A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells

Embryonic stem cells (ESCs) represent a transient biological state, where pluripotency is coupled with fast proliferation. ESCs display a constitutively active DNA damage response (DDR), but its molecular determinants have remained elusive. Here we show in cultured ESCs and mouse embryos that H2AX p...

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Bibliographic Details
Published in:	Nature communications Vol. 7; no. 1; p. 10660
Main Authors:	Ahuja, Akshay K., Jodkowska, Karolina, Teloni, Federico, Bizard, Anna H., Zellweger, Ralph, Herrador, Raquel, Ortega, Sagrario, Hickson, Ian D., Altmeyer, Matthias, Mendez, Juan, Lopes, Massimo
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 15.02.2016 Nature Publishing Group Nature Portfolio
Subjects:	631/136/2086 631/136/532/2117 631/337/1427/2566 631/80/86 Animals Ataxia Telangiectasia Mutated Proteins - metabolism Blastocyst - metabolism Blotting, Western Chromatin - metabolism Chromosomal Proteins, Non-Histone - metabolism DNA Damage DNA Replication DNA, Single-Stranded - metabolism DNA-Binding Proteins - metabolism Electrophoresis, Gel, Pulsed-Field Flow Cytometry G1 Phase G1 Phase Cell Cycle Checkpoints Histones - metabolism Humanities and Social Sciences Inactivation Mice Microscopy, Confocal Microscopy, Electron Microscopy, Fluorescence Mitosis Morula - metabolism Mouse Embryonic Stem Cells - metabolism multidisciplinary Phosphorylation Poly(ADP-ribose) Polymerases - metabolism Rad51 Recombinase - metabolism Replication Protein A - metabolism Science Science (multidisciplinary) Stem cells Tumor Suppressor p53-Binding Protein 1
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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