Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators

To identify the genetic basis of circulating concentrations of monocyte chemoattractant protein-1 (MCP-1), we conducted genome-wide association analyses for MCP-1 in 3 independent cohorts (n = 9598). The strongest association was for serum MCP-1 with a nonsynonymous polymorphism, rs12075 (Asp42Gly)...

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Vydáno v:	Blood Ročník 115; číslo 26; s. 5289
Hlavní autoři:	Schnabel, Renate B, Baumert, Jens, Barbalic, Maja, Dupuis, Josée, Ellinor, Patrick T, Durda, Peter, Dehghan, Abbas, Bis, Joshua C, Illig, Thomas, Morrison, Alanna C, Jenny, Nancy S, Keaney, Jr, John F, Gieger, Christian, Tilley, Cathy, Yamamoto, Jennifer F, Khuseyinova, Natalie, Heiss, Gerardo, Doyle, Margaret, Blankenberg, Stefan, Herder, Christian, Walston, Jeremy D, Zhu, Yanyan, Vasan, Ramachandran S, Klopp, Norman, Boerwinkle, Eric, Larson, Martin G, Psaty, Bruce M, Peters, Annette, Ballantyne, Christie M, Witteman, Jacqueline C M, Hoogeveen, Ron C, Benjamin, Emelia J, Koenig, Wolfgang, Tracy, Russell P
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.07.2010
Témata:	Adult Chemokine CCL2 - blood Chemokine CCL2 - genetics Chromosomes, Human, Pair 1 Cohort Studies Duffy Blood-Group System - genetics Duffy Blood-Group System - metabolism Erythrocytes - metabolism Female Genetic Loci Genome-Wide Association Study Humans Inflammation Mediators - blood Male Middle Aged Polymorphism, Single Nucleotide Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism
ISSN:	1528-0020, 1528-0020
On-line přístup:	Zjistit podrobnosti o přístupu
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