion criteria were age >42 years, previous treatment for CIN, previous premature labour or twin pregnancies. The Student’s t‐test, Mann–Whitney U‐test, analysis of variants (ANOVA) and logistic regression were employed to analyse the data. Main outcome measures Gestational age at birth, PTL (i.e. <37 weeks of gestation) and miscarriage rate (<24 weeks of gestation). Results Out of 1808 women who underwent LLETZ treatment, a total of 353 women were identified who subsequently had a pregnancy at the CWIUH, with 321 being eligible for inclusion in the study. Of these, 76.3% delivered at term, 9.1% delivered at <37 weeks of gestation and 14.6% miscarried at <24 weeks of gestation. There was a three‐fold increase in the risk of PTL if the excision volume exceeded 6 cm3 (RR = 3.00; 95% CI 1.45–5.92), or when the thickness of the excised tissue was greater than 12 mm (RR = 2.98; 95% CI 1.27–7.01). The time interval between LLETZ and pregnancy did not appear to have an effect on PTL rates. We found no association between the grade of CIN and the risk of PTL. Conclusions This study reveals that the thickness and the total volume of the excised transformation zone are associated with an increased risk of PTL. Excisions thicker than 1.2 cm and larger than 6 cm3 carry a three times greater risk for PTL. Objective: The aim of this study was to determine if the individual physical characteristics of the extirpated transformation zone after large loop excision of the transformation zone (LLETZ) might predict the relative risk of adverse obstetric outcome, specifically preterm labor (PTL). Design: A retrospective observational study. Setting: University teaching hospital in Dublin (Coombe Women & Infants University Hospital, CWIUH). Population: Women who had LLETZ treatment for cervical intraepithelial neoplasia (CIN) in the colposcopy service between 1999 and 2002, and who subsequently had a pregnancy at the CWIUH. Methods: Case records and histology reports for eligible women were examined. Age, parity, smoking history, pregnancy complications and CIN grade were recorded. Exclusion criteria were age >42years, previous treatment for CIN, previous premature labor or twin pregnancies. The Student's t-test, Mann-Whitney U-test, analysis of variants (ANOVA) and logistic regression were employed to analyze the data. Main outcome measures: Gestational age at birth, PTL (i.e. <37weeks of gestation) and miscarriage rate (<24weeks of gestation). Results: Out of 1808 women who underwent LLETZ treatment, a total of 353 women were identified who subsequently had a pregnancy at the CWIUH, with 321 being eligible for inclusion in the study. Of these, 76.3% delivered at term, 9.1% delivered at <37weeks of gestation and 14.6% miscarried at <24weeks of gestation. There was a three-fold increase in the risk of PTL if the excision volume exceeded 6cm3 (RR=3.00; 95%CI 1.45-5.92), or when the thickness of the excised tissue was greater than 12mm (RR=2.98; 95%CI 1.27-7.01). The time interval between LLETZ and pregnancy did not appear to have an effect on PTL rates. We found no association between the grade of CIN and the risk of PTL. Conclusions: This study reveals that the thickness and the total volume of the excised transformation zone are associated with an increased risk of PTL. Excisions thicker than 1.2cm and larger than 6cm3 carry a three times greater risk for PTL. [PUBLICATION ABSTRACT] The aim of this study was to determine if the individual physical characteristics of the extirpated transformation zone after large loop excision of the transformation zone (LLETZ) might predict the relative risk of adverse obstetric outcome, specifically preterm labour (PTL).OBJECTIVEThe aim of this study was to determine if the individual physical characteristics of the extirpated transformation zone after large loop excision of the transformation zone (LLETZ) might predict the relative risk of adverse obstetric outcome, specifically preterm labour (PTL).A retrospective observational study.DESIGNA retrospective observational study.University teaching hospital in Dublin (Coombe Women & Infants University Hospital, CWIUH).SETTINGUniversity teaching hospital in Dublin (Coombe Women & Infants University Hospital, CWIUH).Women who had LLETZ treatment for cervical intraepithelial neoplasia (CIN) in the colposcopy service between 1999 and 2002, and who subsequently had a pregnancy at the CWIUH.POPULATIONWomen who had LLETZ treatment for cervical intraepithelial neoplasia (CIN) in the colposcopy service between 1999 and 2002, and who subsequently had a pregnancy at the CWIUH.Case records and histology reports for eligible women were examined. Age, parity, smoking history, pregnancy complications and CIN grade were recorded. Exclusion criteria were age >42 years, previous treatment for CIN, previous premature labour or twin pregnancies. The Student's t-test, Mann-Whitney U-test, analysis of variants (ANOVA) and logistic regression were employed to analyse the data.METHODSCase records and histology reports for eligible women were examined. Age, parity, smoking history, pregnancy complications and CIN grade were recorded. Exclusion criteria were age >42 years, previous treatment for CIN, previous premature labour or twin pregnancies. The Student's t-test, Mann-Whitney U-test, analysis of variants (ANOVA) and logistic regression were employed to analyse the data.Gestational age at birth, PTL (i.e. <37 weeks of gestation) and miscarriage rate (<24 weeks of gestation).MAIN OUTCOME MEASURESGestational age at birth, PTL (i.e. <37 weeks of gestation) and miscarriage rate (<24 weeks of gestation).Out of 1808 women who underwent LLETZ treatment, a total of 353 women were identified who subsequently had a pregnancy at the CWIUH, with 321 being eligible for inclusion in the study. Of these, 76.3% delivered at term, 9.1% delivered at <37 weeks of gestation and 14.6% miscarried at <24 weeks of gestation. There was a three-fold increase in the risk of PTL if the excision volume exceeded 6 cm(3) (RR = 3.00; 95% CI 1.45-5.92), or when the thickness of the excised tissue was greater than 12 mm (RR = 2.98; 95% CI 1.27-7.01). The time interval between LLETZ and pregnancy did not appear to have an effect on PTL rates. We found no association between the grade of CIN and the risk of PTL.RESULTSOut of 1808 women who underwent LLETZ treatment, a total of 353 women were identified who subsequently had a pregnancy at the CWIUH, with 321 being eligible for inclusion in the study. Of these, 76.3% delivered at term, 9.1% delivered at <37 weeks of gestation and 14.6% miscarried at <24 weeks of gestation. There was a three-fold increase in the risk of PTL if the excision volume exceeded 6 cm(3) (RR = 3.00; 95% CI 1.45-5.92), or when the thickness of the excised tissue was greater than 12 mm (RR = 2.98; 95% CI 1.27-7.01). The time interval between LLETZ and pregnancy did not appear to have an effect on PTL rates. We found no association between the grade of CIN and the risk of PTL.This study reveals that the thickness and the total volume of the excised transformation zone are associated with an increased risk of PTL. Excisions thicker than 1.2 cm and larger than 6 cm(3) carry a three times greater risk for PTL.CONCLUSIONSThis study reveals that the thickness and the total volume of the excised transformation zone are associated with an increased risk of PTL. Excisions thicker than 1.2 cm and larger than 6 cm(3) carry a three times greater risk for PTL. |
| Author | Dimitriou, E Conroy, R Harrity, C Khalid, S Paraskevaidis, E Prendiville, W Arbyn, M Kyrgiou, M |
| Author_xml | – sequence: 1 givenname: S surname: Khalid fullname: Khalid, S organization: RCSI Department of Gynaecology, Coombe Women & Infants University Hospital, Dublin, Ireland – sequence: 2 givenname: E surname: Dimitriou fullname: Dimitriou, E organization: RCSI Department of Gynaecology, Coombe Women & Infants University Hospital, Dublin, Ireland – sequence: 3 givenname: R surname: Conroy fullname: Conroy, R organization: Division of Population Health Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland – sequence: 4 givenname: E surname: Paraskevaidis fullname: Paraskevaidis, E organization: University Hospital of Ioannina, Ioannina, Greece – sequence: 5 givenname: M surname: Kyrgiou fullname: Kyrgiou, M organization: Department of Gynaecologic Oncology - Obstetrics & Gynaecology, Queen Charlotte's & Chelsea - Hammersmith Hospital, London, UK – sequence: 6 givenname: C surname: Harrity fullname: Harrity, C organization: RCSI Department of Gynaecology, Coombe Women & Infants University Hospital, Dublin, Ireland – sequence: 7 givenname: M surname: Arbyn fullname: Arbyn, M organization: Unit of Cancer Epidemiology, Scientific Institute of Public Health, Brussels, Belgium – sequence: 8 givenname: W surname: Prendiville fullname: Prendiville, W organization: RCSI Department of Gynaecology, Coombe Women & Infants University Hospital, Dublin, Ireland |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25783995$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/22329499$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkV1v0zAUhiM0xD7gLyALCXGVYB_HjXMBEhtjfFTsplC0G8t1TqjbxCl2Otp_j9N2Q9rV7Asf6X3eY_u8p8mR6xwmCWE0Y3G9XWQsL1hKBcgMKGMZ5SAg2zxJTu6Fo11N0yjJ4-Q0hAWlbASUP0uOATiUeVmeJPPJHEk_t2bpMASiXUVuu2bdIulqMh5fTm5IWKGxLbpAjHZk5bGypo8eJB4b3dvbWNiwHAxR_O20M9t0J2FF2s7PbGX77fPkaa2bgC8O51ny49Pl5OJzOr6--nLxYZwawTikOUrOWS01AIWRAToTEkCUvBoVVFJBgZpKVrmgvMZC8BFINFAAm4m4DfKz5M2-78p3f9YYetXaYLBptMNuHVRZ8pJKyPNIvnpALrq1d_FxEYJSRgQi9PIArWctVmrlbav9Vt1NMAKvD4AORje1j9-34T8nCsnLUkTu_Z4zvgvBY62M7eP0Otd7bRvFqBqiVQs1JKiGBNUQrdpFqzaxgXzQ4O6OR1jf7a1_bYPbR_vU-dfroYr-dO-3ocfNvV_7pRoVvBBq-v1KTX9Nf96MP56rb_wf0yrH4w |
| CODEN | BIOGFQ |
| CitedBy_id | crossref_primary_10_1007_s00404_013_2873_1 crossref_primary_10_1016_j_jgyn_2013_05_004 crossref_primary_10_1155_2013_686027 crossref_primary_10_1016_j_ogc_2013_03_004 crossref_primary_10_1186_s12884_018_1765_6 crossref_primary_10_1055_a_1909_0735 crossref_primary_10_1007_s00404_022_06760_5 crossref_primary_10_1016_j_ijgo_2013_03_013 crossref_primary_10_1016_j_ijgo_2014_07_038 crossref_primary_10_1097_AOG_0000000000000632 crossref_primary_10_1097_LGT_0000000000000156 crossref_primary_10_1016_j_ejogrb_2016_03_021 crossref_primary_10_1111_1471_0528_12105 crossref_primary_10_1007_s00404_021_06209_1 crossref_primary_10_1016_j_jgyn_2014_11_002 crossref_primary_10_1097_LGT_0b013e3182854399 crossref_primary_10_1111_jog_13767 crossref_primary_10_1016_j_jgyn_2015_07_005 crossref_primary_10_1111_j_1471_0528_2012_03291_x crossref_primary_10_4103_njcp_njcp_624_23 crossref_primary_10_1007_s00404_013_3011_9 crossref_primary_10_1016_S1470_2045_22_00191_7 crossref_primary_10_1111_aogs_12298 crossref_primary_10_1111_aogs_13543 crossref_primary_10_1136_bmjopen_2017_020675 crossref_primary_10_1155_2016_3056407 crossref_primary_10_3390_life13081775 crossref_primary_10_1007_s00404_013_2882_0 crossref_primary_10_1016_j_ogrm_2020_02_008 crossref_primary_10_1097_LGT_0000000000000283 crossref_primary_10_1186_s12879_015_1277_1 crossref_primary_10_1007_s00129_016_3839_8 crossref_primary_10_1007_s00404_018_5019_7 crossref_primary_10_3109_14767058_2015_1006619 crossref_primary_10_1007_s11845_018_1893_z crossref_primary_10_1016_j_ogc_2013_02_002 crossref_primary_10_1080_03630242_2025_2501074 crossref_primary_10_2147_IJWH_S436624 crossref_primary_10_1586_14737140_2014_867810 crossref_primary_10_31083_j_ceog5011239 crossref_primary_10_1016_j_ajog_2014_06_032 crossref_primary_10_1111_jog_13582 crossref_primary_10_1016_j_jgyn_2013_03_014 crossref_primary_10_1097_CEJ_0000000000000196 crossref_primary_10_1093_humrep_deu195 crossref_primary_10_1016_j_bpobgyn_2021_05_007 crossref_primary_10_1186_s12916_022_02276_6 crossref_primary_10_1007_s00404_019_05416_1 crossref_primary_10_1016_j_ejogrb_2014_06_011 crossref_primary_10_1136_bmjopen_2018_028008 crossref_primary_10_1007_s00404_013_3134_z crossref_primary_10_1016_j_jogoh_2016_11_001 crossref_primary_10_1097_IGC_0b013e3182885496 crossref_primary_10_1136_bmjopen_2018_028009 crossref_primary_10_1371_journal_pmed_1003665 crossref_primary_10_1016_j_ejogrb_2014_12_004 crossref_primary_10_12968_hmed_2016_77_8_C124 crossref_primary_10_1016_j_ejogrb_2019_02_025 crossref_primary_10_7759_cureus_30154 crossref_primary_10_1111_1471_0528_12390 crossref_primary_10_3109_01443615_2015_1060202 crossref_primary_10_1111_1471_0528_13839 crossref_primary_10_1016_j_ajog_2018_07_023 crossref_primary_10_1007_s00404_018_4704_x crossref_primary_10_1111_1471_0528_2012_03505_x crossref_primary_10_12688_f1000research_9701_1 crossref_primary_10_1007_s00404_013_2955_0 crossref_primary_10_1016_j_ejogrb_2016_05_029 crossref_primary_10_1186_s12905_019_0727_0 crossref_primary_10_1007_s00404_020_05718_9 crossref_primary_10_1016_j_jgyn_2015_02_016 crossref_primary_10_1186_s41205_022_00143_x |
| Cites_doi | 10.1136/bmj.a1284 10.1111/j.1471-0528.2011.02944.x 10.1097/01.AOG.0000251497.55065.74 10.1016/S0140-6736(06)68181-6 10.1097/AOG.0b013e3181bf1ef2 10.1111/j.1471-0528.1989.tb03380.x 10.1001/jama.291.17.2100 10.1016/S0029-7844(97)00489-4 |
| ContentType | Journal Article |
| Copyright | 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG 2015 INIST-CNRS 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG. |
| Copyright_xml | – notice: 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG – notice: 2015 INIST-CNRS – notice: 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG. |
| DBID | BSCLL AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7QP ASE FPQ K6X K9. 7X8 |
| DOI | 10.1111/j.1471-0528.2011.03252.x |
| DatabaseName | Istex CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Calcium & Calcified Tissue Abstracts British Nursing Index British Nursing Index (BNI) (1985 to Present) British Nursing Index ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Health & Medical Complete (Alumni) British Nursing Index Calcium & Calcified Tissue Abstracts MEDLINE - Academic |
| DatabaseTitleList | CrossRef MEDLINE ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1471-0528 |
| EndPage | 691 |
| ExternalDocumentID | 2629919851 22329499 25783995 10_1111_j_1471_0528_2011_03252_x BJO3252 ark_67375_WNG_WXWVZLDB_K |
| Genre | article Research Support, Non-U.S. Gov't Journal Article Feature |
| GeographicLocations | Dublin Ireland |
| GeographicLocations_xml | – name: Dublin Ireland |
| GroupedDBID | --- --K .3N .55 .GA .GJ .Y3 05W 0R~ 10A 1B1 1OB 1OC 1~5 23N 33P 36B 3O- 3SF 4.4 4G. 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5HH 5LA 5RE 5VS 66C 6J9 6P2 6PF 7-5 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAEDT AAESR AAEVG AAHQN AAIPD AALRI AAMNL AANHP AANLZ AAONW AAQFI AASGY AAWTL AAXRX AAXUO AAYCA AAZKR ABCQN ABCUV ABEML ABLJU ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCZN ACFBH ACGFO ACGFS ACGOF ACIUM ACMXC ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADMUD ADNMO ADOZA ADXAS ADZMN AEIGN AEIMD AEUYR AEYWJ AFBPY AFEBI AFFPM AFGKR AFWVQ AFZJQ AGHNM AGQPQ AGYGG AHBTC AHEFC AHMBA AIACR AIAGR AIQQE AITYG AIURR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BROTX BRXPI BSCLL BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DUUFO EBS EJD EMOBN EX3 F00 F01 F04 F5P FDB FEDTE FZ0 G-S G.N GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M41 MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NEJ NF~ O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 R.K RIWAO RJQFR ROL RPZ RX1 SAMSI SEW SSZ SUPJJ TEORI V9Y W8V W99 WBKPD WHWMO WIH WIJ WIK WOHZO WOW WQJ WVDHM WXI WXSBR X7M XG1 XIF XV2 ZXP ZY1 ~IA ~WT 9DU AAYXX CITATION O8X IQODW RIG AAHHS ACCFJ ADZOD AEEZP AEQDE AIWBW AJBDE CGR CUY CVF ECM EIF NPM 7QP ASE FPQ K6X K9. 7X8 |
| ID | FETCH-LOGICAL-c5132-4e8331f8a22026c20b5822593d670805020cd8d4503fe753628ec2721b5b5bce3 |
| IEDL.DBID | DRFUL |
| ISICitedReferencesCount | 89 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000302605500037&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1470-0328 1471-0528 |
| IngestDate | Fri Jul 11 09:43:20 EDT 2025 Fri Oct 03 03:31:15 EDT 2025 Thu Apr 03 07:01:10 EDT 2025 Mon Jul 21 09:18:02 EDT 2025 Sat Nov 29 01:57:05 EST 2025 Tue Nov 18 21:00:25 EST 2025 Sun Sep 21 06:21:42 EDT 2025 Sun Sep 21 06:19:47 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Keywords | Thickness Pregnancy Prognosis Volume Gynecology Risk factor Predictive factor Obstetrics Morbidity |
| Language | English |
| License | CC BY 4.0 2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5132-4e8331f8a22026c20b5822593d670805020cd8d4503fe753628ec2721b5b5bce3 |
| Notes | istex:886D05FDC3E585AEAFEC4C3139D07229124D7A90 ark:/67375/WNG-WXWVZLDB-K ArticleID:BJO3252 [Corrections added after online publication 17 February 2012: E Paraskevaides was changed to E Paraskevaidis in the author list and ‘Unit of Cancer Epidemiology’ was added to the affiliation for M Arbyn]. SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://zenodo.org/record/3436801 |
| PMID | 22329499 |
| PQID | 992984432 |
| PQPubID | 26244 |
| PageCount | 7 |
| ParticipantIDs | proquest_miscellaneous_993908244 proquest_journals_992984432 pubmed_primary_22329499 pascalfrancis_primary_25783995 crossref_citationtrail_10_1111_j_1471_0528_2011_03252_x crossref_primary_10_1111_j_1471_0528_2011_03252_x wiley_primary_10_1111_j_1471_0528_2011_03252_x_BJO3252 istex_primary_ark_67375_WNG_WXWVZLDB_K |
| PublicationCentury | 2000 |
| PublicationDate | May 2012 |
| PublicationDateYYYYMMDD | 2012-05-01 |
| PublicationDate_xml | – month: 05 year: 2012 text: May 2012 |
| PublicationDecade | 2010 |
| PublicationPlace | Oxford, UK |
| PublicationPlace_xml | – name: Oxford, UK – name: Oxford – name: England – name: London |
| PublicationSubtitle | An International Journal of Obstetrics and Gynaecology |
| PublicationTitle | BJOG : an international journal of obstetrics and gynaecology |
| PublicationTitleAlternate | BJOG |
| PublicationYear | 2012 |
| Publisher | Blackwell Publishing Ltd Blackwell Wiley Subscription Services, Inc |
| Publisher_xml | – name: Blackwell Publishing Ltd – name: Blackwell – name: Wiley Subscription Services, Inc |
| References | Prendiville W, De Camargo M, Walker P. The use and abuse of LLETZ. CME J Gynecol Oncol 2000;5:85-7. Raio L, Ghezzi F, Di Naro E, Gomez R, Luscher KP. Duration of pregnancy after carbon dioxide conization of the cervix: influence of cone height. Obstet Gynecol 1997;90:978-82. Himes KP, Simhan HN. Time from cervical conization to pregnancy and preterm birth. Obstet Gynecol 2007;6:314-19. Kyrgiou M, Koliopoulos G, Martin-Hirsch P, Arbyn M, Prendiville W, Paraskevaidis E. Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysis. Lancet 2006;367:489-98. Bruinsma F, Quinn M. The risk of preterm birth following treatment for precancerous changes in the cervix: a systematic review and meta-analysis. BJOG 2011;118:1031-41. Noehr B, Jensen A, Frederiksen K, Tabor A, Kjaer S. Depth of cervical cone removed by loop electrosurgical excision procedure and subsequent risk of spontaneous preterm delivery. Obstet Gynecol 2009;114:1232-8. Prendiville W, Cullimore J, Norman S. Large loop excision of the transformation zone (LLETZ). A new method of management for women with cervical intraepithelial neoplasia. Br J Obstet Gynaecol 1989;96:1054-60. Arbyn M, Kyrgiou M, Simoens C, Raifu AO, Koliopoulos G, Martin-Hirsch P, et al. Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia: meta-analysis. BMJ 2008;337:a1284; Doi: 10.1136/bmj.a1284 (Epub ahead of print). Sadler L, Saftlas A, Wang W, Exeter M, Whittaker J, McCowan L. Treatment for cervical intraepithelial neoplasia and risk of preterm delivery. JAMA 2004;291:2100-6. 1989; 96 1997; 90 2007; 6 2008; 337 2011; 118 2004; 291 2000; 5 2009; 114 2006; 367 e_1_2_12_3_2 e_1_2_12_2_2 e_1_2_12_5_2 e_1_2_12_4_2 e_1_2_12_7_2 e_1_2_12_6_2 Prendiville W (e_1_2_12_10_2) 2000; 5 e_1_2_12_9_2 e_1_2_12_8_2 |
| References_xml | – reference: Kyrgiou M, Koliopoulos G, Martin-Hirsch P, Arbyn M, Prendiville W, Paraskevaidis E. Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysis. Lancet 2006;367:489-98. – reference: Bruinsma F, Quinn M. The risk of preterm birth following treatment for precancerous changes in the cervix: a systematic review and meta-analysis. BJOG 2011;118:1031-41. – reference: Noehr B, Jensen A, Frederiksen K, Tabor A, Kjaer S. Depth of cervical cone removed by loop electrosurgical excision procedure and subsequent risk of spontaneous preterm delivery. Obstet Gynecol 2009;114:1232-8. – reference: Raio L, Ghezzi F, Di Naro E, Gomez R, Luscher KP. Duration of pregnancy after carbon dioxide conization of the cervix: influence of cone height. Obstet Gynecol 1997;90:978-82. – reference: Sadler L, Saftlas A, Wang W, Exeter M, Whittaker J, McCowan L. Treatment for cervical intraepithelial neoplasia and risk of preterm delivery. JAMA 2004;291:2100-6. – reference: Himes KP, Simhan HN. Time from cervical conization to pregnancy and preterm birth. Obstet Gynecol 2007;6:314-19. – reference: Arbyn M, Kyrgiou M, Simoens C, Raifu AO, Koliopoulos G, Martin-Hirsch P, et al. Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia: meta-analysis. BMJ 2008;337:a1284; Doi: 10.1136/bmj.a1284 (Epub ahead of print). – reference: Prendiville W, Cullimore J, Norman S. Large loop excision of the transformation zone (LLETZ). A new method of management for women with cervical intraepithelial neoplasia. Br J Obstet Gynaecol 1989;96:1054-60. – reference: Prendiville W, De Camargo M, Walker P. The use and abuse of LLETZ. CME J Gynecol Oncol 2000;5:85-7. – volume: 90 start-page: 978 year: 1997 end-page: 82 article-title: Duration of pregnancy after carbon dioxide conization of the cervix: influence of cone height publication-title: Obstet Gynecol – volume: 96 start-page: 1054 year: 1989 end-page: 60 article-title: Large loop excision of the transformation zone (LLETZ). A new method of management for women with cervical intraepithelial neoplasia publication-title: Br J Obstet Gynaecol – volume: 5 start-page: 85 year: 2000 end-page: 7 article-title: The use and abuse of LLETZ publication-title: CME J Gynecol Oncol – volume: 6 start-page: 314 year: 2007 end-page: 19 article-title: Time from cervical conization to pregnancy and preterm birth publication-title: Obstet Gynecol – volume: 337 year: 2008 article-title: Perinatal mortality and other severe adverse pregnancy outcomes associated with treatment of cervical intraepithelial neoplasia: meta‐analysis publication-title: BMJ – volume: 118 start-page: 1031 year: 2011 end-page: 41 article-title: The risk of preterm birth following treatment for precancerous changes in the cervix: a systematic review and meta‐analysis publication-title: BJOG – volume: 291 start-page: 2100 year: 2004 end-page: 6 article-title: Treatment for cervical intraepithelial neoplasia and risk of preterm delivery publication-title: JAMA – volume: 114 start-page: 1232 year: 2009 end-page: 8 article-title: Depth of cervical cone removed by loop electrosurgical excision procedure and subsequent risk of spontaneous preterm delivery publication-title: Obstet Gynecol – volume: 367 start-page: 489 year: 2006 end-page: 98 article-title: Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta‐analysis publication-title: Lancet – ident: e_1_2_12_4_2 doi: 10.1136/bmj.a1284 – ident: e_1_2_12_5_2 doi: 10.1111/j.1471-0528.2011.02944.x – ident: e_1_2_12_9_2 doi: 10.1097/01.AOG.0000251497.55065.74 – ident: e_1_2_12_3_2 doi: 10.1016/S0140-6736(06)68181-6 – ident: e_1_2_12_7_2 doi: 10.1097/AOG.0b013e3181bf1ef2 – ident: e_1_2_12_2_2 doi: 10.1111/j.1471-0528.1989.tb03380.x – ident: e_1_2_12_6_2 doi: 10.1001/jama.291.17.2100 – volume: 5 start-page: 85 year: 2000 ident: e_1_2_12_10_2 article-title: The use and abuse of LLETZ publication-title: CME J Gynecol Oncol – ident: e_1_2_12_8_2 doi: 10.1016/S0029-7844(97)00489-4 |
| SSID | ssj0016203 |
| Score | 2.381574 |
| Snippet | Please cite this paper as: Khalid S, Dimitriou E, Conroy R, Paraskevaidis E, Kyrgiou M, Harrity C, Arbyn M, Prendiville W. The thickness and volume of LLETZ... Please cite this paper as: Khalid S, Dimitriou E, Conroy R, Paraskevaidis E, Kyrgiou M, Harrity C, Arbyn M, Prendiville W. The thickness and volume of LLETZ... The aim of this study was to determine if the individual physical characteristics of the extirpated transformation zone after large loop excision of the... Objective: The aim of this study was to determine if the individual physical characteristics of the extirpated transformation zone after large loop excision of... |
| SourceID | proquest pubmed pascalfrancis crossref wiley istex |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 685 |
| SubjectTerms | Abortion, Spontaneous - epidemiology Biological and medical sciences Cervical intraepithelial neoplasia Cervical Intraepithelial Neoplasia - pathology Cervical Intraepithelial Neoplasia - surgery Cervix Uteri - diagnostic imaging Cervix Uteri - pathology Cervix Uteri - surgery dimensions electrosurgical excision Female Gynecologic Surgical Procedures - adverse effects Gynecologic Surgical Procedures - methods Gynecology. Andrology. Obstetrics Humans Ireland - epidemiology large loop excision of the transformation zone loop electrosurgical excision procedure Medical disorders Medical sciences Morbidity Obstetric Labor, Premature - epidemiology Pregnancy Pregnancy Outcome pregnancy outcomes Premature birth preterm labour Reproductive system Retrospective Studies Risk Factors Surgical techniques Ultrasonography Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - surgery |
| Title | The thickness and volume of LLETZ specimens can predict the relative risk of pregnancy-related morbidity |
| URI | https://api.istex.fr/ark:/67375/WNG-WXWVZLDB-K/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1471-0528.2011.03252.x https://www.ncbi.nlm.nih.gov/pubmed/22329499 https://www.proquest.com/docview/992984432 https://www.proquest.com/docview/993908244 |
| Volume | 119 |
| WOSCitedRecordID | wos000302605500037&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVWIB databaseName: Wiley Online Library Full Collection 2020 customDbUrl: eissn: 1471-0528 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0016203 issn: 1470-0328 databaseCode: DRFUL dateStart: 19970101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9NAEB5BglAvvB-mEO0BcTNy9mFvjpQ2IAgBoZZEvazW6zUKKU5lp1W58RP4jfwSZmzXENRDhVBysLL5LHl2ZvYb7-wMwFMnrJQyjcM4kTaULs9CXISjcGgTnG6Vu5FI62YTyXSq5_PRhzb_ic7CNPUhuhduZBm1vyYDt2n1l5EnGAorrttKnIIr_hz5ZJ-jGqse9Hc_jg8m3Z5CzOs-yYiKQqoit5nXc-G9NharPsn9jJInbYXyy5vGFxcx002iW69U45v_8xlvwY2Wr7IXjYLdhiu-uAPX37U78nfhC-oZo5z5JflMZouMNQ6PrXI2meztHzI6zEk9BCqG08iOS8KuEeNZc5DmFC8W1ZIAOPiZKoB8-_n9Rz3oM_Z1VaaLDIOFe3Aw3tt_-Tps-zeETmGQG0qvhRjm2nKOkZ7jUaqQjqiRyOIEiapCpuoynUkVidxj2BRz7R3HkDRV-HFe3IdesSr8Q2BIRCIbRW6IXwyxhFY2Vk5n5JCcFTqA5HyijGuLm1OPjSPzZ5CTDA2J0pAoTS1KcxbAsEMeNwU-LoF5VutCB7DlkhLkEmVm01dmNp99Opzs7pi3AQw2lKUDkKOkQ8UBbJ9rj2mdR2VGaC1aSsEDYN0oWj1t5djCr07oL4J61UsZwING537fGjkyVRwKIK5V69JPZXbevKerR_8K3IYt_Jk36aCPobcuT_wTuOZO14uqHMDVZK4HrVH-Ar5KL8I |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbtNAEB6hBgEX_gumpewBcTOy98feHCltKNQNCKUk6mW1XtsoBJzKSaty4xF4Rp6kM7ZrCOqhQig5WFqPJc9-M_uNd3YG4LkTVkqZRn4US-tLV2Q-LsKBH9oYp1sVri_SutlEPBzqyaT_oW0HRGdhmvoQ3Qc3sozaX5OB0wfpv6w8xlhYcd2W4hRc8ZdIKHsSUYVw7-18HBwm3aZCxOtGySgV-FRGbjWx59JnraxWPVL8GWVP2gUqsGg6X1xGTVeZbr1UDe7815e8C7dbxspeNRC7B9fy8j7cOGj35B_AF0Qao6z5GXlNZsuMNS6PzQuWJLujI0bHOamLwILhRLLjimSXKJOz5ijNKV5MFzMSwMHPVAPk-68fP-vBPGPf5lU6zTBceAiHg93R6z2_7eDgO4Vhri9zLURYaMs5xnqOB6lCQqL6IotipKoKuarLdCZVIIocA6eI69xxDEpThT-Xi3VYK-dl_hgYUpHABoEL8Y9BltDKRsrpjFySs0J7EF_MlHFteXPqsvHV_BnmxKEhVRpSpalVac48CDvJ46bExxVkXtRg6ARsNaMUuViZ8fCNGU_Gn46SnW2z78HWClo6AXKVdKzYg40L-JjWfSxMH-1FSym4B6wbRbunzRxb5vMTukVQt3opPXjUgO73o5ElU80hD6IaW1d-K7P97j1dPflXwWdwc290kJjk7XB_A27hLbxJDt2EtWV1kj-F6-50OV1UW61tngPVAjLK |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9NAEB6hBFVceD9MoewBcTNy9mE7R0oaHjWhQi2Jelmt12sUAk5kp1W58RP4jfwSZmzXENRDhVBysLQeS56dmf3GOzsfwFMrjJQyDf0wksaXNs98XIQDf2AinG6V26FIa7KJaDKJZ7PhQUsHRGdhmv4Q3Qc38ow6XpODu1WW_-XlEebCisdtK07BFX-OgLIviVOmB_3Rh_FR0m0qhLwmSkapwKc2cpuFPRc-a2O16pPiz6h60lSowLxhvrgImm4i3XqpGt_4ry95E663iJW9aEzsFlxxxW3Yetfuyd-Bz2hpjKrmFxQ1mSky1oQ8tsxZkuwdHjM6zkksAhXDiWSrkmTXKONYc5TmFC_m1YIEcPAT9QD59vP7j3rQZezrskznGaYLd-FovHf48rXfMjj4VmGa60sXCzHIY8M55nqWB6lCQKKGIgsjhKoKsarN4kyqQOQOE6eQx85yTEpThT_rxD3oFcvCPQCGUCQwQWAH-MckS8TKhMrGGYUka0TsQXQ-U9q27c2JZeOL_jPNiQaaVKlJlbpWpT7zYNBJrpoWH5eQeVYbQydgygWVyEVKTyev9HQ2_XicjHb1vgc7G9bSCVCopGPFHmyfm49uw0elh-gvsZSCe8C6UfR72swxhVue0C2C2Oql9OB-Y3S_H40omXoOeRDWtnXpt9K7b9_T1cN_FXwCWwejsU7eTPa34RrewZva0EfQW5cn7jFctafreVXutK75CxKnMkU |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+thickness+and+volume+of+LLETZ+specimens+can+predict+the+relative+risk+of+pregnancy-related+morbidity&rft.jtitle=BJOG+%3A+an+international+journal+of+obstetrics+and+gynaecology&rft.au=Khalid%2C+S&rft.au=Dimitriou%2C+E&rft.au=Conroy%2C+R&rft.au=Paraskevaidis%2C+E&rft.date=2012-05-01&rft.pub=Blackwell+Publishing+Ltd&rft.issn=1470-0328&rft.eissn=1471-0528&rft.volume=119&rft.issue=6&rft.spage=685&rft.epage=691&rft_id=info:doi/10.1111%2Fj.1471-0528.2011.03252.x&rft.externalDBID=n%2Fa&rft.externalDocID=ark_67375_WNG_WXWVZLDB_K |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1470-0328&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1470-0328&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1470-0328&client=summon |