LYVE-1, the lymphatic system and tumor lymphangiogenesis

Previous research into hyaluronan (HA) has focused on the role of this abundant tissue glycosaminoglycan in promoting cell migration through interactions with its transmembrane receptor CD44 on inflammatory leukocytes and tumor cells. The recent discovery of a new HA receptor, LYVE-1 (lymphatic vess...

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Bibliographic Details
Published in:Trends in immunology Vol. 22; no. 6; pp. 317 - 321
Main Authors: Jackson, David G, Prevo, Remko, Clasper, Steven, Banerji, Suneale
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.06.2001
Subjects:
Animals
Biomarkers
CD44
Glycoproteins - physiology
Humans
Hyaluronan
Hyaluronan Receptors - physiology
leukocyte migration
lymphangiogenesis
lymphatic
Lymphatic System - physiology
Lymphatic Vessel Tumors - blood supply
LYVE-1
Neovascularization, Pathologic
Protein Conformation
tumour
Vesicular Transport Proteins
Hyaluronan
Immunology
Cancer biology
tumour
lymphangiogenesis
leukocyte migration
LYVE-1
CD44
lymphatic
ISSN:1471-4906, 1471-4981
Online Access:Get full text
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Summary:Previous research into hyaluronan (HA) has focused on the role of this abundant tissue glycosaminoglycan in promoting cell migration through interactions with its transmembrane receptor CD44 on inflammatory leukocytes and tumor cells. The recent discovery of a new HA receptor, LYVE-1 (lymphatic vessel endothelial HA receptor), expressed predominantly in lymphatic vessels, highlights another aspect of HA biology: its continuous transit through the lymphatic system and its potential involvement in lymph node homing by CD44 + leukocytes and tumor cells. The functional role of LYVE-1 in lymphatic vessels and its application as a marker to study tumor lymphangiogenesis are important areas of investigation.
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ISSN:1471-4906
1471-4981
DOI:10.1016/S1471-4906(01)01936-6