Proinflammatory state, hepcidin, and anemia in older persons

In patients with overt inflammatory diseases, up-regulated hepcidin impairs iron absorption and macrophage release, causing anemia. Whether the mild proinflammatory state of aging is associated with increased hepcidin is unknown. We characterized the relationships between urinary hepcidin, iron stat...

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Vydáno v:Blood Ročník 115; číslo 18; s. 3810
Hlavní autoři: Ferrucci, Luigi, Semba, Richard D, Guralnik, Jack M, Ershler, William B, Bandinelli, Stefania, Patel, Kushang V, Sun, Kai, Woodman, Richard C, Andrews, Nancy C, Cotter, Robert J, Ganz, Tomas, Nemeth, Elizabeta, Longo, Dan L
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 06.05.2010
Témata:
Aged
Aged, 80 and over
Aging
Anemia, Iron-Deficiency - blood
Anemia, Iron-Deficiency - urine
Antimicrobial Cationic Peptides - urine
Biomarkers - blood
Biomarkers - urine
C-Reactive Protein - metabolism
Female
Hepcidins
Humans
Inflammation - blood
Inflammation - immunology
Inflammation - urine
Inflammation Mediators - blood
Interleukin-1beta - blood
Interleukin-6 - blood
Italy
Male
Tumor Necrosis Factor-alpha - blood
Italy
ISSN:1528-0020, 1528-0020
On-line přístup:Zjistit podrobnosti o přístupu
Tagy: Přidat tag
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Abstract In patients with overt inflammatory diseases, up-regulated hepcidin impairs iron absorption and macrophage release, causing anemia. Whether the mild proinflammatory state of aging is associated with increased hepcidin is unknown. We characterized the relationships between urinary hepcidin, iron status, anemia, and inflammation in 582 patients 65 years or older participating in the InCHIANTI (Invecchiare in Chianti, "Aging in the Chianti Area") study, a population-based study of aging in Tuscany, Italy. Compared with nonanemic persons, urinary hepcidin (nanograms/milligram of urinary creatinine) was significantly lower in iron deficiency and inflammation anemia compared with no anemia or other anemia types. Urinary hepcidin was positively correlated with log(ferritin) and negatively correlated with the soluble transferrin receptor/log(ferritin) ratio but not correlated with markers of inflammation: interleukin-6 (IL-6), IL-1beta, tumor necrosis factor-alpha, and C-reactive protein (CRP). Lower iron was significantly correlated with higher IL-6 and CRP. Adjusting for confounders, IL-6 and CRP remained significantly associated with serum iron, with no evidence that such a relationship was accounted for by variability in urinary hepcidin. In conclusion, elevated proinflammatory markers were associated with anemia and low iron status, but not with higher urinary hepcidin. Future studies should test whether hepcidin production becomes up-regulated only in situations of overt inflammation.
AbstractList In patients with overt inflammatory diseases, up-regulated hepcidin impairs iron absorption and macrophage release, causing anemia. Whether the mild proinflammatory state of aging is associated with increased hepcidin is unknown. We characterized the relationships between urinary hepcidin, iron status, anemia, and inflammation in 582 patients 65 years or older participating in the InCHIANTI (Invecchiare in Chianti, "Aging in the Chianti Area") study, a population-based study of aging in Tuscany, Italy. Compared with nonanemic persons, urinary hepcidin (nanograms/milligram of urinary creatinine) was significantly lower in iron deficiency and inflammation anemia compared with no anemia or other anemia types. Urinary hepcidin was positively correlated with log(ferritin) and negatively correlated with the soluble transferrin receptor/log(ferritin) ratio but not correlated with markers of inflammation: interleukin-6 (IL-6), IL-1beta, tumor necrosis factor-alpha, and C-reactive protein (CRP). Lower iron was significantly correlated with higher IL-6 and CRP. Adjusting for confounders, IL-6 and CRP remained significantly associated with serum iron, with no evidence that such a relationship was accounted for by variability in urinary hepcidin. In conclusion, elevated proinflammatory markers were associated with anemia and low iron status, but not with higher urinary hepcidin. Future studies should test whether hepcidin production becomes up-regulated only in situations of overt inflammation.In patients with overt inflammatory diseases, up-regulated hepcidin impairs iron absorption and macrophage release, causing anemia. Whether the mild proinflammatory state of aging is associated with increased hepcidin is unknown. We characterized the relationships between urinary hepcidin, iron status, anemia, and inflammation in 582 patients 65 years or older participating in the InCHIANTI (Invecchiare in Chianti, "Aging in the Chianti Area") study, a population-based study of aging in Tuscany, Italy. Compared with nonanemic persons, urinary hepcidin (nanograms/milligram of urinary creatinine) was significantly lower in iron deficiency and inflammation anemia compared with no anemia or other anemia types. Urinary hepcidin was positively correlated with log(ferritin) and negatively correlated with the soluble transferrin receptor/log(ferritin) ratio but not correlated with markers of inflammation: interleukin-6 (IL-6), IL-1beta, tumor necrosis factor-alpha, and C-reactive protein (CRP). Lower iron was significantly correlated with higher IL-6 and CRP. Adjusting for confounders, IL-6 and CRP remained significantly associated with serum iron, with no evidence that such a relationship was accounted for by variability in urinary hepcidin. In conclusion, elevated proinflammatory markers were associated with anemia and low iron status, but not with higher urinary hepcidin. Future studies should test whether hepcidin production becomes up-regulated only in situations of overt inflammation.
In patients with overt inflammatory diseases, up-regulated hepcidin impairs iron absorption and macrophage release, causing anemia. Whether the mild proinflammatory state of aging is associated with increased hepcidin is unknown. We characterized the relationships between urinary hepcidin, iron status, anemia, and inflammation in 582 patients 65 years or older participating in the InCHIANTI (Invecchiare in Chianti, "Aging in the Chianti Area") study, a population-based study of aging in Tuscany, Italy. Compared with nonanemic persons, urinary hepcidin (nanograms/milligram of urinary creatinine) was significantly lower in iron deficiency and inflammation anemia compared with no anemia or other anemia types. Urinary hepcidin was positively correlated with log(ferritin) and negatively correlated with the soluble transferrin receptor/log(ferritin) ratio but not correlated with markers of inflammation: interleukin-6 (IL-6), IL-1beta, tumor necrosis factor-alpha, and C-reactive protein (CRP). Lower iron was significantly correlated with higher IL-6 and CRP. Adjusting for confounders, IL-6 and CRP remained significantly associated with serum iron, with no evidence that such a relationship was accounted for by variability in urinary hepcidin. In conclusion, elevated proinflammatory markers were associated with anemia and low iron status, but not with higher urinary hepcidin. Future studies should test whether hepcidin production becomes up-regulated only in situations of overt inflammation.
Author Ershler, William B
Bandinelli, Stefania
Cotter, Robert J
Patel, Kushang V
Longo, Dan L
Woodman, Richard C
Ganz, Tomas
Nemeth, Elizabeta
Sun, Kai
Andrews, Nancy C
Guralnik, Jack M
Ferrucci, Luigi
Semba, Richard D
Author_xml – sequence: 1
  givenname: Luigi
  surname: Ferrucci
  fullname: Ferrucci, Luigi
  email: ferruccilu@grc.nia.nih.gov
  organization: Intramural Research Program, National Institute on Aging, Baltimore, MD 21225, USA. ferruccilu@grc.nia.nih.gov
– sequence: 2
  givenname: Richard D
  surname: Semba
  fullname: Semba, Richard D
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  surname: Guralnik
  fullname: Guralnik, Jack M
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  surname: Ershler
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  surname: Bandinelli
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– sequence: 13
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  surname: Longo
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Snippet In patients with overt inflammatory diseases, up-regulated hepcidin impairs iron absorption and macrophage release, causing anemia. Whether the mild...
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SubjectTerms Aged
Aged, 80 and over
Aging
Anemia, Iron-Deficiency - blood
Anemia, Iron-Deficiency - urine
Antimicrobial Cationic Peptides - urine
Biomarkers - blood
Biomarkers - urine
C-Reactive Protein - metabolism
Female
Hepcidins
Humans
Inflammation - blood
Inflammation - immunology
Inflammation - urine
Inflammation Mediators - blood
Interleukin-1beta - blood
Interleukin-6 - blood
Italy
Male
Tumor Necrosis Factor-alpha - blood
Title Proinflammatory state, hepcidin, and anemia in older persons
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