Epigenetic control of CD8 + T cell differentiation

Upon stimulation, small numbers of naive CD8 T cells proliferate and differentiate into a variety of memory and effector cell types. CD8 T cells can persist for years and kill tumour cells and virally infected cells. The functional and phenotypic changes that occur during CD8 T cell differentiation...

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Bibliographic Details
Published in:	Nature reviews. Immunology Vol. 18; no. 5; p. 340
Main Authors:	Henning, Amanda N, Roychoudhuri, Rahul, Restifo, Nicholas P
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.05.2018
Subjects:	Animals Cancer CD8 antigen CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell differentiation Cell Differentiation - genetics Cell Differentiation - immunology Cellular Reprogramming Techniques - methods Chromatin Chromatin Assembly and Disassembly - genetics Chromatin Assembly and Disassembly - immunology Deoxyribonucleic acid DNA DNA Methylation - immunology Enhancer Elements, Genetic Epigenesis, Genetic - immunology Epigenetics Gene expression Histone Code - genetics Histones Humans Immunotherapy - methods Lymphocytes Lymphocytes T Memory cells Models, Genetic Models, Immunological Regulatory sequences Transcription, Genetic Tumors
ISSN:	1474-1733, 1474-1741, 1474-1741
Online Access:	Get full text
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