A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

We have discovered a distinct mature B-cell subset that accumulates with age, which we have termed age-associated B cells. These cells comprise up to 30% of mature B cells by 22 months. Despite sharing some features with other mature B-cell subsets, they are refractory to BCR and CD40 stimulation. I...

Full description

Saved in:

Bibliographic Details
Published in:	Blood Vol. 118; no. 5; p. 1294
Main Authors:	Hao, Yi, O'Neill, Patrick, Naradikian, Martin S, Scholz, Jean L, Cancro, Michael P
Format:	Journal Article
Language:	English
Published:	United States 04.08.2011
Subjects:	Aging - immunology Animals B-Cell Activating Factor - metabolism B-Lymphocyte Subsets - cytology B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - metabolism B-Lymphocyte Subsets - physiology Cell Proliferation Cells, Cultured Female Immunity, Innate - immunology Immunity, Innate - physiology Lymphocyte Activation - immunology Lymphocyte Activation - physiology Lymphocyte Count Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Mice, Transgenic
ISSN:	1528-0020, 1528-0020
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!