Advanced paternal age effects in neurodevelopmental disorders—review of potential underlying mechanisms

Multiple epidemiological studies suggest a relationship between advanced paternal age (APA) at conception and adverse neurodevelopmental outcomes in offspring, particularly with regard to increased risk for autism and schizophrenia. Conclusive evidence about how age-related changes in paternal gamet...

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Veröffentlicht in:Translational psychiatry Jg. 7; H. 1; S. e1019
Hauptverfasser: Janecka, M, Mill, J, Basson, M A, Goriely, A, Spiers, H, Reichenberg, A, Schalkwyk, L, Fernandes, C
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 31.01.2017
Nature Publishing Group
Schlagworte:
38
38/23
631/208/2489
631/477/2811
Age Factors
Autistic Disorder - epidemiology
Autistic Disorder - genetics
Behavioral Sciences
Biological Psychology
Epigenesis, Genetic
Humans
Medicine
Medicine & Public Health
Neurodevelopmental disorders
Neurodevelopmental Disorders - epidemiology
Neurodevelopmental Disorders - genetics
Neurosciences
Paternal Age
Pharmacotherapy
Psychiatry
Review
Risk Factors
Schizophrenia - epidemiology
Schizophrenia - genetics
ISSN:2158-3188, 2158-3188
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Abstract Multiple epidemiological studies suggest a relationship between advanced paternal age (APA) at conception and adverse neurodevelopmental outcomes in offspring, particularly with regard to increased risk for autism and schizophrenia. Conclusive evidence about how age-related changes in paternal gametes, or age-independent behavioral traits affect neural development is still lacking. Recent evidence suggests that the origins of APA effects are likely to be multidimensional, involving both inherited predisposition and de novo events. Here we provide a review of the epidemiological and molecular findings to date. Focusing on the latter, we present the evidence for genetic and epigenetic mechanisms underpinning the association between late fatherhood and disorder in offspring. We also discuss the limitations of the APA literature. We propose that different hypotheses relating to the origins of the APA effects are not mutually exclusive. Instead, multiple mechanisms likely contribute, reflecting the etiological complexity of neurodevelopmental disorders.
AbstractList Multiple epidemiological studies suggest a relationship between advanced paternal age (APA) at conception and adverse neurodevelopmental outcomes in offspring, particularly with regard to increased risk for autism and schizophrenia. Conclusive evidence about how age-related changes in paternal gametes, or age-independent behavioral traits affect neural development is still lacking. Recent evidence suggests that the origins of APA effects are likely to be multidimensional, involving both inherited predisposition and de novo events. Here we provide a review of the epidemiological and molecular findings to date. Focusing on the latter, we present the evidence for genetic and epigenetic mechanisms underpinning the association between late fatherhood and disorder in offspring. We also discuss the limitations of the APA literature. We propose that different hypotheses relating to the origins of the APA effects are not mutually exclusive. Instead, multiple mechanisms likely contribute, reflecting the etiological complexity of neurodevelopmental disorders.
Multiple epidemiological studies suggest a relationship between advanced paternal age (APA) at conception and adverse neurodevelopmental outcomes in offspring, particularly with regard to increased risk for autism and schizophrenia. Conclusive evidence about how age-related changes in paternal gametes, or age-independent behavioral traits affect neural development is still lacking. Recent evidence suggests that the origins of APA effects are likely to be multidimensional, involving both inherited predisposition and de novo events. Here we provide a review of the epidemiological and molecular findings to date. Focusing on the latter, we present the evidence for genetic and epigenetic mechanisms underpinning the association between late fatherhood and disorder in offspring. We also discuss the limitations of the APA literature. We propose that different hypotheses relating to the origins of the APA effects are not mutually exclusive. Instead, multiple mechanisms likely contribute, reflecting the etiological complexity of neurodevelopmental disorders.Multiple epidemiological studies suggest a relationship between advanced paternal age (APA) at conception and adverse neurodevelopmental outcomes in offspring, particularly with regard to increased risk for autism and schizophrenia. Conclusive evidence about how age-related changes in paternal gametes, or age-independent behavioral traits affect neural development is still lacking. Recent evidence suggests that the origins of APA effects are likely to be multidimensional, involving both inherited predisposition and de novo events. Here we provide a review of the epidemiological and molecular findings to date. Focusing on the latter, we present the evidence for genetic and epigenetic mechanisms underpinning the association between late fatherhood and disorder in offspring. We also discuss the limitations of the APA literature. We propose that different hypotheses relating to the origins of the APA effects are not mutually exclusive. Instead, multiple mechanisms likely contribute, reflecting the etiological complexity of neurodevelopmental disorders.
Multiple epidemiological studies suggest a relationship between advanced paternal age (APA) at conception and adverse neurodevelopmental outcomes in offspring, particularly with regard to increased risk for autism and schizophrenia. Conclusive evidence about how age-related changes in paternal gametes, or age-independent behavioral traits affect neural development is still lacking. Recent evidence suggests that the origins of APA effects are likely to be multidimensional, involving both inherited predisposition and de novo events. Here we provide a review of the epidemiological and molecular findings to date. Focusing on the latter, we present the evidence for genetic and epigenetic mechanisms underpinning the association between late fatherhood and disorder in offspring. We also discuss the limitations of the APA literature. We propose that different hypotheses relating to the origins of the APA effects are not mutually exclusive. Instead, multiple mechanisms likely contribute, reflecting the etiological complexity of neurodevelopmental disorders.
Author Janecka, M
Reichenberg, A
Schalkwyk, L
Fernandes, C
Mill, J
Goriely, A
Spiers, H
Basson, M A
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  fullname: Janecka, M
  email: magdalena.janecka@mssm.edu
  organization: Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, Department of Psychiatry, Icahn School of Medicine at Mount Sinai
– sequence: 2
  givenname: J
  surname: Mill
  fullname: Mill, J
  organization: Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, University of Exeter Medical School, University of Exeter
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  surname: Basson
  fullname: Basson, M A
  organization: Department of Craniofacial and Stem Cell Biology, MRC Centre for Neurodevelopmental Disorders, King’s College London
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  surname: Goriely
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  organization: Weatherall Institute of Molecular Medicine, University of Oxford
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  organization: School of Biological Sciences, University of Essex
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  surname: Fernandes
  fullname: Fernandes, C
  organization: Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28140401$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1001/archpsyc.60.7.673
10.1038/ng.3039
10.1016/j.annepidem.2011.12.006
10.1038/mp.2013.41
10.1038/ejhg.2009.177
10.1016/j.molcel.2012.11.001
10.1016/j.conb.2014.12.001
10.1098/rspb.2014.2898
10.1007/s10803-009-0755-y
10.1093/schbul/sbu154
10.1038/mp.2015.70
10.1186/gb-2013-14-10-r115
10.1038/sj.mp.4002102
10.1016/S0920-9964(12)70011-7
10.1002/humu.10147
10.1038/nn.4353
10.1073/pnas.0506468103
10.1016/j.schres.2012.12.001
10.1038/nature09165
10.1038/tp.2014.27
10.1093/oxfordjournals.schbul.a006882
10.1038/nrg3435
10.1016/j.tig.2012.01.005
10.1093/schbul/sbq011
10.1176/appi.ajp.159.9.1528
10.1086/504729
10.1016/j.molmed.2014.11.005
10.1097/00001648-199505000-00016
10.1111/j.1460-9568.2010.07074.x
10.1007/978-3-662-03356-2
10.2307/1129848
10.1176/appi.ajp.159.9.1591
10.1016/j.neuron.2015.09.016
10.1038/342281a0
10.1038/ng.3629
10.1001/jamapsychiatry.2013.1180
10.1038/ng1089
10.1016/S0920-9964(12)70012-9
10.1186/2040-2392-5-24
10.1210/jcem.86.6.7603
10.1002/ajmg.b.20066
10.1269/jrr.47.B75
10.1016/0092-8674(92)90561-P
10.1016/j.celrep.2014.08.068
10.1016/j.neuron.2011.05.002
10.1016/j.fertnstert.2013.05.039
10.1101/cshperspect.a002592
10.1002/ajmg.1320590218
10.1038/nature11011
10.1038/ng.835
10.1176/appi.ajp.2013.12101352
10.1371/journal.pbio.0050224
10.1530/eje.0.151u119
10.1002/ajmg.c.31363
10.1038/ncomms10486
10.1093/schbul/sbp104
10.1016/j.fertnstert.2013.06.024
10.1038/nature09534
10.1038/ng.2805
10.1016/j.schres.2011.08.013
10.1016/j.jaac.2010.05.005
10.1001/jamapsychiatry.2014.3059
10.1146/annurev-genom-031714-125740
10.1073/pnas.1415301111
10.1016/j.cell.2012.11.019
10.1001/jamapsychiatry.2013.4525
10.1176/appi.ajp.2010.10020252
10.1097/00001648-199911000-00016
10.1016/j.schres.2005.03.004
10.1038/nature11396
10.1016/j.tig.2005.06.008
10.1007/s10803-013-1801-3
10.1093/ije/dyt262
10.1186/1471-2393-13-29
10.1186/1744-859X-10-15
10.1073/pnas.0801267105
10.1001/archpedi.161.4.334
10.1001/jamapsychiatry.2016.0129
10.1136/bmj.38243.672396.55
10.1038/ng.3431
10.1093/schbul/sbm093
10.1038/nature00819
10.1038/ng.3577
10.1017/S1092852900022239
10.1038/nrg2529
10.1186/2040-2392-3-9
10.1093/humrep/dem403
10.1371/journal.pmed.1000040
10.1186/1471-2350-12-47
10.1002/j.1460-2075.1992.tb05326.x
10.1101/gr.201541.115
10.1016/j.schres.2011.09.027
10.1371/journal.pone.0009939
10.1038/nrg2809-c1
10.1073/pnas.0437971100
10.1016/j.ajhg.2014.03.018
10.1002/gene.10168
10.1038/ng.3597
10.1038/nrn2235
10.1111/gbb.12227
10.5698/1535-7511-16.2.91
10.1136/jmedgenet-2011-100147
10.1038/ng.3469
10.1176/ajp.154.2.185
10.1038/mp.2010.121
10.1016/j.neubiorev.2004.11.007
10.1093/aje/kwn250
10.1016/j.ridd.2011.03.004
10.1001/archpsyc.1984.01790130023003
10.1038/nature13908
10.1038/35049558
10.1016/j.ajhg.2011.12.017
10.1001/archpsyc.63.9.1026
10.1111/j.1469-7610.2010.02223.x
10.1093/schbul/sbu188
10.1534/genetics.111.132597
10.1038/ng0596-48
10.1186/1471-2407-5-143
10.1038/nrg3032
10.1073/pnas.1521325113
10.1038/sj.mp.4001966
10.1126/science.1085710
10.1095/biolreprod.108.072066
10.1038/mp.2012.88
10.1038/tp.2013.111
10.1186/gb-2014-15-2-r37
10.3389/fnbeh.2011.00032
10.1371/journal.pone.0008456
10.1016/j.schres.2011.02.006
10.1192/bjp.183.5.405
10.1038/mp.2013.69
10.1016/0888-7543(92)90001-9
10.1016/j.cell.2013.04.041
10.1001/jama.2015.4845
10.1038/mp.2014.84
10.1038/ng.162
10.1038/nature08185
10.1038/nature08186
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These authors contributed equally to this work.
OpenAccessLink https://www.proquest.com/docview/1869323563?pq-origsite=%requestingapplication%
PMID 28140401
PQID 1869323563
PQPubID 2041978
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proquest_journals_1869323563
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crossref_citationtrail_10_1038_tp_2016_294
crossref_primary_10_1038_tp_2016_294
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PublicationDate 2017-01-31
PublicationDateYYYYMMDD 2017-01-31
PublicationDate_xml – month: 01
  year: 2017
  text: 2017-01-31
  day: 31
PublicationDecade 2010
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PublicationTitle Translational psychiatry
PublicationTitleAbbrev Transl Psychiatry
PublicationTitleAlternate Transl Psychiatry
PublicationYear 2017
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Zammit, Allebeck, Dalman, Lundberg, Hemmingson, Owen (CR48) 2003; 183
McIntosh, Olshan, Baird (CR7) 1995; 6
Sampino, Juszczak, Zacchini, Swiergiel, Modlinski, Loi (CR59) 2014; 4
Puleo, Reichenberg, Smith, Kryzak, Silverman (CR44) 2008; 13
Crow (CR86) 2006; 47
Goriely (CR90) 2016; 48
Naserbakht, Ahmadkhaniha, Mokri, Smith (CR19) 2011; 10
Loh, Bhatia, Gusev, Finucane, Bulik-Sullivan, Pollack (CR98) 2015; 47
Wilkinson, Davies, Isles (CR133) 2007; 8
Qin, Calabrese, Tiemann-Boege, Shinde, Yoon, Gelfand (CR95) 2007; 5
Flanagan, Popendikyte, Pozdniakovaite, Sobolev, Assadzadeh, Schumacher (CR125) 2006; 79
Lee, McGrath (CR28) 2015; 21
Malaspina, Brown, Goetz, Alia-Klein, Harkavy-Friedman, Harlap (CR49) 2002; 7
Ferguson-Smith (CR127) 2011; 12
Foldi, Eyles, Flatscher-Bader, McGrath, Burne (CR70) 2011; 5
Foldi, Eyles, McGrath, Burne (CR58) 2010; 31
Purcell, Wray, Stone, Visscher, O'Donovan (CR76) 2009; 460
Goriely, McGrath, Hultman, Wilkie, Malaspina (CR100) 2013; 170
Choi, Lee, Park, Noh, Ahn, Yoo (CR103) 2005; 5
Ben Itzchak, Lahat, Zachor (CR6) 2011; 32
Gaugler, Klei, Sanders, Bodea, Goldberg, Lee (CR79) 2014; 46
Lundström, Haworth, Carlström, Gillberg, Mill, Råstam (CR12) 2010; 51
Petty, Ornitz, Michelman, Zimmerman (CR39) 1984; 41
Wockner, Noble, Lawford, Young, Morris, Whitehall (CR108) 2014; 4
Smith, Reichenberg, Kember, Buxbaum, Schalkwyk, Fernandes (CR120) 2012; 18
Bestor, Edwards, Boulard (CR129) 2014; 112
Svenson, Gatti, Valdar, Welsh, Cheng, Chesler (CR141) 2012; 190
D’Onofrio, Rickert, Frans, Kuja-Halkola, Almqvist, Sjölander (CR9) 2014; 71
Adkins, Thomas, Tylavsky, Krushkal (CR124) 2011; 12
Frans, McGrath, Sandin, Lichtenstein, Reichenberg, Långström (CR22) 2011; 133
Choufani, Shuman, Weksberg (CR136) 2013; 163
Nilsen, Waldenström, Rasmussen, Hjelmstedt, Schytt (CR42) 2013; 13
Golding (CR32) 2004; 151
Frans, Sandin, Reichenberg, Långström, Lichtenstein, McGrath (CR34) 2013; 70
Vogel, Motulsky (CR88) 1997
Constância, Hemberger, Hughes, Dean, Ferguson-Smith, Fundele (CR131) 2002; 417
Waterhouse, Fein (CR36) 1984; 55
Oakes, Smiraglia, Plass, Trasler, Robaire (CR117) 2003; 100
O’Roak, Deriziotis, Lee, Vives, Schwartz, Girirajan (CR67) 2011; 43
Sanders, He, Willsey, Devlin, Roeder, State (CR99) 2015; 87
Miller, Messias, Miettunen, Alaräisänen, Järvelin, Koponen (CR18) 2011; 37
Cantor, Yoon, Furr, Lajonchere (CR23) 2007; 12
Horvath (CR119) 2013; 14
Miller, Suvisaari, Miettunen, Järvelin, Haukka, Tanskanen (CR45) 2011; 133
Hultman, Sandin, Levine, Lichtenstein, Reichenberg (CR55) 2011; 16
Janecka, Manduca, Servadio, Trezza, Smith, Mill (CR57) 2015; 14
Dallman, Allebeck (CR14) 2002; 420
Klei, Sanders, Murtha, Hus, Lowe, Willsey (CR78) 2012; 3
Lane, Dean, Erhardt, Hajkova, Surani, Walter (CR138) 2003; 35
Durkin, Maenner, Newschaffer, Lee, Cunniff, Daniels (CR25) 2008; 168
Jenkins, Aston, Cairns, Carrell (CR116) 2014; 100
Pinto, Delaby, Merico, Barbosa, Merikangas, Klei (CR101) 2014; 94
Seisenberger, Andrews, Krueger, Arand, Walter, Santos (CR118) 2012; 48
Brown, Schaefer, Wyatt, Begg, Goetz, Bresnahan (CR13) 2002; 159
Durbin, Altshuler, Durbin, Abecasis, Bentley, Chakravarti (CR80) 2010; 467
Dong, Walker, Carriero, DiCola, Willsey, Ye (CR65) 2014; 9
Rutten, Mill (CR109) 2009; 35
Morison, Ramsay, Spencer (CR140) 2005; 21
Hehir-Kwa, Rodriguez-Santiago, Vissers, de Leeuw, Pfundt, Buitelaar (CR69) 2011; 48
Michaelson, Shi, Gujral, Zheng, Malhotra, Jin (CR83) 2012; 151
Goriely, Wilkie (CR82) 2012; 90
Crow (CR85) 2000; 1
Palmert, Boepple (CR142) 2001; 86
Sullivan, Magnusson, Reichenberg, Boman, Dalman, Davidson (CR38) 2012; 2
Mehta, Tropf, Gratten, Bakshi, Zhu, Bacanu (CR46) 2016; 73
Neale, Kou, Liu, Ma’ayan, Samocha, Sabo (CR68) 2012; 485
Jiang, Zhang, Wang, Wang, Zhang, Li (CR139) 2013; 153
Pedersen, McGrath, Mortensen, Petersen (CR54) 2014; 19
Wong, Solomon, Bodian, Kothiyal, Eley, Huddleston (CR89) 2016; 7
Lugnegård, Unenge Hallerbäck, Hjärthag, Gillberg (CR35) 2013; 143
Forster, Hohoff, Dunkelmann, Pfeiffer, Neuhuber, Brinkmann (CR87) 2015; 282
Puleo, Reichenberg, Smith, Kryzak, Silverman (CR30) 2008; 13
Nicholls, Knoll, Butler, Karam, Lalande (CR134) 1989; 342
Sipos, Rasmussen, Harrison, Tynelius, Lewis, Leon (CR47) 2004; 329
Wyrobek, Eskenazi, Young, Arnheim, Tiemann-Boege, Jabs (CR3) 2006; 103
Chen, Wen, Krewski, Fleming, Yang, Walker (CR10) 2008; 23
Goriely, McVean, Rojmyr, Ingemarsson, Wilkie (CR94) 2003; 301
Jaenisch, Bird (CR106) 2003; 33
Sanders, Ercan-Sencicek, Hus, Luo, Murtha, Moreno-De-Luca (CR74) 2011; 70
Croen, Najjar, Fireman, Grether (CR24) 2007; 161
Fowden, Sibley, Reik, Constancia (CR132) 2006; 65
Grossniklaus, Kelly, Kelly, Ferguson-Smith, Pembrey, Lindquist (CR137) 2013; 14
Petersen, Mortensen, Pedersen (CR53) 2011; 168
Hultman (CR26) 2012; 136
Anello, Reichenberg, Luo, Schmeidler, Hollander, Smith (CR31) 2009; 39
Moloney, Slaney, Oldridge, Wall, Sahlin, Stenman (CR1) 1996; 13
Bestor (CR115) 1992; 11
Krishnan, Zhang, Yao, Theesfeld, Wong, Tadych (CR102) 2016; 19
Stefansson, Ophoff, Steinberg, Andreassen, Cichon, Rujescu (CR77) 2009; 460
Maunakea, Nagarajan, Bilenky, Ballinger, D’Souza, Fouse (CR113) 2010; 466
Tsuchiya, Takagai, Kawai, Matsumoto, Nakamura, Minabe (CR21) 2005; 76
Kondrashov (CR81) 2003; 21
Wong, Meaburn, Ronald, Price, Jeffries, Schalkwyk (CR107) 2014; 19
Gratten, Wray, Peyrot, McGrath, Visscher, Goddard (CR62) 2016; 48
Mefford (CR64) 2016; 16
Teperek, Simeone, Gaggioli, Miyamoto, Allen, Erkek (CR111) 2016; 26
Milekic, Xin, O’Donnell, Kumar, Bradley-Moore, Malaspina (CR61) 2015; 20
Frans, Sandin, Reichenberg, Langstrom, Lichtenstein, McGrath (CR105) 2013; 70
Idring, Magnusson, Lundberg, Ek, Rai, Svensson (CR27) 2014; 43
Ek, Wicks, Svensson, Idring, Dalman (CR52) 2014; 41
Iossifov, O’Roak, Sanders, Ronemus, Krumm, Levy (CR66) 2014; 515
Saha, Barnett, Foldi, Burne, Eyles, Buka (CR8) 2009; 6
Xu, Roos, Levy, van Rensburg, Gogos, Karayiorgou (CR73) 2008; 40
Arnheim, Calabrese (CR93) 2009; 10
Malaspina, Keller, Antonius, Perrin, Opler, Ahn (CR15) 2012; 136
De Jonge (CR122) 2013; 100
Orioli, Castilla, Scarano, Mastroiacovo (CR2) 1995; 59
Goriely, Wilkie (CR97) 2010; 11
Grafodatskaya, Chung, Szatmari, Weksberg (CR110) 2010; 49
Smith, Fernandes, Kember, Schalkwyk, Buxbaum, Reichenberg (CR121) 2014; 5
Kong, Frigge, Masson, Besenbacher, Sulem, Magnusson (CR71) 2012; 488
Byrne, Agerbo, Ewald, Eaton, Mortensen (CR17) 2003; 60
Maher, McGowan, Giannoulatou, Verrill, Goriely, Wilkie (CR96) 2016; 113
Choi, Yoon, Calabrese, Arnheim (CR92) 2008; 105
Davies, Isles, Wilkinson (CR130) 2005; 29
Smith, Kember, Mill, Fernandes, Schalkwyk, Buxbaum (CR56) 2009; 4
Rahbari, Wuster, Lindsay, Hardwick, Alexandrov, Al Turki (CR72) 2016; 48
Segurel, Wyman, Przeworski (CR84) 2014; 15
Sandin, Schendel, Magnusson, Hultman, Surén, Susser (CR11) 2016; 21
Goldmann, Wong, Pinelli, Farrah, Bodian, Stittrich (CR75) 2016; 48
Driscoll, Waters, Williams, Zori, Glenn, Avidano (CR135) 1992; 13
Selten, Lundberg, Rai, Magnusson (CR40) 2015; 72
Lampi, Hinkka-Yli-Salomäki, Lehti, Helenius, Gissler, Brown (CR20) 2013; 43
Mannik, Reedik, Aurelien, Cole, Guyatt, Shihab (CR63) 2015; 313
Reichenberg, Gross, Weiser, Bresnahan, Silverman, Harlap (CR4) 2006; 63
Parner, Baron-Cohen, Lauritsen, Jørgensen, Schieve, Yeargin-Allsopp (CR29) 2012; 22
Hommer, Swedo (CR37) 2015; 41
Neale, Sklar (CR91) 2015; 30
Pulver, McGrath, Liang, Lasseter, Nestadt, Wolyniec (CR50) 2004; 124B
Malaspina (CR5) 2001; 27
Hackett, Zylicz, Surani (CR126) 2012; 28
Leonhardt, Page, Weier, Bestor (CR114) 1992; 71
Perrin, Brown, Malaspina (CR123) 2007; 33
Piven, Palmer, Jacobi, Childress, Arndt (CR43) 1997; 154
Lee, Malaspina, Ahn, Perrin, Opler, Kleinhaus (CR16) 2011; 128
García-Palomares, Pertusa, Miñarro, García-Pérez, Hermenegildo, Rausell (CR60) 2009; 80
Bartolomei, Ferguson-smith (CR128) 2011; 3
Golding, Steer, Pembrey (CR33) 2010; 5
Hemminki, Kyyrönen (CR104) 1999; 10
Yang, Visscher, Wray (CR51) 2009; 18
Lee, Ripke, Neale, Faraone, Purcell, Perlis (CR41) 2013; 45
Wagner, Busche, Ge, Kwan, Pastinen, Blanchette (CR112) 2014; 15
J Yang (BFtp2016294_CR51) 2009; 18
N Arnheim (BFtp2016294_CR93) 2009; 10
CM Hultman (BFtp2016294_CR26) 2012; 136
J Wyrobek (BFtp2016294_CR3) 2006; 103
M Teperek (BFtp2016294_CR111) 2016; 26
L Waterhouse (BFtp2016294_CR36) 1984; 55
J-Y Choi (BFtp2016294_CR103) 2005; 5
E Ben Itzchak (BFtp2016294_CR6) 2011; 32
RD Nicholls (BFtp2016294_CR134) 1989; 342
KL Svenson (BFtp2016294_CR141) 2012; 190
S Lundström (BFtp2016294_CR12) 2010; 51
RG Smith (BFtp2016294_CR56) 2009; 4
M Constância (BFtp2016294_CR131) 2002; 417
A Krishnan (BFtp2016294_CR102) 2016; 19
P-R Loh (BFtp2016294_CR98) 2015; 47
S Zammit (BFtp2016294_CR48) 2003; 183
CM Hultman (BFtp2016294_CR55) 2011; 16
AS Brown (BFtp2016294_CR13) 2002; 159
H Lee (BFtp2016294_CR16) 2011; 128
R Rahbari (BFtp2016294_CR72) 2016; 48
BK Lee (BFtp2016294_CR28) 2015; 21
L Klei (BFtp2016294_CR78) 2012; 3
MH Milekic (BFtp2016294_CR61) 2015; 20
RM Durbin (BFtp2016294_CR80) 2010; 467
M Janecka (BFtp2016294_CR57) 2015; 14
A Goriely (BFtp2016294_CR97) 2010; 11
BM D’Onofrio (BFtp2016294_CR9) 2014; 71
D Mehta (BFtp2016294_CR46) 2016; 73
B Xu (BFtp2016294_CR73) 2008; 40
EM Frans (BFtp2016294_CR105) 2013; 70
SJ Sanders (BFtp2016294_CR74) 2011; 70
SH Lee (BFtp2016294_CR41) 2013; 45
L Croen (BFtp2016294_CR24) 2007; 161
S Idring (BFtp2016294_CR27) 2014; 43
C Dallman (BFtp2016294_CR14) 2002; 420
S Sandin (BFtp2016294_CR11) 2016; 21
D Grafodatskaya (BFtp2016294_CR110) 2010; 49
L Segurel (BFtp2016294_CR84) 2014; 15
AK Maunakea (BFtp2016294_CR113) 2010; 466
JA Hackett (BFtp2016294_CR126) 2012; 28
M Ek (BFtp2016294_CR52) 2014; 41
D Malaspina (BFtp2016294_CR49) 2002; 7
ET Parner (BFtp2016294_CR29) 2012; 22
WSW Wong (BFtp2016294_CR89) 2016; 7
A Goriely (BFtp2016294_CR94) 2003; 301
K Hemminki (BFtp2016294_CR104) 1999; 10
S Horvath (BFtp2016294_CR119) 2013; 14
J Golding (BFtp2016294_CR33) 2010; 5
JJ Michaelson (BFtp2016294_CR83) 2012; 151
P Forster (BFtp2016294_CR87) 2015; 282
SJ Sanders (BFtp2016294_CR99) 2015; 87
MS Bartolomei (BFtp2016294_CR128) 2011; 3
A Sipos (BFtp2016294_CR47) 2004; 329
S-K Choi (BFtp2016294_CR92) 2008; 105
K Mannik (BFtp2016294_CR63) 2015; 313
N Lane (BFtp2016294_CR138) 2003; 35
AC Ferguson-Smith (BFtp2016294_CR127) 2011; 12
D Malaspina (BFtp2016294_CR15) 2012; 136
GC McIntosh (BFtp2016294_CR7) 1995; 6
A Goriely (BFtp2016294_CR82) 2012; 90
C Pedersen (BFtp2016294_CR54) 2014; 19
B Miller (BFtp2016294_CR18) 2011; 37
D Pinto (BFtp2016294_CR101) 2014; 94
S Seisenberger (BFtp2016294_CR118) 2012; 48
MR Palmert (BFtp2016294_CR142) 2001; 86
BM Neale (BFtp2016294_CR68) 2012; 485
H Leonhardt (BFtp2016294_CR114) 1992; 71
LF Wockner (BFtp2016294_CR108) 2014; 4
JR Wagner (BFtp2016294_CR112) 2014; 15
RE Hommer (BFtp2016294_CR37) 2015; 41
LS Wilkinson (BFtp2016294_CR133) 2007; 8
T Lugnegård (BFtp2016294_CR35) 2013; 143
CJ De Jonge (BFtp2016294_CR122) 2013; 100
CJ Foldi (BFtp2016294_CR58) 2010; 31
B Miller (BFtp2016294_CR45) 2011; 133
T Gaugler (BFtp2016294_CR79) 2014; 46
TH Bestor (BFtp2016294_CR115) 1992; 11
S Choufani (BFtp2016294_CR136) 2013; 163
AE Pulver (BFtp2016294_CR50) 2004; 124B
B Neale (BFtp2016294_CR91) 2015; 30
W Davies (BFtp2016294_CR130) 2005; 29
I Orioli (BFtp2016294_CR2) 1995; 59
RG Smith (BFtp2016294_CR121) 2014; 5
A Fowden (BFtp2016294_CR132) 2006; 65
DJ Driscoll (BFtp2016294_CR135) 1992; 13
LK Petty (BFtp2016294_CR39) 1984; 41
D Malaspina (BFtp2016294_CR5) 2001; 27
KJ Tsuchiya (BFtp2016294_CR21) 2005; 76
EM Frans (BFtp2016294_CR22) 2011; 133
CCY Wong (BFtp2016294_CR107) 2014; 19
MC Perrin (BFtp2016294_CR123) 2007; 33
TH Bestor (BFtp2016294_CR129) 2014; 112
JF Crow (BFtp2016294_CR86) 2006; 47
JM Goldmann (BFtp2016294_CR75) 2016; 48
D Moloney (BFtp2016294_CR1) 1996; 13
R Jaenisch (BFtp2016294_CR106) 2003; 33
JF Crow (BFtp2016294_CR85) 2000; 1
T Jenkins (BFtp2016294_CR116) 2014; 100
L Jiang (BFtp2016294_CR139) 2013; 153
I Iossifov (BFtp2016294_CR66) 2014; 515
SM Purcell (BFtp2016294_CR76) 2009; 460
F Vogel (BFtp2016294_CR88) 1997
M Naserbakht (BFtp2016294_CR19) 2011; 10
A Kong (BFtp2016294_CR71) 2012; 488
J Qin (BFtp2016294_CR95) 2007; 5
J Flanagan (BFtp2016294_CR125) 2006; 79
BPF Rutten (BFtp2016294_CR109) 2009; 35
L Petersen (BFtp2016294_CR53) 2011; 168
A Goriely (BFtp2016294_CR90) 2016; 48
EM Frans (BFtp2016294_CR34) 2013; 70
H Mefford (BFtp2016294_CR64) 2016; 16
J Golding (BFtp2016294_CR32) 2004; 151
PF Sullivan (BFtp2016294_CR38) 2012; 2
RM Cantor (BFtp2016294_CR23) 2007; 12
S Dong (BFtp2016294_CR65) 2014; 9
CJ Foldi (BFtp2016294_CR70) 2011; 5
A Anello (BFtp2016294_CR31) 2009; 39
J Gratten (BFtp2016294_CR62) 2016; 48
C Puleo (BFtp2016294_CR30) 2008; 13
AS Kondrashov (BFtp2016294_CR81) 2003; 21
XK Chen (BFtp2016294_CR10) 2008; 23
CM Puleo (BFtp2016294_CR44) 2008; 13
M Byrne (BFtp2016294_CR17) 2003; 60
GJ Maher (BFtp2016294_CR96) 2016; 113
J Piven (BFtp2016294_CR43) 1997; 154
S Saha (BFtp2016294_CR8) 2009; 6
H Stefansson (BFtp2016294_CR77) 2009; 460
A Goriely (BFtp2016294_CR100) 2013; 170
CC Oakes (BFtp2016294_CR117) 2003; 100
RG Smith (BFtp2016294_CR120) 2012; 18
IM Morison (BFtp2016294_CR140) 2005; 21
U Grossniklaus (BFtp2016294_CR137) 2013; 14
MS Durkin (BFtp2016294_CR25) 2008; 168
RM Adkins (BFtp2016294_CR124) 2011; 12
KM Lampi (BFtp2016294_CR20) 2013; 43
BJ O’Roak (BFtp2016294_CR67) 2011; 43
A Reichenberg (BFtp2016294_CR4) 2006; 63
S Sampino (BFtp2016294_CR59) 2014; 4
ABV Nilsen (BFtp2016294_CR42) 2013; 13
S García-Palomares (BFtp2016294_CR60) 2009; 80
JY Hehir-Kwa (BFtp2016294_CR69) 2011; 48
J-P Selten (BFtp2016294_CR40) 2015; 72
References_xml – volume: 60
  start-page: 673
  year: 2003
  end-page: 678
  ident: CR17
  article-title: Parental age and risk of schizophrenia
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.60.7.673
– volume: 46
  start-page: 881
  year: 2014
  end-page: 885
  ident: CR79
  article-title: Most genetic risk for autism resides with common variation
  publication-title: Nat Genet
  doi: 10.1038/ng.3039
– volume: 22
  start-page: 143
  year: 2012
  end-page: 150
  ident: CR29
  article-title: Parental age and autism spectrum disorders
  publication-title: Ann Epidemiol
  doi: 10.1016/j.annepidem.2011.12.006
– volume: 19
  start-page: 495
  year: 2014
  end-page: 503
  ident: CR107
  article-title: Methylomic analysis of monozygotic twins discordant for autism spectrum disorder and related behavioural traits
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2013.41
– volume: 18
  start-page: 1039
  year: 2009
  end-page: 1043
  ident: CR51
  article-title: Sporadic cases are the norm for complex disease
  publication-title: Eur J Hum Genet
  doi: 10.1038/ejhg.2009.177
– volume: 48
  start-page: 849
  year: 2012
  end-page: 862
  ident: CR118
  article-title: The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2012.11.001
– volume: 30
  start-page: 131
  year: 2015
  end-page: 138
  ident: CR91
  article-title: Genetic analysis of schizophrenia and bipolar disorder reveals polygenicity but also suggests new directions for molecular interrogation
  publication-title: Curr Opin Neurobiol
  doi: 10.1016/j.conb.2014.12.001
– volume: 282
  start-page: 20142898
  year: 2015
  ident: CR87
  article-title: Elevated germline mutation rate in teenage fathers
  publication-title: Proc Biol Sci
  doi: 10.1098/rspb.2014.2898
– volume: 39
  start-page: 1487
  year: 2009
  end-page: 1492
  ident: CR31
  article-title: Brief report: parental age and the sex ratio in autism
  publication-title: J Autism Dev Disord
  doi: 10.1007/s10803-009-0755-y
– volume: 41
  start-page: 708
  year: 2014
  end-page: 714
  ident: CR52
  article-title: Advancing paternal age and schizophrenia: the impact of delayed fatherhood
  publication-title: Schizophr Bull
  doi: 10.1093/schbul/sbu154
– volume: 460
  start-page: 744
  year: 2009
  end-page: 747
  ident: CR77
  article-title: Common variants conferring risk of schizophrenia
  publication-title: Nature
– volume: 21
  start-page: 693
  year: 2016
  end-page: 700
  ident: CR11
  article-title: Autism risk associated with parental age and with increasing difference in age between the parents
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2015.70
– volume: 14
  start-page: R115
  year: 2013
  ident: CR119
  article-title: DNA methylation age of human tissues and cell types
  publication-title: Genome Biol
  doi: 10.1186/gb-2013-14-10-r115
– volume: 13
  start-page: 243
  year: 2008
  end-page: 244
  ident: CR44
  article-title: Do autism-related personality traits explain higher paternal age in autism?
  publication-title: Mol Psychiatry
  doi: 10.1038/sj.mp.4002102
– volume: 136
  start-page: S3
  year: 2012
  ident: CR15
  article-title: Advanced paternal age contributes to a specific subtype of schizophrenia
  publication-title: Schizophr Res
  doi: 10.1016/S0920-9964(12)70011-7
– volume: 21
  start-page: 12
  year: 2003
  end-page: 27
  ident: CR81
  article-title: Direct estimates of human per nucleotide mutation rates at 20 loci causing mendelian diseases
  publication-title: Hum Mutat
  doi: 10.1002/humu.10147
– volume: 19
  start-page: 1454
  year: 2016
  end-page: 1462
  ident: CR102
  article-title: Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder
  publication-title: Nat Neurosci
  doi: 10.1038/nn.4353
– volume: 103
  start-page: 9601
  year: 2006
  end-page: 9606
  ident: CR3
  article-title: Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0506468103
– volume: 143
  start-page: 277
  year: 2013
  end-page: 284
  ident: CR35
  article-title: Social cognition impairments in Asperger syndrome and schizophrenia
  publication-title: Schizophr Res
  doi: 10.1016/j.schres.2012.12.001
– volume: 466
  start-page: 253
  year: 2010
  end-page: 257
  ident: CR113
  article-title: Conserved role of intragenic DNA methylation in regulating alternative promoters
  publication-title: Nature
  doi: 10.1038/nature09165
– volume: 4
  start-page: e386
  year: 2014
  ident: CR59
  article-title: Grand-paternal age and the development of autism-like symptoms in mice progeny
  publication-title: Transl Psychiatry
  doi: 10.1038/tp.2014.27
– volume: 27
  start-page: 379
  year: 2001
  end-page: 393
  ident: CR5
  article-title: Paternal factors and schizophrenia risk: mutations and imprinting
  publication-title: Schizophr Bull
  doi: 10.1093/oxfordjournals.schbul.a006882
– volume: 14
  start-page: 228
  year: 2013
  end-page: 235
  ident: CR137
  article-title: Transgenerational epigenetic inheritance: how important is it?
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg3435
– volume: 28
  start-page: 164
  year: 2012
  end-page: 174
  ident: CR126
  article-title: Parallel mechanisms of epigenetic reprogramming in the germline
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2012.01.005
– volume: 37
  start-page: 1039
  year: 2011
  end-page: 1047
  ident: CR18
  article-title: Meta-analysis of paternal age and schizophrenia risk in male versus female offspring
  publication-title: Schizophr Bull
  doi: 10.1093/schbul/sbq011
– volume: 460
  start-page: 748
  year: 2009
  end-page: 752
  ident: CR76
  article-title: Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
  publication-title: Nature
– volume: 159
  start-page: 1528
  year: 2002
  end-page: 1533
  ident: CR13
  article-title: Paternal age and risk of schizophrenia in adult offspring
  publication-title: Am J Psychiatry
  doi: 10.1176/appi.ajp.159.9.1528
– volume: 79
  start-page: 67
  year: 2006
  end-page: 84
  ident: CR125
  article-title: Intra- and inter- individual epigenetic variation in human germ cells
  publication-title: Am J Hum Genet
  doi: 10.1086/504729
– volume: 21
  start-page: 118
  year: 2015
  end-page: 125
  ident: CR28
  article-title: Advancing parental age and autism: multifactorial pathways
  publication-title: Trends Mol Med
  doi: 10.1016/j.molmed.2014.11.005
– volume: 6
  start-page: 282
  year: 1995
  end-page: 288
  ident: CR7
  article-title: Paternal age and the risk of birth defects in offspring
  publication-title: Epidemiology
  doi: 10.1097/00001648-199505000-00016
– volume: 31
  start-page: 556
  year: 2010
  end-page: 564
  ident: CR58
  article-title: Advanced paternal age is associated with alterations in discrete behavioural domains and cortical neuroanatomy of C57BL/6 J mice
  publication-title: Eur J Neurosci
  doi: 10.1111/j.1460-9568.2010.07074.x
– start-page: 404
  year: 1997
  ident: CR88
  publication-title: Human Genetics: Problems and Approaches
  doi: 10.1007/978-3-662-03356-2
– volume: 55
  start-page: 236
  year: 1984
  end-page: 248
  ident: CR36
  article-title: Developmental trends in cognitive skills for children diagnosed as autistic and schizophrenic
  publication-title: Child Dev
  doi: 10.2307/1129848
– volume: 420
  start-page: 1591
  year: 2002
  end-page: 1592
  ident: CR14
  article-title: Paternal age and schizophrenia: further support for an association
  publication-title: Am J Psychiatry
  doi: 10.1176/appi.ajp.159.9.1591
– volume: 87
  start-page: 1215
  year: 2015
  end-page: 1233
  ident: CR99
  article-title: Insights into autism spectrum disorder genomic architecture and biology from 71 risk loci
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.09.016
– volume: 342
  start-page: 281
  year: 1989
  end-page: 285
  ident: CR134
  article-title: Genetic imprinting suggested by maternal heterodisomy in nondeletion Prader-Willi syndrome
  publication-title: Nature
  doi: 10.1038/342281a0
– volume: 48
  start-page: 823
  year: 2016
  end-page: 824
  ident: CR90
  article-title: Decoding germline point mutations
  publication-title: Nat Genet
  doi: 10.1038/ng.3629
– volume: 70
  start-page: 516
  year: 2013
  end-page: 521
  ident: CR105
  article-title: Autism risk across generations. A population-based study of advancing grandpaternal and paternal age
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2013.1180
– volume: 33
  start-page: 245
  issue: Suppl
  year: 2003
  end-page: 54
  ident: CR106
  article-title: Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
  publication-title: Nat Genet
  doi: 10.1038/ng1089
– volume: 136
  start-page: S3
  year: 2012
  ident: CR26
  article-title: Advanced paternal and grandpaternal age as a risk factor for psychiatric disorders
  publication-title: Schizophr Res
  doi: 10.1016/S0920-9964(12)70012-9
– volume: 5
  start-page: 24
  year: 2014
  ident: CR121
  article-title: Transcriptomic changes in the frontal cortex associated with paternal age
  publication-title: Mol Autism
  doi: 10.1186/2040-2392-5-24
– volume: 86
  start-page: 2364
  year: 2001
  end-page: 2368
  ident: CR142
  article-title: Variation in the timing of puberty: clinical spectrum and genetic investigation
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jcem.86.6.7603
– volume: 2
  start-page: 1
  year: 2012
  end-page: 5
  ident: CR38
  article-title: Family history of schizophrenia and bipolar disorder as risk factors for autism
  publication-title: Arch Gen Psychiatry
– volume: 124B
  start-page: 6
  year: 2004
  end-page: 9
  ident: CR50
  article-title: An indirect test of the new mutation hypothesis associating advanced paternal age with the etiology of schizophrenia
  publication-title: Am J Med Genet B Neuropsychiatr Genet
  doi: 10.1002/ajmg.b.20066
– volume: 47
  start-page: 75
  year: 2006
  end-page: 82
  ident: CR86
  article-title: Age and sex effects on human mutation rates: an old problem with new complexities
  publication-title: J Radiat Res
  doi: 10.1269/jrr.47.B75
– volume: 71
  start-page: 865
  year: 1992
  end-page: 873
  ident: CR114
  article-title: A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei
  publication-title: Cell
  doi: 10.1016/0092-8674(92)90561-P
– volume: 9
  start-page: 16
  year: 2014
  end-page: 23
  ident: CR65
  article-title: insertions and deletions of predominantly paternal origin are associated with autism spectrum disorder
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2014.08.068
– volume: 70
  start-page: 863
  year: 2011
  end-page: 885
  ident: CR74
  article-title: Multiple recurrent CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.05.002
– volume: 100
  start-page: 945
  year: 2014
  end-page: 951
  ident: CR116
  article-title: Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels
  publication-title: Fertil Steril
  doi: 10.1016/j.fertnstert.2013.05.039
– volume: 3
  start-page: 1
  year: 2011
  end-page: 17
  ident: CR128
  article-title: Mammalian genomic imprinting
  publication-title: Cold Spring Harb Perspect Biol
  doi: 10.1101/cshperspect.a002592
– volume: 65
  start-page: 50
  year: 2006
  end-page: 58
  ident: CR132
  article-title: Imprinted genes, placental development and fetal growth
  publication-title: Horm Res
– volume: 59
  start-page: 209
  year: 1995
  end-page: 217
  ident: CR2
  article-title: Effect of paternal age in achondroplasia, thanatophoric dysplasia, and osteogenesis imperfecta
  publication-title: Am J Med Genet
  doi: 10.1002/ajmg.1320590218
– volume: 485
  start-page: 242
  year: 2012
  end-page: 245
  ident: CR68
  article-title: Patterns and rates of exonic mutations in autism spectrum disorders
  publication-title: Nature
  doi: 10.1038/nature11011
– volume: 43
  start-page: 585
  year: 2011
  end-page: 589
  ident: CR67
  article-title: Exome sequencing in sporadic autism spectrum disorders identifies severe mutations
  publication-title: Nat Genet
  doi: 10.1038/ng.835
– volume: 170
  start-page: 599
  year: 2013
  end-page: 608
  ident: CR100
  article-title: “Selfish spermatogonial selection”: a novel mechanism for the association between advanced paternal age and neurodevelopmental disorders
  publication-title: Am J Psychiatry
  doi: 10.1176/appi.ajp.2013.12101352
– volume: 5
  start-page: 1912
  year: 2007
  end-page: 1922
  ident: CR95
  article-title: The molecular anatomy of spontaneous germline mutations in human testes
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.0050224
– volume: 151
  start-page: U119
  year: 2004
  end-page: U123
  ident: CR32
  article-title: The Avon Longitudinal Study of Parents and Children (ALSPAC) - study design and collaborative opportunities
  publication-title: Eur J Endocrinol
  doi: 10.1530/eje.0.151u119
– volume: 163
  start-page: 131
  year: 2013
  end-page: 140
  ident: CR136
  article-title: Molecular findings in Beckwith-Wiedemann syndrome
  publication-title: Am J Med Genet C Semin Med Genet
  doi: 10.1002/ajmg.c.31363
– volume: 7
  start-page: 10486
  year: 2016
  ident: CR89
  article-title: New observations on maternal age effect on germline mutations
  publication-title: Nat Commun
  doi: 10.1038/ncomms10486
– volume: 35
  start-page: 1045
  year: 2009
  end-page: 1056
  ident: CR109
  article-title: Epigenetic mediation of environmental influences in major psychotic disorders
  publication-title: Schizophr Bull
  doi: 10.1093/schbul/sbp104
– volume: 100
  start-page: 940
  year: 2013
  end-page: 941
  ident: CR122
  article-title: Paternal age and sperm methylation status
  publication-title: Fertil Steril
  doi: 10.1016/j.fertnstert.2013.06.024
– volume: 467
  start-page: 1061
  year: 2010
  end-page: 1073
  ident: CR80
  article-title: A map of human genome variation from population-scale sequencing
  publication-title: Nature
  doi: 10.1038/nature09534
– volume: 45
  start-page: 984
  year: 2013
  end-page: 994
  ident: CR41
  article-title: Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
  publication-title: Nat Genet
  doi: 10.1038/ng.2805
– volume: 133
  start-page: 125
  year: 2011
  end-page: 132
  ident: CR45
  article-title: Advanced paternal age and parental history of schizophrenia
  publication-title: Schizophr Res
  doi: 10.1016/j.schres.2011.08.013
– volume: 49
  start-page: 794
  year: 2010
  end-page: 809
  ident: CR110
  article-title: Autism spectrum disorders and epigenetics
  publication-title: J Am Acad Child Adolesc Psychiatry
  doi: 10.1016/j.jaac.2010.05.005
– volume: 72
  start-page: 483
  year: 2015
  end-page: 489
  ident: CR40
  article-title: Risks for nonaffective psychotic disorder and bipolar disorder in young people with autism spectrum disorder: a population-based study
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2014.3059
– volume: 15
  start-page: 47
  year: 2014
  end-page: 70
  ident: CR84
  article-title: Determinants of mutation rate variation in the human germline
  publication-title: Annu Rev Genomics Hum Genet
  doi: 10.1146/annurev-genom-031714-125740
– volume: 112
  start-page: 6796
  year: 2014
  end-page: 6799
  ident: CR129
  article-title: Notes on the role of dynamic DNA methylation in mammalian development
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1415301111
– volume: 151
  start-page: 1431
  year: 2012
  end-page: 1442
  ident: CR83
  article-title: Whole-genome sequencing in autism identifies hot spots for germline mutation
  publication-title: Cell
  doi: 10.1016/j.cell.2012.11.019
– volume: 71
  start-page: 432
  year: 2014
  end-page: 438
  ident: CR9
  article-title: Paternal age at childbearing and offspring psychiatric and academic morbidity
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2013.4525
– volume: 168
  start-page: 82
  year: 2011
  end-page: 88
  ident: CR53
  article-title: Paternal age at birth of first child and risk of schizophrenia
  publication-title: Am J Psychiatry
  doi: 10.1176/appi.ajp.2010.10020252
– volume: 10
  start-page: 747
  year: 1999
  end-page: 751
  ident: CR104
  article-title: Parental age and risk of sporadic and familial cancer in offspring: implications for germ cell mutagenesis
  publication-title: Epidemiology
  doi: 10.1097/00001648-199911000-00016
– volume: 76
  start-page: 337
  year: 2005
  end-page: 342
  ident: CR21
  article-title: Advanced paternal age associated with an elevated risk for schizophrenia in offspring in a Japanese population
  publication-title: Schizophr Res
  doi: 10.1016/j.schres.2005.03.004
– volume: 488
  start-page: 471
  year: 2012
  end-page: 475
  ident: CR71
  article-title: Rate of mutations and the importance of father’s age to disease risk
  publication-title: Nature
  doi: 10.1038/nature11396
– volume: 21
  start-page: 457
  year: 2005
  end-page: 465
  ident: CR140
  article-title: A census of mammalian imprinting
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2005.06.008
– volume: 43
  start-page: 2526
  year: 2013
  end-page: 2535
  ident: CR20
  article-title: Parental age and risk of autism spectrum disorders in a Finnish national birth cohort
  publication-title: J Autism Dev Disord
  doi: 10.1007/s10803-013-1801-3
– volume: 43
  start-page: 107
  year: 2014
  end-page: 115
  ident: CR27
  article-title: Parental age and the risk of autism spectrum disorders: findings from a Swedish population-based cohort
  publication-title: Int J Epidemiol
  doi: 10.1093/ije/dyt262
– volume: 13
  start-page: 29
  year: 2013
  ident: CR42
  article-title: Characteristics of first-time fathers of advanced age: a Norwegian population-based study
  publication-title: BMC Pregnancy Childbirth
  doi: 10.1186/1471-2393-13-29
– volume: 10
  start-page: 15
  year: 2011
  ident: CR19
  article-title: Advanced paternal age is a risk factor for schizophrenia in Iranians
  publication-title: Ann Gen Psychiatry
  doi: 10.1186/1744-859X-10-15
– volume: 105
  start-page: 10143
  year: 2008
  end-page: 10148
  ident: CR92
  article-title: A germ-line-selective advantage rather than an increased mutation rate can explain some unexpectedly common human disease mutations
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0801267105
– volume: 161
  start-page: 334
  year: 2007
  end-page: 340
  ident: CR24
  article-title: Maternal and paternal age and risk of autism spectrum disorders
  publication-title: Arch Pediatr Adolesc Med
  doi: 10.1001/archpedi.161.4.334
– volume: 73
  start-page: 497
  year: 2016
  end-page: 505
  ident: CR46
  article-title: Evidence for genetic overlap between schizophrenia and age at first birth in women
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2016.0129
– volume: 329
  start-page: 1070
  year: 2004
  ident: CR47
  article-title: Paternal age and schizophrenia: a population based cohort study
  publication-title: BMJ
  doi: 10.1136/bmj.38243.672396.55
– volume: 47
  start-page: 1385
  year: 2015
  end-page: 1392
  ident: CR98
  article-title: Contrasting regional architectures of schizophrenia and other complex diseases using fast variance components analysis
  publication-title: Nat Genet
  doi: 10.1038/ng.3431
– volume: 33
  start-page: 1270
  year: 2007
  end-page: 1273
  ident: CR123
  article-title: Aberrant epigenetic regulation could explain the relationship of paternal age to schizophrenia
  publication-title: Schizophr Bull
  doi: 10.1093/schbul/sbm093
– volume: 417
  start-page: 945
  year: 2002
  end-page: 948
  ident: CR131
  article-title: Placental-specific IGF-II is a major modulator of placental and fetal growth
  publication-title: Nature
  doi: 10.1038/nature00819
– volume: 48
  start-page: 718
  year: 2016
  end-page: 724
  ident: CR62
  article-title: Risk of psychiatric illness from advanced paternal age is not predominantly from mutations
  publication-title: Nat Genet
  doi: 10.1038/ng.3577
– volume: 7
  start-page: 26
  year: 2002
  end-page: 29
  ident: CR49
  article-title: Schizophrenia risk and paternal age: a potential role for mutations in schizophrenia vulnerability genes
  publication-title: CNS Spectr
  doi: 10.1017/S1092852900022239
– volume: 10
  start-page: 478
  year: 2009
  end-page: 488
  ident: CR93
  article-title: Understanding what determines the frequency and pattern of human germline mutations
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg2529
– volume: 3
  start-page: 9
  year: 2012
  ident: CR78
  article-title: Common genetic variants, acting additively, are a major source of risk for autism
  publication-title: Mol Autism
  doi: 10.1186/2040-2392-3-9
– volume: 23
  start-page: 1290
  year: 2008
  end-page: 1296
  ident: CR10
  article-title: Paternal age and adverse birth outcomes: teenager or 40+, who is at risk?
  publication-title: Hum Reprod
  doi: 10.1093/humrep/dem403
– volume: 6
  start-page: e40
  year: 2009
  ident: CR8
  article-title: Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood
  publication-title: PLoS Med
  doi: 10.1371/journal.pmed.1000040
– volume: 12
  start-page: 47
  year: 2011
  ident: CR124
  article-title: Parental ages and levels of DNA methylation in the newborn are correlated
  publication-title: BMC Med Genet
  doi: 10.1186/1471-2350-12-47
– volume: 11
  start-page: 2611
  year: 1992
  end-page: 2617
  ident: CR115
  article-title: Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain
  publication-title: EMBO J
  doi: 10.1002/j.1460-2075.1992.tb05326.x
– volume: 26
  start-page: 1034
  year: 2016
  end-page: 1046
  ident: CR111
  article-title: Sperm is epigenetically programmed to regulate gene transcription in embryos
  publication-title: Genome Res
  doi: 10.1101/gr.201541.115
– volume: 133
  start-page: 120
  year: 2011
  end-page: 124
  ident: CR22
  article-title: Advanced paternal and grandpaternal age and schizophrenia: a three-generation perspective
  publication-title: Schizophr Res
  doi: 10.1016/j.schres.2011.09.027
– volume: 5
  start-page: e9939
  year: 2010
  ident: CR33
  article-title: Parental and grandparental ages in the autistic spectrum disorders: a birth cohort study
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0009939
– volume: 11
  start-page: 589
  year: 2010
  ident: CR97
  article-title: Missing heritability: paternal age effect mutations and selfish spermatogonia
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg2809-c1
– volume: 100
  start-page: 1775
  year: 2003
  end-page: 1780
  ident: CR117
  article-title: Aging results in hypermethylation of ribosomal DNA in sperm and liver of male rats
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0437971100
– volume: 94
  start-page: 677
  year: 2014
  end-page: 694
  ident: CR101
  article-title: Convergence of genes and cellular pathways dysregulated in autism spectrum disorders
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2014.03.018
– volume: 35
  start-page: 88
  year: 2003
  end-page: 93
  ident: CR138
  article-title: Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse
  publication-title: Genesis
  doi: 10.1002/gene.10168
– volume: 48
  start-page: 935
  year: 2016
  end-page: 939
  ident: CR75
  article-title: Parent-of-origin-specific signatures of mutations
  publication-title: Nat Genet
  doi: 10.1038/ng.3597
– volume: 8
  start-page: 832
  year: 2007
  end-page: 843
  ident: CR133
  article-title: Genomic imprinting effects on brain development and function
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn2235
– volume: 14
  start-page: 443
  year: 2015
  end-page: 453
  ident: CR57
  article-title: Effects of advanced paternal age on trajectories of social behavior in offspring
  publication-title: Genes Brain Behavior
  doi: 10.1111/gbb.12227
– volume: 16
  start-page: 91
  year: 2016
  end-page: 93
  ident: CR64
  article-title: Copy number variants in the population: unselected does not mean unaffected
  publication-title: Epilepsy Curr
  doi: 10.5698/1535-7511-16.2.91
– volume: 48
  start-page: 776
  year: 2011
  end-page: 778
  ident: CR69
  article-title: copy number variants associated with intellectual disability have a paternal origin and age bias
  publication-title: J Med Genet
  doi: 10.1136/jmedgenet-2011-100147
– volume: 48
  start-page: 126
  year: 2016
  end-page: 133
  ident: CR72
  article-title: Timing, rates and spectra of human germline mutation
  publication-title: Nat Genet
  doi: 10.1038/ng.3469
– volume: 154
  start-page: 185
  year: 1997
  end-page: 190
  ident: CR43
  article-title: Broader autism phenotype: evidence from a family history study of multiple-incidence autism families
  publication-title: Am J Psychiatry
  doi: 10.1176/ajp.154.2.185
– volume: 16
  start-page: 1203
  year: 2011
  end-page: 1212
  ident: CR55
  article-title: Advancing paternal age and risk of autism: new evidence from a population-based study and a meta-analysis of epidemiological studies
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2010.121
– volume: 29
  start-page: 421
  year: 2005
  end-page: 430
  ident: CR130
  article-title: Imprinted gene expression in the brain
  publication-title: Neurosci Biobehav Rev
  doi: 10.1016/j.neubiorev.2004.11.007
– volume: 168
  start-page: 1268
  year: 2008
  end-page: 1276
  ident: CR25
  article-title: Advanced parental age and the risk of autism spectrum disorder
  publication-title: Am J Epidemiol
  doi: 10.1093/aje/kwn250
– volume: 32
  start-page: 1776
  year: 2011
  end-page: 1781
  ident: CR6
  article-title: Advanced parental ages and low birth weight in autism spectrum disorders—rates and effect on functioning
  publication-title: Res Dev Disabil
  doi: 10.1016/j.ridd.2011.03.004
– volume: 41
  start-page: 129
  year: 1984
  end-page: 135
  ident: CR39
  article-title: Autistic children who become schizophrenic
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.1984.01790130023003
– volume: 515
  start-page: 216
  year: 2014
  end-page: 221
  ident: CR66
  article-title: The contribution of coding mutations to autism spectrum disorder
  publication-title: Nature
  doi: 10.1038/nature13908
– volume: 1
  start-page: 40
  year: 2000
  end-page: 47
  ident: CR85
  article-title: The origins, patterns and implications of human spontaneous mutation
  publication-title: Nat Rev Genet
  doi: 10.1038/35049558
– volume: 90
  start-page: 175
  year: 2012
  end-page: 200
  ident: CR82
  article-title: Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2011.12.017
– volume: 63
  start-page: 1026
  year: 2006
  end-page: 1032
  ident: CR4
  article-title: Advancing paternal age and autism
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.63.9.1026
– volume: 51
  start-page: 850
  year: 2010
  end-page: 856
  ident: CR12
  article-title: Trajectories leading to autism spectrum disorders are affected by paternal age: findings from two nationally representative twin studies
  publication-title: J Child Psychol Psychiatry
  doi: 10.1111/j.1469-7610.2010.02223.x
– volume: 41
  start-page: 313
  year: 2015
  end-page: 314
  ident: CR37
  article-title: Schizophrenia and autism-related disorders
  publication-title: Schizophr Bull
  doi: 10.1093/schbul/sbu188
– volume: 190
  start-page: 437
  year: 2012
  end-page: 447
  ident: CR141
  article-title: High-resolution genetic mapping using the Mouse Diversity outbred population
  publication-title: Genetics
  doi: 10.1534/genetics.111.132597
– volume: 13
  start-page: 48
  year: 1996
  end-page: 53
  ident: CR1
  article-title: Exclusive paternal origin of new mutations in Apert syndrome
  publication-title: Nat Genet
  doi: 10.1038/ng0596-48
– volume: 5
  start-page: 143
  year: 2005
  ident: CR103
  article-title: Association of paternal age at birth and the risk of breast cancer in offspring: a case control study
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-5-143
– volume: 12
  start-page: 565
  year: 2011
  end-page: 575
  ident: CR127
  article-title: Genomic imprinting: the emergence of an epigenetic paradigm
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg3032
– volume: 13
  start-page: 243
  year: 2008
  end-page: 244
  ident: CR30
  article-title: Do autism-related personality traits explain higher paternal age in autism?
  publication-title: Mol Psychiatry
  doi: 10.1038/sj.mp.4002102
– volume: 113
  start-page: 2454
  year: 2016
  end-page: 2459
  ident: CR96
  article-title: Visualizing the origins of selfish mutations in individual seminiferous tubules of human testes
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1521325113
– volume: 12
  start-page: 419
  year: 2007
  end-page: 421
  ident: CR23
  article-title: Paternal age and autism are associated in a family-based sample
  publication-title: Mol Psychiatry
  doi: 10.1038/sj.mp.4001966
– volume: 301
  start-page: 643
  year: 2003
  end-page: 646
  ident: CR94
  article-title: Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line
  publication-title: Science
  doi: 10.1126/science.1085710
– volume: 80
  start-page: 337
  year: 2009
  end-page: 342
  ident: CR60
  article-title: Long-term effects of delayed fatherhood in mice on postnatal development and behavioral traits of offspring
  publication-title: Biol Reprod
  doi: 10.1095/biolreprod.108.072066
– volume: 18
  start-page: 635
  year: 2012
  end-page: 636
  ident: CR120
  article-title: Advanced paternal age is associated with altered DNA methylation at brain-expressed imprinted loci in inbred mice: implications for neuropsychiatric disease
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2012.88
– volume: 4
  start-page: e339
  year: 2014
  ident: CR108
  article-title: Genome-wide DNA methylation analysis of human brain tissue from schizophrenia patients
  publication-title: Transl Psychiatry
  doi: 10.1038/tp.2013.111
– volume: 15
  start-page: R37
  year: 2014
  ident: CR112
  article-title: The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts
  publication-title: Genome Biol
  doi: 10.1186/gb-2014-15-2-r37
– volume: 5
  start-page: 32
  year: 2011
  ident: CR70
  article-title: New perspectives on rodent models of advanced paternal age: relevance to autism
  publication-title: Front Behav Neurosci
  doi: 10.3389/fnbeh.2011.00032
– volume: 4
  start-page: e8456
  year: 2009
  ident: CR56
  article-title: Advancing paternal age is associated with deficits in social and exploratory behaviors in the offspring: a mouse model
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0008456
– volume: 128
  start-page: 143
  year: 2011
  end-page: 149
  ident: CR16
  article-title: Paternal age related schizophrenia (PARS): latent subgroups detected by k -means clustering analysis
  publication-title: Schizophr Res
  doi: 10.1016/j.schres.2011.02.006
– volume: 183
  start-page: 405
  year: 2003
  end-page: 408
  ident: CR48
  article-title: Paternal age and risk for schizophrenia
  publication-title: Br J Psychiatry
  doi: 10.1192/bjp.183.5.405
– volume: 70
  start-page: 516
  year: 2013
  end-page: 521
  ident: CR34
  article-title: Autism risk across generations: a population-based study of advancing grandpaternal and paternal age
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2013.1180
– volume: 19
  start-page: 530
  year: 2014
  end-page: 535
  ident: CR54
  article-title: The importance of father’s age to schizophrenia risk
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2013.69
– volume: 13
  start-page: 917
  year: 1992
  end-page: 924
  ident: CR135
  article-title: A DNA methylation imprint, determined by the sex of the parent, distinguishes the Angelman and Prader-Willi syndromes
  publication-title: Genomics
  doi: 10.1016/0888-7543(92)90001-9
– volume: 153
  start-page: 773
  year: 2013
  end-page: 784
  ident: CR139
  article-title: Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos
  publication-title: Cell
  doi: 10.1016/j.cell.2013.04.041
– volume: 313
  start-page: 2044
  year: 2015
  end-page: 2054
  ident: CR63
  article-title: Copy number variations and cognitive phenotypes in unselected populations
  publication-title: JAMA
  doi: 10.1001/jama.2015.4845
– volume: 20
  start-page: 995
  year: 2015
  end-page: 1001
  ident: CR61
  article-title: Age-related sperm DNA methylation changes are transmitted to offspring and associated with abnormal behavior and dysregulated gene expression
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2014.84
– volume: 40
  start-page: 880
  year: 2008
  end-page: 885
  ident: CR73
  article-title: Strong association of copy number mutations with sporadic schizophrenia
  publication-title: Nat Genet
  doi: 10.1038/ng.162
– volume: 301
  start-page: 643
  year: 2003
  ident: BFtp2016294_CR94
  publication-title: Science
  doi: 10.1126/science.1085710
– volume: 43
  start-page: 585
  year: 2011
  ident: BFtp2016294_CR67
  publication-title: Nat Genet
  doi: 10.1038/ng.835
– volume: 190
  start-page: 437
  year: 2012
  ident: BFtp2016294_CR141
  publication-title: Genetics
  doi: 10.1534/genetics.111.132597
– volume: 12
  start-page: 565
  year: 2011
  ident: BFtp2016294_CR127
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg3032
– volume: 168
  start-page: 82
  year: 2011
  ident: BFtp2016294_CR53
  publication-title: Am J Psychiatry
  doi: 10.1176/appi.ajp.2010.10020252
– volume: 70
  start-page: 516
  year: 2013
  ident: BFtp2016294_CR105
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2013.1180
– volume: 47
  start-page: 75
  year: 2006
  ident: BFtp2016294_CR86
  publication-title: J Radiat Res
  doi: 10.1269/jrr.47.B75
– volume: 33
  start-page: 245
  issue: Suppl
  year: 2003
  ident: BFtp2016294_CR106
  publication-title: Nat Genet
  doi: 10.1038/ng1089
– volume: 48
  start-page: 776
  year: 2011
  ident: BFtp2016294_CR69
  publication-title: J Med Genet
  doi: 10.1136/jmedgenet-2011-100147
– volume: 10
  start-page: 478
  year: 2009
  ident: BFtp2016294_CR93
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg2529
– volume: 143
  start-page: 277
  year: 2013
  ident: BFtp2016294_CR35
  publication-title: Schizophr Res
  doi: 10.1016/j.schres.2012.12.001
– volume: 3
  start-page: 1
  year: 2011
  ident: BFtp2016294_CR128
  publication-title: Cold Spring Harb Perspect Biol
  doi: 10.1101/cshperspect.a002592
– volume: 168
  start-page: 1268
  year: 2008
  ident: BFtp2016294_CR25
  publication-title: Am J Epidemiol
  doi: 10.1093/aje/kwn250
– volume: 14
  start-page: R115
  year: 2013
  ident: BFtp2016294_CR119
  publication-title: Genome Biol
  doi: 10.1186/gb-2013-14-10-r115
– volume: 87
  start-page: 1215
  year: 2015
  ident: BFtp2016294_CR99
  publication-title: Neuron
  doi: 10.1016/j.neuron.2015.09.016
– volume: 170
  start-page: 599
  year: 2013
  ident: BFtp2016294_CR100
  publication-title: Am J Psychiatry
  doi: 10.1176/appi.ajp.2013.12101352
– volume: 11
  start-page: 589
  year: 2010
  ident: BFtp2016294_CR97
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg2809-c1
– volume: 113
  start-page: 2454
  year: 2016
  ident: BFtp2016294_CR96
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1521325113
– volume: 27
  start-page: 379
  year: 2001
  ident: BFtp2016294_CR5
  publication-title: Schizophr Bull
  doi: 10.1093/oxfordjournals.schbul.a006882
– volume: 13
  start-page: 917
  year: 1992
  ident: BFtp2016294_CR135
  publication-title: Genomics
  doi: 10.1016/0888-7543(92)90001-9
– volume: 105
  start-page: 10143
  year: 2008
  ident: BFtp2016294_CR92
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0801267105
– volume: 39
  start-page: 1487
  year: 2009
  ident: BFtp2016294_CR31
  publication-title: J Autism Dev Disord
  doi: 10.1007/s10803-009-0755-y
– volume: 37
  start-page: 1039
  year: 2011
  ident: BFtp2016294_CR18
  publication-title: Schizophr Bull
  doi: 10.1093/schbul/sbq011
– volume: 5
  start-page: 32
  year: 2011
  ident: BFtp2016294_CR70
  publication-title: Front Behav Neurosci
  doi: 10.3389/fnbeh.2011.00032
– volume: 12
  start-page: 419
  year: 2007
  ident: BFtp2016294_CR23
  publication-title: Mol Psychiatry
  doi: 10.1038/sj.mp.4001966
– volume: 14
  start-page: 443
  year: 2015
  ident: BFtp2016294_CR57
  publication-title: Genes Brain Behavior
  doi: 10.1111/gbb.12227
– volume: 10
  start-page: 15
  year: 2011
  ident: BFtp2016294_CR19
  publication-title: Ann Gen Psychiatry
  doi: 10.1186/1744-859X-10-15
– volume: 9
  start-page: 16
  year: 2014
  ident: BFtp2016294_CR65
  publication-title: Cell Rep
  doi: 10.1016/j.celrep.2014.08.068
– volume: 100
  start-page: 1775
  year: 2003
  ident: BFtp2016294_CR117
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0437971100
– volume: 86
  start-page: 2364
  year: 2001
  ident: BFtp2016294_CR142
  publication-title: J Clin Endocrinol Metab
  doi: 10.1210/jcem.86.6.7603
– volume: 41
  start-page: 129
  year: 1984
  ident: BFtp2016294_CR39
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.1984.01790130023003
– volume: 19
  start-page: 1454
  year: 2016
  ident: BFtp2016294_CR102
  publication-title: Nat Neurosci
  doi: 10.1038/nn.4353
– volume: 35
  start-page: 1045
  year: 2009
  ident: BFtp2016294_CR109
  publication-title: Schizophr Bull
  doi: 10.1093/schbul/sbp104
– volume: 159
  start-page: 1528
  year: 2002
  ident: BFtp2016294_CR13
  publication-title: Am J Psychiatry
  doi: 10.1176/appi.ajp.159.9.1528
– volume: 22
  start-page: 143
  year: 2012
  ident: BFtp2016294_CR29
  publication-title: Ann Epidemiol
  doi: 10.1016/j.annepidem.2011.12.006
– volume: 2
  start-page: 1
  year: 2012
  ident: BFtp2016294_CR38
  publication-title: Arch Gen Psychiatry
– volume: 14
  start-page: 228
  year: 2013
  ident: BFtp2016294_CR137
  publication-title: Nat Rev Genet
  doi: 10.1038/nrg3435
– volume: 48
  start-page: 823
  year: 2016
  ident: BFtp2016294_CR90
  publication-title: Nat Genet
  doi: 10.1038/ng.3629
– volume: 100
  start-page: 945
  year: 2014
  ident: BFtp2016294_CR116
  publication-title: Fertil Steril
  doi: 10.1016/j.fertnstert.2013.05.039
– volume: 46
  start-page: 881
  year: 2014
  ident: BFtp2016294_CR79
  publication-title: Nat Genet
  doi: 10.1038/ng.3039
– volume: 55
  start-page: 236
  year: 1984
  ident: BFtp2016294_CR36
  publication-title: Child Dev
  doi: 10.2307/1129848
– volume: 4
  start-page: e386
  year: 2014
  ident: BFtp2016294_CR59
  publication-title: Transl Psychiatry
  doi: 10.1038/tp.2014.27
– volume: 12
  start-page: 47
  year: 2011
  ident: BFtp2016294_CR124
  publication-title: BMC Med Genet
  doi: 10.1186/1471-2350-12-47
– volume: 4
  start-page: e339
  year: 2014
  ident: BFtp2016294_CR108
  publication-title: Transl Psychiatry
  doi: 10.1038/tp.2013.111
– volume: 151
  start-page: 1431
  year: 2012
  ident: BFtp2016294_CR83
  publication-title: Cell
  doi: 10.1016/j.cell.2012.11.019
– volume: 11
  start-page: 2611
  year: 1992
  ident: BFtp2016294_CR115
  publication-title: EMBO J
  doi: 10.1002/j.1460-2075.1992.tb05326.x
– volume: 485
  start-page: 242
  year: 2012
  ident: BFtp2016294_CR68
  publication-title: Nature
  doi: 10.1038/nature11011
– volume: 94
  start-page: 677
  year: 2014
  ident: BFtp2016294_CR101
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2014.03.018
– volume: 19
  start-page: 495
  year: 2014
  ident: BFtp2016294_CR107
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2013.41
– volume: 6
  start-page: e40
  year: 2009
  ident: BFtp2016294_CR8
  publication-title: PLoS Med
  doi: 10.1371/journal.pmed.1000040
– volume: 1
  start-page: 40
  year: 2000
  ident: BFtp2016294_CR85
  publication-title: Nat Rev Genet
  doi: 10.1038/35049558
– volume: 18
  start-page: 1039
  year: 2009
  ident: BFtp2016294_CR51
  publication-title: Eur J Hum Genet
  doi: 10.1038/ejhg.2009.177
– volume: 80
  start-page: 337
  year: 2009
  ident: BFtp2016294_CR60
  publication-title: Biol Reprod
  doi: 10.1095/biolreprod.108.072066
– volume: 48
  start-page: 718
  year: 2016
  ident: BFtp2016294_CR62
  publication-title: Nat Genet
  doi: 10.1038/ng.3577
– volume: 26
  start-page: 1034
  year: 2016
  ident: BFtp2016294_CR111
  publication-title: Genome Res
  doi: 10.1101/gr.201541.115
– volume: 112
  start-page: 6796
  year: 2014
  ident: BFtp2016294_CR129
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1415301111
– volume: 63
  start-page: 1026
  year: 2006
  ident: BFtp2016294_CR4
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.63.9.1026
– volume: 51
  start-page: 850
  year: 2010
  ident: BFtp2016294_CR12
  publication-title: J Child Psychol Psychiatry
  doi: 10.1111/j.1469-7610.2010.02223.x
– volume: 76
  start-page: 337
  year: 2005
  ident: BFtp2016294_CR21
  publication-title: Schizophr Res
  doi: 10.1016/j.schres.2005.03.004
– volume: 136
  start-page: S3
  year: 2012
  ident: BFtp2016294_CR26
  publication-title: Schizophr Res
  doi: 10.1016/S0920-9964(12)70012-9
– volume: 15
  start-page: 47
  year: 2014
  ident: BFtp2016294_CR84
  publication-title: Annu Rev Genomics Hum Genet
  doi: 10.1146/annurev-genom-031714-125740
– volume: 65
  start-page: 50
  year: 2006
  ident: BFtp2016294_CR132
  publication-title: Horm Res
– volume: 13
  start-page: 48
  year: 1996
  ident: BFtp2016294_CR1
  publication-title: Nat Genet
  doi: 10.1038/ng0596-48
– volume: 19
  start-page: 530
  year: 2014
  ident: BFtp2016294_CR54
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2013.69
– volume: 183
  start-page: 405
  year: 2003
  ident: BFtp2016294_CR48
  publication-title: Br J Psychiatry
  doi: 10.1192/bjp.183.5.405
– volume: 488
  start-page: 471
  year: 2012
  ident: BFtp2016294_CR71
  publication-title: Nature
  doi: 10.1038/nature11396
– volume: 466
  start-page: 253
  year: 2010
  ident: BFtp2016294_CR113
  publication-title: Nature
  doi: 10.1038/nature09165
– volume: 6
  start-page: 282
  year: 1995
  ident: BFtp2016294_CR7
  publication-title: Epidemiology
  doi: 10.1097/00001648-199505000-00016
– volume: 7
  start-page: 10486
  year: 2016
  ident: BFtp2016294_CR89
  publication-title: Nat Commun
  doi: 10.1038/ncomms10486
– volume: 420
  start-page: 1591
  year: 2002
  ident: BFtp2016294_CR14
  publication-title: Am J Psychiatry
  doi: 10.1176/appi.ajp.159.9.1591
– volume: 342
  start-page: 281
  year: 1989
  ident: BFtp2016294_CR134
  publication-title: Nature
  doi: 10.1038/342281a0
– volume: 23
  start-page: 1290
  year: 2008
  ident: BFtp2016294_CR10
  publication-title: Hum Reprod
  doi: 10.1093/humrep/dem403
– volume: 133
  start-page: 120
  year: 2011
  ident: BFtp2016294_CR22
  publication-title: Schizophr Res
  doi: 10.1016/j.schres.2011.09.027
– volume: 48
  start-page: 126
  year: 2016
  ident: BFtp2016294_CR72
  publication-title: Nat Genet
  doi: 10.1038/ng.3469
– volume: 70
  start-page: 516
  year: 2013
  ident: BFtp2016294_CR34
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2013.1180
– volume: 154
  start-page: 185
  year: 1997
  ident: BFtp2016294_CR43
  publication-title: Am J Psychiatry
  doi: 10.1176/ajp.154.2.185
– volume: 13
  start-page: 29
  year: 2013
  ident: BFtp2016294_CR42
  publication-title: BMC Pregnancy Childbirth
  doi: 10.1186/1471-2393-13-29
– volume: 136
  start-page: S3
  year: 2012
  ident: BFtp2016294_CR15
  publication-title: Schizophr Res
  doi: 10.1016/S0920-9964(12)70011-7
– volume: 47
  start-page: 1385
  year: 2015
  ident: BFtp2016294_CR98
  publication-title: Nat Genet
  doi: 10.1038/ng.3431
– volume: 133
  start-page: 125
  year: 2011
  ident: BFtp2016294_CR45
  publication-title: Schizophr Res
  doi: 10.1016/j.schres.2011.08.013
– volume: 41
  start-page: 708
  year: 2014
  ident: BFtp2016294_CR52
  publication-title: Schizophr Bull
  doi: 10.1093/schbul/sbu154
– volume: 40
  start-page: 880
  year: 2008
  ident: BFtp2016294_CR73
  publication-title: Nat Genet
  doi: 10.1038/ng.162
– volume: 21
  start-page: 12
  year: 2003
  ident: BFtp2016294_CR81
  publication-title: Hum Mutat
  doi: 10.1002/humu.10147
– volume: 32
  start-page: 1776
  year: 2011
  ident: BFtp2016294_CR6
  publication-title: Res Dev Disabil
  doi: 10.1016/j.ridd.2011.03.004
– volume: 21
  start-page: 693
  year: 2016
  ident: BFtp2016294_CR11
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2015.70
– volume: 29
  start-page: 421
  year: 2005
  ident: BFtp2016294_CR130
  publication-title: Neurosci Biobehav Rev
  doi: 10.1016/j.neubiorev.2004.11.007
– volume: 124B
  start-page: 6
  year: 2004
  ident: BFtp2016294_CR50
  publication-title: Am J Med Genet B Neuropsychiatr Genet
  doi: 10.1002/ajmg.b.20066
– volume: 21
  start-page: 118
  year: 2015
  ident: BFtp2016294_CR28
  publication-title: Trends Mol Med
  doi: 10.1016/j.molmed.2014.11.005
– volume: 28
  start-page: 164
  year: 2012
  ident: BFtp2016294_CR126
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2012.01.005
– volume: 313
  start-page: 2044
  year: 2015
  ident: BFtp2016294_CR63
  publication-title: JAMA
  doi: 10.1001/jama.2015.4845
– volume: 5
  start-page: 143
  year: 2005
  ident: BFtp2016294_CR103
  publication-title: BMC Cancer
  doi: 10.1186/1471-2407-5-143
– volume: 60
  start-page: 673
  year: 2003
  ident: BFtp2016294_CR17
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.60.7.673
– volume: 48
  start-page: 935
  year: 2016
  ident: BFtp2016294_CR75
  publication-title: Nat Genet
  doi: 10.1038/ng.3597
– volume: 5
  start-page: 1912
  year: 2007
  ident: BFtp2016294_CR95
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.0050224
– volume: 13
  start-page: 243
  year: 2008
  ident: BFtp2016294_CR44
  publication-title: Mol Psychiatry
  doi: 10.1038/sj.mp.4002102
– volume: 10
  start-page: 747
  year: 1999
  ident: BFtp2016294_CR104
  publication-title: Epidemiology
  doi: 10.1097/00001648-199911000-00016
– volume: 161
  start-page: 334
  year: 2007
  ident: BFtp2016294_CR24
  publication-title: Arch Pediatr Adolesc Med
  doi: 10.1001/archpedi.161.4.334
– volume: 515
  start-page: 216
  year: 2014
  ident: BFtp2016294_CR66
  publication-title: Nature
  doi: 10.1038/nature13908
– volume: 153
  start-page: 773
  year: 2013
  ident: BFtp2016294_CR139
  publication-title: Cell
  doi: 10.1016/j.cell.2013.04.041
– volume: 41
  start-page: 313
  year: 2015
  ident: BFtp2016294_CR37
  publication-title: Schizophr Bull
  doi: 10.1093/schbul/sbu188
– volume: 16
  start-page: 1203
  year: 2011
  ident: BFtp2016294_CR55
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2010.121
– volume: 71
  start-page: 432
  year: 2014
  ident: BFtp2016294_CR9
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2013.4525
– volume: 20
  start-page: 995
  year: 2015
  ident: BFtp2016294_CR61
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2014.84
– volume: 43
  start-page: 107
  year: 2014
  ident: BFtp2016294_CR27
  publication-title: Int J Epidemiol
  doi: 10.1093/ije/dyt262
– volume: 3
  start-page: 9
  year: 2012
  ident: BFtp2016294_CR78
  publication-title: Mol Autism
  doi: 10.1186/2040-2392-3-9
– volume: 15
  start-page: R37
  year: 2014
  ident: BFtp2016294_CR112
  publication-title: Genome Biol
  doi: 10.1186/gb-2014-15-2-r37
– volume: 4
  start-page: e8456
  year: 2009
  ident: BFtp2016294_CR56
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0008456
– volume: 5
  start-page: e9939
  year: 2010
  ident: BFtp2016294_CR33
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0009939
– volume: 467
  start-page: 1061
  year: 2010
  ident: BFtp2016294_CR80
  publication-title: Nature
  doi: 10.1038/nature09534
– volume: 151
  start-page: U119
  year: 2004
  ident: BFtp2016294_CR32
  publication-title: Eur J Endocrinol
  doi: 10.1530/eje.0.151u119
– volume: 35
  start-page: 88
  year: 2003
  ident: BFtp2016294_CR138
  publication-title: Genesis
  doi: 10.1002/gene.10168
– volume: 73
  start-page: 497
  year: 2016
  ident: BFtp2016294_CR46
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2016.0129
– volume: 43
  start-page: 2526
  year: 2013
  ident: BFtp2016294_CR20
  publication-title: J Autism Dev Disord
  doi: 10.1007/s10803-013-1801-3
– volume: 18
  start-page: 635
  year: 2012
  ident: BFtp2016294_CR120
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2012.88
– volume: 79
  start-page: 67
  year: 2006
  ident: BFtp2016294_CR125
  publication-title: Am J Hum Genet
  doi: 10.1086/504729
– volume: 128
  start-page: 143
  year: 2011
  ident: BFtp2016294_CR16
  publication-title: Schizophr Res
  doi: 10.1016/j.schres.2011.02.006
– volume: 8
  start-page: 832
  year: 2007
  ident: BFtp2016294_CR133
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn2235
– volume: 460
  start-page: 748
  year: 2009
  ident: BFtp2016294_CR76
  publication-title: Nature
  doi: 10.1038/nature08185
– volume: 33
  start-page: 1270
  year: 2007
  ident: BFtp2016294_CR123
  publication-title: Schizophr Bull
  doi: 10.1093/schbul/sbm093
– volume: 417
  start-page: 945
  year: 2002
  ident: BFtp2016294_CR131
  publication-title: Nature
  doi: 10.1038/nature00819
– volume: 90
  start-page: 175
  year: 2012
  ident: BFtp2016294_CR82
  publication-title: Am J Hum Genet
  doi: 10.1016/j.ajhg.2011.12.017
– volume: 59
  start-page: 209
  year: 1995
  ident: BFtp2016294_CR2
  publication-title: Am J Med Genet
  doi: 10.1002/ajmg.1320590218
– volume: 163
  start-page: 131
  year: 2013
  ident: BFtp2016294_CR136
  publication-title: Am J Med Genet C Semin Med Genet
  doi: 10.1002/ajmg.c.31363
– volume: 70
  start-page: 863
  year: 2011
  ident: BFtp2016294_CR74
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.05.002
– volume: 329
  start-page: 1070
  year: 2004
  ident: BFtp2016294_CR47
  publication-title: BMJ
  doi: 10.1136/bmj.38243.672396.55
– volume: 5
  start-page: 24
  year: 2014
  ident: BFtp2016294_CR121
  publication-title: Mol Autism
  doi: 10.1186/2040-2392-5-24
– volume: 45
  start-page: 984
  year: 2013
  ident: BFtp2016294_CR41
  publication-title: Nat Genet
  doi: 10.1038/ng.2805
– volume: 49
  start-page: 794
  year: 2010
  ident: BFtp2016294_CR110
  publication-title: J Am Acad Child Adolesc Psychiatry
  doi: 10.1016/j.jaac.2010.05.005
– volume: 31
  start-page: 556
  year: 2010
  ident: BFtp2016294_CR58
  publication-title: Eur J Neurosci
  doi: 10.1111/j.1460-9568.2010.07074.x
– volume: 460
  start-page: 744
  year: 2009
  ident: BFtp2016294_CR77
  publication-title: Nature
  doi: 10.1038/nature08186
– volume: 13
  start-page: 243
  year: 2008
  ident: BFtp2016294_CR30
  publication-title: Mol Psychiatry
  doi: 10.1038/sj.mp.4002102
– volume: 16
  start-page: 91
  year: 2016
  ident: BFtp2016294_CR64
  publication-title: Epilepsy Curr
  doi: 10.5698/1535-7511-16.2.91
– volume: 282
  start-page: 20142898
  year: 2015
  ident: BFtp2016294_CR87
  publication-title: Proc Biol Sci
  doi: 10.1098/rspb.2014.2898
– volume: 103
  start-page: 9601
  year: 2006
  ident: BFtp2016294_CR3
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.0506468103
– volume: 30
  start-page: 131
  year: 2015
  ident: BFtp2016294_CR91
  publication-title: Curr Opin Neurobiol
  doi: 10.1016/j.conb.2014.12.001
– volume: 100
  start-page: 940
  year: 2013
  ident: BFtp2016294_CR122
  publication-title: Fertil Steril
  doi: 10.1016/j.fertnstert.2013.06.024
– volume: 48
  start-page: 849
  year: 2012
  ident: BFtp2016294_CR118
  publication-title: Mol Cell
  doi: 10.1016/j.molcel.2012.11.001
– volume: 72
  start-page: 483
  year: 2015
  ident: BFtp2016294_CR40
  publication-title: JAMA Psychiatry
  doi: 10.1001/jamapsychiatry.2014.3059
– volume: 7
  start-page: 26
  year: 2002
  ident: BFtp2016294_CR49
  publication-title: CNS Spectr
  doi: 10.1017/S1092852900022239
– volume: 71
  start-page: 865
  year: 1992
  ident: BFtp2016294_CR114
  publication-title: Cell
  doi: 10.1016/0092-8674(92)90561-P
– start-page: 404
  volume-title: Human Genetics: Problems and Approaches
  year: 1997
  ident: BFtp2016294_CR88
  doi: 10.1007/978-3-662-03356-2
– volume: 21
  start-page: 457
  year: 2005
  ident: BFtp2016294_CR140
  publication-title: Trends Genet
  doi: 10.1016/j.tig.2005.06.008
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Snippet Multiple epidemiological studies suggest a relationship between advanced paternal age (APA) at conception and adverse neurodevelopmental outcomes in offspring,...
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springer
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StartPage e1019
SubjectTerms 38
38/23
631/208/2489
631/477/2811
Age Factors
Autistic Disorder - epidemiology
Autistic Disorder - genetics
Behavioral Sciences
Biological Psychology
Epigenesis, Genetic
Humans
Medicine
Medicine & Public Health
Neurodevelopmental disorders
Neurodevelopmental Disorders - epidemiology
Neurodevelopmental Disorders - genetics
Neurosciences
Paternal Age
Pharmacotherapy
Psychiatry
Review
Risk Factors
Schizophrenia - epidemiology
Schizophrenia - genetics
Title Advanced paternal age effects in neurodevelopmental disorders—review of potential underlying mechanisms
URI https://link.springer.com/article/10.1038/tp.2016.294
https://www.ncbi.nlm.nih.gov/pubmed/28140401
https://www.proquest.com/docview/1869323563
https://www.proquest.com/docview/1863220537
https://pubmed.ncbi.nlm.nih.gov/PMC5299396
Volume 7
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