The relationship between plasma serotonin and kynurenine pathway metabolite levels and the treatment response to escitalopram and desvenlafaxine

•Response to escitalopram was associated with higher baseline serotonin levels.•Response to escitalopram was associated with lower baseline Kyn/Trp ratio and quinolinic acid (QuinA)/tryptophan (Trp) ratio.•Remitters to escitalopram showed significant increases in KynA/3HK ratio. The response of pati...

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Bibliographic Details

Published in:	Brain, behavior, and immunity Vol. 87; pp. 404 - 412
Main Authors:	Sun, Yu, Drevets, Wayne, Turecki, Gustavo, Li, Qingqin S.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01.07.2020
Subjects:	Citalopram - therapeutic use Depressive Disorder, Major - drug therapy Desvenlafaxine Succinate Humans Kynurenic Acid Kynurenine Plasma Serotonin
ISSN:	0889-1591, 1090-2139, 1090-2139
Online Access:	Get full text
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