The Crosstalk of Adipose-Derived Stem Cells (ADSC), Oxidative Stress, and Inflammation in Protective and Adaptive Responses

The potential use of stem cell-based therapies for the repair and regeneration of various tissues and organs is a major goal in repair medicine. Stem cells are classified by their potential to differentiate into functional cells. Compared with other sources, adipose-derived stem cells (ADSCs) have t...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:International journal of molecular sciences Ročník 21; číslo 23; s. 9262
Hlavní autoři: Rochette, Luc, Mazini, Loubna, Malka, Gabriel, Zeller, Marianne, Cottin, Yves, Vergely, Catherine
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 04.12.2020
MDPI
Témata:
Adaptation, Biological
Adipocytes
Adipose Tissue - cytology
Animals
Antioxidants - metabolism
Biotechnology
Cardiac function
Cardiomyocytes
Cell adhesion & migration
Cells, Cultured
Cellular Biology
Clinical trials
Endothelium
Fibroblasts
Growth factors
Guided Tissue Regeneration
Heart attacks
Homeostasis
Humans
Inflammation
Inflammation - etiology
Inflammation - metabolism
Inflammation - pathology
Iron
Life Sciences
Mesenchymal Stem Cells - cytology
Mesenchymal Stem Cells - metabolism
Oxidants - metabolism
Oxidative Stress
Peptides
Reactive oxygen species
Review
Smooth muscle
Stem cells
Tissue engineering
stem cells
adipose derived stem cells
tissue protection
oxidative stress
ISSN:1422-0067, 1661-6596, 1422-0067
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:The potential use of stem cell-based therapies for the repair and regeneration of various tissues and organs is a major goal in repair medicine. Stem cells are classified by their potential to differentiate into functional cells. Compared with other sources, adipose-derived stem cells (ADSCs) have the advantage of being abundant and easy to obtain. ADSCs are considered to be tools for replacing, repairing, and regenerating dead or damaged cells. The capacity of ADSCs to maintain their properties depends on the balance of complex signals in their microenvironment. Their properties and the associated outcomes are in part regulated by reactive oxygen species, which mediate the oxidation-reduction state of cells as a secondary messenger. ADSC therapy has demonstrated beneficial effects, suggesting that secreted factors may provide protection. There is evidence that ADSCs secrete a number of cytokines, growth factors, and antioxidant factors into their microenvironment, thus regulating intracellular signaling pathways in neighboring cells. In this review, we introduce the roles of ADSCs in the protection of cells by modulating inflammation and immunity, and we develop their potential therapeutic properties.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21239262