Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic steatohepatitis (NASH) which can progress to cirrhosis and hepatocellular carcinoma. One of the crucial events clearly involved in N...

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Vydáno v:Cell death & disease Ročník 11; číslo 9; s. 802
Hlavní autoři: Rada, Patricia, González-Rodríguez, Águeda, García-Monzón, Carmelo, Valverde, Ángela M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 25.09.2020
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Antibodies
Biochemistry
Biomedical and Life Sciences
CD36 Antigens - metabolism
Cell Biology
Cell Culture
Disease Progression
Fatty Acids, Nonesterified - metabolism
Humans
Immunology
Life Sciences
Non-alcoholic Fatty Liver Disease - genetics
Non-alcoholic Fatty Liver Disease - pathology
Prognosis
Review
Review Article
ISSN:2041-4889, 2041-4889
On-line přístup:Získat plný text
Tagy: Přidat tag
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Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic steatohepatitis (NASH) which can progress to cirrhosis and hepatocellular carcinoma. One of the crucial events clearly involved in NAFLD progression is the lipotoxicity resulting from an excessive fatty acid (FFA) influx to hepatocytes. Hepatic lipotoxicity occurs when the capacity of the hepatocyte to manage and export FFAs as triglycerides (TGs) is overwhelmed. This review provides succinct insights into the molecular mechanisms responsible for lipotoxicity in NAFLD, including ER and oxidative stress, autophagy, lipoapotosis and inflammation. In addition, we highlight the role of CD36/FAT fatty acid translocase in NAFLD pathogenesis. Up-to-date, it is well known that CD36 increases FFA uptake and, in the liver, it drives hepatosteatosis onset and might contribute to its progression to NASH. Clinical studies have reinforced the significance of CD36 by showing increased content in the liver of NAFLD patients. Interestingly, circulating levels of a soluble form of CD36 (sCD36) are abnormally elevated in NAFLD patients and positively correlate with the histological grade of hepatic steatosis. In fact, the induction of CD36 translocation to the plasma membrane of the hepatocytes may be a determining factor in the physiopathology of hepatic steatosis in NAFLD patients. Given all these data, targeting the fatty acid translocase CD36 or some of its functional regulators may be a promising therapeutic approach for the prevention and treatment of NAFLD.
AbstractList Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic steatohepatitis (NASH) which can progress to cirrhosis and hepatocellular carcinoma. One of the crucial events clearly involved in NAFLD progression is the lipotoxicity resulting from an excessive fatty acid (FFA) influx to hepatocytes. Hepatic lipotoxicity occurs when the capacity of the hepatocyte to manage and export FFAs as triglycerides (TGs) is overwhelmed. This review provides succinct insights into the molecular mechanisms responsible for lipotoxicity in NAFLD, including ER and oxidative stress, autophagy, lipoapotosis and inflammation. In addition, we highlight the role of CD36/FAT fatty acid translocase in NAFLD pathogenesis. Up-to-date, it is well known that CD36 increases FFA uptake and, in the liver, it drives hepatosteatosis onset and might contribute to its progression to NASH. Clinical studies have reinforced the significance of CD36 by showing increased content in the liver of NAFLD patients. Interestingly, circulating levels of a soluble form of CD36 (sCD36) are abnormally elevated in NAFLD patients and positively correlate with the histological grade of hepatic steatosis. In fact, the induction of CD36 translocation to the plasma membrane of the hepatocytes may be a determining factor in the physiopathology of hepatic steatosis in NAFLD patients. Given all these data, targeting the fatty acid translocase CD36 or some of its functional regulators may be a promising therapeutic approach for the prevention and treatment of NAFLD.
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic steatohepatitis (NASH) which can progress to cirrhosis and hepatocellular carcinoma. One of the crucial events clearly involved in NAFLD progression is the lipotoxicity resulting from an excessive fatty acid (FFA) influx to hepatocytes. Hepatic lipotoxicity occurs when the capacity of the hepatocyte to manage and export FFAs as triglycerides (TGs) is overwhelmed. This review provides succinct insights into the molecular mechanisms responsible for lipotoxicity in NAFLD, including ER and oxidative stress, autophagy, lipoapotosis and inflammation. In addition, we highlight the role of CD36/FAT fatty acid translocase in NAFLD pathogenesis. Up-to-date, it is well known that CD36 increases FFA uptake and, in the liver, it drives hepatosteatosis onset and might contribute to its progression to NASH. Clinical studies have reinforced the significance of CD36 by showing increased content in the liver of NAFLD patients. Interestingly, circulating levels of a soluble form of CD36 (sCD36) are abnormally elevated in NAFLD patients and positively correlate with the histological grade of hepatic steatosis. In fact, the induction of CD36 translocation to the plasma membrane of the hepatocytes may be a determining factor in the physiopathology of hepatic steatosis in NAFLD patients. Given all these data, targeting the fatty acid translocase CD36 or some of its functional regulators may be a promising therapeutic approach for the prevention and treatment of NAFLD.Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD stages range from simple steatosis (NAFL) to non-alcoholic steatohepatitis (NASH) which can progress to cirrhosis and hepatocellular carcinoma. One of the crucial events clearly involved in NAFLD progression is the lipotoxicity resulting from an excessive fatty acid (FFA) influx to hepatocytes. Hepatic lipotoxicity occurs when the capacity of the hepatocyte to manage and export FFAs as triglycerides (TGs) is overwhelmed. This review provides succinct insights into the molecular mechanisms responsible for lipotoxicity in NAFLD, including ER and oxidative stress, autophagy, lipoapotosis and inflammation. In addition, we highlight the role of CD36/FAT fatty acid translocase in NAFLD pathogenesis. Up-to-date, it is well known that CD36 increases FFA uptake and, in the liver, it drives hepatosteatosis onset and might contribute to its progression to NASH. Clinical studies have reinforced the significance of CD36 by showing increased content in the liver of NAFLD patients. Interestingly, circulating levels of a soluble form of CD36 (sCD36) are abnormally elevated in NAFLD patients and positively correlate with the histological grade of hepatic steatosis. In fact, the induction of CD36 translocation to the plasma membrane of the hepatocytes may be a determining factor in the physiopathology of hepatic steatosis in NAFLD patients. Given all these data, targeting the fatty acid translocase CD36 or some of its functional regulators may be a promising therapeutic approach for the prevention and treatment of NAFLD.
ArticleNumber 802
Author Valverde, Ángela M.
García-Monzón, Carmelo
González-Rodríguez, Águeda
Rada, Patricia
Author_xml – sequence: 1
  givenname: Patricia
  orcidid: 0000-0002-6731-2098
  surname: Rada
  fullname: Rada, Patricia
  organization: Instituto de Investigaciones Biomédicas Alberto Sols (CSIC/UAM), Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM, ISCIII)
– sequence: 2
  givenname: Águeda
  surname: González-Rodríguez
  fullname: González-Rodríguez, Águeda
  email: aguedagr.phd@gmail.com
  organization: Unidad de Investigación, Hospital Universitario Santa Cristina, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)
– sequence: 3
  givenname: Carmelo
  surname: García-Monzón
  fullname: García-Monzón, Carmelo
  email: cgarciamonzon@hotmail.com
  organization: Unidad de Investigación, Hospital Universitario Santa Cristina, Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD)
– sequence: 4
  givenname: Ángela M.
  surname: Valverde
  fullname: Valverde, Ángela M.
  email: avalverde@iib.uam.es
  organization: Instituto de Investigaciones Biomédicas Alberto Sols (CSIC/UAM), Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM, ISCIII)
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32978374$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1111/febs.14389
10.1074/jbc.M109.033480
10.1194/jlr.R800085-JLR200
10.1111/j.1440-1746.2009.05785.x
10.1016/j.envpol.2019.01.112
10.1002/hep.28431
10.2174/138920012803762729
10.1194/jlr.M063412
10.1152/ajpendo.00011.2002
10.1258/ebm.2011.011128
10.1152/ajpendo.00642.2009
10.1016/S0016-5085(03)00907-7
10.1161/CIRCULATIONAHA.106.626135
10.1016/j.cmet.2006.01.011
10.1002/hep.21655
10.1136/gut.2010.222844
10.1073/pnas.0630588100
10.1016/j.cmet.2013.10.002
10.1089/ars.2016.6776
10.1172/JCI88881
10.1016/j.bbrc.2007.08.004
10.1038/nature02866
10.1194/jlr.M800101-JLR200
10.1210/jc.2009-2002
10.1016/j.metabol.2015.12.012
10.1210/en.2015-1866
10.1055/s-2007-991510
10.1038/cddis.2014.162
10.1038/ijo.2016.223
10.1002/hep.28252
10.1007/s00125-010-1708-x
10.1111/j.1572-0241.2004.40009.x
10.1113/jphysiol.2006.106013
10.1007/s11010-009-0142-1
10.1080/01926230701320337
10.1053/j.gastro.2007.11.037
10.1159/000447866
10.1152/ajpgi.00365.2011
10.1074/jbc.M111.280420
10.1016/j.cca.2011.04.013
10.1136/gutjnl-2017-315691
10.1111/j.1365-2796.2011.02442.x
10.14814/phy2.13902
10.1111/eci.12192
10.2337/dc07-1424
10.1016/j.freeradbiomed.2020.02.025
10.1538/expanim.17-0112
10.1097/MPG.0b013e31820e82a1
10.1016/j.trsl.2016.08.006
10.1152/physiologyonline.2007.22.1.15
10.1016/j.bbrc.2005.08.070
10.1074/jbc.M115.640292
10.1038/s41598-017-03389-2
10.3109/08923970903252220
10.2337/diabetes.51.10.3113
10.1186/1476-511X-12-165
10.1194/jlr.M001966
10.1016/S0168-8278(03)00460-4
10.1124/jpet.111.184341
10.1124/mol.105.016121
10.1152/ajpendo.00653.2011
10.1002/hep.26046
10.1016/j.jhep.2019.11.024
10.1053/j.gastro.2015.12.037
10.1194/jlr.M039453
10.1371/journal.pone.0048535
10.1111/j.1530-0277.2009.01141.x
10.1194/jlr.M037812
10.1126/science.1103160
10.1016/j.taap.2010.03.016
10.1152/ajpgi.00523.2006
10.1016/j.freeradbiomed.2019.05.029
10.1074/jbc.M115.649483
10.1016/S0021-9150(02)00421-5
10.1210/en.2005-0570
10.1111/j.1440-1746.2008.05733.x
10.1080/10715762.2019.1608982
10.4049/jimmunol.1000332
10.1042/bj20021121
10.1016/j.bbrc.2014.03.103
10.1146/annurev.nutr.22.020402.130846
10.1074/jbc.M406963200
10.1016/j.jhep.2018.01.035
10.1126/science.1254312
10.1152/physiolgenomics.00139.2007
10.1111/hepr.12816
10.1371/journal.pone.0159217
10.1111/j.1478-3231.2010.02248.x
10.1111/j.1365-2893.2012.01641.x
10.1016/j.jhep.2019.06.021
10.1016/j.cmet.2010.04.005
10.1002/hep.20283
10.3389/fphar.2018.01428
10.1016/j.jnutbio.2018.04.013
10.1053/jhep.2003.50472
10.1016/j.tem.2016.11.006
10.1007/s10620-016-4049-x
10.1016/j.jnutbio.2008.05.009
10.4161/auto.19496
10.18632/aging.100652
10.1053/jhep.2001.29628
10.1002/hep.22351
10.1111/apha.12022
10.1089/ars.2016.6808
10.3109/13813455.2010.543136
10.1179/1351000213Y.0000000050
10.1140/epjc/s10052-016-4206-6
10.1371/journal.pone.0115922
10.1074/jbc.275.19.14501
10.1016/j.jhep.2018.04.006
10.1161/ATVBAHA.115.306032
10.1371/journal.pone.0081949
10.1194/jlr.M041863
10.1155/2015/597134
10.1016/j.bbadis.2011.01.003
10.1152/ajpgi.00074.2008
10.1053/j.gastro.2011.06.061
10.2337/db07-0907
10.1136/gutjnl-2011-301146
10.4137/JCD.S39824
10.1074/jbc.M510660200
10.1074/jbc.M112.412569
10.2337/db14-0582
10.1074/jbc.273.27.16710
10.1038/s41467-018-03072-8
10.3390/ijms15058591
10.1161/STROKEAHA.108.517128
10.1016/j.fct.2015.03.029
10.1136/gut.2006.118059
10.1016/j.freeradbiomed.2009.11.007
10.1016/j.jhep.2010.06.021
10.1007/s12272-019-01178-1
10.1096/fj.201601393R
10.1053/jhep.2001.27828
10.1038/s41575-018-0082-x
10.1016/j.taap.2016.12.019
10.1038/s41467-017-00566-9
10.1016/j.plipres.2012.10.004
10.1016/j.jcmgh.2014.11.005
10.1146/annurev-nutr-071812-161220
10.1186/s12967-018-1490-y
10.1152/physrev.00003.2009
10.1016/j.tem.2008.11.001
10.1038/nm1625
10.1016/j.jhep.2014.11.033
10.2217/clp.09.85
10.1194/jlr.M090969
10.5754/hge11399
10.1038/s42255-019-0076-1
10.1208/s12248-016-9919-9
10.1038/nature07976
10.1016/j.jhep.2010.01.003
10.3390/medicina55020026
10.3390/cells8101298
10.1111/liv.14519
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References Singh (CR44) 2009; 458
Pardo, Gonzalez-Rodriguez, Guijas, Balsinde, Valverde (CR60) 2015; 290
Chowdhry (CR34) 2010; 48
Koyama, Brenner (CR57) 2017; 127
Liu, Purushotham, Wendel, Belury (CR90) 2007; 292
Um (CR141) 2004; 431
Wang (CR41) 2018; 32
Kawanishi, Mizokami, Yada, Suzuki (CR92) 2018; 6
Haas (CR66) 2019; 1
Kazankov (CR59) 2019; 16
Li, He, Yang, Chen, Fan (CR69) 2017; 180
Ibrahim, Kohli, Gores (CR48) 2011; 53
Zou (CR158) 2007; 13
Feldstein (CR8) 2003; 125
Mei (CR39) 2011; 339
Lopez-Parra (CR91) 2008; 49
Hirsova, Gores (CR49) 2015; 1
Rodriguez (CR42) 2006; 3
Wang, Wei, Pagliassotti (CR18) 2006; 147
Handberg, Levin, Hojlund, Beck-Nielsen (CR122) 2006; 114
Koek, Liedorp, Bast (CR26) 2011; 412
Zhao (CR84) 2018; 69
Aguer (CR123) 2010; 53
Liang (CR4) 2014; 9
Sampson, Davies, Braschi, Ivory, Hughes (CR124) 2003; 167
Chen (CR63) 2012; 59
Koonen (CR88) 2007; 56
Cazanave, Gores (CR50) 2010; 5
Heeboll (CR132) 2017; 41
Zhou (CR100) 2008; 134
Glintborg (CR127) 2008; 31
Bonen, Chabowski, Luiken, Glatz (CR78) 2007; 22
Schneiderhan (CR115) 2001; 34
Charlton (CR3) 2011; 141
Petta (CR131) 2013; 20
Spahis, Delvin, Borys, Levy (CR30) 2017; 26
Canbay (CR53) 2003; 38
Duryee (CR113) 2005; 68
Savary (CR52) 2012; 13
Ribeiro (CR151) 2004; 99
Chambel, Santos-Goncalves, Duarte (CR32) 2015; 2015
Yamaguchi (CR51) 2007; 45
Buque (CR86) 2010; 51
Inoue (CR85) 2005; 336
Ibrahim (CR65) 2016; 63
Akiyama (CR43) 2018; 67
Idrissova (CR149) 2015; 62
Su, Abumrad (CR75) 2009; 20
Peverill, Powell, Skoien (CR5) 2014; 15
Zhong (CR117) 2017; 27
Luiken (CR136) 2002; 51
Affo (CR144) 2013; 62
Wei, Wang, Gentile, Pagliassotti (CR11) 2009; 331
Lu (CR146) 2014; 345
Lee (CR95) 2017; 7
Younossi (CR1) 2019; 71
Tang, Sui, Lian, Li, Hua (CR61) 2013; 8
Greco (CR118) 2008; 294
Cursio, Colosetti, Codogno, Cuervo, Shen (CR37) 2015; 2015
Gao, Ma, Alsaggar, Liu (CR99) 2016; 18
Wang (CR36) 2013; 12
Wilson (CR116) 2016; 157
Nakatani (CR139) 2004; 279
Ortiz-Masia (CR104) 2012; 7
Cazanave (CR145) 2011; 286
Connolly (CR70) 2010; 185
Armengol (CR112) 2013; 33
Chabowski (CR93) 2013; 207
Gonzalez-Rodriguez (CR38) 2014; 5
Handberg (CR130) 2012; 271
Svegliati-Baroni (CR24) 2019; 144
Luiken (CR135) 2002; 283
Mordier, Iynedjian (CR140) 2007; 362
Clugston (CR81) 2014; 55
Nassir, Adewole, Brunt, Abumrad (CR82) 2013; 54
Rong (CR20) 2013; 18
Garcia-Monzon (CR7) 2011; 54
Glatz, Luiken, Bonen (CR77) 2010; 90
Elmore (CR47) 2007; 35
Bechmann (CR119) 2010; 30
Item (CR157) 2017; 8
Buzzetti, Pinzani, Tsochatzis (CR6) 2016; 65
Lee, Park, Roh (CR31) 2019; 42
Miller (CR71) 2010; 34
Kakazu, Mauer, Yin, Malhi (CR64) 2016; 57
Zhang (CR94) 2018; 68
Garcia-Monzon (CR138) 2014; 44
Savari, Badavi, Rezaie, Gharib-Naseri, Mard (CR155) 2019; 53
Zhang, Yeager, Tanaka, Klaassen (CR35) 2010; 245
Kushnareva, Murphy, Andreyev (CR29) 2002; 368
Hirsova (CR56) 2016; 150
CR110
Ucar (CR27) 2013; 18
Miquilena-Colina (CR120) 2011; 60
Akazawa, Gores (CR142) 2007; 27
Hosui (CR111) 2017; 47
Rutkowski (CR15) 2019; 286
Deleve, Wang, Guo (CR73) 2008; 48
Ricchi (CR14) 2009; 24
Klionsky (CR40) 2012; 8
Samovski (CR80) 2015; 64
Wang (CR106) 2014; 447
Chu (CR68) 2018; 16
Hajri, Abumrad (CR74) 2002; 22
Sunny, Bril, Cusi (CR25) 2017; 28
Steneberg (CR89) 2015; 290
Buque (CR137) 2012; 303
Koonen, Jensen, Handberg (CR128) 2011; 117
Khachatryan (CR96) 2016; 76
Flowers (CR19) 2008; 33
Bonen, Luiken, Arumugam, Glatz, Tandon (CR134) 2000; 275
Listenberger (CR12) 2003; 100
Miura, Yang, van Rooijen, Ohnishi, Seki (CR62) 2012; 302
Sheedfar (CR121) 2014; 6
Younossi (CR2) 2016; 64
Crespo (CR150) 2001; 34
Goldberg, Eckel, Abumrad (CR133) 2009; 50
Yang, Li, Fu, Calay, Hotamisligil (CR46) 2010; 11
Niu (CR114) 2018; 18
Leamy, Egnatchik, Young (CR21) 2013; 52
Chen, Tian, She, Cai, Li (CR23) 2020; 152
He, Lee, Febbraio, Xie (CR76) 2011; 236
Mwaikambo, Yang, Chemtob, Hardy (CR103) 2009; 284
Li (CR83) 2019; 60
Cao, Quan, Zeng, Yang, Wang (CR143) 2016; 9
Kim (CR16) 2010; 32
Hetherington (CR67) 2016; 39
Arrese, Cabrera, Kalergis, Feldstein (CR58) 2016; 61
Ding (CR108) 2019; 248
Xiong, Tao, DePinho, Dong (CR45) 2012; 287
Malhi, Barreyro, Isomoto, Bronk, Gores (CR147) 2007; 56
Feldstein (CR152) 2004; 40
Pardo, Gonzalez-Rodriguez, Muntane, Kozma, Valverde (CR9) 2015; 80
Guo (CR109) 2018; 9
McMahan, Porsche, Edwards, Rosen (CR72) 2016; 11
Chen, Lu, Zou, Ye (CR102) 2014; 55
Feldstein (CR156) 2003; 39
Ozcan (CR22) 2004; 306
Benton (CR98) 2006; 573
Demers (CR107) 2015; 35
CR28
Xu (CR33) 2018; 9
Aparicio-Vergara (CR153) 2013; 57
Ibrahim, Hirsova, Gores (CR54) 2018; 67
Harrison (CR55) 2020; 72
Farrell (CR148) 2009; 24
Pfaffenbach (CR17) 2010; 298
Fernandez-Real (CR129) 2009; 20
Lambertucci (CR154) 2018; 58
Choi (CR101) 2017; 316
Motojima, Passilly, Peters, Gonzalez, Latruffe (CR97) 1998; 273
Handberg (CR125) 2010; 95
CR105
Akazawa (CR10) 2010; 52
Handberg (CR126) 2008; 39
Malhi, Bronk, Werneburg, Gores (CR13) 2006; 281
Pepino, Kuda, Samovski, Abumrad (CR79) 2014; 34
Gaemers (CR87) 2011; 1812
T Tang (3003_CR61) 2013; 8
X Rong (3003_CR20) 2013; 18
DT Rutkowski (3003_CR15) 2019; 286
AE Feldstein (3003_CR156) 2003; 39
AK Leamy (3003_CR21) 2013; 52
ZM Younossi (3003_CR2) 2016; 64
R Cursio (3003_CR37) 2015; 2015
G Svegliati-Baroni (3003_CR24) 2019; 144
L Chen (3003_CR63) 2012; 59
IJ Goldberg (3003_CR133) 2009; 50
JT Haas (3003_CR66) 2019; 1
3003_CR110
J He (3003_CR76) 2011; 236
R Singh (3003_CR44) 2009; 458
DS Kim (3003_CR16) 2010; 32
T Hajri (3003_CR74) 2002; 22
M Inoue (3003_CR85) 2005; 336
M Lopez-Parra (3003_CR91) 2008; 49
K Yamaguchi (3003_CR51) 2007; 45
H Malhi (3003_CR13) 2006; 281
F Nassir (3003_CR82) 2013; 54
MY Pepino (3003_CR79) 2014; 34
D Ortiz-Masia (3003_CR104) 2012; 7
D Greco (3003_CR118) 2008; 294
A Bonen (3003_CR134) 2000; 275
A Demers (3003_CR107) 2015; 35
3003_CR105
SH Ibrahim (3003_CR54) 2018; 67
X Chu (3003_CR68) 2018; 16
L Cao (3003_CR143) 2016; 9
A Canbay (3003_CR53) 2003; 38
A Bonen (3003_CR78) 2007; 22
N Kawanishi (3003_CR92) 2018; 6
D Ding (3003_CR108) 2019; 248
Y Kushnareva (3003_CR29) 2002; 368
M Lu (3003_CR146) 2014; 345
D Xu (3003_CR33) 2018; 9
L Idrissova (3003_CR149) 2015; 62
SS Chambel (3003_CR32) 2015; 2015
LP Bechmann (3003_CR119) 2010; 30
P Hirsova (3003_CR49) 2015; 1
RH McMahan (3003_CR72) 2016; 11
S Petta (3003_CR131) 2013; 20
Z Chen (3003_CR23) 2020; 152
ME Miquilena-Colina (3003_CR120) 2011; 60
JM Fernandez-Real (3003_CR129) 2009; 20
A Hosui (3003_CR111) 2017; 47
MR Charlton (3003_CR3) 2011; 141
BR Mwaikambo (3003_CR103) 2009; 284
M Aparicio-Vergara (3003_CR153) 2013; 57
SA Harrison (3003_CR55) 2020; 72
S Affo (3003_CR144) 2013; 62
YJ Choi (3003_CR101) 2017; 316
DJ Klionsky (3003_CR40) 2012; 8
J Guo (3003_CR109) 2018; 9
RD Clugston (3003_CR81) 2014; 55
V Khachatryan (3003_CR96) 2016; 76
JL Chen (3003_CR102) 2014; 55
CG Wilson (3003_CR116) 2016; 157
JJ Luiken (3003_CR135) 2002; 283
S Spahis (3003_CR30) 2017; 26
AE Feldstein (3003_CR152) 2004; 40
C Armengol (3003_CR112) 2013; 33
S Mordier (3003_CR140) 2007; 362
V Pardo (3003_CR60) 2015; 290
M Arrese (3003_CR58) 2016; 61
K Miura (3003_CR62) 2012; 302
KT Pfaffenbach (3003_CR17) 2010; 298
S Zhong (3003_CR117) 2017; 27
S Elmore (3003_CR47) 2007; 35
SH Um (3003_CR141) 2004; 431
A Gonzalez-Rodriguez (3003_CR38) 2014; 5
F Item (3003_CR157) 2017; 8
JF Glatz (3003_CR77) 2010; 90
P Hirsova (3003_CR56) 2016; 150
IC Gaemers (3003_CR87) 2011; 1812
A Handberg (3003_CR122) 2006; 114
GC Farrell (3003_CR148) 2009; 24
U Ozcan (3003_CR22) 2004; 306
L Yang (3003_CR46) 2010; 11
Y Akazawa (3003_CR142) 2007; 27
F Ucar (3003_CR27) 2013; 18
D Samovski (3003_CR80) 2015; 64
SH Ibrahim (3003_CR65) 2016; 63
P Zhang (3003_CR94) 2018; 68
DP Koonen (3003_CR88) 2007; 56
E Buzzetti (3003_CR6) 2016; 65
L Zhao (3003_CR84) 2018; 69
CR Benton (3003_CR98) 2006; 573
F Lambertucci (3003_CR154) 2018; 58
LL Listenberger (3003_CR12) 2003; 100
MJ Duryee (3003_CR113) 2005; 68
AM Miller (3003_CR71) 2010; 34
X Buque (3003_CR86) 2010; 51
YS Lee (3003_CR95) 2017; 7
J Crespo (3003_CR150) 2001; 34
MK Connolly (3003_CR70) 2010; 185
ZM Younossi (3003_CR1) 2019; 71
C Zou (3003_CR158) 2007; 13
S Mei (3003_CR39) 2011; 339
W Schneiderhan (3003_CR115) 2001; 34
F Savari (3003_CR155) 2019; 53
X Wang (3003_CR41) 2018; 32
J Zhou (3003_CR100) 2008; 134
SC Cazanave (3003_CR145) 2011; 286
E Kakazu (3003_CR64) 2016; 57
C Wang (3003_CR106) 2014; 447
C Garcia-Monzon (3003_CR138) 2014; 44
A Handberg (3003_CR130) 2012; 271
SH Ibrahim (3003_CR48) 2011; 53
C Aguer (3003_CR123) 2010; 53
YK Zhang (3003_CR35) 2010; 245
LD Deleve (3003_CR73) 2008; 48
P Steneberg (3003_CR89) 2015; 290
Y Li (3003_CR83) 2019; 60
X Xiong (3003_CR45) 2012; 287
K Kazankov (3003_CR59) 2019; 16
K Motojima (3003_CR97) 1998; 273
M Gao (3003_CR99) 2016; 18
X Buque (3003_CR137) 2012; 303
F Sheedfar (3003_CR121) 2014; 6
M Ricchi (3003_CR14) 2009; 24
SC Cazanave (3003_CR50) 2010; 5
S Savary (3003_CR52) 2012; 13
B Niu (3003_CR114) 2018; 18
Y Akazawa (3003_CR10) 2010; 52
Y Koyama (3003_CR57) 2017; 127
BH Li (3003_CR69) 2017; 180
MT Flowers (3003_CR19) 2008; 33
3003_CR28
K Akiyama (3003_CR43) 2018; 67
W Liang (3003_CR4) 2014; 9
D Wang (3003_CR18) 2006; 147
PS Ribeiro (3003_CR151) 2004; 99
A Chabowski (3003_CR93) 2013; 207
J Lee (3003_CR31) 2019; 42
V Pardo (3003_CR9) 2015; 80
A Handberg (3003_CR126) 2008; 39
H Malhi (3003_CR147) 2007; 56
C Garcia-Monzon (3003_CR7) 2011; 54
A Rodriguez (3003_CR42) 2006; 3
C Wang (3003_CR36) 2013; 12
DP Koonen (3003_CR128) 2011; 117
D Glintborg (3003_CR127) 2008; 31
LF Liu (3003_CR90) 2007; 292
S Heeboll (3003_CR132) 2017; 41
S Chowdhry (3003_CR34) 2010; 48
GH Koek (3003_CR26) 2011; 412
JJ Luiken (3003_CR136) 2002; 51
W Peverill (3003_CR5) 2014; 15
Y Wei (3003_CR11) 2009; 331
X Su (3003_CR75) 2009; 20
A Handberg (3003_CR125) 2010; 95
NE Sunny (3003_CR25) 2017; 28
Y Nakatani (3003_CR139) 2004; 279
AE Feldstein (3003_CR8) 2003; 125
AM Hetherington (3003_CR67) 2016; 39
MJ Sampson (3003_CR124) 2003; 167
References_xml – volume: 286
  start-page: 356
  year: 2019
  end-page: 378
  ident: CR15
  article-title: Liver function and dysfunction - a unique window into the physiological reach of ER stress and the unfolded protein response
  publication-title: FEBS J.
  doi: 10.1111/febs.14389
– volume: 284
  start-page: 26695
  year: 2009
  end-page: 26707
  ident: CR103
  article-title: Hypoxia up-regulates CD36 expression and function via hypoxia-inducible factor-1- and phosphatidylinositol 3-kinase-dependent mechanisms
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M109.033480
– volume: 50
  start-page: S86
  year: 2009
  end-page: S90
  ident: CR133
  article-title: Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.R800085-JLR200
– volume: 24
  start-page: 443
  year: 2009
  end-page: 452
  ident: CR148
  article-title: Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression
  publication-title: J. Gastroenterol. Hepatol.
  doi: 10.1111/j.1440-1746.2009.05785.x
– volume: 248
  start-page: 269
  year: 2019
  end-page: 278
  ident: CR108
  article-title: MicroRNA-26a-CD36 signaling pathway: pivotal role in lipid accumulation in hepatocytes induced by PM2.5 liposoluble extracts
  publication-title: Environ. Pollut.
  doi: 10.1016/j.envpol.2019.01.112
– volume: 64
  start-page: 73
  year: 2016
  end-page: 84
  ident: CR2
  article-title: Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes
  publication-title: Hepatology
  doi: 10.1002/hep.28431
– volume: 13
  start-page: 1358
  year: 2012
  end-page: 1370
  ident: CR52
  article-title: Fatty acids - induced lipotoxicity and inflammation
  publication-title: Curr. Drug Metab.
  doi: 10.2174/138920012803762729
– volume: 57
  start-page: 233
  year: 2016
  end-page: 245
  ident: CR64
  article-title: Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1alpha-dependent manner
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M063412
– volume: 283
  start-page: E612
  year: 2002
  end-page: E621
  ident: CR135
  article-title: Changes in fatty acid transport and transporters are related to the severity of insulin deficiency
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.00011.2002
– volume: 236
  start-page: 1116
  year: 2011
  end-page: 1121
  ident: CR76
  article-title: The emerging roles of fatty acid translocase/CD36 and the aryl hydrocarbon receptor in fatty liver disease
  publication-title: Exp. Biol. Med.
  doi: 10.1258/ebm.2011.011128
– volume: 298
  start-page: E1027
  year: 2010
  end-page: E1035
  ident: CR17
  article-title: Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.00642.2009
– volume: 125
  start-page: 437
  year: 2003
  end-page: 443
  ident: CR8
  article-title: Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis
  publication-title: Gastroenterology
  doi: 10.1016/S0016-5085(03)00907-7
– volume: 114
  start-page: 1169
  year: 2006
  end-page: 1176
  ident: CR122
  article-title: Identification of the oxidized low-density lipoprotein scavenger receptor CD36 in plasma: a novel marker of insulin resistance
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.106.626135
– volume: 3
  start-page: 211
  year: 2006
  end-page: 222
  ident: CR42
  article-title: Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2006.01.011
– volume: 45
  start-page: 1366
  year: 2007
  end-page: 1374
  ident: CR51
  article-title: Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
  publication-title: Hepatology
  doi: 10.1002/hep.21655
– volume: 60
  start-page: 1394
  year: 2011
  end-page: 1402
  ident: CR120
  article-title: Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C
  publication-title: Gut
  doi: 10.1136/gut.2010.222844
– volume: 100
  start-page: 3077
  year: 2003
  end-page: 3082
  ident: CR12
  article-title: Triglyceride accumulation protects against fatty acid-induced lipotoxicity
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0630588100
– volume: 18
  start-page: 685
  year: 2013
  end-page: 697
  ident: CR20
  article-title: LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2013.10.002
– volume: 26
  start-page: 519
  year: 2017
  end-page: 541
  ident: CR30
  article-title: Oxidative stress as a critical factor in nonalcoholic fatty liver disease pathogenesis
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2016.6776
– volume: 127
  start-page: 55
  year: 2017
  end-page: 64
  ident: CR57
  article-title: Liver inflammation and fibrosis
  publication-title: J. Clin. Invest
  doi: 10.1172/JCI88881
– volume: 362
  start-page: 206
  year: 2007
  end-page: 211
  ident: CR140
  article-title: Activation of mammalian target of rapamycin complex 1 and insulin resistance induced by palmitate in hepatocytes
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2007.08.004
– volume: 431
  start-page: 200
  year: 2004
  end-page: 205
  ident: CR141
  article-title: Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
  publication-title: Nature
  doi: 10.1038/nature02866
– volume: 49
  start-page: 2513
  year: 2008
  end-page: 2523
  ident: CR91
  article-title: Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M800101-JLR200
– volume: 95
  start-page: 1939
  year: 2010
  end-page: 1946
  ident: CR125
  article-title: Soluble CD36 (sCD36) clusters with markers of insulin resistance, and high sCD36 is associated with increased type 2 diabetes risk
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2009-2002
– volume: 65
  start-page: 1038
  year: 2016
  end-page: 1048
  ident: CR6
  article-title: The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)
  publication-title: Metabolism
  doi: 10.1016/j.metabol.2015.12.012
– volume: 157
  start-page: 570
  year: 2016
  end-page: 585
  ident: CR116
  article-title: Hepatocyte-specific disruption of CD36 attenuates fatty liver and improves insulin sensitivity in HFD-fed mice
  publication-title: Endocrinology
  doi: 10.1210/en.2015-1866
– volume: 27
  start-page: 327
  year: 2007
  end-page: 338
  ident: CR142
  article-title: Death receptor-mediated liver injury
  publication-title: Semin. Liver Dis.
  doi: 10.1055/s-2007-991510
– volume: 5
  year: 2014
  ident: CR38
  article-title: Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD
  publication-title: Cell Death Dis.
  doi: 10.1038/cddis.2014.162
– volume: 41
  start-page: 262
  year: 2017
  end-page: 267
  ident: CR132
  article-title: Circulating sCD36 levels in patients with non-alcoholic fatty liver disease and controls
  publication-title: Int. J. Obes.
  doi: 10.1038/ijo.2016.223
– volume: 63
  start-page: 731
  year: 2016
  end-page: 744
  ident: CR65
  article-title: Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes
  publication-title: Hepatology
  doi: 10.1002/hep.28252
– volume: 53
  start-page: 1151
  year: 2010
  end-page: 1163
  ident: CR123
  article-title: Intramyocellular lipid accumulation is associated with permanent relocation ex vivo and in vitro of fatty acid translocase (FAT)/CD36 in obese patients
  publication-title: Diabetologia
  doi: 10.1007/s00125-010-1708-x
– volume: 99
  start-page: 1708
  year: 2004
  end-page: 1717
  ident: CR151
  article-title: Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients
  publication-title: Am. J. Gastroenterol.
  doi: 10.1111/j.1572-0241.2004.40009.x
– volume: 573
  start-page: 199
  year: 2006
  end-page: 210
  ident: CR98
  article-title: Differential effects of contraction and PPAR agonists on the expression of fatty acid transporters in rat skeletal muscle
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2006.106013
– volume: 331
  start-page: 31
  year: 2009
  end-page: 40
  ident: CR11
  article-title: Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells
  publication-title: Mol. Cell. Biochem.
  doi: 10.1007/s11010-009-0142-1
– volume: 35
  start-page: 495
  year: 2007
  end-page: 516
  ident: CR47
  article-title: Apoptosis: a review of programmed cell death
  publication-title: Toxicol. Pathol.
  doi: 10.1080/01926230701320337
– volume: 134
  start-page: 556
  year: 2008
  end-page: 567
  ident: CR100
  article-title: Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPARgamma in promoting steatosis
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2007.11.037
– volume: 39
  start-page: 1648
  year: 2016
  end-page: 1662
  ident: CR67
  article-title: Differential lipotoxic effects of palmitate and oleate in activated human hepatic stellate cells and epithelial hepatoma cells
  publication-title: Cell. Physiol. Biochem.
  doi: 10.1159/000447866
– volume: 302
  start-page: G1310
  year: 2012
  end-page: G1321
  ident: CR62
  article-title: Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00365.2011
– volume: 286
  start-page: 39336
  year: 2011
  end-page: 39348
  ident: CR145
  article-title: Death receptor 5 signaling promotes hepatocyte lipoapoptosis
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.280420
– volume: 412
  start-page: 1297
  year: 2011
  end-page: 1305
  ident: CR26
  article-title: The role of oxidative stress in non-alcoholic steatohepatitis
  publication-title: Clin. Chim. Acta
  doi: 10.1016/j.cca.2011.04.013
– volume: 67
  start-page: 963
  year: 2018
  end-page: 972
  ident: CR54
  article-title: Non-alcoholic steatohepatitis pathogenesis: sublethal hepatocyte injury as a driver of liver inflammation
  publication-title: Gut
  doi: 10.1136/gutjnl-2017-315691
– volume: 271
  start-page: 294
  year: 2012
  end-page: 304
  ident: CR130
  article-title: Plasma sCD36 is associated with markers of atherosclerosis, insulin resistance and fatty liver in a nondiabetic healthy population
  publication-title: J. Intern. Med.
  doi: 10.1111/j.1365-2796.2011.02442.x
– volume: 6
  year: 2018
  ident: CR92
  article-title: Exercise training suppresses scavenger receptor CD36 expression in kupffer cells of nonalcoholic steatohepatitis model mice
  publication-title: Physiol. Rep.
  doi: 10.14814/phy2.13902
– volume: 44
  start-page: 65
  year: 2014
  end-page: 73
  ident: CR138
  article-title: Increased soluble CD36 is linked to advanced steatosis in nonalcoholic fatty liver disease
  publication-title: Eur. J. Clin. Invest
  doi: 10.1111/eci.12192
– volume: 31
  start-page: 328
  year: 2008
  end-page: 334
  ident: CR127
  article-title: Soluble CD36 and risk markers of insulin resistance and atherosclerosis are elevated in polycystic ovary syndrome and significantly reduced during pioglitazone treatment
  publication-title: Diabetes Care
  doi: 10.2337/dc07-1424
– volume: 152
  start-page: 116
  year: 2020
  end-page: 141
  ident: CR23
  article-title: Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2020.02.025
– volume: 67
  start-page: 201
  year: 2018
  end-page: 218
  ident: CR43
  article-title: Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis
  publication-title: Exp. Anim.
  doi: 10.1538/expanim.17-0112
– volume: 53
  start-page: 131
  year: 2011
  end-page: 140
  ident: CR48
  article-title: Mechanisms of lipotoxicity in NAFLD and clinical implications
  publication-title: J. Pediatr. Gastroenterol. Nutr.
  doi: 10.1097/MPG.0b013e31820e82a1
– volume: 33
  start-page: 57
  year: 2013
  end-page: 96
  ident: CR112
  article-title: Role of scavenger receptors in the pathophysiology of chronic liver diseases
  publication-title: Crit. Rev. Immunol.
– volume: 180
  start-page: 103
  year: 2017
  end-page: 117
  ident: CR69
  article-title: Steatosis induced CCL5 contributes to early-stage liver fibrosis in nonalcoholic fatty liver disease progress
  publication-title: Transl. Res.
  doi: 10.1016/j.trsl.2016.08.006
– volume: 22
  start-page: 15
  year: 2007
  end-page: 29
  ident: CR78
  article-title: Is membrane transport of FFA mediated by lipid, protein, or both? Mechanisms and regulation of protein-mediated cellular fatty acid uptake: molecular, biochemical, and physiological evidence
  publication-title: Physiology
  doi: 10.1152/physiologyonline.2007.22.1.15
– volume: 336
  start-page: 215
  year: 2005
  end-page: 222
  ident: CR85
  article-title: Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2005.08.070
– volume: 290
  start-page: 19034
  year: 2015
  end-page: 19043
  ident: CR89
  article-title: Hyperinsulinemia enhances hepatic expression of the fatty acid transporter Cd36 and provokes hepatosteatosis and hepatic insulin resistance
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M115.640292
– volume: 7
  year: 2017
  ident: CR95
  article-title: Exosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cells
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-03389-2
– volume: 32
  start-page: 251
  year: 2010
  end-page: 257
  ident: CR16
  article-title: Metformin regulates palmitate-induced apoptosis and ER stress response in HepG2 liver cells
  publication-title: Immunopharmacol. Immunotoxicol.
  doi: 10.3109/08923970903252220
– volume: 51
  start-page: 3113
  year: 2002
  end-page: 3119
  ident: CR136
  article-title: Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of FAT/CD36
  publication-title: Diabetes
  doi: 10.2337/diabetes.51.10.3113
– volume: 12
  year: 2013
  ident: CR36
  article-title: Nrf2 deletion causes “benign” simple steatosis to develop into nonalcoholic steatohepatitis in mice fed a high-fat diet
  publication-title: Lipids Health Dis.
  doi: 10.1186/1476-511X-12-165
– volume: 51
  start-page: 500
  year: 2010
  end-page: 513
  ident: CR86
  article-title: A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M001966
– volume: 39
  start-page: 978
  year: 2003
  end-page: 983
  ident: CR156
  article-title: Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice
  publication-title: J. Hepatol.
  doi: 10.1016/S0168-8278(03)00460-4
– volume: 339
  start-page: 487
  year: 2011
  end-page: 498
  ident: CR39
  article-title: Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes
  publication-title: J. Pharmacol. Exp. Ther.
  doi: 10.1124/jpet.111.184341
– volume: 68
  start-page: 1423
  year: 2005
  end-page: 1430
  ident: CR113
  article-title: Scavenger receptors on sinusoidal liver endothelial cells are involved in the uptake of aldehyde-modified proteins
  publication-title: Mol. Pharmacol.
  doi: 10.1124/mol.105.016121
– volume: 303
  start-page: E504
  year: 2012
  end-page: E514
  ident: CR137
  article-title: High insulin levels are required for FAT/CD36 plasma membrane translocation and enhanced fatty acid uptake in obese Zucker rat hepatocytes
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.00653.2011
– volume: 57
  start-page: 566
  year: 2013
  end-page: 576
  ident: CR153
  article-title: Tumor necrosis factor receptor 1 gain-of-function mutation aggravates nonalcoholic fatty liver disease but does not cause insulin resistance in a murine model
  publication-title: Hepatology
  doi: 10.1002/hep.26046
– volume: 72
  start-page: 816
  year: 2020
  end-page: 827
  ident: CR55
  article-title: A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2019.11.024
– volume: 150
  start-page: 956
  year: 2016
  end-page: 967
  ident: CR56
  article-title: Lipid-induced signaling causes release of inflammatory extracellular vesicles from hepatocytes
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2015.12.037
– volume: 55
  start-page: 32
  year: 2014
  end-page: CD40
  ident: CR102
  article-title: Kruppel-like factor 2 promotes liver steatosis through upregulation of CD36
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M039453
– volume: 7
  year: 2012
  ident: CR104
  article-title: Induction of CD36 and thrombospondin-1 in macrophages by hypoxia-inducible factor 1 and its relevance in the inflammatory process
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0048535
– volume: 34
  start-page: 719
  year: 2010
  end-page: 725
  ident: CR71
  article-title: Anti-inflammatory and anti-apoptotic roles of endothelial cell STAT3 in alcoholic liver injury
  publication-title: Alcohol. Clin. Exp. Res.
  doi: 10.1111/j.1530-0277.2009.01141.x
– volume: 54
  start-page: 2988
  year: 2013
  end-page: 2997
  ident: CR82
  article-title: CD36 deletion reduces VLDL secretion, modulates liver prostaglandins, and exacerbates hepatic steatosis in ob/ob mice
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M037812
– volume: 306
  start-page: 457
  year: 2004
  end-page: 461
  ident: CR22
  article-title: Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
  publication-title: Science
  doi: 10.1126/science.1103160
– volume: 245
  start-page: 326
  year: 2010
  end-page: 334
  ident: CR35
  article-title: Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet
  publication-title: Toxicol. Appl. Pharmacol.
  doi: 10.1016/j.taap.2010.03.016
– volume: 292
  start-page: G1671
  year: 2007
  end-page: G1682
  ident: CR90
  article-title: Combined effects of rosiglitazone and conjugated linoleic acid on adiposity, insulin sensitivity, and hepatic steatosis in high-fat-fed mice
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00523.2006
– volume: 144
  start-page: 293
  year: 2019
  end-page: 309
  ident: CR24
  article-title: Lipidomic biomarkers and mechanisms of lipotoxicity in non-alcoholic fatty liver disease
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2019.05.029
– volume: 290
  start-page: 11663
  year: 2015
  end-page: 11677
  ident: CR60
  article-title: Opposite cross-talk by oleate and palmitate on insulin signaling in hepatocytes through macrophage activation
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M115.649483
– volume: 167
  start-page: 129
  year: 2003
  end-page: 134
  ident: CR124
  article-title: Increased expression of a scavenger receptor (CD36) in monocytes from subjects with Type 2 diabetes
  publication-title: Atherosclerosis
  doi: 10.1016/S0021-9150(02)00421-5
– volume: 147
  start-page: 943
  year: 2006
  end-page: 951
  ident: CR18
  article-title: Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis
  publication-title: Endocrinology
  doi: 10.1210/en.2005-0570
– volume: 24
  start-page: 830
  year: 2009
  end-page: 840
  ident: CR14
  article-title: Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes
  publication-title: J. Gastroenterol. Hepatol.
  doi: 10.1111/j.1440-1746.2008.05733.x
– volume: 53
  start-page: 486
  year: 2019
  end-page: 496
  ident: CR155
  article-title: Evaluation of the therapeutic potential effect of Fas receptor gene knockdown in experimental model of non-alcoholic steatohepatitis
  publication-title: Free Radic. Res.
  doi: 10.1080/10715762.2019.1608982
– volume: 185
  start-page: 2200
  year: 2010
  end-page: 2208
  ident: CR70
  article-title: In hepatic fibrosis, liver sinusoidal endothelial cells acquire enhanced immunogenicity
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1000332
– volume: 368
  start-page: 545
  year: 2002
  end-page: 553
  ident: CR29
  article-title: Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state
  publication-title: Biochem. J.
  doi: 10.1042/bj20021121
– volume: 447
  start-page: 57
  year: 2014
  end-page: 63
  ident: CR106
  article-title: Rapamycin-mediated CD36 translational suppression contributes to alleviation of hepatic steatosis
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2014.03.103
– volume: 22
  start-page: 383
  year: 2002
  end-page: 415
  ident: CR74
  article-title: Fatty acid transport across membranes: relevance to nutrition and metabolic pathology
  publication-title: Annu. Rev. Nutr.
  doi: 10.1146/annurev.nutr.22.020402.130846
– volume: 279
  start-page: 45803
  year: 2004
  end-page: 45809
  ident: CR139
  article-title: Modulation of the JNK pathway in liver affects insulin resistance status
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M406963200
– volume: 68
  start-page: 1247
  year: 2018
  end-page: 1255
  ident: CR94
  article-title: Prolactin improves hepatic steatosis via CD36 pathway
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2018.01.035
– volume: 345
  start-page: 98
  year: 2014
  end-page: 101
  ident: CR146
  article-title: Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis
  publication-title: Science
  doi: 10.1126/science.1254312
– volume: 33
  start-page: 361
  year: 2008
  end-page: 372
  ident: CR19
  article-title: Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet
  publication-title: Physiol. Genomics
  doi: 10.1152/physiolgenomics.00139.2007
– volume: 47
  start-page: 813
  year: 2017
  end-page: 825
  ident: CR111
  article-title: Signal transducer and activator of transcription 5 plays a crucial role in hepatic lipid metabolism through regulation of CD36 expression
  publication-title: Hepatol. Res.
  doi: 10.1111/hepr.12816
– volume: 11
  year: 2016
  ident: CR72
  article-title: Free fatty acids differentially downregulate chemokines in liver sinusoidal endothelial cells: insights into non-alcoholic fatty liver disease
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0159217
– volume: 30
  start-page: 850
  year: 2010
  end-page: 859
  ident: CR119
  article-title: Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis
  publication-title: Liver Int.
  doi: 10.1111/j.1478-3231.2010.02248.x
– volume: 20
  start-page: 174
  year: 2013
  end-page: 182
  ident: CR131
  article-title: High sCD36 plasma level is associated with steatosis and its severity in patients with genotype 1 chronic hepatitis C
  publication-title: J. Viral Hepat.
  doi: 10.1111/j.1365-2893.2012.01641.x
– volume: 71
  start-page: 793
  year: 2019
  end-page: 801
  ident: CR1
  article-title: The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: A systematic review and meta-analysis
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2019.06.021
– volume: 11
  start-page: 467
  year: 2010
  end-page: 478
  ident: CR46
  article-title: Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2010.04.005
– volume: 2015
  start-page: 480508
  year: 2015
  ident: CR37
  article-title: The role of autophagy in liver diseases: mechanisms and potential therapeutic targets
  publication-title: BioMed. Res. Int.
– volume: 40
  start-page: 185
  year: 2004
  end-page: 194
  ident: CR152
  article-title: Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway
  publication-title: Hepatology
  doi: 10.1002/hep.20283
– volume: 9
  start-page: 1428
  year: 2018
  ident: CR33
  article-title: The role of Nrf2 in liver disease: novel molecular mechanisms and therapeutic approaches
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2018.01428
– volume: 58
  start-page: 17
  year: 2018
  end-page: 27
  ident: CR154
  article-title: Disruption of tumor necrosis factor alpha receptor 1 signaling accelerates NAFLD progression in mice upon a high-fat diet
  publication-title: J. Nutr. Biochem.
  doi: 10.1016/j.jnutbio.2018.04.013
– volume: 38
  start-page: 1188
  year: 2003
  end-page: 1198
  ident: CR53
  article-title: Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression
  publication-title: Hepatology
  doi: 10.1053/jhep.2003.50472
– volume: 28
  start-page: 250
  year: 2017
  end-page: 260
  ident: CR25
  article-title: Mitochondrial adaptation in nonalcoholic fatty liver disease: novel mechanisms and treatment strategies
  publication-title: Trends Endocrinol. Metab.
  doi: 10.1016/j.tem.2016.11.006
– volume: 61
  start-page: 1294
  year: 2016
  end-page: 1303
  ident: CR58
  article-title: Innate immunity and inflammation in NAFLD/NASH
  publication-title: Dig. Dis. Sci.
  doi: 10.1007/s10620-016-4049-x
– volume: 20
  start-page: 477
  year: 2009
  end-page: 484
  ident: CR129
  article-title: Circulating soluble CD36 is a novel marker of liver injury in subjects with altered glucose tolerance
  publication-title: J. Nutr. Biochem.
  doi: 10.1016/j.jnutbio.2008.05.009
– volume: 8
  start-page: 445
  year: 2012
  end-page: 544
  ident: CR40
  article-title: Guidelines for the use and interpretation of assays for monitoring autophagy
  publication-title: Autophagy
  doi: 10.4161/auto.19496
– volume: 6
  start-page: 281
  year: 2014
  end-page: 295
  ident: CR121
  article-title: Increased hepatic CD36 expression with age is associated with enhanced susceptibility to nonalcoholic fatty liver disease
  publication-title: Aging
  doi: 10.18632/aging.100652
– volume: 34
  start-page: 1158
  year: 2001
  end-page: 1163
  ident: CR150
  article-title: Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
  publication-title: Hepatology
  doi: 10.1053/jhep.2001.29628
– volume: 48
  start-page: 920
  year: 2008
  end-page: 930
  ident: CR73
  article-title: Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence
  publication-title: Hepatology
  doi: 10.1002/hep.22351
– volume: 207
  start-page: 346
  year: 2013
  end-page: 357
  ident: CR93
  article-title: Fatty acid transporters involved in the palmitate and oleate induced insulin resistance in primary rat hepatocytes
  publication-title: Acta Physiol.
  doi: 10.1111/apha.12022
– volume: 27
  start-page: 201
  year: 2017
  end-page: 214
  ident: CR117
  article-title: Cluster of differentiation 36 deficiency aggravates macrophage infiltration and hepatic inflammation by upregulating monocyte chemotactic protein-1 expression of hepatocytes through histone deacetylase 2-dependent pathway
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2016.6808
– volume: 117
  start-page: 57
  year: 2011
  end-page: 63
  ident: CR128
  article-title: Soluble CD36- a marker of the (pathophysiological) role of CD36 in the metabolic syndrome?
  publication-title: Arch. Physiol. Biochem.
  doi: 10.3109/13813455.2010.543136
– ident: CR105
– volume: 18
  start-page: 127
  year: 2013
  end-page: 133
  ident: CR27
  article-title: The relationship between oxidative stress and nonalcoholic fatty liver disease: Its effects on the development of nonalcoholic steatohepatitis
  publication-title: Redox Rep.
  doi: 10.1179/1351000213Y.0000000050
– volume: 76
  start-page: 371
  year: 2016
  ident: CR96
  article-title: Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks
  publication-title: Eur. Phys. J. C
  doi: 10.1140/epjc/s10052-016-4206-6
– volume: 9
  year: 2014
  ident: CR4
  article-title: Establishment of a general NAFLD scoring system for rodent models and comparison to human liver pathology
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0115922
– volume: 275
  start-page: 14501
  year: 2000
  end-page: 14508
  ident: CR134
  article-title: Acute regulation of fatty acid uptake involves the cellular redistribution of fatty acid translocase
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.275.19.14501
– volume: 18
  start-page: 1609
  year: 2018
  end-page: 1615
  ident: CR114
  article-title: SIRT1 upregulation protects against liver injury induced by a HFD through inhibiting CD36 and the NFkappaB pathway in mouse kupffer cells
  publication-title: Mol. Med. Rep.
– volume: 69
  start-page: 705
  year: 2018
  end-page: 717
  ident: CR84
  article-title: CD36 palmitoylation disrupts free fatty acid metabolism and promotes tissue inflammation in non-alcoholic steatohepatitis
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2018.04.006
– volume: 35
  start-page: 2517
  year: 2015
  end-page: 2525
  ident: CR107
  article-title: PCSK9 induces CD36 degradation and affects long-chain fatty acid uptake and triglyceride metabolism in adipocytes and in mouse liver
  publication-title: Arterioscl. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.115.306032
– volume: 8
  year: 2013
  ident: CR61
  article-title: Pro-inflammatory activated Kupffer cells by lipids induce hepatic NKT cells deficiency through activation-induced cell death
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0081949
– volume: 55
  start-page: 239
  year: 2014
  end-page: 246
  ident: CR81
  article-title: CD36-deficient mice are resistant to alcohol- and high-carbohydrate-induced hepatic steatosis
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M041863
– volume: 2015
  start-page: 597134
  year: 2015
  ident: CR32
  article-title: The dual role of Nrf2 in nonalcoholic fatty liver disease: regulation of antioxidant defenses and hepatic lipid metabolism
  publication-title: BioMed. Res. Int.
  doi: 10.1155/2015/597134
– volume: 1812
  start-page: 447
  year: 2011
  end-page: 458
  ident: CR87
  article-title: Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbadis.2011.01.003
– volume: 294
  start-page: G1281
  year: 2008
  end-page: G1287
  ident: CR118
  article-title: Gene expression in human NAFLD
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00074.2008
– volume: 141
  start-page: 1249
  year: 2011
  end-page: 1253
  ident: CR3
  article-title: Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2011.06.061
– volume: 56
  start-page: 2863
  year: 2007
  end-page: 2871
  ident: CR88
  article-title: Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity
  publication-title: Diabetes
  doi: 10.2337/db07-0907
– volume: 62
  start-page: 452
  year: 2013
  end-page: 460
  ident: CR144
  article-title: Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis
  publication-title: Gut
  doi: 10.1136/gutjnl-2011-301146
– volume: 9
  start-page: 19
  year: 2016
  end-page: 29
  ident: CR143
  article-title: Mechanism of hepatocyte apoptosis
  publication-title: J. Cell Death
  doi: 10.4137/JCD.S39824
– volume: 281
  start-page: 12093
  year: 2006
  end-page: 12101
  ident: CR13
  article-title: Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M510660200
– volume: 287
  start-page: 39107
  year: 2012
  end-page: 39114
  ident: CR45
  article-title: The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.412569
– volume: 64
  start-page: 353
  year: 2015
  end-page: 359
  ident: CR80
  article-title: Regulation of AMPK activation by CD36 links fatty acid uptake to beta-oxidation
  publication-title: Diabetes
  doi: 10.2337/db14-0582
– volume: 273
  start-page: 16710
  year: 1998
  end-page: 16714
  ident: CR97
  article-title: Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor alpha and gamma activators in a tissue- and inducer-specific manner
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.273.27.16710
– volume: 9
  year: 2018
  ident: CR109
  article-title: Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-03072-8
– volume: 15
  start-page: 8591
  year: 2014
  end-page: 8638
  ident: CR5
  article-title: Evolving concepts in the pathogenesis of NASH: beyond steatosis and inflammation
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms15058591
– volume: 39
  start-page: 3092
  year: 2008
  end-page: 3095
  ident: CR126
  article-title: Soluble CD36 in plasma is increased in patients with symptomatic atherosclerotic carotid plaques and is related to plaque instability
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.108.517128
– volume: 80
  start-page: 298
  year: 2015
  end-page: 309
  ident: CR9
  article-title: Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2015.03.029
– volume: 56
  start-page: 1124
  year: 2007
  end-page: 1131
  ident: CR147
  article-title: Free fatty acids sensitise hepatocytes to TRAIL mediated cytotoxicity
  publication-title: Gut
  doi: 10.1136/gut.2006.118059
– volume: 48
  start-page: 357
  year: 2010
  end-page: 371
  ident: CR34
  article-title: Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2009.11.007
– volume: 54
  start-page: 142
  year: 2011
  end-page: 152
  ident: CR7
  article-title: Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2010.06.021
– volume: 42
  start-page: 935
  year: 2019
  end-page: 946
  ident: CR31
  article-title: Molecular insights into the role of mitochondria in non-alcoholic fatty liver disease
  publication-title: Arch. Pharm. Res.
  doi: 10.1007/s12272-019-01178-1
– volume: 32
  start-page: 37
  year: 2018
  end-page: 51
  ident: CR41
  article-title: Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis
  publication-title: FASEB J.
  doi: 10.1096/fj.201601393R
– volume: 34
  start-page: 729
  year: 2001
  end-page: 737
  ident: CR115
  article-title: Oxidized low-density lipoproteins bind to the scavenger receptor, CD36, of hepatic stellate cells and stimulate extracellular matrix synthesis
  publication-title: Hepatology
  doi: 10.1053/jhep.2001.27828
– volume: 16
  start-page: 145
  year: 2019
  end-page: 159
  ident: CR59
  article-title: The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Nature reviews
  publication-title: GNat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/s41575-018-0082-x
– volume: 316
  start-page: 74
  year: 2017
  end-page: 82
  ident: CR101
  article-title: Activation of AMPK by berberine induces hepatic lipid accumulation by upregulation of fatty acid translocase CD36 in mice
  publication-title: Toxicol. Appl. Pharmacol.
  doi: 10.1016/j.taap.2016.12.019
– volume: 8
  year: 2017
  ident: CR157
  article-title: Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-00566-9
– volume: 52
  start-page: 165
  year: 2013
  end-page: 174
  ident: CR21
  article-title: Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease
  publication-title: Prog. Lipid Res.
  doi: 10.1016/j.plipres.2012.10.004
– volume: 1
  start-page: 17
  year: 2015
  end-page: 27
  ident: CR49
  article-title: Death receptor-mediated cell death and proinflammatory signaling in nonalcoholic steatohepatitis
  publication-title: Cell. Mol. Gastroenterol. Hepatol.
  doi: 10.1016/j.jcmgh.2014.11.005
– volume: 34
  start-page: 281
  year: 2014
  end-page: 303
  ident: CR79
  article-title: Structure-function of CD36 and importance of fatty acid signal transduction in fat metabolism
  publication-title: Annu. Rev. Nutr.
  doi: 10.1146/annurev-nutr-071812-161220
– volume: 16
  year: 2018
  ident: CR68
  article-title: CCL20 is up-regulated in non-alcoholic fatty liver disease fibrosis and is produced by hepatic stellate cells in response to fatty acid loading
  publication-title: J. Transl. Med.
  doi: 10.1186/s12967-018-1490-y
– volume: 90
  start-page: 367
  year: 2010
  end-page: 417
  ident: CR77
  article-title: Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00003.2009
– ident: CR110
– volume: 20
  start-page: 72
  year: 2009
  end-page: 77
  ident: CR75
  article-title: Cellular fatty acid uptake: a pathway under construction
  publication-title: Trends Endocrinol. Metab.
  doi: 10.1016/j.tem.2008.11.001
– volume: 13
  start-page: 1078
  year: 2007
  end-page: 1085
  ident: CR158
  article-title: Lack of Fas antagonism by Met in human fatty liver disease
  publication-title: Nat. Med.
  doi: 10.1038/nm1625
– ident: CR28
– volume: 62
  start-page: 1156
  year: 2015
  end-page: 1163
  ident: CR149
  article-title: TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2014.11.033
– volume: 5
  start-page: 71
  year: 2010
  end-page: 85
  ident: CR50
  article-title: Mechanisms and clinical implications of hepatocyte lipoapoptosis
  publication-title: Clin. Lipidol.
  doi: 10.2217/clp.09.85
– volume: 60
  start-page: 844
  year: 2019
  end-page: 855
  ident: CR83
  article-title: CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M090969
– volume: 59
  start-page: 1208
  year: 2012
  end-page: 1212
  ident: CR63
  article-title: Selective depletion of hepatic Kupffer cells significantly alleviated hepatosteatosis and intrahepatic inflammation induced by high fat diet
  publication-title: Hepatogastroenterology
  doi: 10.5754/hge11399
– volume: 1
  start-page: 604
  year: 2019
  end-page: 614
  ident: CR66
  article-title: Transcriptional network analysis implicates altered hepatic immune function in NASH development and resolution
  publication-title: Nat. Metab.
  doi: 10.1038/s42255-019-0076-1
– volume: 18
  start-page: 1023
  year: 2016
  end-page: 1031
  ident: CR99
  article-title: Dual outcomes of rosiglitazone treatment on fatty liver
  publication-title: AAPS J.
  doi: 10.1208/s12248-016-9919-9
– volume: 458
  start-page: 1131
  year: 2009
  end-page: 1135
  ident: CR44
  article-title: Autophagy regulates lipid metabolism
  publication-title: Nature
  doi: 10.1038/nature07976
– volume: 52
  start-page: 586
  year: 2010
  end-page: 593
  ident: CR10
  article-title: Palmitoleate attenuates palmitate-induced Bim and PUMA up-regulation and hepatocyte lipoapoptosis
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2010.01.003
– volume: 286
  start-page: 356
  year: 2019
  ident: 3003_CR15
  publication-title: FEBS J.
  doi: 10.1111/febs.14389
– volume: 152
  start-page: 116
  year: 2020
  ident: 3003_CR23
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2020.02.025
– ident: 3003_CR28
  doi: 10.3390/medicina55020026
– volume: 1
  start-page: 17
  year: 2015
  ident: 3003_CR49
  publication-title: Cell. Mol. Gastroenterol. Hepatol.
  doi: 10.1016/j.jcmgh.2014.11.005
– volume: 18
  start-page: 1023
  year: 2016
  ident: 3003_CR99
  publication-title: AAPS J.
  doi: 10.1208/s12248-016-9919-9
– volume: 56
  start-page: 1124
  year: 2007
  ident: 3003_CR147
  publication-title: Gut
  doi: 10.1136/gut.2006.118059
– volume: 22
  start-page: 15
  year: 2007
  ident: 3003_CR78
  publication-title: Physiology
  doi: 10.1152/physiologyonline.2007.22.1.15
– volume: 8
  year: 2017
  ident: 3003_CR157
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-00566-9
– volume: 62
  start-page: 1156
  year: 2015
  ident: 3003_CR149
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2014.11.033
– volume: 53
  start-page: 486
  year: 2019
  ident: 3003_CR155
  publication-title: Free Radic. Res.
  doi: 10.1080/10715762.2019.1608982
– volume: 412
  start-page: 1297
  year: 2011
  ident: 3003_CR26
  publication-title: Clin. Chim. Acta
  doi: 10.1016/j.cca.2011.04.013
– volume: 316
  start-page: 74
  year: 2017
  ident: 3003_CR101
  publication-title: Toxicol. Appl. Pharmacol.
  doi: 10.1016/j.taap.2016.12.019
– volume: 33
  start-page: 57
  year: 2013
  ident: 3003_CR112
  publication-title: Crit. Rev. Immunol.
– volume: 34
  start-page: 719
  year: 2010
  ident: 3003_CR71
  publication-title: Alcohol. Clin. Exp. Res.
  doi: 10.1111/j.1530-0277.2009.01141.x
– volume: 67
  start-page: 963
  year: 2018
  ident: 3003_CR54
  publication-title: Gut
  doi: 10.1136/gutjnl-2017-315691
– ident: 3003_CR110
  doi: 10.3390/cells8101298
– volume: 34
  start-page: 729
  year: 2001
  ident: 3003_CR115
  publication-title: Hepatology
  doi: 10.1053/jhep.2001.27828
– volume: 53
  start-page: 1151
  year: 2010
  ident: 3003_CR123
  publication-title: Diabetologia
  doi: 10.1007/s00125-010-1708-x
– volume: 26
  start-page: 519
  year: 2017
  ident: 3003_CR30
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2016.6776
– volume: 80
  start-page: 298
  year: 2015
  ident: 3003_CR9
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2015.03.029
– volume: 185
  start-page: 2200
  year: 2010
  ident: 3003_CR70
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1000332
– volume: 55
  start-page: 32
  year: 2014
  ident: 3003_CR102
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M039453
– volume: 57
  start-page: 233
  year: 2016
  ident: 3003_CR64
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M063412
– volume: 6
  year: 2018
  ident: 3003_CR92
  publication-title: Physiol. Rep.
  doi: 10.14814/phy2.13902
– volume: 54
  start-page: 142
  year: 2011
  ident: 3003_CR7
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2010.06.021
– volume: 40
  start-page: 185
  year: 2004
  ident: 3003_CR152
  publication-title: Hepatology
  doi: 10.1002/hep.20283
– volume: 68
  start-page: 1247
  year: 2018
  ident: 3003_CR94
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2018.01.035
– volume: 245
  start-page: 326
  year: 2010
  ident: 3003_CR35
  publication-title: Toxicol. Appl. Pharmacol.
  doi: 10.1016/j.taap.2010.03.016
– volume: 59
  start-page: 1208
  year: 2012
  ident: 3003_CR63
  publication-title: Hepatogastroenterology
  doi: 10.5754/hge11399
– volume: 52
  start-page: 165
  year: 2013
  ident: 3003_CR21
  publication-title: Prog. Lipid Res.
  doi: 10.1016/j.plipres.2012.10.004
– volume: 33
  start-page: 361
  year: 2008
  ident: 3003_CR19
  publication-title: Physiol. Genomics
  doi: 10.1152/physiolgenomics.00139.2007
– volume: 61
  start-page: 1294
  year: 2016
  ident: 3003_CR58
  publication-title: Dig. Dis. Sci.
  doi: 10.1007/s10620-016-4049-x
– volume: 302
  start-page: G1310
  year: 2012
  ident: 3003_CR62
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00365.2011
– volume: 292
  start-page: G1671
  year: 2007
  ident: 3003_CR90
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00523.2006
– volume: 13
  start-page: 1358
  year: 2012
  ident: 3003_CR52
  publication-title: Curr. Drug Metab.
  doi: 10.2174/138920012803762729
– volume: 303
  start-page: E504
  year: 2012
  ident: 3003_CR137
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.00653.2011
– volume: 8
  year: 2013
  ident: 3003_CR61
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0081949
– volume: 144
  start-page: 293
  year: 2019
  ident: 3003_CR24
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2019.05.029
– volume: 18
  start-page: 127
  year: 2013
  ident: 3003_CR27
  publication-title: Redox Rep.
  doi: 10.1179/1351000213Y.0000000050
– volume: 44
  start-page: 65
  year: 2014
  ident: 3003_CR138
  publication-title: Eur. J. Clin. Invest
  doi: 10.1111/eci.12192
– volume: 32
  start-page: 37
  year: 2018
  ident: 3003_CR41
  publication-title: FASEB J.
  doi: 10.1096/fj.201601393R
– volume: 76
  start-page: 371
  year: 2016
  ident: 3003_CR96
  publication-title: Eur. Phys. J. C
  doi: 10.1140/epjc/s10052-016-4206-6
– volume: 65
  start-page: 1038
  year: 2016
  ident: 3003_CR6
  publication-title: Metabolism
  doi: 10.1016/j.metabol.2015.12.012
– volume: 271
  start-page: 294
  year: 2012
  ident: 3003_CR130
  publication-title: J. Intern. Med.
  doi: 10.1111/j.1365-2796.2011.02442.x
– volume: 573
  start-page: 199
  year: 2006
  ident: 3003_CR98
  publication-title: J. Physiol.
  doi: 10.1113/jphysiol.2006.106013
– volume: 275
  start-page: 14501
  year: 2000
  ident: 3003_CR134
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.275.19.14501
– volume: 1812
  start-page: 447
  year: 2011
  ident: 3003_CR87
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbadis.2011.01.003
– volume: 431
  start-page: 200
  year: 2004
  ident: 3003_CR141
  publication-title: Nature
  doi: 10.1038/nature02866
– volume: 273
  start-page: 16710
  year: 1998
  ident: 3003_CR97
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.273.27.16710
– volume: 286
  start-page: 39336
  year: 2011
  ident: 3003_CR145
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.280420
– volume: 11
  year: 2016
  ident: 3003_CR72
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0159217
– volume: 35
  start-page: 2517
  year: 2015
  ident: 3003_CR107
  publication-title: Arterioscl. Thromb. Vasc. Biol.
  doi: 10.1161/ATVBAHA.115.306032
– volume: 9
  year: 2018
  ident: 3003_CR109
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-03072-8
– volume: 24
  start-page: 830
  year: 2009
  ident: 3003_CR14
  publication-title: J. Gastroenterol. Hepatol.
  doi: 10.1111/j.1440-1746.2008.05733.x
– volume: 12
  year: 2013
  ident: 3003_CR36
  publication-title: Lipids Health Dis.
  doi: 10.1186/1476-511X-12-165
– volume: 150
  start-page: 956
  year: 2016
  ident: 3003_CR56
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2015.12.037
– volume: 345
  start-page: 98
  year: 2014
  ident: 3003_CR146
  publication-title: Science
  doi: 10.1126/science.1254312
– volume: 8
  start-page: 445
  year: 2012
  ident: 3003_CR40
  publication-title: Autophagy
  doi: 10.4161/auto.19496
– volume: 339
  start-page: 487
  year: 2011
  ident: 3003_CR39
  publication-title: J. Pharmacol. Exp. Ther.
  doi: 10.1124/jpet.111.184341
– volume: 41
  start-page: 262
  year: 2017
  ident: 3003_CR132
  publication-title: Int. J. Obes.
  doi: 10.1038/ijo.2016.223
– volume: 62
  start-page: 452
  year: 2013
  ident: 3003_CR144
  publication-title: Gut
  doi: 10.1136/gutjnl-2011-301146
– ident: 3003_CR105
  doi: 10.1111/liv.14519
– volume: 47
  start-page: 813
  year: 2017
  ident: 3003_CR111
  publication-title: Hepatol. Res.
  doi: 10.1111/hepr.12816
– volume: 368
  start-page: 545
  year: 2002
  ident: 3003_CR29
  publication-title: Biochem. J.
  doi: 10.1042/bj20021121
– volume: 45
  start-page: 1366
  year: 2007
  ident: 3003_CR51
  publication-title: Hepatology
  doi: 10.1002/hep.21655
– volume: 27
  start-page: 327
  year: 2007
  ident: 3003_CR142
  publication-title: Semin. Liver Dis.
  doi: 10.1055/s-2007-991510
– volume: 331
  start-page: 31
  year: 2009
  ident: 3003_CR11
  publication-title: Mol. Cell. Biochem.
  doi: 10.1007/s11010-009-0142-1
– volume: 2015
  start-page: 597134
  year: 2015
  ident: 3003_CR32
  publication-title: BioMed. Res. Int.
  doi: 10.1155/2015/597134
– volume: 90
  start-page: 367
  year: 2010
  ident: 3003_CR77
  publication-title: Physiol. Rev.
  doi: 10.1152/physrev.00003.2009
– volume: 207
  start-page: 346
  year: 2013
  ident: 3003_CR93
  publication-title: Acta Physiol.
  doi: 10.1111/apha.12022
– volume: 56
  start-page: 2863
  year: 2007
  ident: 3003_CR88
  publication-title: Diabetes
  doi: 10.2337/db07-0907
– volume: 35
  start-page: 495
  year: 2007
  ident: 3003_CR47
  publication-title: Toxicol. Pathol.
  doi: 10.1080/01926230701320337
– volume: 2015
  start-page: 480508
  year: 2015
  ident: 3003_CR37
  publication-title: BioMed. Res. Int.
– volume: 32
  start-page: 251
  year: 2010
  ident: 3003_CR16
  publication-title: Immunopharmacol. Immunotoxicol.
  doi: 10.3109/08923970903252220
– volume: 283
  start-page: E612
  year: 2002
  ident: 3003_CR135
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.00011.2002
– volume: 279
  start-page: 45803
  year: 2004
  ident: 3003_CR139
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M406963200
– volume: 5
  start-page: 71
  year: 2010
  ident: 3003_CR50
  publication-title: Clin. Lipidol.
  doi: 10.2217/clp.09.85
– volume: 141
  start-page: 1249
  year: 2011
  ident: 3003_CR3
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2011.06.061
– volume: 50
  start-page: S86
  year: 2009
  ident: 3003_CR133
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.R800085-JLR200
– volume: 125
  start-page: 437
  year: 2003
  ident: 3003_CR8
  publication-title: Gastroenterology
  doi: 10.1016/S0016-5085(03)00907-7
– volume: 53
  start-page: 131
  year: 2011
  ident: 3003_CR48
  publication-title: J. Pediatr. Gastroenterol. Nutr.
  doi: 10.1097/MPG.0b013e31820e82a1
– volume: 60
  start-page: 844
  year: 2019
  ident: 3003_CR83
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M090969
– volume: 18
  start-page: 1609
  year: 2018
  ident: 3003_CR114
  publication-title: Mol. Med. Rep.
– volume: 39
  start-page: 978
  year: 2003
  ident: 3003_CR156
  publication-title: J. Hepatol.
  doi: 10.1016/S0168-8278(03)00460-4
– volume: 31
  start-page: 328
  year: 2008
  ident: 3003_CR127
  publication-title: Diabetes Care
  doi: 10.2337/dc07-1424
– volume: 27
  start-page: 201
  year: 2017
  ident: 3003_CR117
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2016.6808
– volume: 18
  start-page: 685
  year: 2013
  ident: 3003_CR20
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2013.10.002
– volume: 51
  start-page: 500
  year: 2010
  ident: 3003_CR86
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M001966
– volume: 71
  start-page: 793
  year: 2019
  ident: 3003_CR1
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2019.06.021
– volume: 20
  start-page: 72
  year: 2009
  ident: 3003_CR75
  publication-title: Trends Endocrinol. Metab.
  doi: 10.1016/j.tem.2008.11.001
– volume: 167
  start-page: 129
  year: 2003
  ident: 3003_CR124
  publication-title: Atherosclerosis
  doi: 10.1016/S0021-9150(02)00421-5
– volume: 157
  start-page: 570
  year: 2016
  ident: 3003_CR116
  publication-title: Endocrinology
  doi: 10.1210/en.2015-1866
– volume: 9
  start-page: 19
  year: 2016
  ident: 3003_CR143
  publication-title: J. Cell Death
  doi: 10.4137/JCD.S39824
– volume: 48
  start-page: 357
  year: 2010
  ident: 3003_CR34
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2009.11.007
– volume: 287
  start-page: 39107
  year: 2012
  ident: 3003_CR45
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.412569
– volume: 24
  start-page: 443
  year: 2009
  ident: 3003_CR148
  publication-title: J. Gastroenterol. Hepatol.
  doi: 10.1111/j.1440-1746.2009.05785.x
– volume: 290
  start-page: 19034
  year: 2015
  ident: 3003_CR89
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M115.640292
– volume: 22
  start-page: 383
  year: 2002
  ident: 3003_CR74
  publication-title: Annu. Rev. Nutr.
  doi: 10.1146/annurev.nutr.22.020402.130846
– volume: 67
  start-page: 201
  year: 2018
  ident: 3003_CR43
  publication-title: Exp. Anim.
  doi: 10.1538/expanim.17-0112
– volume: 69
  start-page: 705
  year: 2018
  ident: 3003_CR84
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2018.04.006
– volume: 6
  start-page: 281
  year: 2014
  ident: 3003_CR121
  publication-title: Aging
  doi: 10.18632/aging.100652
– volume: 7
  year: 2017
  ident: 3003_CR95
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-03389-2
– volume: 11
  start-page: 467
  year: 2010
  ident: 3003_CR46
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2010.04.005
– volume: 30
  start-page: 850
  year: 2010
  ident: 3003_CR119
  publication-title: Liver Int.
  doi: 10.1111/j.1478-3231.2010.02248.x
– volume: 39
  start-page: 1648
  year: 2016
  ident: 3003_CR67
  publication-title: Cell. Physiol. Biochem.
  doi: 10.1159/000447866
– volume: 49
  start-page: 2513
  year: 2008
  ident: 3003_CR91
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M800101-JLR200
– volume: 34
  start-page: 1158
  year: 2001
  ident: 3003_CR150
  publication-title: Hepatology
  doi: 10.1053/jhep.2001.29628
– volume: 458
  start-page: 1131
  year: 2009
  ident: 3003_CR44
  publication-title: Nature
  doi: 10.1038/nature07976
– volume: 248
  start-page: 269
  year: 2019
  ident: 3003_CR108
  publication-title: Environ. Pollut.
  doi: 10.1016/j.envpol.2019.01.112
– volume: 147
  start-page: 943
  year: 2006
  ident: 3003_CR18
  publication-title: Endocrinology
  doi: 10.1210/en.2005-0570
– volume: 20
  start-page: 174
  year: 2013
  ident: 3003_CR131
  publication-title: J. Viral Hepat.
  doi: 10.1111/j.1365-2893.2012.01641.x
– volume: 63
  start-page: 731
  year: 2016
  ident: 3003_CR65
  publication-title: Hepatology
  doi: 10.1002/hep.28252
– volume: 298
  start-page: E1027
  year: 2010
  ident: 3003_CR17
  publication-title: Am. J. Physiol. Endocrinol. Metab.
  doi: 10.1152/ajpendo.00642.2009
– volume: 99
  start-page: 1708
  year: 2004
  ident: 3003_CR151
  publication-title: Am. J. Gastroenterol.
  doi: 10.1111/j.1572-0241.2004.40009.x
– volume: 236
  start-page: 1116
  year: 2011
  ident: 3003_CR76
  publication-title: Exp. Biol. Med.
  doi: 10.1258/ebm.2011.011128
– volume: 42
  start-page: 935
  year: 2019
  ident: 3003_CR31
  publication-title: Arch. Pharm. Res.
  doi: 10.1007/s12272-019-01178-1
– volume: 180
  start-page: 103
  year: 2017
  ident: 3003_CR69
  publication-title: Transl. Res.
  doi: 10.1016/j.trsl.2016.08.006
– volume: 134
  start-page: 556
  year: 2008
  ident: 3003_CR100
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2007.11.037
– volume: 58
  start-page: 17
  year: 2018
  ident: 3003_CR154
  publication-title: J. Nutr. Biochem.
  doi: 10.1016/j.jnutbio.2018.04.013
– volume: 9
  year: 2014
  ident: 3003_CR4
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0115922
– volume: 95
  start-page: 1939
  year: 2010
  ident: 3003_CR125
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2009-2002
– volume: 72
  start-page: 816
  year: 2020
  ident: 3003_CR55
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2019.11.024
– volume: 16
  year: 2018
  ident: 3003_CR68
  publication-title: J. Transl. Med.
  doi: 10.1186/s12967-018-1490-y
– volume: 15
  start-page: 8591
  year: 2014
  ident: 3003_CR5
  publication-title: Int. J. Mol. Sci.
  doi: 10.3390/ijms15058591
– volume: 281
  start-page: 12093
  year: 2006
  ident: 3003_CR13
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M510660200
– volume: 52
  start-page: 586
  year: 2010
  ident: 3003_CR10
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2010.01.003
– volume: 48
  start-page: 920
  year: 2008
  ident: 3003_CR73
  publication-title: Hepatology
  doi: 10.1002/hep.22351
– volume: 336
  start-page: 215
  year: 2005
  ident: 3003_CR85
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2005.08.070
– volume: 3
  start-page: 211
  year: 2006
  ident: 3003_CR42
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2006.01.011
– volume: 306
  start-page: 457
  year: 2004
  ident: 3003_CR22
  publication-title: Science
  doi: 10.1126/science.1103160
– volume: 290
  start-page: 11663
  year: 2015
  ident: 3003_CR60
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M115.649483
– volume: 64
  start-page: 73
  year: 2016
  ident: 3003_CR2
  publication-title: Hepatology
  doi: 10.1002/hep.28431
– volume: 60
  start-page: 1394
  year: 2011
  ident: 3003_CR120
  publication-title: Gut
  doi: 10.1136/gut.2010.222844
– volume: 294
  start-page: G1281
  year: 2008
  ident: 3003_CR118
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00074.2008
– volume: 28
  start-page: 250
  year: 2017
  ident: 3003_CR25
  publication-title: Trends Endocrinol. Metab.
  doi: 10.1016/j.tem.2016.11.006
– volume: 5
  year: 2014
  ident: 3003_CR38
  publication-title: Cell Death Dis.
  doi: 10.1038/cddis.2014.162
– volume: 127
  start-page: 55
  year: 2017
  ident: 3003_CR57
  publication-title: J. Clin. Invest
  doi: 10.1172/JCI88881
– volume: 64
  start-page: 353
  year: 2015
  ident: 3003_CR80
  publication-title: Diabetes
  doi: 10.2337/db14-0582
– volume: 20
  start-page: 477
  year: 2009
  ident: 3003_CR129
  publication-title: J. Nutr. Biochem.
  doi: 10.1016/j.jnutbio.2008.05.009
– volume: 16
  start-page: 145
  year: 2019
  ident: 3003_CR59
  publication-title: GNat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/s41575-018-0082-x
– volume: 68
  start-page: 1423
  year: 2005
  ident: 3003_CR113
  publication-title: Mol. Pharmacol.
  doi: 10.1124/mol.105.016121
– volume: 39
  start-page: 3092
  year: 2008
  ident: 3003_CR126
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.108.517128
– volume: 362
  start-page: 206
  year: 2007
  ident: 3003_CR140
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2007.08.004
– volume: 34
  start-page: 281
  year: 2014
  ident: 3003_CR79
  publication-title: Annu. Rev. Nutr.
  doi: 10.1146/annurev-nutr-071812-161220
– volume: 114
  start-page: 1169
  year: 2006
  ident: 3003_CR122
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.106.626135
– volume: 9
  start-page: 1428
  year: 2018
  ident: 3003_CR33
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2018.01428
– volume: 57
  start-page: 566
  year: 2013
  ident: 3003_CR153
  publication-title: Hepatology
  doi: 10.1002/hep.26046
– volume: 100
  start-page: 3077
  year: 2003
  ident: 3003_CR12
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0630588100
– volume: 447
  start-page: 57
  year: 2014
  ident: 3003_CR106
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2014.03.103
– volume: 51
  start-page: 3113
  year: 2002
  ident: 3003_CR136
  publication-title: Diabetes
  doi: 10.2337/diabetes.51.10.3113
– volume: 55
  start-page: 239
  year: 2014
  ident: 3003_CR81
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M041863
– volume: 284
  start-page: 26695
  year: 2009
  ident: 3003_CR103
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M109.033480
– volume: 13
  start-page: 1078
  year: 2007
  ident: 3003_CR158
  publication-title: Nat. Med.
  doi: 10.1038/nm1625
– volume: 1
  start-page: 604
  year: 2019
  ident: 3003_CR66
  publication-title: Nat. Metab.
  doi: 10.1038/s42255-019-0076-1
– volume: 117
  start-page: 57
  year: 2011
  ident: 3003_CR128
  publication-title: Arch. Physiol. Biochem.
  doi: 10.3109/13813455.2010.543136
– volume: 54
  start-page: 2988
  year: 2013
  ident: 3003_CR82
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.M037812
– volume: 38
  start-page: 1188
  year: 2003
  ident: 3003_CR53
  publication-title: Hepatology
  doi: 10.1053/jhep.2003.50472
– volume: 7
  year: 2012
  ident: 3003_CR104
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0048535
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Snippet Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. NAFLD stages range from simple steatosis (NAFL) to...
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Antibodies
Biochemistry
Biomedical and Life Sciences
CD36 Antigens - metabolism
Cell Biology
Cell Culture
Disease Progression
Fatty Acids, Nonesterified - metabolism
Humans
Immunology
Life Sciences
Non-alcoholic Fatty Liver Disease - genetics
Non-alcoholic Fatty Liver Disease - pathology
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Review Article
Title Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?
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