CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation

In germinal centres (GC) mature B cells undergo intense proliferation and immunoglobulin gene modification before they differentiate into memory B cells or long-lived plasma cells (PC). GC B-cell-to-PC transition involves a major transcriptional switch that promotes a halt in cell proliferation and...

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Bibliographic Details
Published in:	Nature communications Vol. 8; no. 1; pp. 16067 - 12
Main Authors:	Pérez-García, Arantxa, Marina-Zárate, Ester, Álvarez-Prado, Ángel F., Ligos, Jose M., Galjart, Niels, Ramiro, Almudena R.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 05.07.2017 Nature Publishing Group Nature Portfolio
Subjects:	13/31 14/19 38/15 38/22 38/77 45/91 631/250/2152/2153/1982 64/110 Animals B-Lymphocytes - physiology CCCTC-Binding Factor - physiology Cell activation Cell Differentiation Cell proliferation Differentiation (biology) Female Genetic modification Germinal Center - metabolism Germinal centers Humanities and Social Sciences Immunoglobulins Immunological memory In vitro methods and tests Lymphocytes B Male Memory cells Mice multidisciplinary Plasma Cells Positive Regulatory Domain I-Binding Factor 1 - metabolism Primary Cell Culture Restoration Science Science (multidisciplinary) T cell receptors Transcription Transcription, Genetic
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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