A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

We have discovered a distinct mature B-cell subset that accumulates with age, which we have termed age-associated B cells. These cells comprise up to 30% of mature B cells by 22 months. Despite sharing some features with other mature B-cell subsets, they are refractory to BCR and CD40 stimulation. I...

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Vydáno v:	Blood Ročník 118; číslo 5; s. 1294
Hlavní autoři:	Hao, Yi, O'Neill, Patrick, Naradikian, Martin S, Scholz, Jean L, Cancro, Michael P
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 04.08.2011
Témata:	Aging - immunology Animals B-Cell Activating Factor - metabolism B-Lymphocyte Subsets - cytology B-Lymphocyte Subsets - immunology B-Lymphocyte Subsets - metabolism B-Lymphocyte Subsets - physiology Cell Proliferation Cells, Cultured Female Immunity, Innate - immunology Immunity, Innate - physiology Lymphocyte Activation - immunology Lymphocyte Activation - physiology Lymphocyte Count Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred DBA Mice, Transgenic
ISSN:	1528-0020, 1528-0020
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