LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry

Abstract Limbic-predominant age-related TDP-43 encephalopathy (LATE) affects approximately one-third of older individuals and is associated with cognitive impairment. However, there is a highly incomplete understanding of the genetic determinants of LATE neuropathologic changes (LATE-NC) in diverse...

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Vydáno v:Journal of neuropathology and experimental neurology Ročník 82; číslo 9; s. 760 - 768
Hlavní autoři: Katsumata, Yuriko, Fardo, David W, Shade, Lincoln M P, Nelson, Peter T
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Oxford University Press 01.09.2023
Témata:
African Americans
Aging - pathology
Alleles
Allelomorphism
Alzheimer Disease - genetics
Alzheimer Disease - pathology
Cognition disorders
Degeneration
Dementia
Genetic aspects
Genetic variation
Genomics
Health aspects
Health risk assessment
Humans
Membrane Proteins - genetics
Nerve Tissue Proteins - genetics
Nervous system
Neurological research
Neuropathology
Original
Polymorphism, Single Nucleotide - genetics
Progranulins - genetics
Risk factors
Sulfonylurea Receptors - genetics
TDP-43 Proteinopathies - pathology
United States
KATP
Genome-Wide Association Studies (GWAS)
Epidemiology
Diversity
FTLD
Dementia
KCNMB2
ISSN:0022-3069, 1554-6578, 1554-6578
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Abstract Abstract Limbic-predominant age-related TDP-43 encephalopathy (LATE) affects approximately one-third of older individuals and is associated with cognitive impairment. However, there is a highly incomplete understanding of the genetic determinants of LATE neuropathologic changes (LATE-NC) in diverse populations. The defining neuropathologic feature of LATE-NC is TDP-43 proteinopathy, often with comorbid hippocampal sclerosis (HS). In terms of genetic risk factors, LATE-NC and/or HS are associated with single nucleotide variants (SNVs) in 3 genes—TMEM106B (rs1990622), GRN (rs5848), and ABCC9 (rs1914361 and rs701478). We evaluated these 3 genes in convenience samples of individuals of African ancestry. The allele frequencies of the LATE-associated alleles were significantly different between persons of primarily African (versus European) ancestry: In persons of African ancestry, the risk-associated alleles for TMEM106B and ABCC9 were less frequent, whereas the risk allele in GRN was more frequent. We performed an exploratory analysis of data from African-American subjects processed by the Alzheimer’s Disease Genomics Consortium, with a subset of African-American participants (n = 166) having corroborating neuropathologic data through the National Alzheimer’s Coordinating Center (NACC). In this limited-size sample, the ABCC9/rs1914361 SNV was associated with HS pathology. More work is required concerning the genetic factors influencing non-Alzheimer disease pathology such as LATE-NC in diverse cohorts.
AbstractList Limbic-predominant age-related TDP-43 encephalopathy (LATE) affects approximately one-third of older individuals and is associated with cognitive impairment. However, there is a highly incomplete understanding of the genetic determinants of LATE neuropathologic changes (LATE-NC) in diverse populations. The defining neuropathologic feature of LATE-NC is TDP-43 proteinopathy, often with comorbid hippocampal sclerosis (HS). In terms of genetic risk factors, LATE-NC and/or HS are associated with single nucleotide variants (SNVs) in 3 genes—TMEM106B (rs1990622), GRN (rs5848), and ABCC9 (rs1914361 and rs701478). We evaluated these 3 genes in convenience samples of individuals of African ancestry. The allele frequencies of the LATE-associated alleles were significantly different between persons of primarily African (versus European) ancestry: In persons of African ancestry, the risk-associated alleles for TMEM106B and ABCC9 were less frequent, whereas the risk allele in GRN was more frequent. We performed an exploratory analysis of data from African-American subjects processed by the Alzheimer’s Disease Genomics Consortium, with a subset of African-American participants (n = 166) having corroborating neuropathologic data through the National Alzheimer’s Coordinating Center (NACC). In this limited-size sample, the ABCC9/rs1914361 SNV was associated with HS pathology. More work is required concerning the genetic factors influencing non-Alzheimer disease pathology such as LATE-NC in diverse cohorts.
Limbic-predominant age-related TDP-43 encephalopathy (LATE) affects approximately one-third of older individuals and is associated with cognitive impairment. However, there is a highly incomplete understanding of the genetic determinants of LATE neuropathologic changes (LATE-NC) in diverse populations. The defining neuropathologic feature of LATE-NC is TDP-43 proteinopathy, often with comorbid hippocampal sclerosis (HS). In terms of genetic risk factors, LATE-NC and/or HS are associated with single nucleotide variants (SNVs) in 3 genes--TMEM106B (rs1990622), GRN (rs5848), and ABCC9 (rs1914361 and rs701478). We evaluated these 3 genes in convenience samples of individuals of African ancestry. The allele frequencies of the LATE-associated alleles were significantly different between persons of primarily African (versus European) ancestry: In persons of African ancestry, the risk-associated alleles for TMEM106B and ABCC9 were less frequent, whereas the risk allele in GRN was more frequent. We performed an exploratory analysis of data from African-American subjects processed by the Alzheimer's Disease Genomics Consortium, with a subset of African-American participants (n = 166) having corroborating neuropathologic data through the National Alzheimer's Coordinating Center (NACC). In this limited-size sample, the ABCC9/rs1914361 SNV was associated with HS pathology. More work is required concerning the genetic factors influencing non-Alzheimer disease pathology such as LATE-NC in diverse cohorts. KEYWORDS: Dementia, Diversity, Epidemiology, Genome-Wide Association Studies (GWAS), KCNMB2, FTLD, KATP
Abstract Limbic-predominant age-related TDP-43 encephalopathy (LATE) affects approximately one-third of older individuals and is associated with cognitive impairment. However, there is a highly incomplete understanding of the genetic determinants of LATE neuropathologic changes (LATE-NC) in diverse populations. The defining neuropathologic feature of LATE-NC is TDP-43 proteinopathy, often with comorbid hippocampal sclerosis (HS). In terms of genetic risk factors, LATE-NC and/or HS are associated with single nucleotide variants (SNVs) in 3 genes—TMEM106B (rs1990622), GRN (rs5848), and ABCC9 (rs1914361 and rs701478). We evaluated these 3 genes in convenience samples of individuals of African ancestry. The allele frequencies of the LATE-associated alleles were significantly different between persons of primarily African (versus European) ancestry: In persons of African ancestry, the risk-associated alleles for TMEM106B and ABCC9 were less frequent, whereas the risk allele in GRN was more frequent. We performed an exploratory analysis of data from African-American subjects processed by the Alzheimer’s Disease Genomics Consortium, with a subset of African-American participants (n = 166) having corroborating neuropathologic data through the National Alzheimer’s Coordinating Center (NACC). In this limited-size sample, the ABCC9/rs1914361 SNV was associated with HS pathology. More work is required concerning the genetic factors influencing non-Alzheimer disease pathology such as LATE-NC in diverse cohorts.
Limbic-predominant age-related TDP-43 encephalopathy (LATE) affects approximately one-third of older individuals and is associated with cognitive impairment. However, there is a highly incomplete understanding of the genetic determinants of LATE neuropathologic changes (LATE-NC) in diverse populations. The defining neuropathologic feature of LATE-NC is TDP-43 proteinopathy, often with comorbid hippocampal sclerosis (HS). In terms of genetic risk factors, LATE-NC and/or HS are associated with single nucleotide variants (SNVs) in 3 genes-TMEM106B (rs1990622), GRN (rs5848), and ABCC9 (rs1914361 and rs701478). We evaluated these 3 genes in convenience samples of individuals of African ancestry. The allele frequencies of the LATE-associated alleles were significantly different between persons of primarily African (versus European) ancestry: In persons of African ancestry, the risk-associated alleles for TMEM106B and ABCC9 were less frequent, whereas the risk allele in GRN was more frequent. We performed an exploratory analysis of data from African-American subjects processed by the Alzheimer's Disease Genomics Consortium, with a subset of African-American participants (n = 166) having corroborating neuropathologic data through the National Alzheimer's Coordinating Center (NACC). In this limited-size sample, the ABCC9/rs1914361 SNV was associated with HS pathology. More work is required concerning the genetic factors influencing non-Alzheimer disease pathology such as LATE-NC in diverse cohorts.Limbic-predominant age-related TDP-43 encephalopathy (LATE) affects approximately one-third of older individuals and is associated with cognitive impairment. However, there is a highly incomplete understanding of the genetic determinants of LATE neuropathologic changes (LATE-NC) in diverse populations. The defining neuropathologic feature of LATE-NC is TDP-43 proteinopathy, often with comorbid hippocampal sclerosis (HS). In terms of genetic risk factors, LATE-NC and/or HS are associated with single nucleotide variants (SNVs) in 3 genes-TMEM106B (rs1990622), GRN (rs5848), and ABCC9 (rs1914361 and rs701478). We evaluated these 3 genes in convenience samples of individuals of African ancestry. The allele frequencies of the LATE-associated alleles were significantly different between persons of primarily African (versus European) ancestry: In persons of African ancestry, the risk-associated alleles for TMEM106B and ABCC9 were less frequent, whereas the risk allele in GRN was more frequent. We performed an exploratory analysis of data from African-American subjects processed by the Alzheimer's Disease Genomics Consortium, with a subset of African-American participants (n = 166) having corroborating neuropathologic data through the National Alzheimer's Coordinating Center (NACC). In this limited-size sample, the ABCC9/rs1914361 SNV was associated with HS pathology. More work is required concerning the genetic factors influencing non-Alzheimer disease pathology such as LATE-NC in diverse cohorts.
Audience Academic
Author Nelson, Peter T
Shade, Lincoln M P
Katsumata, Yuriko
Fardo, David W
Author_xml – sequence: 1
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  surname: Katsumata
  fullname: Katsumata, Yuriko
– sequence: 2
  givenname: David W
  surname: Fardo
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  givenname: Lincoln M P
  surname: Shade
  fullname: Shade, Lincoln M P
– sequence: 5
  givenname: Peter T
  orcidid: 0000-0002-6161-1265
  surname: Nelson
  fullname: Nelson, Peter T
  email: pnels2@email.uky.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37528055$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/mp.2011.136
10.1016/j.ajhg.2012.04.010
10.1186/s13742-015-0047-8
10.1212/NXG.0000000000000125
10.1186/s13024-018-0268-2
10.1016/j.jalz.2018.03.002
10.1186/s12859-020-3340-1
10.1007/s00401-013-1157-y
10.1016/j.jalz.2018.12.013
10.1002/ana.24388
10.1007/s00401-022-02444-1
10.1159/000066696
10.1002/gepi.20579
10.1371/journal.pgen.1004606
10.1212/WNL.41.4.479
10.1007/s00401-022-02416-5
10.1001/jama.2013.2973
10.1016/j.neurobiolaging.2016.02.024
10.1212/NXG.0000000000000079
10.1093/brain/awz099
10.1007/s00401-011-0910-3
10.1007/s10709-010-9505-5
10.1086/519795
10.3233/JAD-180992
10.3233/JAD-220558
10.1002/alz.12763
10.1001/jama.287.3.329
10.1093/hmg/ddn257
10.1016/j.jalz.2015.02.012
10.1371/journal.pone.0079771
10.1212/WNL.0000000000010602
10.1016/S1474-4422(18)30251-5
10.1007/s00401-006-0127-z
10.1159/000289231
10.1007/s00401-014-1282-2
10.1038/s41586-021-03205-y
10.1371/journal.pgen.1008432
10.1016/j.ajhg.2014.11.010
10.1007/s00401-020-02211-0
10.1007/s00401-014-1358-z
10.1002/ana.410420418
10.1002/ana.21154
10.3233/JAD-170242
10.1111/j.1750-3639.2008.00244.x
10.1016/j.xgen.2022.100155
10.1007/s00401-014-1302-2
10.1093/bioinformatics/btv402
10.1111/bpa.12296
10.1016/j.neurobiolaging.2017.01.003
10.1007/s00401-022-02524-2
10.1017/S1041610221000107
10.1212/WNL.58.12.1791
ContentType Journal Article
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Keene, C Dirk
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Hyman, Bradley T
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Albin, Roger L
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Gearing, Marla
Williamson, Jennifer
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Karydas, Anna
Burns, Jeffrey M
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Spina, Salvatore
Vonsattel, Jean Paul
Masurkar, Arjun V
DeCarli, Charles
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Smith, Amanda G
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Larson, Eric B
Vinters, Harry V
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Vassar, Robert
Lopez, Oscar L
Petersen, Ronald C
Quinn, Joseph F
Woltjer, Randall L
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Brewer, James B
Frosch, Matthew P
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Kamboh, M Ilyas
Parisi, Joseph E
Schneider, Julie A
Harrell, Lindy E
Abner, Erin
Boxer, Adam
McCurry, Susan M
Kim, Ronald
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Keywords KATP
Genome-Wide Association Studies (GWAS)
Epidemiology
Diversity
FTLD
Dementia
KCNMB2
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References Knopman (2024032523530725900_nlad059-B5) 2018; 14
Hohman (2024032523530725900_nlad059-B49) 2016; 12
Aoki (2024032523530725900_nlad059-B17) 2015; 129
Ionita-Laza (2024032523530725900_nlad059-B16) 2012; 90
Dickson (2024032523530725900_nlad059-B21) 2010; 7
Nelson (2024032523530725900_nlad059-B7) 2022; 144
Rademakers (2024032523530725900_nlad059-B35) 2008; 17
Ridge (2024032523530725900_nlad059-B2) 2013; 8
So (2024032523530725900_nlad059-B3) 2011; 35
Braak (2024032523530725900_nlad059-B28) 2006; 112
Mirra (2024032523530725900_nlad059-B30) 1991; 41
Purcell (2024032523530725900_nlad059-B33) 2007; 81
Nag (2024032523530725900_nlad059-B8) 2015; 77
Nelson (2024032523530725900_nlad059-B26) 2023; 145
Diaz-Papkovich (2024032523530725900_nlad059-B32) 2019; 15
Park (2024032523530725900_nlad059-B44) 2010; 138
Ridge (2024032523530725900_nlad059-B1) 2016; 41
Thal (2024032523530725900_nlad059-B29) 2002; 58
Cykowski (2024032523530725900_nlad059-B41) 2022; 143
Murray (2024032523530725900_nlad059-B18) 2014; 128
Alexander (2024032523530725900_nlad059-B24) 2020; 21
Beecham (2024032523530725900_nlad059-B19) 2014; 10
Nelson (2024032523530725900_nlad059-B6) 2010; 20
Yang (2024032523530725900_nlad059-B22) 2018; 17
Taliun (2024032523530725900_nlad059-B31) 2021; 590
Grothe (2024032523530725900_nlad059-B42) 2023; 19
Katsumata (2024032523530725900_nlad059-B25) 2020; 140
Sahota (2024032523530725900_nlad059-B51) 1997; 42
Raj (2024032523530725900_nlad059-B50) 2017; 3
Khan (2024032523530725900_nlad059-B40) 2022; 2
Amador-Ortiz (2024032523530725900_nlad059-B10) 2007; 61
Ren (2024032523530725900_nlad059-B36) 2018; 13
Nascimento (2024032523530725900_nlad059-B12) 2016; 26
Santos (2024032523530725900_nlad059-B14) 2019; 15
Bryc (2024032523530725900_nlad059-B39) 2015; 96
Nelson (2024032523530725900_nlad059-B20) 2014; 127
Schlesinger (2024032523530725900_nlad059-B46) 2013; 18
Nag (2024032523530725900_nlad059-B11) 2020; 95
Huie (2024032523530725900_nlad059-B13) 2023; 91
Machiela (2024032523530725900_nlad059-B23) 2015; 31
Chang (2024032523530725900_nlad059-B34) 2015; 4
Suemoto (2024032523530725900_nlad059-B52) 2021; 33
Kovacs (2024032523530725900_nlad059-B4) 2013; 126
Ighodaro (2024032523530725900_nlad059-B38) 2017; 60
Nelson (2024032523530725900_nlad059-B9) 2019; 142
Katsumata (2024032523530725900_nlad059-B37) 2017; 53
Green (2024032523530725900_nlad059-B45) 2002; 287
Montine (2024032523530725900_nlad059-B27) 2012; 123
Gordon (2024032523530725900_nlad059-B43) 2002; 54
Cukier (2024032523530725900_nlad059-B48) 2016; 2
Filshtein (2024032523530725900_nlad059-B15) 2019; 68
Reitz (2024032523530725900_nlad059-B47) 2013; 309
References_xml – volume: 18
  start-page: 79
  year: 2013
  ident: 2024032523530725900_nlad059-B46
  article-title: African ancestry protects against Alzheimer's disease-related neuropathology
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2011.136
– volume: 90
  start-page: 1002
  year: 2012
  ident: 2024032523530725900_nlad059-B16
  article-title: Scan-statistic approach identifies clusters of rare disease variants in LRP2, a gene linked and associated with autism spectrum disorders, in three datasets
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2012.04.010
– volume: 4
  start-page: 7
  year: 2015
  ident: 2024032523530725900_nlad059-B34
  article-title: Second-generation PLINK: Rising to the challenge of larger and richer datasets
  publication-title: Gigascience
  doi: 10.1186/s13742-015-0047-8
– volume: 3
  start-page: e125
  year: 2017
  ident: 2024032523530725900_nlad059-B50
  article-title: Genetic architecture of age-related cognitive decline in African Americans
  publication-title: Neurol Genet
  doi: 10.1212/NXG.0000000000000125
– volume: 13
  start-page: 35
  year: 2018
  ident: 2024032523530725900_nlad059-B36
  article-title: TMEM106B haplotypes have distinct gene expression patterns in aged brain
  publication-title: Mol Neurodegener
  doi: 10.1186/s13024-018-0268-2
– volume: 14
  start-page: 563
  year: 2018
  ident: 2024032523530725900_nlad059-B5
  article-title: The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the research roundtable
  publication-title: Alzheimers Dement
  doi: 10.1016/j.jalz.2018.03.002
– volume: 21
  start-page: 14
  year: 2020
  ident: 2024032523530725900_nlad059-B24
  article-title: LDpop: An interactive online tool to calculate and visualize geographic LD patterns
  publication-title: BMC Bioinformatics
  doi: 10.1186/s12859-020-3340-1
– volume: 126
  start-page: 365
  year: 2013
  ident: 2024032523530725900_nlad059-B4
  article-title: Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: A community-based autopsy series
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-013-1157-y
– volume: 15
  start-page: 635
  year: 2019
  ident: 2024032523530725900_nlad059-B14
  article-title: Ethnoracial differences in Alzheimer's disease from the FLorida Autopsied Multi-Ethnic (FLAME) cohort
  publication-title: Alzheimers Dement
  doi: 10.1016/j.jalz.2018.12.013
– volume: 77
  start-page: 942
  year: 2015
  ident: 2024032523530725900_nlad059-B8
  article-title: Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease
  publication-title: Ann Neurol
  doi: 10.1002/ana.24388
– volume: 144
  start-page: 27
  year: 2022
  ident: 2024032523530725900_nlad059-B7
  article-title: Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: Combined data from 13 community-based or population-based autopsy cohorts
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-022-02444-1
– volume: 54
  start-page: 22
  year: 2002
  ident: 2024032523530725900_nlad059-B43
  article-title: Power and sample size calculations for case-control genetic association tests when errors are present: Application to single nucleotide polymorphisms
  publication-title: Hum Hered
  doi: 10.1159/000066696
– volume: 35
  start-page: 310
  year: 2011
  ident: 2024032523530725900_nlad059-B3
  article-title: Evaluating the heritability explained by known susceptibility variants: A survey of ten complex diseases
  publication-title: Genet Epidemiol
  doi: 10.1002/gepi.20579
– volume: 10
  start-page: e1004606
  year: 2014
  ident: 2024032523530725900_nlad059-B19
  article-title: Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1004606
– volume: 41
  start-page: 479
  year: 1991
  ident: 2024032523530725900_nlad059-B30
  article-title: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
  publication-title: Neurology
  doi: 10.1212/WNL.41.4.479
– volume: 143
  start-page: 531
  year: 2022
  ident: 2024032523530725900_nlad059-B41
  article-title: Patterns of amygdala region pathology in LATE-NC: Subtypes that differ with regard to TDP-43 histopathology, genetic risk factors, and comorbid pathologies
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-022-02416-5
– volume: 309
  start-page: 1483
  year: 2013
  ident: 2024032523530725900_nlad059-B47
  article-title: Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E 4,and the risk of late-onset Alzheimer disease in African Americans
  publication-title: JAMA
  doi: 10.1001/jama.2013.2973
– volume: 41
  start-page: 200.e13
  year: 2016
  ident: 2024032523530725900_nlad059-B1
  article-title: Assessment of the genetic variance of late-onset Alzheimer's disease
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2016.02.024
– volume: 2
  start-page: e79
  year: 2016
  ident: 2024032523530725900_nlad059-B48
  article-title: ABCA7 frameshift deletion associated with Alzheimer disease in African Americans
  publication-title: Neurol Genet
  doi: 10.1212/NXG.0000000000000079
– volume: 142
  start-page: 1503
  year: 2019
  ident: 2024032523530725900_nlad059-B9
  article-title: Limbic-predominant age-related TDP-43 encephalopathy (LATE): Consensus working group report
  publication-title: Brain
  doi: 10.1093/brain/awz099
– volume: 123
  start-page: 1
  year: 2012
  ident: 2024032523530725900_nlad059-B27
  article-title: National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: A practical approach
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-011-0910-3
– volume: 138
  start-page: 1147
  year: 2010
  ident: 2024032523530725900_nlad059-B44
  article-title: Identifying disease polymorphisms from case-control genetic association data
  publication-title: Genetica
  doi: 10.1007/s10709-010-9505-5
– volume: 81
  start-page: 559
  year: 2007
  ident: 2024032523530725900_nlad059-B33
  article-title: PLINK: A tool set for whole-genome association and population-based linkage analyses
  publication-title: Am J Hum Genet
  doi: 10.1086/519795
– volume: 68
  start-page: 145
  year: 2019
  ident: 2024032523530725900_nlad059-B15
  article-title: Neuropathological diagnoses of demented Hispanic, Black, and Non-Hispanic White decedents seen at an Alzheimer's disease center
  publication-title: J Alzheimers Dis
  doi: 10.3233/JAD-180992
– volume: 91
  start-page: 1291
  year: 2023
  ident: 2024032523530725900_nlad059-B13
  article-title: TDP-43 pathology in the setting of intermediate and high Alzheimer's disease neuropathologic changes: A preliminary evaluation across ethnoracial groups
  publication-title: J Alzheimers Dis
  doi: 10.3233/JAD-220558
– volume: 19
  start-page: 1234
  year: 2023
  ident: 2024032523530725900_nlad059-B42
  article-title: Differential diagnosis of amnestic dementia patients based on an FDG-PET signature of autopsy-confirmed LATE-NC
  publication-title: Alzheimers Dement
  doi: 10.1002/alz.12763
– volume: 287
  start-page: 329
  year: 2002
  ident: 2024032523530725900_nlad059-B45
  article-title: Risk of dementia among White and African American relatives of patients with Alzheimer disease
  publication-title: JAMA
  doi: 10.1001/jama.287.3.329
– volume: 17
  start-page: 3631
  year: 2008
  ident: 2024032523530725900_nlad059-B35
  article-title: Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia
  publication-title: Hum Mol Genet
  doi: 10.1093/hmg/ddn257
– volume: 12
  start-page: 233
  year: 2016
  ident: 2024032523530725900_nlad059-B49
  article-title: Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk
  publication-title: Alzheimers Dement
  doi: 10.1016/j.jalz.2015.02.012
– volume: 8
  start-page: e79771
  year: 2013
  ident: 2024032523530725900_nlad059-B2
  article-title: Alzheimer's disease: Analyzing the missing heritability
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0079771
– volume: 95
  start-page: e2056
  year: 2020
  ident: 2024032523530725900_nlad059-B11
  article-title: Limbic-predominant age-related TDP-43 encephalopathy in Black and White decedents
  publication-title: Neurology
  doi: 10.1212/WNL.0000000000010602
– volume: 17
  start-page: 773
  year: 2018
  ident: 2024032523530725900_nlad059-B22
  article-title: Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE epsilon4 haplotype status: A community-based cohort study
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(18)30251-5
– volume: 112
  start-page: 389
  year: 2006
  ident: 2024032523530725900_nlad059-B28
  article-title: Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-006-0127-z
– volume: 7
  start-page: 170
  year: 2010
  ident: 2024032523530725900_nlad059-B21
  article-title: Common variant in GRN is a genetic risk factor for hippocampal sclerosis in the elderly
  publication-title: Neurodegener Dis
  doi: 10.1159/000289231
– volume: 127
  start-page: 825
  year: 2014
  ident: 2024032523530725900_nlad059-B20
  article-title: ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-014-1282-2
– volume: 590
  start-page: 290
  year: 2021
  ident: 2024032523530725900_nlad059-B31
  article-title: Sequencing of 53,831 diverse genomes from the NHLBI
  publication-title: Nature
  doi: 10.1038/s41586-021-03205-y
– volume: 15
  start-page: e1008432
  year: 2019
  ident: 2024032523530725900_nlad059-B32
  article-title: UMAP reveals cryptic population structure and phenotype heterogeneity in large genomic cohorts
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1008432
– volume: 96
  start-page: 37
  year: 2015
  ident: 2024032523530725900_nlad059-B39
  article-title: The genetic ancestry of African Americans, Latinos, and European Americans across the United States
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2014.11.010
– volume: 140
  start-page: 659
  year: 2020
  ident: 2024032523530725900_nlad059-B25
  article-title: Distinct clinicopathologic clusters of persons with TDP-43 proteinopathy
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-020-02211-0
– volume: 129
  start-page: 53
  year: 2015
  ident: 2024032523530725900_nlad059-B17
  article-title: Hippocampal sclerosis in Lewy body disease is a TDP-43 proteinopathy similar to FTLD-TDP type A
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-014-1358-z
– volume: 42
  start-page: 659
  year: 1997
  ident: 2024032523530725900_nlad059-B51
  article-title: Apolipoprotein E-associated risk for Alzheimer's disease in the African-American population is genotype dependent
  publication-title: Ann Neurol
  doi: 10.1002/ana.410420418
– volume: 61
  start-page: 435
  year: 2007
  ident: 2024032523530725900_nlad059-B10
  article-title: TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease
  publication-title: Ann Neurol
  doi: 10.1002/ana.21154
– volume: 60
  start-page: 1
  year: 2017
  ident: 2024032523530725900_nlad059-B38
  article-title: Challenges and considerations related to studying Dementia in Blacks/African Americans
  publication-title: J Alzheimers Dis
  doi: 10.3233/JAD-170242
– volume: 20
  start-page: 66
  year: 2010
  ident: 2024032523530725900_nlad059-B6
  article-title: Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons
  publication-title: Brain Pathol
  doi: 10.1111/j.1750-3639.2008.00244.x
– volume: 2
  start-page: 100155
  year: 2022
  ident: 2024032523530725900_nlad059-B40
  article-title: Recommendations on the use and reporting of race, ethnicity, and ancestry in genetic research: Experiences from the NHLBI TOPMed program
  publication-title: Cell Genom
  doi: 10.1016/j.xgen.2022.100155
– volume: 128
  start-page: 411
  year: 2014
  ident: 2024032523530725900_nlad059-B18
  article-title: Differential clinicopathologic and genetic features of late-onset amnestic dementias
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-014-1302-2
– volume: 31
  start-page: 3555
  year: 2015
  ident: 2024032523530725900_nlad059-B23
  article-title: LDlink: A web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btv402
– volume: 26
  start-page: 177
  year: 2016
  ident: 2024032523530725900_nlad059-B12
  article-title: Higher prevalence of TDP-43 proteinopathy in cognitively normal Asians: A clinicopathological study on a multiethnic sample
  publication-title: Brain Pathol
  doi: 10.1111/bpa.12296
– volume: 53
  start-page: 193.e17
  year: 2017
  ident: 2024032523530725900_nlad059-B37
  article-title: Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN, TMEM106B, ABCC9, and KCNMB2
  publication-title: Neurobiol Aging
  doi: 10.1016/j.neurobiolaging.2017.01.003
– volume: 145
  start-page: 159
  year: 2023
  ident: 2024032523530725900_nlad059-B26
  article-title: LATE-NC staging in routine neuropathologic diagnosis: An update
  publication-title: Acta Neuropathol
  doi: 10.1007/s00401-022-02524-2
– volume: 33
  start-page: 213
  year: 2021
  ident: 2024032523530725900_nlad059-B52
  article-title: Attenuated effect of the apolipoprotein E varepsilon4 allele on neuropsychiatric symptoms among African older adults
  publication-title: Int Psychogeriatr
  doi: 10.1017/S1041610221000107
– volume: 58
  start-page: 1791
  year: 2002
  ident: 2024032523530725900_nlad059-B29
  article-title: Phases of A beta-deposition in the human brain and its relevance for the development of AD
  publication-title: Neurology
  doi: 10.1212/WNL.58.12.1791
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Snippet Abstract Limbic-predominant age-related TDP-43 encephalopathy (LATE) affects approximately one-third of older individuals and is associated with cognitive...
Limbic-predominant age-related TDP-43 encephalopathy (LATE) affects approximately one-third of older individuals and is associated with cognitive impairment....
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SourceType Open Access Repository
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Index Database
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Publisher
StartPage 760
SubjectTerms African Americans
Aging - pathology
Alleles
Allelomorphism
Alzheimer Disease - genetics
Alzheimer Disease - pathology
Cognition disorders
Degeneration
Dementia
Genetic aspects
Genetic variation
Genomics
Health aspects
Health risk assessment
Humans
Membrane Proteins - genetics
Nerve Tissue Proteins - genetics
Nervous system
Neurological research
Neuropathology
Original
Polymorphism, Single Nucleotide - genetics
Progranulins - genetics
Risk factors
Sulfonylurea Receptors - genetics
TDP-43 Proteinopathies - pathology
Title LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry
URI https://www.ncbi.nlm.nih.gov/pubmed/37528055
https://www.proquest.com/docview/3051824092
https://www.proquest.com/docview/2845103333
https://pubmed.ncbi.nlm.nih.gov/PMC10440720
Volume 82
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