The chemokine CX3CL1 promotes intraperitoneal tumour growth despite enhanced T-cell recruitment in ovarian cancer

T-cell recruiting chemokines are required for a successful immune intervention in ovarian cancer, and also for the efficacy of modern anticancer agents such as PARP inhibitors. The chemokine CX3CL1 recruits tumour-suppressive T-cells into solid tumours, but also mediates cell–cell adhesions, e.g. of...

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Bibliographic Details
Published in:	Neoplasia (New York, N.Y.) Vol. 60; p. 101130
Main Authors:	Seitz, Stefanie, Dreyer, Tobias F., Stange, Christoph, Steiger, Katja, Wohlleber, Dirk, Anton, Martina, Pham, Thuý An, Sauter-Peschke, Dominique, Reuning, Ute, Multhoff, Gabriele, Weichert, Wilko, Kiechle, Marion, Magdolen, Viktor, Bronger, Holger
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.02.2025 Elsevier
Subjects:	Animals Cell Line, Tumor Cell Proliferation Chemokine CX3CL1 - genetics Chemokine CX3CL1 - metabolism Chemokines CX3CL1 Disease Models, Animal Female Humans Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Mice Mouse model Ovarian Neoplasms - genetics Ovarian Neoplasms - immunology Ovarian Neoplasms - metabolism Ovarian Neoplasms - mortality Ovarian Neoplasms - pathology PARP inhibition T-Lymphocytes - immunology T-Lymphocytes - metabolism Tumour-infiltrating lymphocytes Xenograft Model Antitumor Assays Mouse model Chemokines CX3CL1 Tumour-infiltrating lymphocytes PARP inhibition
ISSN:	1476-5586, 1476-5586
Online Access:	Get full text
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