Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators

To identify the genetic basis of circulating concentrations of monocyte chemoattractant protein-1 (MCP-1), we conducted genome-wide association analyses for MCP-1 in 3 independent cohorts (n = 9598). The strongest association was for serum MCP-1 with a nonsynonymous polymorphism, rs12075 (Asp42Gly)...

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Veröffentlicht in:	Blood Jg. 115; H. 26; S. 5289
Hauptverfasser:	Schnabel, Renate B, Baumert, Jens, Barbalic, Maja, Dupuis, Josée, Ellinor, Patrick T, Durda, Peter, Dehghan, Abbas, Bis, Joshua C, Illig, Thomas, Morrison, Alanna C, Jenny, Nancy S, Keaney, Jr, John F, Gieger, Christian, Tilley, Cathy, Yamamoto, Jennifer F, Khuseyinova, Natalie, Heiss, Gerardo, Doyle, Margaret, Blankenberg, Stefan, Herder, Christian, Walston, Jeremy D, Zhu, Yanyan, Vasan, Ramachandran S, Klopp, Norman, Boerwinkle, Eric, Larson, Martin G, Psaty, Bruce M, Peters, Annette, Ballantyne, Christie M, Witteman, Jacqueline C M, Hoogeveen, Ron C, Benjamin, Emelia J, Koenig, Wolfgang, Tracy, Russell P
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.07.2010
Schlagworte:	Adult Chemokine CCL2 - blood Chemokine CCL2 - genetics Chromosomes, Human, Pair 1 Cohort Studies Duffy Blood-Group System - genetics Duffy Blood-Group System - metabolism Erythrocytes - metabolism Female Genetic Loci Genome-Wide Association Study Humans Inflammation Mediators - blood Male Middle Aged Polymorphism, Single Nucleotide Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism
ISSN:	1528-0020, 1528-0020
Online-Zugang:	Weitere Angaben
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