Repair shielding of platinum-DNA lesions in testicular germ cell tumors by high-mobility group box protein 4 imparts cisplatin hypersensitivity

Cisplatin is the most commonly used anticancer drug for the treatment of testicular germ cell tumors (TGCTs). The hypersensitivity of TGCTs to cisplatin is a subject of widespread interest. Here, we show that high-mobility group box protein 4 (HMGB4), a protein preferentially expressed in testes, un...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 114; H. 5; S. 950 - 955
Hauptverfasser:	Awuah, Samuel G, Riddell, Imogen A, Lippard, Stephen J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 31.01.2017
Schlagworte:	Antineoplastic Agents - pharmacology Cell Line, Tumor Cisplatin - pharmacology CRISPR-Cas Systems DNA Damage DNA Repair Gene Editing HMGB Proteins - genetics HMGB Proteins - metabolism Humans Neoplasms, Germ Cell and Embryonal - metabolism Testicular Neoplasms - metabolism testicular cancer high-mobility group protein platinum anticancer drug
ISSN:	1091-6490
Online-Zugang:	Weitere Angaben
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