The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival

The cyclin D3–CDK6 kinase complex, which is overactive in some cancers, inhibits two key glycolysis enzymes and thereby enhances the levels of antioxidants in cells, promoting tumour cell survival. Cancer cell survival by cyclin D3–CDK6 metabolism Cyclin–CDK complexes are commonly amplified in cance...

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Bibliographic Details
Published in:	Nature (London) Vol. 546; no. 7658; pp. 426 - 430
Main Authors:	Wang, Haizhen, Nicolay, Brandon N., Chick, Joel M., Gao, Xueliang, Geng, Yan, Ren, Hong, Gao, Hui, Yang, Guizhi, Williams, Juliet A., Suski, Jan M., Keibler, Mark A., Sicinska, Ewa, Gerdemann, Ulrike, Haining, W. Nicholas, Roberts, Thomas M., Polyak, Kornelia, Gygi, Steven P., Dyson, Nicholas J., Sicinski, Piotr
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 15.06.2017 Nature Publishing Group
Subjects:	13 13/106 13/2 13/31 6-Phosphofructokinase 631/67/2327 631/80/641 631/80/82 Aminopyridines - pharmacology Aminopyridines - therapeutic use Animals Antioxidants Apoptosis Apoptosis - drug effects Brain cancer Cancer Catalysis Catalytic activity Cell cycle Cell Cycle - drug effects Cell death Cell Line, Tumor Cell survival Cell Survival - drug effects Clinical trials Cyclin D Cyclin D3 Cyclin D3 - metabolism Cyclin-dependent kinase 4 Cyclin-Dependent Kinase 4 - antagonists & inhibitors Cyclin-Dependent Kinase 4 - metabolism Cyclin-dependent kinase 6 Cyclin-Dependent Kinase 6 - antagonists & inhibitors Cyclin-Dependent Kinase 6 - metabolism Cyclin-dependent kinases Enzymes Female Glutathione Glycolysis Glycolysis - drug effects Humanities and Social Sciences Humans Intermediates Kinases letter Machinery and equipment Mass spectrometry Medical research Metabolism Metabolites Mice multidisciplinary NADP Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - metabolism Neoplasms - pathology Oxidative Stress - drug effects Oxygen Pentose Pentose phosphate pathway Pentose Phosphate Pathway - drug effects Phosphofructokinase Phosphofructokinase-1 - metabolism Phosphorylation Phosphorylation - drug effects Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - enzymology Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology Proteins Purines - pharmacology Purines - therapeutic use Pyruvate kinase Pyruvate Kinase - metabolism Reactive Nitrogen Species - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism Science Scientific imaging Serine - metabolism Survival Tumors Xenograft Model Antitumor Assays Xenografts
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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