Epigenetic control of CD8+ T cell differentiation

Key Points According to the linear differentiation model, progressive changes to gene expression and the epigenetic landscape regulate the gradual acquisition of effector function and restriction of differentiation potential that occur during CD8 + T cell differentiation. DNA methylation, histone mo...

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Vydáno v:	Nature reviews. Immunology Ročník 18; číslo 5; s. 340 - 356
Hlavní autoři:	Henning, Amanda N., Roychoudhuri, Rahul, Restifo, Nicholas P.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 01.05.2018 Nature Publishing Group
Témata:	631/250/1619/554/1834 631/250/2502 631/250/2502/2170 631/250/251 Animals Biomedicine Cancer Care and treatment CD8 antigen CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell differentiation Cell Differentiation - genetics Cell Differentiation - immunology Cellular proteins Cellular Reprogramming Techniques - methods Chromatin Chromatin Assembly and Disassembly - genetics Chromatin Assembly and Disassembly - immunology Chronic diseases Deoxyribonucleic acid Development and progression DNA DNA Methylation - immunology Enhancer Elements, Genetic Epigenesis, Genetic - immunology Epigenetic inheritance Epigenetics Gene expression Genetic aspects Health aspects Histone Code - genetics Histones Humans Immunology Immunotherapy - methods Lymphocytes Lymphocytes T Memory cells Models, Genetic Models, Immunological Regulatory sequences review-article T cells Transcription, Genetic Tumors
ISSN:	1474-1733, 1474-1741, 1474-1741
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