Elevated APOBEC3B correlates with poor outcomes for estrogen-receptor-positive breast cancers

Recent observations connected DNA cytosine deaminase APOBEC3B to the genetic evolution of breast cancer. We addressed whether APOBEC3B is associated with breast cancer clinical outcomes. APOBEC3B messenger RNA (mRNA) levels were related in 1,491 primary breast cancers to disease-free (DFS), metastas...

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Veröffentlicht in:	Hormones & cancer Jg. 5; H. 6; S. 405
Hauptverfasser:	Sieuwerts, Anieta M, Willis, Scooter, Burns, Michael B, Look, Maxime P, Meijer-Van Gelder, Marion E, Schlicker, Andreas, Heideman, Marinus R, Jacobs, Heinz, Wessels, Lodewyk, Leyland-Jones, Brian, Gray, Kathryn P, Foekens, John A, Harris, Reuben S, Martens, John W M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.12.2014
Schlagworte:	Adult Aged Biomarkers, Tumor - metabolism Breast Neoplasms - diagnosis Breast Neoplasms - genetics Breast Neoplasms - mortality Cohort Studies Cytidine Deaminase - genetics Cytidine Deaminase - metabolism Female Follow-Up Studies Gene Expression Regulation, Neoplastic Humans Microarray Analysis Middle Aged Minor Histocompatibility Antigens Neoplasm Staging Prognosis Receptors, Estrogen - metabolism RNA, Messenger - analysis Survival Analysis Up-Regulation
ISSN:	1868-8500, 1868-8500
Online-Zugang:	Weitere Angaben
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