Epigenetic control of CD8 + T cell differentiation

Upon stimulation, small numbers of naive CD8 T cells proliferate and differentiate into a variety of memory and effector cell types. CD8 T cells can persist for years and kill tumour cells and virally infected cells. The functional and phenotypic changes that occur during CD8 T cell differentiation...

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Bibliographic Details
Published in:Nature reviews. Immunology Vol. 18; no. 5; p. 340
Main Authors: Henning, Amanda N, Roychoudhuri, Rahul, Restifo, Nicholas P
Format: Journal Article
Language:English
Published: England Nature Publishing Group 01.05.2018
Subjects:
Animals
Cancer
CD8 antigen
CD8-Positive T-Lymphocytes - cytology
CD8-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - metabolism
Cell differentiation
Cell Differentiation - genetics
Cell Differentiation - immunology
Cellular Reprogramming Techniques - methods
Chromatin
Chromatin Assembly and Disassembly - genetics
Chromatin Assembly and Disassembly - immunology
Deoxyribonucleic acid
DNA
DNA Methylation - immunology
Enhancer Elements, Genetic
Epigenesis, Genetic - immunology
Epigenetics
Gene expression
Histone Code - genetics
Histones
Humans
Immunotherapy - methods
Lymphocytes
Lymphocytes T
Memory cells
Models, Genetic
Models, Immunological
Regulatory sequences
Transcription, Genetic
Tumors
ISSN:1474-1733, 1474-1741, 1474-1741
Online Access:Get full text
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Description
Summary:Upon stimulation, small numbers of naive CD8 T cells proliferate and differentiate into a variety of memory and effector cell types. CD8 T cells can persist for years and kill tumour cells and virally infected cells. The functional and phenotypic changes that occur during CD8 T cell differentiation are well characterized, but the epigenetic states that underlie these changes are incompletely understood. Here, we review the epigenetic processes that direct CD8 T cell differentiation and function. We focus on epigenetic modification of DNA and associated histones at genes and their regulatory elements. We also describe structural changes in chromatin organization that affect gene expression. Finally, we examine the translational potential of epigenetic interventions to improve CD8 T cell function in individuals with chronic infections and cancer.
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ISSN:1474-1733
1474-1741
1474-1741
DOI:10.1038/nri.2017.146