miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia

MicroRNAs are subject to precise regulation and have key roles in tumorigenesis. In contrast to the oncogenic role of miR-22 reported in myelodysplastic syndrome (MDS) and breast cancer, here we show that miR-22 is an essential anti-tumour gatekeeper in de novo acute myeloid leukaemia (AML) where it...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature communications Jg. 7; H. 1; S. 11452
Hauptverfasser: Jiang, Xi, Hu, Chao, Arnovitz, Stephen, Bugno, Jason, Yu, Miao, Zuo, Zhixiang, Chen, Ping, Huang, Hao, Ulrich, Bryan, Gurbuxani, Sandeep, Weng, Hengyou, Strong, Jennifer, Wang, Yungui, Li, Yuanyuan, Salat, Justin, Li, Shenglai, Elkahloun, Abdel G., Yang, Yang, Neilly, Mary Beth, Larson, Richard A., Le Beau, Michelle M., Herold, Tobias, Bohlander, Stefan K., Liu, Paul P., Zhang, Jiwang, Li, Zejuan, He, Chuan, Jin, Jie, Hong, Seungpyo, Chen, Jianjun
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 26.04.2016
Nature Publishing Group
Nature Portfolio
Schlagworte:
13
14
38
631/337/384/331
631/67/1059
631/67/1990/283/1897
631/80/86
64
96
Acute Disease
Animals
Breast cancer
Cell Line
Cell Line, Tumor
Cell Proliferation - genetics
Down-Regulation
Epigenesis, Genetic
Epigenetics
Gene Expression Profiling
Gene Expression Regulation, Leukemic
Genes, Tumor Suppressor
HEK293 Cells
Hematology
Humanities and Social Sciences
Humans
Leukemia
Leukemia, Myeloid - drug therapy
Leukemia, Myeloid - genetics
Leukemia, Myeloid - pathology
Medicine
Mice, Inbred C57BL
MicroRNAs
MicroRNAs - chemistry
MicroRNAs - genetics
MicroRNAs - therapeutic use
multidisciplinary
Mutation
Myelodysplastic syndromes
Myelodysplastic Syndromes - genetics
Myelodysplastic Syndromes - pathology
Oncology
Pathogenesis
Roles
Science
Science (multidisciplinary)
Signal Transduction - genetics
Chicago Illinois
United States > US
Illinois
China
ISSN:2041-1723, 2041-1723
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Abstract MicroRNAs are subject to precise regulation and have key roles in tumorigenesis. In contrast to the oncogenic role of miR-22 reported in myelodysplastic syndrome (MDS) and breast cancer, here we show that miR-22 is an essential anti-tumour gatekeeper in de novo acute myeloid leukaemia (AML) where it is significantly downregulated. Forced expression of miR-22 significantly suppresses leukaemic cell viability and growth in vitro , and substantially inhibits leukaemia development and maintenance in vivo . Mechanistically, miR-22 targets multiple oncogenes, including CRTC1 , FLT3 and MYCBP , and thus represses the CREB and MYC pathways. The downregulation of miR-22 in AML is caused by TET1/GFI1/EZH2/SIN3A-mediated epigenetic repression and/or DNA copy-number loss. Furthermore, nanoparticles carrying miR-22 oligos significantly inhibit leukaemia progression in vivo . Together, our study uncovers a TET1/GFI1/EZH2/SIN3A/miR-22/CREB-MYC signalling circuit and thereby provides insights into epigenetic/genetic mechanisms underlying the pathogenesis of AML, and also highlights the clinical potential of miR-22-based AML therapy. Mir-22 has been shown to be an oncogenic microRNA in breast cancer and myelodysplastic syndrome. Here, the authors show that mir-22 functions as a tumour suppressor in de novo acute myeloid leukaemia by inhibiting the expression of several oncogenes and that restoring mir-22 expression suppresses AML progression.
AbstractList MicroRNAs are subject to precise regulation and have key roles in tumorigenesis. In contrast to the oncogenic role of miR-22 reported in myelodysplastic syndrome (MDS) and breast cancer, here we show that miR-22 is an essential anti-tumour gatekeeper in de novo acute myeloid leukaemia (AML) where it is significantly downregulated. Forced expression of miR-22 significantly suppresses leukaemic cell viability and growth in vitro, and substantially inhibits leukaemia development and maintenance in vivo. Mechanistically, miR-22 targets multiple oncogenes, including CRTC1, FLT3 and MYCBP, and thus represses the CREB and MYC pathways. The downregulation of miR-22 in AML is caused by TET1/GFI1/EZH2/SIN3A-mediated epigenetic repression and/or DNA copy-number loss. Furthermore, nanoparticles carrying miR-22 oligos significantly inhibit leukaemia progression in vivo. Together, our study uncovers a TET1/GFI1/EZH2/SIN3A/miR-22/CREB-MYC signalling circuit and thereby provides insights into epigenetic/genetic mechanisms underlying the pathogenesis of AML, and also highlights the clinical potential of miR-22-based AML therapy. Mir-22 has been shown to be an oncogenic microRNA in breast cancer and myelodysplastic syndrome. Here, the authors show that mir-22 functions as a tumour suppressor in de novo acute myeloid leukaemia by inhibiting the expression of several oncogenes and that restoring mir-22 expression suppresses AML progression.
MicroRNAs are subject to precise regulation and have key roles in tumorigenesis. In contrast to the oncogenic role of miR-22 reported in myelodysplastic syndrome (MDS) and breast cancer, here we show that miR-22 is an essential anti-tumour gatekeeper in de novo acute myeloid leukaemia (AML) where it is significantly downregulated. Forced expression of miR-22 significantly suppresses leukaemic cell viability and growth in vitro, and substantially inhibits leukaemia development and maintenance in vivo. Mechanistically, miR-22 targets multiple oncogenes, including CRTC1, FLT3 and MYCBP, and thus represses the CREB and MYC pathways. The downregulation of miR-22 in AML is caused by TET1/GFI1/EZH2/SIN3A-mediated epigenetic repression and/or DNA copy-number loss. Furthermore, nanoparticles carrying miR-22 oligos significantly inhibit leukaemia progression in vivo. Together, our study uncovers a TET1/GFI1/EZH2/SIN3A/miR-22/CREB-MYC signalling circuit and thereby provides insights into epigenetic/genetic mechanisms underlying the pathogenesis of AML, and also highlights the clinical potential of miR-22-based AML therapy.
MicroRNAs are subject to precise regulation and have key roles in tumorigenesis. In contrast to the oncogenic role of miR-22 reported in myelodysplastic syndrome (MDS) and breast cancer, here we show that miR-22 is an essential anti-tumour gatekeeper in de novo acute myeloid leukaemia (AML) where it is significantly downregulated. Forced expression of miR-22 significantly suppresses leukaemic cell viability and growth in vitro , and substantially inhibits leukaemia development and maintenance in vivo . Mechanistically, miR-22 targets multiple oncogenes, including CRTC1 , FLT3 and MYCBP , and thus represses the CREB and MYC pathways. The downregulation of miR-22 in AML is caused by TET1/GFI1/EZH2/SIN3A-mediated epigenetic repression and/or DNA copy-number loss. Furthermore, nanoparticles carrying miR-22 oligos significantly inhibit leukaemia progression in vivo . Together, our study uncovers a TET1/GFI1/EZH2/SIN3A/miR-22/CREB-MYC signalling circuit and thereby provides insights into epigenetic/genetic mechanisms underlying the pathogenesis of AML, and also highlights the clinical potential of miR-22-based AML therapy.
Mir-22 has been shown to be an oncogenic microRNA in breast cancer and myelodysplastic syndrome. Here, the authors show that mir-22 functions as a tumour suppressor in de novoacute myeloid leukaemia by inhibiting the expression of several oncogenes and that restoring mir-22 expression suppresses AML progression.
MicroRNAs are subject to precise regulation and have key roles in tumorigenesis. In contrast to the oncogenic role of miR-22 reported in myelodysplastic syndrome (MDS) and breast cancer, here we show that miR-22 is an essential anti-tumour gatekeeper in de novo acute myeloid leukaemia (AML) where it is significantly downregulated. Forced expression of miR-22 significantly suppresses leukaemic cell viability and growth in vitro , and substantially inhibits leukaemia development and maintenance in vivo . Mechanistically, miR-22 targets multiple oncogenes, including CRTC1 , FLT3 and MYCBP , and thus represses the CREB and MYC pathways. The downregulation of miR-22 in AML is caused by TET1/GFI1/EZH2/SIN3A-mediated epigenetic repression and/or DNA copy-number loss. Furthermore, nanoparticles carrying miR-22 oligos significantly inhibit leukaemia progression in vivo . Together, our study uncovers a TET1/GFI1/EZH2/SIN3A/miR-22/CREB-MYC signalling circuit and thereby provides insights into epigenetic/genetic mechanisms underlying the pathogenesis of AML, and also highlights the clinical potential of miR-22-based AML therapy. Mir-22 has been shown to be an oncogenic microRNA in breast cancer and myelodysplastic syndrome. Here, the authors show that mir-22 functions as a tumour suppressor in de novo acute myeloid leukaemia by inhibiting the expression of several oncogenes and that restoring mir-22 expression suppresses AML progression.
ArticleNumber 11452
Author Li, Yuanyuan
Bohlander, Stefan K.
Hu, Chao
Salat, Justin
Jin, Jie
Zhang, Jiwang
Strong, Jennifer
Neilly, Mary Beth
Le Beau, Michelle M.
Bugno, Jason
Yu, Miao
Gurbuxani, Sandeep
Li, Shenglai
Arnovitz, Stephen
He, Chuan
Larson, Richard A.
Yang, Yang
Hong, Seungpyo
Ulrich, Bryan
Elkahloun, Abdel G.
Herold, Tobias
Chen, Ping
Jiang, Xi
Zuo, Zhixiang
Liu, Paul P.
Huang, Hao
Chen, Jianjun
Li, Zejuan
Wang, Yungui
Weng, Hengyou
Author_xml – sequence: 1
  givenname: Xi
  surname: Jiang
  fullname: Jiang, Xi
  organization: Department of Cancer Biology, University of Cincinnati, Department of Medicine, Section of Hematology/Oncology, University of Chicago
– sequence: 2
  givenname: Chao
  surname: Hu
  fullname: Hu, Chao
  organization: Department of Cancer Biology, University of Cincinnati, Department of Medicine, Section of Hematology/Oncology, University of Chicago, Department of Hematology, The First Affiliated Hospital Zhejiang University
– sequence: 3
  givenname: Stephen
  surname: Arnovitz
  fullname: Arnovitz, Stephen
  organization: Department of Medicine, Section of Hematology/Oncology, University of Chicago
– sequence: 4
  givenname: Jason
  surname: Bugno
  fullname: Bugno, Jason
  organization: Department of Biopharmaceutical Sciences College of Pharmacy, The University of Illinois
– sequence: 5
  givenname: Miao
  surname: Yu
  fullname: Yu, Miao
  organization: Department of Chemistry and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago
– sequence: 6
  givenname: Zhixiang
  surname: Zuo
  fullname: Zuo, Zhixiang
  organization: Department of Cancer Biology, University of Cincinnati, Department of Medicine, Section of Hematology/Oncology, University of Chicago, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center
– sequence: 7
  givenname: Ping
  surname: Chen
  fullname: Chen, Ping
  organization: Department of Medicine, Section of Hematology/Oncology, University of Chicago
– sequence: 8
  givenname: Hao
  surname: Huang
  fullname: Huang, Hao
  organization: Department of Medicine, Section of Hematology/Oncology, University of Chicago
– sequence: 9
  givenname: Bryan
  surname: Ulrich
  fullname: Ulrich, Bryan
  organization: Department of Medicine, Section of Hematology/Oncology, University of Chicago
– sequence: 10
  givenname: Sandeep
  surname: Gurbuxani
  fullname: Gurbuxani, Sandeep
  organization: Department of Pathology, University of Chicago
– sequence: 11
  givenname: Hengyou
  surname: Weng
  fullname: Weng, Hengyou
  organization: Department of Cancer Biology, University of Cincinnati, Department of Medicine, Section of Hematology/Oncology, University of Chicago
– sequence: 12
  givenname: Jennifer
  surname: Strong
  fullname: Strong, Jennifer
  organization: Department of Cancer Biology, University of Cincinnati
– sequence: 13
  givenname: Yungui
  surname: Wang
  fullname: Wang, Yungui
  organization: Department of Cancer Biology, University of Cincinnati, Department of Medicine, Section of Hematology/Oncology, University of Chicago, Department of Hematology, The First Affiliated Hospital Zhejiang University
– sequence: 14
  givenname: Yuanyuan
  surname: Li
  fullname: Li, Yuanyuan
  organization: Department of Medicine, Section of Hematology/Oncology, University of Chicago
– sequence: 15
  givenname: Justin
  surname: Salat
  fullname: Salat, Justin
  organization: Department of Medicine, Section of Hematology/Oncology, University of Chicago
– sequence: 16
  givenname: Shenglai
  surname: Li
  fullname: Li, Shenglai
  organization: Department of Medicine, Section of Hematology/Oncology, University of Chicago
– sequence: 17
  givenname: Abdel G.
  surname: Elkahloun
  fullname: Elkahloun, Abdel G.
  organization: Division of Intramural Research, National Human Genome Research Institute, NIH
– sequence: 18
  givenname: Yang
  surname: Yang
  fullname: Yang, Yang
  organization: Department of Biopharmaceutical Sciences College of Pharmacy, The University of Illinois
– sequence: 19
  givenname: Mary Beth
  surname: Neilly
  fullname: Neilly, Mary Beth
  organization: Department of Medicine, Section of Hematology/Oncology, University of Chicago
– sequence: 20
  givenname: Richard A.
  surname: Larson
  fullname: Larson, Richard A.
  organization: Department of Medicine, Section of Hematology/Oncology, University of Chicago
– sequence: 21
  givenname: Michelle M.
  surname: Le Beau
  fullname: Le Beau, Michelle M.
  organization: Department of Medicine, Section of Hematology/Oncology, University of Chicago
– sequence: 22
  givenname: Tobias
  surname: Herold
  fullname: Herold, Tobias
  organization: Department of Internal Medicine 3, University Hospital Grosshadern, Ludwig-Maximilians-Universität
– sequence: 23
  givenname: Stefan K.
  surname: Bohlander
  fullname: Bohlander, Stefan K.
  organization: Department of Molecular Medicine and Pathology, University of Auckland
– sequence: 24
  givenname: Paul P.
  surname: Liu
  fullname: Liu, Paul P.
  organization: Division of Intramural Research, National Human Genome Research Institute, NIH
– sequence: 25
  givenname: Jiwang
  surname: Zhang
  fullname: Zhang, Jiwang
  organization: Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center
– sequence: 26
  givenname: Zejuan
  surname: Li
  fullname: Li, Zejuan
  organization: Department of Medicine, Section of Hematology/Oncology, University of Chicago, Department of Human Genetics, University of Chicago
– sequence: 27
  givenname: Chuan
  surname: He
  fullname: He, Chuan
  organization: Department of Chemistry and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, University of Chicago
– sequence: 28
  givenname: Jie
  surname: Jin
  fullname: Jin, Jie
  organization: Department of Hematology, The First Affiliated Hospital Zhejiang University
– sequence: 29
  givenname: Seungpyo
  surname: Hong
  fullname: Hong, Seungpyo
  organization: Department of Biopharmaceutical Sciences College of Pharmacy, The University of Illinois, Integrated Science and Engineering Division, Underwood International College, Yonsei University
– sequence: 30
  givenname: Jianjun
  surname: Chen
  fullname: Chen, Jianjun
  email: chen3jj@ucmail.uc.edu
  organization: Department of Cancer Biology, University of Cincinnati, Department of Medicine, Section of Hematology/Oncology, University of Chicago
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27116251$$D View this record in MEDLINE/PubMed
BookMark eNp1ktFrFDEQxoNUbK198l0Cvgi6mmSTzd5LQUrVQkEQffElzGZn73JmN2eSVfrfN-ed5Vo0LwmT33zzTTJPydEUJiTkOWdvOavbd5MN45g4l0o8IieCSV5xLeqjg_MxOUtpzcqqF7yV8gk5FprzRih-Qr6P7kslBF1BokA3IeOUKUzZVXkewxxpDB7pb5dXNK8wwgbn7OwedOCpmyjYOSMdb9AH11OP8w_A0cEz8ngAn_Bsv5-Sbx8uv158qq4_f7y6eH9dWcVFrrp60ctO9SA5s3VrUQnBUfdd3yklVaOASWBNrREaxZoSbbHTqlWW16Id2vqUXO10-wBrs4luhHhjAjjzJxDi0kAspj2aobFK6aJnS81W83aAodEAHYiu1O-K1vlOazN3I_a2NBnB3xO9fzO5lVmGX0ZJreWiKQKv9gIx_JwxZTO6ZNF7mDDMyXDdKsGbmm3Rlw_QdXnwqTzVlpJ1cSpkoV4cOrqz8vcLC_B6B9gYUoo43CGcme2MmIMZKTR_QFuXIbuwbcf5_-S82eWkojwtMR4Y_Qd-C3l3z1k
CitedBy_id crossref_primary_10_3727_096504019X15528367532612
crossref_primary_10_4137_GRSB_S40768
crossref_primary_10_3389_fcell_2021_744990
crossref_primary_10_3390_cancers14246255
crossref_primary_10_1186_s13148_018_0475_2
crossref_primary_10_1016_j_omtn_2021_10_003
crossref_primary_10_1038_s41375_018_0238_2
crossref_primary_10_1093_nar_gkaf812
crossref_primary_10_1016_j_archoralbio_2018_10_003
crossref_primary_10_1177_15330338231212309
crossref_primary_10_1016_j_bioadv_2025_214284
crossref_primary_10_1016_j_gendis_2025_101513
crossref_primary_10_1016_j_pbiomolbio_2019_05_004
crossref_primary_10_3892_ijo_2016_3811
crossref_primary_10_1016_j_biopha_2020_109997
crossref_primary_10_1371_journal_pgen_1006505
crossref_primary_10_1158_0008_5472_CAN_16_0709
crossref_primary_10_3389_fonc_2021_694594
crossref_primary_10_1016_j_cbi_2022_110224
crossref_primary_10_31083_j_fbl2711313
crossref_primary_10_1038_s41420_021_00734_3
crossref_primary_10_1016_j_fmre_2023_04_012
crossref_primary_10_1002_jcp_26331
crossref_primary_10_1016_j_ccell_2016_11_017
crossref_primary_10_1080_10428194_2020_1734591
crossref_primary_10_3390_ijms18081657
crossref_primary_10_3892_ol_2018_7944
crossref_primary_10_3389_fonc_2017_00331
crossref_primary_10_3748_wjg_v24_i45_5120
crossref_primary_10_1038_s41375_024_02321_8
crossref_primary_10_1016_j_ejphar_2020_172976
crossref_primary_10_1007_s13346_019_00645_y
crossref_primary_10_1186_s13045_019_0700_2
crossref_primary_10_3390_ijms19020460
crossref_primary_10_3390_ijms23105355
crossref_primary_10_1038_s41598_022_07628_z
crossref_primary_10_1002_jcp_27776
crossref_primary_10_1002_1873_3468_12565
crossref_primary_10_1016_j_nexres_2025_100484
crossref_primary_10_1007_s12032_023_02286_1
crossref_primary_10_1007_s11033_023_08458_6
crossref_primary_10_1111_cpr_12632
crossref_primary_10_1038_s41388_025_03300_8
crossref_primary_10_1007_s11864_024_01202_7
crossref_primary_10_1007_s00018_022_04177_6
crossref_primary_10_1097_MD_0000000000040380
crossref_primary_10_1186_s13045_019_0734_5
crossref_primary_10_3390_genes16040446
crossref_primary_10_3892_mmr_2018_9680
crossref_primary_10_1038_s41392_023_01342_6
crossref_primary_10_3389_fimmu_2020_582915
crossref_primary_10_1038_s41419_017_0206_1
crossref_primary_10_1080_08830185_2017_1281272
crossref_primary_10_1038_s41427_019_0184_0
crossref_primary_10_3390_cells9071726
crossref_primary_10_3390_cancers9070074
crossref_primary_10_1038_s41467_017_02290_w
crossref_primary_10_1111_cas_14159
crossref_primary_10_1007_s40778_016_0057_1
crossref_primary_10_1007_s12010_024_05103_1
crossref_primary_10_1097_CAD_0000000000001231
crossref_primary_10_1128_MCB_00128_17
crossref_primary_10_1016_j_stem_2022_12_006
crossref_primary_10_1186_s13045_022_01235_1
crossref_primary_10_1089_dna_2019_5187
crossref_primary_10_1186_s11658_021_00288_3
crossref_primary_10_3389_fcvm_2023_1142575
crossref_primary_10_1182_blood_2016_10_697698
crossref_primary_10_1016_j_biotechadv_2025_108626
crossref_primary_10_1002_jcla_23370
crossref_primary_10_3390_cancers12113166
crossref_primary_10_3390_ijms19092810
crossref_primary_10_3892_or_2017_5762
crossref_primary_10_1371_journal_pgen_1006259
crossref_primary_10_1007_s11033_022_08000_0
crossref_primary_10_1038_s41598_017_01913_y
crossref_primary_10_1371_journal_pone_0168049
crossref_primary_10_1182_bloodadvances_2018023804
crossref_primary_10_1007_s00277_019_03713_y
crossref_primary_10_1007_s11033_022_08016_6
crossref_primary_10_3892_mmr_2021_12550
crossref_primary_10_1038_s41467_018_04600_2
crossref_primary_10_7554_eLife_66703
crossref_primary_10_1016_j_ejphar_2021_174601
crossref_primary_10_3390_ijms21197140
crossref_primary_10_1007_s11033_023_08922_3
crossref_primary_10_1016_j_mgene_2018_03_001
crossref_primary_10_3389_fcimb_2022_786543
crossref_primary_10_1097_MOH_0000000000000295
crossref_primary_10_1186_s12985_017_0743_3
crossref_primary_10_1016_j_tig_2017_03_002
crossref_primary_10_1016_j_bioactmat_2025_06_056
crossref_primary_10_1016_j_omtn_2019_04_005
crossref_primary_10_1016_j_exphem_2017_09_001
crossref_primary_10_1016_j_ejpb_2024_114234
crossref_primary_10_1089_hum_2016_104
crossref_primary_10_3389_fonc_2021_666551
crossref_primary_10_3390_ijms24010250
crossref_primary_10_1007_s10528_022_10196_6
crossref_primary_10_1155_2022_7843565
crossref_primary_10_1007_s00277_019_03887_5
crossref_primary_10_3748_wjg_v26_i19_2349
crossref_primary_10_18632_oncotarget_13037
crossref_primary_10_3748_wjg_v26_i19_2348
crossref_primary_10_3390_ijms23073469
Cites_doi 10.1159/000337297
10.1038/nature10066
10.1056/NEJMoa1301689
10.1016/j.ccr.2011.06.001
10.1002/gcc.21918
10.1038/leu.2010.158
10.1158/1078-0432.CCR-09-2639
10.1182/blood-2009-01-200519
10.1158/0008-5472.CAN-04-0044
10.1038/sj.leu.2400973
10.1182/asheducation-2011.1.543
10.1586/erm.12.18
10.1128/MCB.24.2.617-628.2004
10.1371/journal.pone.0010859
10.1073/pnas.1009843107
10.1073/pnas.1310656110
10.1073/pnas.0812105106
10.1523/JNEUROSCI.1419-12.2012
10.1016/j.ccr.2012.08.028
10.1073/pnas.0808266105
10.1016/j.stem.2008.11.015
10.1016/j.stem.2013.06.003
10.1016/j.molcel.2007.06.039
10.1038/nrd4140
10.1016/j.ccr.2012.10.017
10.1038/ncomms1681
10.1093/nar/gkr1312
10.1177/1947601913489020
10.1038/nature09934
10.1126/scisignal.2000594
10.1101/gad.1111603
10.1016/j.exphem.2006.06.019
10.1186/1756-8722-4-13
10.1016/j.cell.2013.06.026
10.1016/j.stem.2011.05.004
10.1038/sj.onc.1206304
10.1039/C3NR05042D
10.1016/j.ccr.2010.04.024
10.1038/nrc2765
10.1200/JCO.2012.44.3184
10.1016/j.jbior.2013.09.004
10.1016/j.cell.2004.12.035
10.1016/S1535-6108(03)00003-5
10.1182/blood-2010-01-266999
10.1007/978-1-4419-9967-2_13
10.1182/blood-2014-02-558114
10.1093/nar/gng015
10.1182/blood-2004-03-0940
10.1186/gb-2011-12-4-r41
10.1016/j.hoc.2011.09.018
10.1161/CIRCULATIONAHA.111.044354
10.1101/gr.6861907
10.1016/j.stem.2014.01.001
10.1056/NEJMoa0810069
10.1182/blood-2007-04-083600
10.1038/nrd1775
10.1182/blood-2009-03-210039
10.1038/sj.onc.1201238
10.1038/nature09586
10.1016/S0140-6736(06)69780-8
10.1016/S0076-6879(06)11009-5
10.1038/onc.2010.241
10.3324/haematol.2012.070664
10.1038/nature04980
10.1038/ncb3276
10.1073/pnas.1031694100
10.1038/nm1443
10.1155/2009/634292
10.1038/nature10334
ContentType Journal Article
Copyright The Author(s) 2016
Copyright Nature Publishing Group Apr 2016
Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2016 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Copyright_xml – notice: The Author(s) 2016
– notice: Copyright Nature Publishing Group Apr 2016
– notice: Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2016 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
5PM
DOA
DOI 10.1038/ncomms11452
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection (ProQuest)
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Journals
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Advanced Technologies & Computer Science Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Biological Science Database (ProQuest)
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE
MEDLINE - Academic
CrossRef


Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: PIMPY
  name: ProQuest Publicly Available Content Database
  url: http://search.proquest.com/publiccontent
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
Medicine
EISSN 2041-1723
EndPage 11452
ExternalDocumentID oai_doaj_org_article_f6c55704ac9d48718faf67aaba2ba41b
PMC5477496
4035543981
27116251
10_1038_ncomms11452
Genre Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GeographicLocations Chicago Illinois
United States--US
Illinois
China
GeographicLocations_xml – name: China
– name: United States--US
– name: Illinois
– name: Chicago Illinois
GrantInformation_xml – fundername: NCI NIH HHS
  grantid: R01 CA178454
– fundername: NCI NIH HHS
  grantid: R01 CA127277
– fundername: NCI NIH HHS
  grantid: R01 CA182528
GroupedDBID ---
0R~
39C
3V.
4.4
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADMLS
ADRAZ
AENEX
AEUYN
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BAPOH
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EJD
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AASML
AAYXX
AFFHD
CITATION
PHGZM
PHGZT
PJZUB
PPXIY
PQGLB
CGR
CUY
CVF
ECM
EIF
NPM
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
RC3
SOI
7X8
PUEGO
5PM
ID FETCH-LOGICAL-c512t-b39d4b5da410c38ce5221e7dbdb554565a04a0637ea6506db58eb7585c1328f83
IEDL.DBID M7P
ISICitedReferencesCount 122
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000374896000001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 2041-1723
IngestDate Fri Oct 03 12:46:17 EDT 2025
Tue Nov 04 01:44:53 EST 2025
Fri Sep 05 14:07:52 EDT 2025
Sat Nov 29 14:21:33 EST 2025
Mon Jul 21 06:07:49 EDT 2025
Tue Nov 18 21:49:35 EST 2025
Sat Nov 29 03:46:21 EST 2025
Fri Feb 21 02:40:28 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c512t-b39d4b5da410c38ce5221e7dbdb554565a04a0637ea6506db58eb7585c1328f83
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
OpenAccessLink https://www.proquest.com/docview/1784355724?pq-origsite=%requestingapplication%
PMID 27116251
PQID 1784355724
PQPubID 546298
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_f6c55704ac9d48718faf67aaba2ba41b
pubmedcentral_primary_oai_pubmedcentral_nih_gov_5477496
proquest_miscellaneous_1785216306
proquest_journals_1784355724
pubmed_primary_27116251
crossref_primary_10_1038_ncomms11452
crossref_citationtrail_10_1038_ncomms11452
springer_journals_10_1038_ncomms11452
PublicationCentury 2000
PublicationDate 20160426
PublicationDateYYYYMMDD 2016-04-26
PublicationDate_xml – month: 4
  year: 2016
  text: 20160426
  day: 26
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2016
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Takahashi (CR29) 2011; 4
Abdel-Wahab (CR53) 2009; 114
Williams (CR9) 2011; 473
Hu (CR10) 2014; 14
Bar, Dikstein (CR45) 2010; 5
Pack, Hoffman, Pun, Stayton (CR48) 2005; 4
Duan, Horwitz (CR47) 2003; 100
Griffiths, Gore (CR7) 2013; 754
Song (CR16) 2013; 13
Gurha (CR20) 2012; 125
Yan (CR19) 2006; 12
Krivtsov (CR60) 2006; 442
Parkin (CR67) 2010; 116
Figueroa (CR6) 2009; 114
Song (CR15) 2013; 154
Sekeres (CR62) 2012; 32
Schwable (CR35) 2005; 105
Huang, Cheng, Liu, Lin, Liu (CR55) 2006; 34
Jacoby, Walter (CR39) 2012; 12
Ling, Fabbri, Calin (CR56) 2013; 12
Konishi (CR41) 2003; 22
Poliseno (CR59) 2010; 3
Delhommeau (CR11) 2009; 360
Ley (CR22) 2013; 368
Lewis, Burge, Bartel (CR18) 2005; 120
Grimwade, Mrozek (CR3) 2011; 25
Cheng (CR25) 2008; 111
He, Li, Chen, Huang, Hurst, Chen (CR21) 2012; 40
Estey, Dohner (CR2) 2006; 368
Wunderlich (CR49) 2010; 24
Thambyrajah (CR52) 2016; 18
Li (CR23) 2012; 2
Jiang (CR17) 2012; 22
Jiang, Yang, Ma (CR63) 2009; 106
Saleque, Kim, Rooke, Orkin (CR51) 2007; 27
Zeisig, Kulasekararaj, Mufti, So (CR1) 2012; 22
Huang (CR14) 2013; 110
Cartron, Nadaradjane, Lepape, Lalier, Gardie, Vallette (CR50) 2013; 4
Wang (CR68) 2007; 17
Moran-Crusio (CR13) 2011; 20
Xu (CR38) 2004; 64
Mermel (CR65) 2011; 12
Chattopadhyay (CR43) 1997; 15
Smith (CR36) 2011; 8
Somervaille (CR61) 2009; 4
Drach, Lopez-Berestein, McQueen, Andreeff, Mehta (CR46) 1993; 53
Zuber (CR54) 2011; 478
Graubert, Walter (CR5) 2011; 2011
Haferlach (CR27) 2012; 51
Saeed (CR70) 2006; 411
Chen, Odenike, Rowley (CR4) 2010; 10
Armstrong (CR28) 2003; 3
Van Loo (CR69) 2010; 107
Ko (CR12) 2010; 468
Ninomiya (CR40) 2012; 136
Irizarry (CR58) 2003; 31
Xiong, Du, Liang (CR30) 2010; 29
Wang (CR24) 2010; 17
Wu, Qin, Fako, Zhang (CR37) 2014; 54
Li (CR44) 2013; 31
Sandoval, Pigazzi, Sakamoto (CR26) 2009; 2009
Ayton, Cleary (CR34) 2003; 17
Parkin (CR66) 2010; 16
Wu (CR8) 2011; 473
Placke (CR33) 2014; 124
Zeisig (CR31) 2004; 24
Pigazzi (CR32) 2013; 98
Modi (CR64) 2014; 6
Sankar (CR42) 1998; 12
Li (CR57) 2008; 105
M Wunderlich (BFncomms11452_CR49) 2010; 24
SJ Song (BFncomms11452_CR15) 2013; 154
MJ Huang (BFncomms11452_CR55) 2006; 34
H Ling (BFncomms11452_CR56) 2013; 12
SJ Song (BFncomms11452_CR16) 2013; 13
Z Li (BFncomms11452_CR44) 2013; 31
TC Somervaille (BFncomms11452_CR61) 2009; 4
K Wang (BFncomms11452_CR68) 2007; 17
BB Zeisig (BFncomms11452_CR1) 2012; 22
Z Wang (BFncomms11452_CR24) 2010; 17
S Sandoval (BFncomms11452_CR26) 2009; 2009
S Ninomiya (BFncomms11452_CR40) 2012; 136
MJ Sekeres (BFncomms11452_CR62) 2012; 32
AI Saeed (BFncomms11452_CR70) 2006; 411
ME Figueroa (BFncomms11452_CR6) 2009; 114
T Placke (BFncomms11452_CR33) 2014; 124
E Estey (BFncomms11452_CR2) 2006; 368
J Xiong (BFncomms11452_CR30) 2010; 29
D Grimwade (BFncomms11452_CR3) 2011; 25
P Chattopadhyay (BFncomms11452_CR43) 1997; 15
DA Modi (BFncomms11452_CR64) 2014; 6
DW Pack (BFncomms11452_CR48) 2005; 4
J Schwable (BFncomms11452_CR35) 2005; 105
X Wu (BFncomms11452_CR37) 2014; 54
H Huang (BFncomms11452_CR14) 2013; 110
F Delhommeau (BFncomms11452_CR11) 2009; 360
JC Cheng (BFncomms11452_CR25) 2008; 111
B Parkin (BFncomms11452_CR67) 2010; 116
J Drach (BFncomms11452_CR46) 1993; 53
MA Jacoby (BFncomms11452_CR39) 2012; 12
J Zuber (BFncomms11452_CR54) 2011; 478
BP Lewis (BFncomms11452_CR18) 2005; 120
R Thambyrajah (BFncomms11452_CR52) 2016; 18
EA Griffiths (BFncomms11452_CR7) 2013; 754
K Williams (BFncomms11452_CR9) 2011; 473
AV Krivtsov (BFncomms11452_CR60) 2006; 442
X Hu (BFncomms11452_CR10) 2014; 14
RA Irizarry (BFncomms11452_CR58) 2003; 31
T Graubert (BFncomms11452_CR5) 2011; 2011
C Haferlach (BFncomms11452_CR27) 2012; 51
LL Smith (BFncomms11452_CR36) 2011; 8
M Ko (BFncomms11452_CR12) 2010; 468
M Yan (BFncomms11452_CR19) 2006; 12
Z Duan (BFncomms11452_CR47) 2003; 100
H Wu (BFncomms11452_CR8) 2011; 473
TJ Ley (BFncomms11452_CR22) 2013; 368
PF Cartron (BFncomms11452_CR50) 2013; 4
X Jiang (BFncomms11452_CR63) 2009; 106
X Jiang (BFncomms11452_CR17) 2012; 22
C He (BFncomms11452_CR21) 2012; 40
M Sankar (BFncomms11452_CR42) 1998; 12
Z Li (BFncomms11452_CR23) 2012; 2
L Poliseno (BFncomms11452_CR59) 2010; 3
SA Armstrong (BFncomms11452_CR28) 2003; 3
S Takahashi (BFncomms11452_CR29) 2011; 4
P Gurha (BFncomms11452_CR20) 2012; 125
BB Zeisig (BFncomms11452_CR31) 2004; 24
B Parkin (BFncomms11452_CR66) 2010; 16
S Saleque (BFncomms11452_CR51) 2007; 27
O Abdel-Wahab (BFncomms11452_CR53) 2009; 114
CH Mermel (BFncomms11452_CR65) 2011; 12
J Chen (BFncomms11452_CR4) 2010; 10
N Bar (BFncomms11452_CR45) 2010; 5
P Van Loo (BFncomms11452_CR69) 2010; 107
H Konishi (BFncomms11452_CR41) 2003; 22
Y Xu (BFncomms11452_CR38) 2004; 64
K Moran-Crusio (BFncomms11452_CR13) 2011; 20
M Pigazzi (BFncomms11452_CR32) 2013; 98
PM Ayton (BFncomms11452_CR34) 2003; 17
Z Li (BFncomms11452_CR57) 2008; 105
9266974 - Oncogene. 1997 Aug 14;15(7):871-4
22353710 - Nat Commun. 2012 Feb 21;3:688
16052241 - Nat Rev Drug Discov. 2005 Jul;4(7):581-93
22456238 - Cytogenet Genome Res. 2012;136(4):246-55
21527027 - Genome Biol. 2011;12(4):R41
20837533 - Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16910-5
24529596 - Cell Stem Cell. 2014 Apr 3;14(4):512-22
20505189 - Clin Cancer Res. 2010 Aug 15;16(16):4135-47
12952893 - Genes Dev. 2003 Sep 15;17(18):2298-307
12660825 - Oncogene. 2003 Mar 27;22(12):1892-905
12721361 - Proc Natl Acad Sci U S A. 2003 May 13;100(10):5932-7
22468816 - Expert Rev Mol Diagn. 2012 Apr;12(3):253-64
23100280 - Haematologica. 2013 Apr;98(4):602-10
21453545 - J Hematol Oncol. 2011 Apr 01;4:13
21451524 - Nature. 2011 May 19;473(7347):389-93
20523723 - PLoS One. 2010 May 27;5(5):e10859
23830207 - Cell. 2013 Jul 18;154(2):311-24
24764564 - Blood. 2014 Jul 3;124(1):13-23
19474426 - N Engl J Med. 2009 May 28;360(22):2289-301
19960054 - Adv Hematol. 2009;2009:634292
20686503 - Leukemia. 2010 Oct;24(10):1785-8
23223304 - J Neurosci. 2012 Dec 5;32(49):17857-68
20029422 - Nat Rev Cancer. 2010 Jan;10(1):23-36
12620411 - Cancer Cell. 2003 Feb;3(2):173-83
8481912 - Cancer Res. 1993 May 1;53(9):2100-4
20388916 - Sci Signal. 2010 Apr 13;3(117):ra29
18832181 - Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15535-40
26619147 - Nat Cell Biol. 2016 Jan;18(1):21-32
12582260 - Nucleic Acids Res. 2003 Feb 15;31(4):e15
20729466 - Blood. 2010 Dec 2;116(23):4958-67
22238379 - Nucleic Acids Res. 2012 May;40(9):4002-12
22956506 - Adv Exp Med Biol. 2013;754:253-83
19200802 - Cell Stem Cell. 2009 Feb 6;4(2):129-40
19502428 - Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10183-8
17707228 - Mol Cell. 2007 Aug 17;27(4):562-72
24172333 - Nat Rev Drug Discov. 2013 Nov;12(11):847-65
21814200 - Nature. 2011 Aug 03;478(7370):524-8
23079661 - Cancer Cell. 2012 Oct 16;22(4):524-35
23827711 - Cell Stem Cell. 2013 Jul 3;13(1):87-101
17126723 - Lancet. 2006 Nov 25;368(9550):1894-907
23634996 - N Engl J Med. 2013 May 30;368(22):2059-74
16939790 - Methods Enzymol. 2006;411:134-93
19420352 - Blood. 2009 Jul 2;114(1):144-7
15536149 - Blood. 2005 Mar 1;105(5):2107-14
24080588 - Adv Biol Regul. 2014 Jan;54:214-21
19652201 - Blood. 2009 Oct 15;114(16):3448-58
20541704 - Cancer Cell. 2010 Jun 15;17(6):597-608
9557609 - Leukemia. 1998 Apr;12(4):510-6
22162288 - Genes Chromosomes Cancer. 2012 Apr;51(4):328-37
22093581 - Hematol Oncol Clin North Am. 2011 Dec;25(6):1135-61, vii
22160087 - Hematology Am Soc Hematol Educ Program. 2011;2011:543-9
23382473 - J Clin Oncol. 2013 Mar 20;31(9):1172-81
24069510 - Genes Cancer. 2013 May;4(5-6):235-41
15150086 - Cancer Res. 2004 May 15;64(10):3371-5
17975014 - Blood. 2008 Feb 1;111(3):1182-92
16892037 - Nat Med. 2006 Aug;12(8):945-9
16862118 - Nature. 2006 Aug 17;442(7104):818-22
22570371 - Circulation. 2012 Jun 5;125(22):2751-61
23818607 - Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11994-9
24468839 - Nanoscale. 2014 Mar 7;6(5):2812-20
15652477 - Cell. 2005 Jan 14;120(1):15-20
14701735 - Mol Cell Biol. 2004 Jan;24(2):617-28
20562918 - Oncogene. 2010 Sep 2;29(35):4980-8
21057493 - Nature. 2010 Dec 9;468(7325):839-43
21490601 - Nature. 2011 May 19;473(7347):343-8
21624810 - Cell Stem Cell. 2011 Jun 3;8(6):649-62
17921354 - Genome Res. 2007 Nov;17(11):1665-74
23153541 - Cancer Cell. 2012 Nov 13;22(5):698-698.e1
21723200 - Cancer Cell. 2011 Jul 12;20(1):11-24
17046567 - Exp Hematol. 2006 Nov;34(11):1480-9
References_xml – volume: 136
  start-page: 246
  year: 2012
  end-page: 255
  ident: CR40
  article-title: Integrated analysis of gene copy number, copy neutral LOH, and microRNA profiles in adult acute lymphoblastic leukemia
  publication-title: Cytogenet. Genome Res.
  doi: 10.1159/000337297
– volume: 473
  start-page: 343
  year: 2011
  end-page: 348
  ident: CR9
  article-title: TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
  publication-title: Nature
  doi: 10.1038/nature10066
– volume: 368
  start-page: 2059
  year: 2013
  end-page: 2074
  ident: CR22
  article-title: Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1301689
– volume: 20
  start-page: 11
  year: 2011
  end-page: 24
  ident: CR13
  article-title: Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2011.06.001
– volume: 51
  start-page: 328
  year: 2012
  end-page: 337
  ident: CR27
  article-title: ETV6 rearrangements are recurrent in myeloid malignancies and are frequently associated with other genetic events
  publication-title: Genes Chromosomes Cancer
  doi: 10.1002/gcc.21918
– volume: 24
  start-page: 1785
  year: 2010
  end-page: 1788
  ident: CR49
  article-title: AML xenograft efficiency is significantly improved in NOD/SCID-IL2RG mice constitutively expressing human SCF, GM-CSF and IL-3
  publication-title: Leukemia
  doi: 10.1038/leu.2010.158
– volume: 16
  start-page: 4135
  year: 2010
  end-page: 4147
  ident: CR66
  article-title: NF1 inactivation in adult acute myelogenous leukemia
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-09-2639
– volume: 114
  start-page: 3448
  year: 2009
  end-page: 3458
  ident: CR6
  article-title: MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation
  publication-title: Blood
  doi: 10.1182/blood-2009-01-200519
– volume: 64
  start-page: 3371
  year: 2004
  end-page: 3375
  ident: CR38
  article-title: The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-04-0044
– volume: 12
  start-page: 510
  year: 1998
  end-page: 516
  ident: CR42
  article-title: Identification of a commonly deleted region at 17p13.3 in leukemia and lymphoma associated with 17p abnormality
  publication-title: Leukemia
  doi: 10.1038/sj.leu.2400973
– volume: 2011
  start-page: 543
  year: 2011
  end-page: 549
  ident: CR5
  article-title: Genetics of myelodysplastic syndromes: new insights
  publication-title: Hematology Am. Soc. Hematol. Educ. Program
  doi: 10.1182/asheducation-2011.1.543
– volume: 12
  start-page: 253
  year: 2012
  end-page: 264
  ident: CR39
  article-title: Detection of copy number alterations in acute myeloid leukemia and myelodysplastic syndromes
  publication-title: Expert Rev. Mol. Diagn.
  doi: 10.1586/erm.12.18
– volume: 24
  start-page: 617
  year: 2004
  end-page: 628
  ident: CR31
  article-title: Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.24.2.617-628.2004
– volume: 5
  start-page: e10859
  year: 2010
  ident: CR45
  article-title: miR-22 forms a regulatory loop in PTEN/AKT pathway and modulates signaling kinetics
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0010859
– volume: 107
  start-page: 16910
  year: 2010
  end-page: 16915
  ident: CR69
  article-title: Allele-specific copy number analysis of tumors
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1009843107
– volume: 110
  start-page: 11994
  year: 2013
  end-page: 11999
  ident: CR14
  article-title: TET1 plays an essential oncogenic role in MLL-rearranged leukemia
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1310656110
– volume: 106
  start-page: 10183
  year: 2009
  end-page: 10188
  ident: CR63
  article-title: Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0812105106
– volume: 32
  start-page: 17857
  year: 2012
  end-page: 17868
  ident: CR62
  article-title: Increasing CRTC1 function in the dentate gyrus during memory formation or reactivation increases memory strength without compromising memory quality
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1419-12.2012
– volume: 22
  start-page: 524
  year: 2012
  end-page: 535
  ident: CR17
  article-title: Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.08.028
– volume: 105
  start-page: 15535
  year: 2008
  end-page: 15540
  ident: CR57
  article-title: Distinct microRNA expression profiles in acute myeloid leukemia with common translocations
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0808266105
– volume: 4
  start-page: 129
  year: 2009
  end-page: 140
  ident: CR61
  article-title: Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2008.11.015
– volume: 13
  start-page: 87
  year: 2013
  end-page: 101
  ident: CR16
  article-title: The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2013.06.003
– volume: 27
  start-page: 562
  year: 2007
  end-page: 572
  ident: CR51
  article-title: Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2007.06.039
– volume: 12
  start-page: 847
  year: 2013
  end-page: 865
  ident: CR56
  article-title: MicroRNAs and other non-coding RNAs as targets for anticancer drug development
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd4140
– volume: 22
  start-page: 698
  year: 2012
  end-page: 698.e1
  ident: CR1
  article-title: SnapShot: acute myeloid leukemia
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.10.017
– volume: 2
  start-page: 688
  year: 2012
  ident: CR23
  article-title: miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms1681
– volume: 40
  start-page: 4002
  year: 2012
  end-page: 4012
  ident: CR21
  article-title: Young intragenic miRNAs are less coexpressed with host genes than old ones: implications of miRNA-host gene coevolution
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkr1312
– volume: 4
  start-page: 235
  year: 2013
  end-page: 241
  ident: CR50
  article-title: Identification of TET1 partners that control its DNA-demethylating function
  publication-title: Genes Cancer
  doi: 10.1177/1947601913489020
– volume: 473
  start-page: 389
  year: 2011
  end-page: 393
  ident: CR8
  article-title: Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells
  publication-title: Nature
  doi: 10.1038/nature09934
– volume: 3
  start-page: ra29
  year: 2010
  ident: CR59
  article-title: Identification of the miR-106b∼25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in ransformation
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.2000594
– volume: 17
  start-page: 2298
  year: 2003
  end-page: 2307
  ident: CR34
  article-title: Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9
  publication-title: Genes Dev.
  doi: 10.1101/gad.1111603
– volume: 34
  start-page: 1480
  year: 2006
  end-page: 1489
  ident: CR55
  article-title: A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia
  publication-title: Exp. Hematol.
  doi: 10.1016/j.exphem.2006.06.019
– volume: 4
  start-page: 13
  year: 2011
  ident: CR29
  article-title: Downstream molecular pathways of FLT3 in the pathogenesis of acute myeloid leukemia: biology and therapeutic implications
  publication-title: J. Hematol. Oncol.
  doi: 10.1186/1756-8722-4-13
– volume: 154
  start-page: 311
  year: 2013
  end-page: 324
  ident: CR15
  article-title: MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling
  publication-title: Cell
  doi: 10.1016/j.cell.2013.06.026
– volume: 8
  start-page: 649
  year: 2011
  end-page: 662
  ident: CR36
  article-title: Functional crosstalk between Bmi1 and MLL/Hoxa9 axis in establishment of normal hematopoietic and leukemic stem cells
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2011.05.004
– volume: 22
  start-page: 1892
  year: 2003
  end-page: 1905
  ident: CR41
  article-title: Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at distal 17p13.3 in human lung cancer
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1206304
– volume: 6
  start-page: 2812
  year: 2014
  end-page: 2820
  ident: CR64
  article-title: Targeting of follicle stimulating hormone peptide-conjugated dendrimers to ovarian cancer cells
  publication-title: Nanoscale
  doi: 10.1039/C3NR05042D
– volume: 17
  start-page: 597
  year: 2010
  end-page: 608
  ident: CR24
  article-title: GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2010.04.024
– volume: 10
  start-page: 23
  year: 2010
  end-page: 36
  ident: CR4
  article-title: Leukaemogenesis: more than mutant genes
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc2765
– volume: 31
  start-page: 1172
  year: 2013
  end-page: 1181
  ident: CR44
  article-title: Identification of a 24-gene prognostic signature that improves the European LeukemiaNet risk classification of acute myeloid leukemia: an international collaborative study
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2012.44.3184
– volume: 54
  start-page: 214
  year: 2014
  end-page: 221
  ident: CR37
  article-title: Molecular mechanisms of fatty acid synthase (FASN)-mediated resistance to anti-cancer treatments
  publication-title: Adv. Biol. Regul.
  doi: 10.1016/j.jbior.2013.09.004
– volume: 120
  start-page: 15
  year: 2005
  end-page: 20
  ident: CR18
  article-title: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
  publication-title: Cell
  doi: 10.1016/j.cell.2004.12.035
– volume: 3
  start-page: 173
  year: 2003
  end-page: 183
  ident: CR28
  article-title: Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification
  publication-title: Cancer Cell
  doi: 10.1016/S1535-6108(03)00003-5
– volume: 116
  start-page: 4958
  year: 2010
  end-page: 4967
  ident: CR67
  article-title: Acquired genomic copy number aberrations and survival in adult acute myelogenous leukemia
  publication-title: Blood
  doi: 10.1182/blood-2010-01-266999
– volume: 754
  start-page: 253
  year: 2013
  end-page: 283
  ident: CR7
  article-title: Epigenetic therapies in MDS and AML
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-1-4419-9967-2_13
– volume: 124
  start-page: 13
  year: 2014
  end-page: 23
  ident: CR33
  article-title: Requirement for CDK6 in MLL-rearranged acute myeloid leukemia
  publication-title: Blood
  doi: 10.1182/blood-2014-02-558114
– volume: 31
  start-page: e15
  year: 2003
  ident: CR58
  article-title: Summaries of Affymetrix GeneChip probe level data
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gng015
– volume: 105
  start-page: 2107
  year: 2005
  end-page: 2114
  ident: CR35
  article-title: RGS2 is an important target gene of Flt3-ITD mutations in AML and functions in myeloid differentiation and leukemic transformation
  publication-title: Blood
  doi: 10.1182/blood-2004-03-0940
– volume: 12
  start-page: R41
  year: 2011
  ident: CR65
  article-title: GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
  publication-title: Genome Biol.
  doi: 10.1186/gb-2011-12-4-r41
– volume: 25
  start-page: 1135
  year: 2011
  end-page: 1161
  ident: CR3
  article-title: Diagnostic and prognostic value of cytogenetics in acute myeloid leukemia
  publication-title: Hematol. Oncol. Clin. North Am.
  doi: 10.1016/j.hoc.2011.09.018
– volume: 125
  start-page: 2751
  year: 2012
  end-page: 2761
  ident: CR20
  article-title: Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.111.044354
– volume: 17
  start-page: 1665
  year: 2007
  end-page: 1674
  ident: CR68
  article-title: PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data
  publication-title: Genome Res.
  doi: 10.1101/gr.6861907
– volume: 14
  start-page: 512
  year: 2014
  end-page: 522
  ident: CR10
  article-title: Tet and TDG mediate DNA demethylation essential for mesenchymal-to-epithelial transition in somatic cell reprogramming
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2014.01.001
– volume: 360
  start-page: 2289
  year: 2009
  end-page: 2301
  ident: CR11
  article-title: Mutation in TET2 in myeloid cancers
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0810069
– volume: 111
  start-page: 1182
  year: 2008
  end-page: 1192
  ident: CR25
  article-title: CREB is a critical regulator of normal hematopoiesis and leukemogenesis
  publication-title: Blood
  doi: 10.1182/blood-2007-04-083600
– volume: 4
  start-page: 581
  year: 2005
  end-page: 593
  ident: CR48
  article-title: Design and development of polymers for gene delivery
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd1775
– volume: 114
  start-page: 144
  year: 2009
  end-page: 147
  ident: CR53
  article-title: Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
  publication-title: Blood
  doi: 10.1182/blood-2009-03-210039
– volume: 15
  start-page: 871
  year: 1997
  end-page: 874
  ident: CR43
  article-title: Loss of heterozygosity of a locus on 17p13.3, independent of p53, is associated with higher grades of astrocytic tumours
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1201238
– volume: 53
  start-page: 2100
  year: 1993
  end-page: 2104
  ident: CR46
  article-title: Induction of differentiation in myeloid leukemia cell lines and acute promyelocytic leukemia cells by liposomal all-trans-retinoic acid
  publication-title: Cancer Res.
– volume: 468
  start-page: 839
  year: 2010
  end-page: 843
  ident: CR12
  article-title: Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
  publication-title: Nature
  doi: 10.1038/nature09586
– volume: 368
  start-page: 1894
  year: 2006
  end-page: 1907
  ident: CR2
  article-title: Acute myeloid leukaemia
  publication-title: Lancet
  doi: 10.1016/S0140-6736(06)69780-8
– volume: 411
  start-page: 134
  year: 2006
  end-page: 193
  ident: CR70
  article-title: TM4 microarray software suite
  publication-title: Methods Enzymol.
  doi: 10.1016/S0076-6879(06)11009-5
– volume: 29
  start-page: 4980
  year: 2010
  end-page: 4988
  ident: CR30
  article-title: Tumor-suppressive microRNA-22 inhibits the transcription of E-box-containing c-Myc target genes by silencing c-Myc binding protein
  publication-title: Oncogene
  doi: 10.1038/onc.2010.241
– volume: 98
  start-page: 602
  year: 2013
  end-page: 610
  ident: CR32
  article-title: MicroRNA-34b promoter hypermethylation induces CREB overexpression and contributes to myeloid transformation
  publication-title: Haematologica
  doi: 10.3324/haematol.2012.070664
– volume: 442
  start-page: 818
  year: 2006
  end-page: 822
  ident: CR60
  article-title: Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9
  publication-title: Nature
  doi: 10.1038/nature04980
– volume: 18
  start-page: 21
  year: 2016
  end-page: 32
  ident: CR52
  article-title: GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3276
– volume: 100
  start-page: 5932
  year: 2003
  end-page: 5937
  ident: CR47
  article-title: Targets of the transcriptional repressor oncoprotein Gfi-1
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1031694100
– volume: 12
  start-page: 945
  year: 2006
  end-page: 949
  ident: CR19
  article-title: A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis
  publication-title: Nat. Med.
  doi: 10.1038/nm1443
– volume: 2009
  start-page: 634292
  year: 2009
  ident: CR26
  article-title: CREB: a key regulator of normal and neoplastic hematopoiesis
  publication-title: Adv. Hematol.
  doi: 10.1155/2009/634292
– volume: 478
  start-page: 524
  year: 2011
  end-page: 528
  ident: CR54
  article-title: RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
  publication-title: Nature
  doi: 10.1038/nature10334
– volume: 368
  start-page: 1894
  year: 2006
  ident: BFncomms11452_CR2
  publication-title: Lancet
  doi: 10.1016/S0140-6736(06)69780-8
– volume: 20
  start-page: 11
  year: 2011
  ident: BFncomms11452_CR13
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2011.06.001
– volume: 40
  start-page: 4002
  year: 2012
  ident: BFncomms11452_CR21
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkr1312
– volume: 31
  start-page: 1172
  year: 2013
  ident: BFncomms11452_CR44
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2012.44.3184
– volume: 16
  start-page: 4135
  year: 2010
  ident: BFncomms11452_CR66
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-09-2639
– volume: 17
  start-page: 1665
  year: 2007
  ident: BFncomms11452_CR68
  publication-title: Genome Res.
  doi: 10.1101/gr.6861907
– volume: 34
  start-page: 1480
  year: 2006
  ident: BFncomms11452_CR55
  publication-title: Exp. Hematol.
  doi: 10.1016/j.exphem.2006.06.019
– volume: 114
  start-page: 144
  year: 2009
  ident: BFncomms11452_CR53
  publication-title: Blood
  doi: 10.1182/blood-2009-03-210039
– volume: 22
  start-page: 524
  year: 2012
  ident: BFncomms11452_CR17
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.08.028
– volume: 51
  start-page: 328
  year: 2012
  ident: BFncomms11452_CR27
  publication-title: Genes Chromosomes Cancer
  doi: 10.1002/gcc.21918
– volume: 13
  start-page: 87
  year: 2013
  ident: BFncomms11452_CR16
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2013.06.003
– volume: 110
  start-page: 11994
  year: 2013
  ident: BFncomms11452_CR14
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1310656110
– volume: 4
  start-page: 235
  year: 2013
  ident: BFncomms11452_CR50
  publication-title: Genes Cancer
  doi: 10.1177/1947601913489020
– volume: 3
  start-page: ra29
  year: 2010
  ident: BFncomms11452_CR59
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.2000594
– volume: 12
  start-page: R41
  year: 2011
  ident: BFncomms11452_CR65
  publication-title: Genome Biol.
  doi: 10.1186/gb-2011-12-4-r41
– volume: 6
  start-page: 2812
  year: 2014
  ident: BFncomms11452_CR64
  publication-title: Nanoscale
  doi: 10.1039/C3NR05042D
– volume: 25
  start-page: 1135
  year: 2011
  ident: BFncomms11452_CR3
  publication-title: Hematol. Oncol. Clin. North Am.
  doi: 10.1016/j.hoc.2011.09.018
– volume: 360
  start-page: 2289
  year: 2009
  ident: BFncomms11452_CR11
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa0810069
– volume: 473
  start-page: 389
  year: 2011
  ident: BFncomms11452_CR8
  publication-title: Nature
  doi: 10.1038/nature09934
– volume: 27
  start-page: 562
  year: 2007
  ident: BFncomms11452_CR51
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2007.06.039
– volume: 64
  start-page: 3371
  year: 2004
  ident: BFncomms11452_CR38
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-04-0044
– volume: 114
  start-page: 3448
  year: 2009
  ident: BFncomms11452_CR6
  publication-title: Blood
  doi: 10.1182/blood-2009-01-200519
– volume: 10
  start-page: 23
  year: 2010
  ident: BFncomms11452_CR4
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc2765
– volume: 154
  start-page: 311
  year: 2013
  ident: BFncomms11452_CR15
  publication-title: Cell
  doi: 10.1016/j.cell.2013.06.026
– volume: 17
  start-page: 2298
  year: 2003
  ident: BFncomms11452_CR34
  publication-title: Genes Dev.
  doi: 10.1101/gad.1111603
– volume: 8
  start-page: 649
  year: 2011
  ident: BFncomms11452_CR36
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2011.05.004
– volume: 22
  start-page: 1892
  year: 2003
  ident: BFncomms11452_CR41
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1206304
– volume: 411
  start-page: 134
  year: 2006
  ident: BFncomms11452_CR70
  publication-title: Methods Enzymol.
  doi: 10.1016/S0076-6879(06)11009-5
– volume: 14
  start-page: 512
  year: 2014
  ident: BFncomms11452_CR10
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2014.01.001
– volume: 116
  start-page: 4958
  year: 2010
  ident: BFncomms11452_CR67
  publication-title: Blood
  doi: 10.1182/blood-2010-01-266999
– volume: 473
  start-page: 343
  year: 2011
  ident: BFncomms11452_CR9
  publication-title: Nature
  doi: 10.1038/nature10066
– volume: 53
  start-page: 2100
  year: 1993
  ident: BFncomms11452_CR46
  publication-title: Cancer Res.
– volume: 106
  start-page: 10183
  year: 2009
  ident: BFncomms11452_CR63
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0812105106
– volume: 2009
  start-page: 634292
  year: 2009
  ident: BFncomms11452_CR26
  publication-title: Adv. Hematol.
  doi: 10.1155/2009/634292
– volume: 32
  start-page: 17857
  year: 2012
  ident: BFncomms11452_CR62
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.1419-12.2012
– volume: 468
  start-page: 839
  year: 2010
  ident: BFncomms11452_CR12
  publication-title: Nature
  doi: 10.1038/nature09586
– volume: 105
  start-page: 15535
  year: 2008
  ident: BFncomms11452_CR57
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0808266105
– volume: 15
  start-page: 871
  year: 1997
  ident: BFncomms11452_CR43
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1201238
– volume: 29
  start-page: 4980
  year: 2010
  ident: BFncomms11452_CR30
  publication-title: Oncogene
  doi: 10.1038/onc.2010.241
– volume: 12
  start-page: 510
  year: 1998
  ident: BFncomms11452_CR42
  publication-title: Leukemia
  doi: 10.1038/sj.leu.2400973
– volume: 478
  start-page: 524
  year: 2011
  ident: BFncomms11452_CR54
  publication-title: Nature
  doi: 10.1038/nature10334
– volume: 4
  start-page: 581
  year: 2005
  ident: BFncomms11452_CR48
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd1775
– volume: 2
  start-page: 688
  year: 2012
  ident: BFncomms11452_CR23
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms1681
– volume: 24
  start-page: 617
  year: 2004
  ident: BFncomms11452_CR31
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.24.2.617-628.2004
– volume: 12
  start-page: 253
  year: 2012
  ident: BFncomms11452_CR39
  publication-title: Expert Rev. Mol. Diagn.
  doi: 10.1586/erm.12.18
– volume: 120
  start-page: 15
  year: 2005
  ident: BFncomms11452_CR18
  publication-title: Cell
  doi: 10.1016/j.cell.2004.12.035
– volume: 111
  start-page: 1182
  year: 2008
  ident: BFncomms11452_CR25
  publication-title: Blood
  doi: 10.1182/blood-2007-04-083600
– volume: 24
  start-page: 1785
  year: 2010
  ident: BFncomms11452_CR49
  publication-title: Leukemia
  doi: 10.1038/leu.2010.158
– volume: 18
  start-page: 21
  year: 2016
  ident: BFncomms11452_CR52
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3276
– volume: 12
  start-page: 847
  year: 2013
  ident: BFncomms11452_CR56
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd4140
– volume: 105
  start-page: 2107
  year: 2005
  ident: BFncomms11452_CR35
  publication-title: Blood
  doi: 10.1182/blood-2004-03-0940
– volume: 98
  start-page: 602
  year: 2013
  ident: BFncomms11452_CR32
  publication-title: Haematologica
  doi: 10.3324/haematol.2012.070664
– volume: 4
  start-page: 129
  year: 2009
  ident: BFncomms11452_CR61
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2008.11.015
– volume: 125
  start-page: 2751
  year: 2012
  ident: BFncomms11452_CR20
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.111.044354
– volume: 136
  start-page: 246
  year: 2012
  ident: BFncomms11452_CR40
  publication-title: Cytogenet. Genome Res.
  doi: 10.1159/000337297
– volume: 3
  start-page: 173
  year: 2003
  ident: BFncomms11452_CR28
  publication-title: Cancer Cell
  doi: 10.1016/S1535-6108(03)00003-5
– volume: 12
  start-page: 945
  year: 2006
  ident: BFncomms11452_CR19
  publication-title: Nat. Med.
  doi: 10.1038/nm1443
– volume: 17
  start-page: 597
  year: 2010
  ident: BFncomms11452_CR24
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2010.04.024
– volume: 5
  start-page: e10859
  year: 2010
  ident: BFncomms11452_CR45
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0010859
– volume: 2011
  start-page: 543
  year: 2011
  ident: BFncomms11452_CR5
  publication-title: Hematology Am. Soc. Hematol. Educ. Program
  doi: 10.1182/asheducation-2011.1.543
– volume: 754
  start-page: 253
  year: 2013
  ident: BFncomms11452_CR7
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-1-4419-9967-2_13
– volume: 368
  start-page: 2059
  year: 2013
  ident: BFncomms11452_CR22
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1301689
– volume: 4
  start-page: 13
  year: 2011
  ident: BFncomms11452_CR29
  publication-title: J. Hematol. Oncol.
  doi: 10.1186/1756-8722-4-13
– volume: 100
  start-page: 5932
  year: 2003
  ident: BFncomms11452_CR47
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1031694100
– volume: 54
  start-page: 214
  year: 2014
  ident: BFncomms11452_CR37
  publication-title: Adv. Biol. Regul.
  doi: 10.1016/j.jbior.2013.09.004
– volume: 31
  start-page: e15
  year: 2003
  ident: BFncomms11452_CR58
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gng015
– volume: 22
  start-page: 698
  year: 2012
  ident: BFncomms11452_CR1
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.10.017
– volume: 442
  start-page: 818
  year: 2006
  ident: BFncomms11452_CR60
  publication-title: Nature
  doi: 10.1038/nature04980
– volume: 107
  start-page: 16910
  year: 2010
  ident: BFncomms11452_CR69
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1009843107
– volume: 124
  start-page: 13
  year: 2014
  ident: BFncomms11452_CR33
  publication-title: Blood
  doi: 10.1182/blood-2014-02-558114
– reference: 17046567 - Exp Hematol. 2006 Nov;34(11):1480-9
– reference: 22570371 - Circulation. 2012 Jun 5;125(22):2751-61
– reference: 22160087 - Hematology Am Soc Hematol Educ Program. 2011;2011:543-9
– reference: 14701735 - Mol Cell Biol. 2004 Jan;24(2):617-28
– reference: 9266974 - Oncogene. 1997 Aug 14;15(7):871-4
– reference: 12620411 - Cancer Cell. 2003 Feb;3(2):173-83
– reference: 19960054 - Adv Hematol. 2009;2009:634292
– reference: 19652201 - Blood. 2009 Oct 15;114(16):3448-58
– reference: 20837533 - Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16910-5
– reference: 19502428 - Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10183-8
– reference: 9557609 - Leukemia. 1998 Apr;12(4):510-6
– reference: 20541704 - Cancer Cell. 2010 Jun 15;17(6):597-608
– reference: 23079661 - Cancer Cell. 2012 Oct 16;22(4):524-35
– reference: 22353710 - Nat Commun. 2012 Feb 21;3:688
– reference: 22456238 - Cytogenet Genome Res. 2012;136(4):246-55
– reference: 24764564 - Blood. 2014 Jul 3;124(1):13-23
– reference: 23830207 - Cell. 2013 Jul 18;154(2):311-24
– reference: 23827711 - Cell Stem Cell. 2013 Jul 3;13(1):87-101
– reference: 19474426 - N Engl J Med. 2009 May 28;360(22):2289-301
– reference: 15536149 - Blood. 2005 Mar 1;105(5):2107-14
– reference: 16939790 - Methods Enzymol. 2006;411:134-93
– reference: 22162288 - Genes Chromosomes Cancer. 2012 Apr;51(4):328-37
– reference: 16892037 - Nat Med. 2006 Aug;12(8):945-9
– reference: 12952893 - Genes Dev. 2003 Sep 15;17(18):2298-307
– reference: 20729466 - Blood. 2010 Dec 2;116(23):4958-67
– reference: 22238379 - Nucleic Acids Res. 2012 May;40(9):4002-12
– reference: 23153541 - Cancer Cell. 2012 Nov 13;22(5):698-698.e1
– reference: 24080588 - Adv Biol Regul. 2014 Jan;54:214-21
– reference: 8481912 - Cancer Res. 1993 May 1;53(9):2100-4
– reference: 20388916 - Sci Signal. 2010 Apr 13;3(117):ra29
– reference: 19420352 - Blood. 2009 Jul 2;114(1):144-7
– reference: 23223304 - J Neurosci. 2012 Dec 5;32(49):17857-68
– reference: 15150086 - Cancer Res. 2004 May 15;64(10):3371-5
– reference: 16862118 - Nature. 2006 Aug 17;442(7104):818-22
– reference: 17921354 - Genome Res. 2007 Nov;17(11):1665-74
– reference: 21814200 - Nature. 2011 Aug 03;478(7370):524-8
– reference: 26619147 - Nat Cell Biol. 2016 Jan;18(1):21-32
– reference: 15652477 - Cell. 2005 Jan 14;120(1):15-20
– reference: 20505189 - Clin Cancer Res. 2010 Aug 15;16(16):4135-47
– reference: 21527027 - Genome Biol. 2011;12(4):R41
– reference: 23100280 - Haematologica. 2013 Apr;98(4):602-10
– reference: 20562918 - Oncogene. 2010 Sep 2;29(35):4980-8
– reference: 22956506 - Adv Exp Med Biol. 2013;754:253-83
– reference: 12660825 - Oncogene. 2003 Mar 27;22(12):1892-905
– reference: 17707228 - Mol Cell. 2007 Aug 17;27(4):562-72
– reference: 23818607 - Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11994-9
– reference: 18832181 - Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15535-40
– reference: 24468839 - Nanoscale. 2014 Mar 7;6(5):2812-20
– reference: 24172333 - Nat Rev Drug Discov. 2013 Nov;12(11):847-65
– reference: 21490601 - Nature. 2011 May 19;473(7347):343-8
– reference: 12582260 - Nucleic Acids Res. 2003 Feb 15;31(4):e15
– reference: 20523723 - PLoS One. 2010 May 27;5(5):e10859
– reference: 23382473 - J Clin Oncol. 2013 Mar 20;31(9):1172-81
– reference: 17126723 - Lancet. 2006 Nov 25;368(9550):1894-907
– reference: 21723200 - Cancer Cell. 2011 Jul 12;20(1):11-24
– reference: 21624810 - Cell Stem Cell. 2011 Jun 3;8(6):649-62
– reference: 17975014 - Blood. 2008 Feb 1;111(3):1182-92
– reference: 19200802 - Cell Stem Cell. 2009 Feb 6;4(2):129-40
– reference: 12721361 - Proc Natl Acad Sci U S A. 2003 May 13;100(10):5932-7
– reference: 21451524 - Nature. 2011 May 19;473(7347):389-93
– reference: 21453545 - J Hematol Oncol. 2011 Apr 01;4:13
– reference: 16052241 - Nat Rev Drug Discov. 2005 Jul;4(7):581-93
– reference: 21057493 - Nature. 2010 Dec 9;468(7325):839-43
– reference: 22093581 - Hematol Oncol Clin North Am. 2011 Dec;25(6):1135-61, vii
– reference: 20686503 - Leukemia. 2010 Oct;24(10):1785-8
– reference: 24069510 - Genes Cancer. 2013 May;4(5-6):235-41
– reference: 22468816 - Expert Rev Mol Diagn. 2012 Apr;12(3):253-64
– reference: 20029422 - Nat Rev Cancer. 2010 Jan;10(1):23-36
– reference: 24529596 - Cell Stem Cell. 2014 Apr 3;14(4):512-22
– reference: 23634996 - N Engl J Med. 2013 May 30;368(22):2059-74
SSID ssj0000391844
Score 2.5347505
Snippet MicroRNAs are subject to precise regulation and have key roles in tumorigenesis. In contrast to the oncogenic role of miR-22 reported in myelodysplastic...
Mir-22 has been shown to be an oncogenic microRNA in breast cancer and myelodysplastic syndrome. Here, the authors show that mir-22 functions as a tumour...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 11452
SubjectTerms 13
14
38
631/337/384/331
631/67/1059
631/67/1990/283/1897
631/80/86
64
96
Acute Disease
Animals
Breast cancer
Cell Line
Cell Line, Tumor
Cell Proliferation - genetics
Down-Regulation
Epigenesis, Genetic
Epigenetics
Gene Expression Profiling
Gene Expression Regulation, Leukemic
Genes, Tumor Suppressor
HEK293 Cells
Hematology
Humanities and Social Sciences
Humans
Leukemia
Leukemia, Myeloid - drug therapy
Leukemia, Myeloid - genetics
Leukemia, Myeloid - pathology
Medicine
Mice, Inbred C57BL
MicroRNAs
MicroRNAs - chemistry
MicroRNAs - genetics
MicroRNAs - therapeutic use
multidisciplinary
Mutation
Myelodysplastic syndromes
Myelodysplastic Syndromes - genetics
Myelodysplastic Syndromes - pathology
Oncology
Pathogenesis
Roles
Science
Science (multidisciplinary)
Signal Transduction - genetics
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrZ3Pa9RAFMcfUip4kdaf0Soj1IsQmkwyyeSoYvFURBSKlzC_QoO72bKbCP3v-51JdsnaghcvOSSPMHznTebzMjPvEZ1micobXGKgQhLnmHBj6bTFwHNOpE7ayplQbKK8uJCXl9W3WakvvydsTA88CnfWFMZnicqVqSzgOpWNaopSKa24Vnmq_dcX1DMLpsI3OKsQuuTTgbwkk2cdOnC5Af0LvjcFhUz99-Hl3V2Sfy2Vhhno_IgeT-jIPo5NPqYHrntCD8dikjdP6dey_R5zzq7Uhil2vQIM9wy6tXE_IL5fM7-RkPn_rmx26GoyhBeytmPKDL1jyxu3WLWWLdzwW7llq57Rz_MvPz5_jafKCbHBBN7HOoNYWlgIlJhMGgfKSl1ptdXCI5NQEBRwUjoFQitwFx3kIweD4FQ2MntOB92qcy-J5YU1AkzBLQTVptFJoXz-qMaTguAqog9bMWszpRX31S0WdVjezmQ9Uz6i053x9ZhN436zT75XdiY-BXa4AceoJ8eo_-UYEZ1s-7SexuWmTksJPhQlzyN6t3uMEeWXSVTnVkOwAdMUiKUiejG6wK4lvExTRIxpROWec-w1df9J116FrN0iB2lXeOf7rRvNmnVXg1f_Q4PX9AiAV_jVL16c0EG_HtwbOjR_-nazfhuGzC0Nux9r
  priority: 102
  providerName: Directory of Open Access Journals
Title miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia
URI https://link.springer.com/article/10.1038/ncomms11452
https://www.ncbi.nlm.nih.gov/pubmed/27116251
https://www.proquest.com/docview/1784355724
https://www.proquest.com/docview/1785216306
https://pubmed.ncbi.nlm.nih.gov/PMC5477496
https://doaj.org/article/f6c55704ac9d48718faf67aaba2ba41b
Volume 7
WOSCitedRecordID wos000374896000001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: DOA
  dateStart: 20150101
  isFulltext: true
  titleUrlDefault: https://www.doaj.org/
  providerName: Directory of Open Access Journals
– providerCode: PRVHPJ
  databaseName: ROAD: Directory of Open Access Scholarly Resources
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: M~E
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://road.issn.org
  providerName: ISSN International Centre
– providerCode: PRVPQU
  databaseName: Advanced Technologies & Aerospace Database
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: P5Z
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/hightechjournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Biological Science Database
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: M7P
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/biologicalscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: 7X7
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: BENPR
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Publicly Available Content Database
  customDbUrl:
  eissn: 2041-1723
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0000391844
  issn: 2041-1723
  databaseCode: PIMPY
  dateStart: 20100101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/publiccontent
  providerName: ProQuest
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB7RFhAXHuUVKCsjlQtS1DzsxHtCFLWCQ1dRBdLSS2Q7ThuxSZZNgtR_z9jrXXZpxYWLD_bIsjMz8Tcz9gzAYRwIWmLjI1QIfIoHrs-1LFDxtGah5sVYK1tsIp1M-HQ6zpzDrXPXKlf_RPujLlplfORHYcrxZGdpRD_Mf_qmapSJrroSGjuwZ7IkxPbqXrb2sZjs55xS9ywviPlRg1PWHdoALNo6iGy-_ttA5s27kn8FTO05dProf3fwGB46BEo-LkXmCdzRzT7cW9akvN6H-2cu2v4ULurq3I8iciU6Isi8RXjdE-RE5fdDjdMQczWRGE8u2XjG5QhRrknVEKGGXpP6Ws_aqiAzPfwQuq7EM_h2evL102ff1WLwFUKC3pfxuKCSFYKGgYq50ojbQp0WspDMgDAmAioQ7qRaIOZLsBdZbmwRheYuL3n8HHabttEvgdCkUAxRSlQgc6QqZZAIk5GqNNiDRcKD9yvG5MolKjf1Mma5DZjHPN_gogeHa-L5Mj_H7WTHhsNrEpNU23a0i8vc6WheJsokJKNC4V7RkOSlKJNUCCkiifuWHhysGJs7Te_yP1z14O16GHXUBF5Eo9vB0iBKStA68-DFUpzWK4nSMEQbNPQg3RK0raVujzTVlc0Dzihi9zHO-W4lkhvLuvkNXv17-a_hAYLBxETKouQAdvvFoN_AXfWrr7rFCHbSaWpbPoK945NJdj6y_ouRVTlsM3aBI9mXs-z7b3fYNq0
linkProvider ProQuest
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VAoULj_IKFDBSe0GKmjhO4j0gxKtq1XZVoSJVvQTHdtqITbJsEtD-KX4j47zYpRW3HrjsIRlZM9l5fGOPZwA2PUewBH9shAqOzTDg2lzHCg1Pa9_VXI20bIZNhOMxPzkZHa3Ar_4ujCmr7H1i46hVIc0e-bYbcozsfkjZ2-l320yNMqer_QiNVi329fwnpmzlm72P-P9uUbrz6fjDrt1NFbAlBrfKjr2RYrGvBHMd6XGpEYG4OlSxin0DJ3zhMIGBO9QC0UuAT5F5g6olJm484R6uew2uo1SUN6WCR8Oejum2zhnrrgE6Ht_OUYSsxJzDp0uBr5kPcBmovVib-dcBbRP3du7-b1_sHtzpEDZ515rEfVjR-TrcbGduztdh7bCrJngAp1n62aaUnIuSCDItMH2oCGpaald1hssQU3pJzE41Wbim1hGi3ZI0J0LWlSbZXE-KVJGJrr8JnaXiIXy5EhkfwWpe5PoJEBYo6SMKowqVIZZJ7ATCdNxKDLbyqbDgda8IkewasZt5IJOoKQjweLSgNRZsDsTTtv_I5WTvjUYNJKZpePOgmJ1FnQ-KkkCahmtMSJQVE2WeiCQIhYgFjVHu2IKNXpGizpOV0R8tsuDV8Bp9kDlYErku6oYGUWCA2acFj1v1HTihoetiju1aEC4p9hKry2_y9Lzpc-4zzE1GuOZWbwILbF38Bk__zf5LuLV7fHgQHeyN95_BbQS-gTkVpMEGrFazWj-HG_JHlZazF41RE_h61TbxGxGLi4Y
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VAhUXHuUVKGCk9oIUbeI4ifeAEFBWVIXVCoFUcQmO7dCITbJsEtD-NX4d47zYpRW3HrjsIRlZdvabmW_s8QzAvucIluCPjVTBsRk6XJvrWKHiae27mquxlk2ziXA65Scn49kW_Orvwpi0yt4mNoZaFdLskY_ckKNn90PKRkmXFjE7nLxYfLdNBylz0tq302ghcqxXPzF8K58fHeJ_fUDp5M3H12_trsOALdHRVXbsjRWLfSWY60iPS41sxNWhilXsG2rhC4cJdOKhFshkAnyKCzEMW2IQxxPu4biX4HJoipY3aYOzYX_HVF7njHVXAh2Pj3JcTlZi_OHTDSfY9Ao4j-CezdP867C28YGTG__z17sJ1zvmTV62qnILtnS-C1fbXpyrXdh532UZ3IbPWfrBppScipIIsigwrKgIIjC1qzrDYYhJySRmB5usXV_rBFGfSZoTIetKk2yl50WqyFzX34TOUnEHPl3IGu_Cdl7k-j4QFijpIzujCoERyyR2AmEqcSWGc_lUWPCsB0UkuwLtpk_IPGoSBTwerSHIgv1BeNHWJTlf7JVB1yBiiok3D4rl16izTVESSFOIjQmJa8UAmiciCUIhYkFjXHdswV4PqqizcGX0B1EWPB1eo20yB04i10XdyCA7DDAqteBeC-VhJjR0XYy9XQvCDZBvTHXzTZ6eNvXPfYYxyxjHPOjVYW1aZ7_Bg39P_wnsoCpE746mxw_hGvLhwBwW0mAPtqtlrR_BFfmjSsvl40a_CXy5aJX4DaOFlEM
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=miR-22+has+a+potent+anti-tumour+role+with+therapeutic+potential+in+acute+myeloid+leukaemia&rft.jtitle=Nature+communications&rft.au=Jiang%2C+Xi&rft.au=Hu%2C+Chao&rft.au=Arnovitz%2C+Stephen&rft.au=Bugno%2C+Jason&rft.date=2016-04-26&rft.issn=2041-1723&rft.eissn=2041-1723&rft.volume=7&rft.issue=1&rft_id=info:doi/10.1038%2Fncomms11452&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_ncomms11452
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon