Genetic and environmental influences interact with age and sex in shaping the human methylome
The methylome is subject to genetic and environmental effects. Their impact may depend on sex and age, resulting in sex- and age-related physiological variation and disease susceptibility. Here we estimate the total heritability of DNA methylation levels in whole blood and estimate the variance expl...
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| Published in: | Nature communications Vol. 7; no. 1; pp. 11115 - 13 |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
London
Nature Publishing Group UK
07.04.2016
Nature Publishing Group Nature Portfolio |
| Subjects: | |
| ISSN: | 2041-1723, 2041-1723 |
| Online Access: | Get full text |
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| Abstract | The methylome is subject to genetic and environmental effects. Their impact may depend on sex and age, resulting in sex- and age-related physiological variation and disease susceptibility. Here we estimate the total heritability of DNA methylation levels in whole blood and estimate the variance explained by common single nucleotide polymorphisms at 411,169 sites in 2,603 individuals from twin families, to establish a catalogue of between-individual variation in DNA methylation. Heritability estimates vary across the genome (mean=19%) and interaction analyses reveal thousands of sites with sex-specific heritability as well as sites where the environmental variance increases with age. Integration with previously published data illustrates the impact of genome and environment across the lifespan at methylation sites associated with metabolic traits, smoking and ageing. These findings demonstrate that our catalogue holds valuable information on locations in the genome where methylation variation between people may reflect disease-relevant environmental exposures or genetic variation.
Differential impact of genetic and environmental influences on DNA methylation may result in sex- and age-related physiological variation and disease susceptibility. By analysing DNA methylome of 2,603 individuals from twin families, here, the authors establish a catalogue of between-individual variation in DNA methylation. |
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| AbstractList | The methylome is subject to genetic and environmental effects. Their impact may depend on sex and age, resulting in sex- and age-related physiological variation and disease susceptibility. Here we estimate the total heritability of DNA methylation levels in whole blood and estimate the variance explained by common single nucleotide polymorphisms at 411,169 sites in 2,603 individuals from twin families, to establish a catalogue of between-individual variation in DNA methylation. Heritability estimates vary across the genome (mean=19%) and interaction analyses reveal thousands of sites with sex-specific heritability as well as sites where the environmental variance increases with age. Integration with previously published data illustrates the impact of genome and environment across the lifespan at methylation sites associated with metabolic traits, smoking and ageing. These findings demonstrate that our catalogue holds valuable information on locations in the genome where methylation variation between people may reflect disease-relevant environmental exposures or genetic variation. The methylome is subject to genetic and environmental effects. Their impact may depend on sex and age, resulting in sex- and age-related physiological variation and disease susceptibility. Here we estimate the total heritability of DNA methylation levels in whole blood and estimate the variance explained by common single nucleotide polymorphisms at 411,169 sites in 2,603 individuals from twin families, to establish a catalogue of between-individual variation in DNA methylation. Heritability estimates vary across the genome (mean=19%) and interaction analyses reveal thousands of sites with sex-specific heritability as well as sites where the environmental variance increases with age. Integration with previously published data illustrates the impact of genome and environment across the lifespan at methylation sites associated with metabolic traits, smoking and ageing. These findings demonstrate that our catalogue holds valuable information on locations in the genome where methylation variation between people may reflect disease-relevant environmental exposures or genetic variation.The methylome is subject to genetic and environmental effects. Their impact may depend on sex and age, resulting in sex- and age-related physiological variation and disease susceptibility. Here we estimate the total heritability of DNA methylation levels in whole blood and estimate the variance explained by common single nucleotide polymorphisms at 411,169 sites in 2,603 individuals from twin families, to establish a catalogue of between-individual variation in DNA methylation. Heritability estimates vary across the genome (mean=19%) and interaction analyses reveal thousands of sites with sex-specific heritability as well as sites where the environmental variance increases with age. Integration with previously published data illustrates the impact of genome and environment across the lifespan at methylation sites associated with metabolic traits, smoking and ageing. These findings demonstrate that our catalogue holds valuable information on locations in the genome where methylation variation between people may reflect disease-relevant environmental exposures or genetic variation. Differential impact of genetic and environmental influences on DNA methylation may result in sex- and age-related physiological variation and disease susceptibility. By analysing DNA methylome of 2,603 individuals from twin families, here, the authors establish a catalogue of between-individual variation in DNA methylation. The methylome is subject to genetic and environmental effects. Their impact may depend on sex and age, resulting in sex- and age-related physiological variation and disease susceptibility. Here we estimate the total heritability of DNA methylation levels in whole blood and estimate the variance explained by common single nucleotide polymorphisms at 411,169 sites in 2,603 individuals from twin families, to establish a catalogue of between-individual variation in DNA methylation. Heritability estimates vary across the genome (mean=19%) and interaction analyses reveal thousands of sites with sex-specific heritability as well as sites where the environmental variance increases with age. Integration with previously published data illustrates the impact of genome and environment across the lifespan at methylation sites associated with metabolic traits, smoking and ageing. These findings demonstrate that our catalogue holds valuable information on locations in the genome where methylation variation between people may reflect disease-relevant environmental exposures or genetic variation. Differential impact of genetic and environmental influences on DNA methylation may result in sex- and age-related physiological variation and disease susceptibility. By analysing DNA methylome of 2,603 individuals from twin families, here, the authors establish a catalogue of between-individual variation in DNA methylation. |
| ArticleNumber | 11115 |
| Author | Ehli, Erik A. van Dongen, Jenny Willemsen, Gonneke Hottenga, Jouke-Jan Jansen, Rick Davies, Gareth E. Beck, Stephan Slagboom, P. Eline Boomsma, Dorret I. Dolan, Conor V. van Iterson, Maarten Suchiman, H. Eka Helmer, Quinta Breeze, Charles E. Heijmans, Bastiaan T. Nivard, Michel G. van Meurs, Joyce B. |
| Author_xml | – sequence: 1 givenname: Jenny surname: van Dongen fullname: van Dongen, Jenny email: j.van.dongen@vu.nl organization: Department of Biological Psychology, VU Amsterdam – sequence: 2 givenname: Michel G. surname: Nivard fullname: Nivard, Michel G. organization: Department of Biological Psychology, VU Amsterdam – sequence: 3 givenname: Gonneke surname: Willemsen fullname: Willemsen, Gonneke organization: Department of Biological Psychology, VU Amsterdam – sequence: 4 givenname: Jouke-Jan surname: Hottenga fullname: Hottenga, Jouke-Jan organization: Department of Biological Psychology, VU Amsterdam – sequence: 5 givenname: Quinta surname: Helmer fullname: Helmer, Quinta organization: Department of Biological Psychology, VU Amsterdam – sequence: 6 givenname: Conor V. surname: Dolan fullname: Dolan, Conor V. organization: Department of Biological Psychology, VU Amsterdam – sequence: 7 givenname: Erik A. surname: Ehli fullname: Ehli, Erik A. organization: Avera Institute for Human Genetics – sequence: 8 givenname: Gareth E. surname: Davies fullname: Davies, Gareth E. organization: Avera Institute for Human Genetics – sequence: 9 givenname: Maarten surname: van Iterson fullname: van Iterson, Maarten organization: Department of Molecular Epidemiology, Leiden University Medical Center – sequence: 10 givenname: Charles E. surname: Breeze fullname: Breeze, Charles E. organization: UCL Cancer Institute, University College London – sequence: 11 givenname: Stephan surname: Beck fullname: Beck, Stephan organization: UCL Cancer Institute, University College London – sequence: 13 givenname: H. Eka surname: Suchiman fullname: Suchiman, H. Eka organization: Department of Molecular Epidemiology, Leiden University Medical Center – sequence: 14 givenname: Rick surname: Jansen fullname: Jansen, Rick organization: Department of Psychiatry, VU University Medical Center – sequence: 15 givenname: Joyce B. surname: van Meurs fullname: van Meurs, Joyce B. organization: Department of Internal Medicine, Erasmus Medical Center – sequence: 16 givenname: Bastiaan T. surname: Heijmans fullname: Heijmans, Bastiaan T. organization: Department of Molecular Epidemiology, Leiden University Medical Center – sequence: 17 givenname: P. Eline surname: Slagboom fullname: Slagboom, P. Eline organization: Department of Molecular Epidemiology, Leiden University Medical Center – sequence: 18 givenname: Dorret I. surname: Boomsma fullname: Boomsma, Dorret I. organization: Department of Biological Psychology, VU Amsterdam |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27051996$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1371/journal.pgen.1003520 10.1038/ng.298 10.1093/carcin/bgs194 10.1093/bioinformatics/btu566 10.1126/science.1248127 10.1101/gr.136598.111 10.1101/gr.176933.114 10.1038/15490 10.1093/hmg/ddu313 10.1038/nature07107 10.2337/db13-1100 10.1093/hmg/ddu751 10.1016/j.ajhg.2013.10.004 10.1016/j.ygeno.2011.07.007 10.1093/bioinformatics/btr171 10.1016/j.ajhg.2010.11.011 10.1371/journal.pgen.1002629 10.1038/nrg3405 10.1038/mp.2011.174 10.1093/bioinformatics/btu049 10.1126/science.1063206 10.1111/j.1474-9726.2012.00835.x 10.1371/journal.pone.0014821 10.1016/j.jpsychires.2013.10.017 10.1093/hmg/ddt430 10.1093/hmg/ddt375 10.1038/ncomms6592 10.1093/humrep/des038 10.1038/nrg3243 10.1111/acel.12030 10.1186/gb-2014-15-5-r73 10.1093/hmg/ddp353 10.1375/twin.13.3.231 10.1038/ncomms4365 10.1371/journal.pone.0010028 10.1016/j.tig.2004.06.009 10.1038/nbt1010-1045 10.1371/journal.pone.0006767 10.1101/gr.103606.109 10.1101/gr.111922.110 10.1186/gb-2013-14-10-r115 10.1016/S0140-6736(13)62674-4 10.1038/ng.471 10.1186/gb-2013-14-5-r42 10.1080/07853890600989211 10.1073/pnas.0500398102 10.1111/acel.12293 10.3390/genes5020347 10.1038/nbt.2487 10.1073/pnas.1214056110 10.1093/bioinformatics/btr323 10.1186/1756-8935-6-26 10.1093/jn/135.6.1382 10.1186/s13059-014-0503-2 10.1093/ije/dyu277 10.1371/journal.pbio.0060022 10.1016/j.cell.2013.07.020 10.1186/gb-2012-13-10-r97 10.1038/nature12433 10.1186/s13059-015-0584-6 10.1186/s13059-015-0644-y 10.1101/gr.171439.113 10.4161/epi.23470 10.1375/136905202762342026 10.1111/j.1467-8624.2011.01641.x 10.1038/ng.823 10.1161/CIRCGENETICS.114.000804 10.1007/s10519-008-9212-5 10.1038/ng.3021 |
| ContentType | Journal Article |
| Contributor | Wijmenga, Cisca Veldink, Jan H van der Kallen, Carla J H Uitterlinden, André G Franke, Lude Moed, Matthijs van der Breggen, Ruud Nooren, Irene Tigchelaar, Ettje F Zhernakova, Dasha V van Dijk, Freerk Zhernakova, Sasha Kielbasa, Szymon M t Hoen, Peter A C Stehouwer, Coen D A Bonder, Marc Jan van den Berg, Leonard H van Heemst, Diana Deelen, Joris Verbiest, Michael Luijk, René Pool, René Lakenberg, Nico Van't Hof, Peter Swertz, Morris A van Duijn, Cornelia M Hofman, Bert A Mei, Hailiang van Greevenbroek, Marleen M J van Galen, Michiel Vermaat, Martijn Isaacs, Aaron Bot, Jan Deelen, Patrick Jhamai, P Mila Beekman, Marian Schalkwijk, Casper G Verkerk, Marijn Arindrarto, Wibowo van Rooij, Jeroen van Zwet, Erik W |
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| Copyright | The Author(s) 2016 Copyright Nature Publishing Group Apr 2016 Copyright © 2016, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2016 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. |
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| References | Bell (CR16) 2012; 8 Bjornsson, Fallin, Feinberg (CR21) 2004; 20 Bernstein (CR39) 2010; 28 Shah (CR40) 2014; 24 Tapp (CR14) 2013; 12 McRae (CR25) 2014; 15 Talens (CR31) 2012; 11 Martino (CR33) 2013; 14 Kaminsky, Wang, Petronis (CR20) 2006; 38 CR70 Boks (CR13) 2009; 4 Teschendorff, West, Beck (CR36) 2013; 22 Gordon (CR26) 2012; 22 Tobi (CR52) 2014; 5 Teschendorff (CR19) 2010; 20 Purcell (CR71) 2002; 5 van der Sluis, Willemsen, de Geus, Boomsma, Posthuma (CR51) 2008; 38 Horvath (CR17) 2012; 13 Morgan, Sutherland, Martin, Whitelaw (CR24) 1999; 23 Yang, Lee, Goddard, Visscher (CR59) 2011; 88 Hidalgo (CR4) 2014; 63 Meissner (CR1) 2008; 454 Rideout, Eggan, Jaenisch (CR22) 2001; 293 Westra (CR65) 2011; 27 Doi (CR47) 2009; 41 Irizarry (CR48) 2009; 41 Tobi (CR28) 2009; 18 Fraga (CR30) 2005; 102 van Iterson (CR62) 2014; 30 Slieker (CR41) 2013; 6 Gamazon (CR10) 2013; 18 Teh (CR50) 2014; 24 Pfeifferm (CR6) 2015; 8 Essex (CR54) 2013; 84 Liu (CR5) 2013; 31 van Dongen (CR57) 2014; 5 Bocklandt (CR32) 2011; 6 Kundakovic (CR29) 2013; 110 CR58 Cortijo (CR23) 2014; 343 Ma (CR34) 2015; 14 Hanna (CR53) 2012; 27 Zhang (CR11) 2014; 23 Bibikova (CR60) 2011; 98 Guida (CR8) 2015; 24 Horvath (CR18) 2013; 14 Petersen (CR42) 2014; 23 Liu, Morgan, Hutchison, Calhoun (CR15) 2010; 5 Flores (CR35) 2012; 33 Marioni (CR43) 2015; 16 Grundberg (CR9) 2013; 93 Shi (CR12) 2014; 5 Lillycrop, Phillips, Jackson, Hanson, Burdge (CR27) 2005; 135 Choufani (CR45) 2011; 21 Chen (CR63) 2013; 8 Zaitlen (CR38) 2013; 9 Marioni (CR44) 2015; 44 Willemsen (CR56) 2010; 13 Fortin (CR66) 2014; 15 Vandiver (CR55) 2015; 16 Mill, Heijmans (CR2) 2013; 14 Aryee (CR64) 2014; 30 Teschendorff, Zhuang, Widschwendter (CR67) 2011; 27 van Dongen, Slagboom, Draisma, Martin, Boomsma (CR69) 2012; 13 Dick (CR3) 2014; 383 van Mil (CR7) 2014; 49 CR61 Stergachis (CR68) 2013; 154 Ziller (CR49) 2013; 500 Yang (CR37) 2011; 43 Illingworth (CR46) 2008; 6 RC Slieker (BFncomms11115_CR41) 2013; 6 J Mill (BFncomms11115_CR2) 2013; 14 D Martino (BFncomms11115_CR33) 2013; 14 HJ Westra (BFncomms11115_CR65) 2011; 27 Y Liu (BFncomms11115_CR5) 2013; 31 BFncomms11115_CR58 X Zhang (BFncomms11115_CR11) 2014; 23 AK Petersen (BFncomms11115_CR42) 2014; 23 AR Vandiver (BFncomms11115_CR55) 2015; 16 N Zaitlen (BFncomms11115_CR38) 2013; 9 Z Kaminsky (BFncomms11115_CR20) 2006; 38 JT Bell (BFncomms11115_CR16) 2012; 8 S Purcell (BFncomms11115_CR71) 2002; 5 KA Lillycrop (BFncomms11115_CR27) 2005; 135 S Bocklandt (BFncomms11115_CR32) 2011; 6 M van Iterson (BFncomms11115_CR62) 2014; 30 MJ Essex (BFncomms11115_CR54) 2013; 84 YA Chen (BFncomms11115_CR63) 2013; 8 E Grundberg (BFncomms11115_CR9) 2013; 93 B Hidalgo (BFncomms11115_CR4) 2014; 63 L Gordon (BFncomms11115_CR26) 2012; 22 KG Flores (BFncomms11115_CR35) 2012; 33 S van der Sluis (BFncomms11115_CR51) 2008; 38 Y Ma (BFncomms11115_CR34) 2015; 14 J Yang (BFncomms11115_CR37) 2011; 43 S Shah (BFncomms11115_CR40) 2014; 24 WM Rideout III (BFncomms11115_CR22) 2001; 293 J Yang (BFncomms11115_CR59) 2011; 88 BFncomms11115_CR61 A Meissner (BFncomms11115_CR1) 2008; 454 J Liu (BFncomms11115_CR15) 2010; 5 EW Tobi (BFncomms11115_CR28) 2009; 18 L Pfeifferm (BFncomms11115_CR6) 2015; 8 HT Bjornsson (BFncomms11115_CR21) 2004; 20 BFncomms11115_CR70 J van Dongen (BFncomms11115_CR57) 2014; 5 J Shi (BFncomms11115_CR12) 2014; 5 R Illingworth (BFncomms11115_CR46) 2008; 6 S Horvath (BFncomms11115_CR17) 2012; 13 RA Irizarry (BFncomms11115_CR48) 2009; 41 EW Tobi (BFncomms11115_CR52) 2014; 5 J van Dongen (BFncomms11115_CR69) 2012; 13 BE Bernstein (BFncomms11115_CR39) 2010; 28 JP Fortin (BFncomms11115_CR66) 2014; 15 RP Talens (BFncomms11115_CR31) 2012; 11 AE Teschendorff (BFncomms11115_CR67) 2011; 27 MJ Ziller (BFncomms11115_CR49) 2013; 500 AE Teschendorff (BFncomms11115_CR36) 2013; 22 S Choufani (BFncomms11115_CR45) 2011; 21 AL Teh (BFncomms11115_CR50) 2014; 24 CW Hanna (BFncomms11115_CR53) 2012; 27 G Willemsen (BFncomms11115_CR56) 2010; 13 MP Boks (BFncomms11115_CR13) 2009; 4 MF Fraga (BFncomms11115_CR30) 2005; 102 RE Marioni (BFncomms11115_CR43) 2015; 16 S Cortijo (BFncomms11115_CR23) 2014; 343 HS Tapp (BFncomms11115_CR14) 2013; 12 S Horvath (BFncomms11115_CR18) 2013; 14 M Bibikova (BFncomms11115_CR60) 2011; 98 NH van Mil (BFncomms11115_CR7) 2014; 49 ER Gamazon (BFncomms11115_CR10) 2013; 18 AB Stergachis (BFncomms11115_CR68) 2013; 154 KJ Dick (BFncomms11115_CR3) 2014; 383 F Guida (BFncomms11115_CR8) 2015; 24 A Doi (BFncomms11115_CR47) 2009; 41 RE Marioni (BFncomms11115_CR44) 2015; 44 MJ Aryee (BFncomms11115_CR64) 2014; 30 AE Teschendorff (BFncomms11115_CR19) 2010; 20 M Kundakovic (BFncomms11115_CR29) 2013; 110 AF McRae (BFncomms11115_CR25) 2014; 15 HD Morgan (BFncomms11115_CR24) 1999; 23 |
| References_xml | – ident: CR70 – volume: 9 start-page: e1003520 year: 2013 ident: CR38 article-title: Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1003520 – volume: 41 start-page: 178 year: 2009 end-page: 186 ident: CR48 article-title: The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores publication-title: Nat. Genet. doi: 10.1038/ng.298 – volume: 33 start-page: 1542 year: 2012 end-page: 1547 ident: CR35 article-title: Sex-specific association of sequence variants in CBS and MTRR with risk for promoter hypermethylation in the lung epithelium of smokers publication-title: Carcinogenesis doi: 10.1093/carcin/bgs194 – volume: 30 start-page: 3435 year: 2014 end-page: 3437 ident: CR62 article-title: MethylAid: visual and interactive quality control of large Illumina 450k datasets publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu566 – volume: 343 start-page: 1145 year: 2014 end-page: 1148 ident: CR23 article-title: Mapping the epigenetic basis of complex traits publication-title: Science doi: 10.1126/science.1248127 – volume: 22 start-page: 1395 year: 2012 end-page: 1406 ident: CR26 article-title: Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence publication-title: Genome Res. doi: 10.1101/gr.136598.111 – volume: 24 start-page: 1725 year: 2014 end-page: 1733 ident: CR40 article-title: Genetic and environmental exposures constrain epigenetic drift over the human life course publication-title: Genome Res. doi: 10.1101/gr.176933.114 – volume: 23 start-page: 314 year: 1999 end-page: 318 ident: CR24 article-title: Epigenetic inheritance at the agouti locus in the mouse publication-title: Nat. Genet. doi: 10.1038/15490 – volume: 23 start-page: 5893 year: 2014 end-page: 5905 ident: CR11 article-title: Linking the genetic architecture of cytosine modifications with human complex traits publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddu313 – volume: 454 start-page: 766 year: 2008 end-page: 770 ident: CR1 article-title: Genome-scale DNA methylation maps of pluripotent and differentiated cells publication-title: Nature doi: 10.1038/nature07107 – volume: 63 start-page: 801 year: 2014 end-page: 807 ident: CR4 article-title: Epigenome-wide association study of fasting measures of glucose, insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network study publication-title: Diabetes doi: 10.2337/db13-1100 – volume: 24 start-page: 2349 year: 2015 end-page: 2359 ident: CR8 article-title: Dynamics of smoking-induced genome-wide methylation changes with time since smoking cessation publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddu751 – volume: 93 start-page: 876 year: 2013 end-page: 890 ident: CR9 article-title: Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2013.10.004 – volume: 98 start-page: 288 year: 2011 end-page: 295 ident: CR60 article-title: High density DNA methylation array with single CpG site resolution publication-title: Genomics doi: 10.1016/j.ygeno.2011.07.007 – ident: CR61 – volume: 27 start-page: 1496 year: 2011 end-page: 1505 ident: CR67 article-title: Independent surrogate variable analysis to deconvolve confounding factors in large-scale microarray profiling studies publication-title: Bioinformatics doi: 10.1093/bioinformatics/btr171 – volume: 88 start-page: 76 year: 2011 end-page: 82 ident: CR59 article-title: GCTA: a tool for genome-wide complex trait analysis publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2010.11.011 – ident: CR58 – volume: 8 start-page: e1002629 year: 2012 ident: CR16 article-title: Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population publication-title: PLoS. Genet. doi: 10.1371/journal.pgen.1002629 – volume: 14 start-page: 585 year: 2013 end-page: 594 ident: CR2 article-title: From promises to practical strategies in epigenetic epidemiology publication-title: Nat. Rev. Genet. doi: 10.1038/nrg3405 – volume: 18 start-page: 340 year: 2013 end-page: 346 ident: CR10 article-title: Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants publication-title: Mol. Psychiatry doi: 10.1038/mp.2011.174 – volume: 30 start-page: 1363 year: 2014 end-page: 1369 ident: CR64 article-title: Minfi: a flexible and comprehensive bioconductor package for the analysis of Infinium DNA methylation microarrays publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu049 – volume: 293 start-page: 1093 year: 2001 end-page: 1098 ident: CR22 article-title: Nuclear cloning and epigenetic reprogramming of the genome publication-title: Science doi: 10.1126/science.1063206 – volume: 11 start-page: 694 year: 2012 end-page: 703 ident: CR31 article-title: Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs publication-title: Aging Cell doi: 10.1111/j.1474-9726.2012.00835.x – volume: 6 start-page: e14821 year: 2011 ident: CR32 article-title: Epigenetic predictor of age publication-title: PLoS ONE doi: 10.1371/journal.pone.0014821 – volume: 49 start-page: 51 year: 2014 end-page: 59 ident: CR7 article-title: DNA methylation profiles at birth and child ADHD symptoms publication-title: J. Psychiatr. Res. doi: 10.1016/j.jpsychires.2013.10.017 – volume: 23 start-page: 534 year: 2014 end-page: 545 ident: CR42 article-title: Epigenetics meets metabolomics: an epigenome-wide association study with blood serum metabolic traits publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddt430 – volume: 22 start-page: R7 year: 2013 end-page: R15 ident: CR36 article-title: Age-associated epigenetic drift: implications, and a case of epigenetic thrift? publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddt375 – volume: 5 start-page: 5592 year: 2014 ident: CR52 article-title: DNA methylation signatures link prenatal famine exposure to growth and metabolism publication-title: Nat. Commun. doi: 10.1038/ncomms6592 – volume: 27 start-page: 1401 year: 2012 end-page: 1410 ident: CR53 article-title: DNA methylation changes in whole blood is associated with exposure to the environmental contaminants, mercury, lead, cadmium and bisphenol A, in women undergoing ovarian stimulation for IVF publication-title: Hum. Reprod. doi: 10.1093/humrep/des038 – volume: 13 start-page: 640 year: 2012 end-page: 653 ident: CR69 article-title: The continuing value of twin studies in the omics era publication-title: Nat. Rev. Genet. doi: 10.1038/nrg3243 – volume: 12 start-page: 148 year: 2013 end-page: 155 ident: CR14 article-title: Nutritional factors and gender influence age-related DNA methylation in the human rectal mucosa publication-title: Aging Cell doi: 10.1111/acel.12030 – volume: 15 start-page: R73 year: 2014 ident: CR25 article-title: Contribution of genetic variation to transgenerational inheritance of DNA methylation publication-title: Genome Biol. doi: 10.1186/gb-2014-15-5-r73 – volume: 18 start-page: 4046 year: 2009 end-page: 4053 ident: CR28 article-title: DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddp353 – volume: 13 start-page: 231 year: 2010 end-page: 245 ident: CR56 article-title: The Netherlands Twin Register biobank: a resource for genetic epidemiological studies publication-title: Twin Res. Hum. Genet. doi: 10.1375/twin.13.3.231 – volume: 5 start-page: 3365 year: 2014 ident: CR12 article-title: Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue publication-title: Nat. Commun. doi: 10.1038/ncomms4365 – volume: 5 start-page: e10028 year: 2010 ident: CR15 article-title: A study of the influence of sex on genome wide methylation publication-title: PLoS ONE doi: 10.1371/journal.pone.0010028 – volume: 20 start-page: 350 year: 2004 end-page: 358 ident: CR21 article-title: An integrated epigenetic and genetic approach to common human disease publication-title: Trends Genet. doi: 10.1016/j.tig.2004.06.009 – volume: 28 start-page: 1045 year: 2010 end-page: 1048 ident: CR39 article-title: The NIH roadmap epigenomics mapping consortium publication-title: Nat. Biotechnol. doi: 10.1038/nbt1010-1045 – volume: 4 start-page: e6767 year: 2009 ident: CR13 article-title: The relationship of DNA methylation with age, gender and genotype in twins and healthy controls publication-title: PLoS ONE doi: 10.1371/journal.pone.0006767 – volume: 20 start-page: 440 year: 2010 end-page: 446 ident: CR19 article-title: Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer publication-title: Genome Res. doi: 10.1101/gr.103606.109 – volume: 21 start-page: 465 year: 2011 end-page: 476 ident: CR45 article-title: A novel approach identifies new differentially methylated regions (DMRs) associated with imprinted genes publication-title: Genome Res. doi: 10.1101/gr.111922.110 – volume: 14 start-page: R115 year: 2013 ident: CR18 article-title: DNA methylation age of human tissues and cell types publication-title: Genome Biol. doi: 10.1186/gb-2013-14-10-r115 – volume: 383 start-page: 1990 year: 2014 end-page: 1998 ident: CR3 article-title: DNA methylation and body-mass index: a genome-wide analysis publication-title: Lancet doi: 10.1016/S0140-6736(13)62674-4 – volume: 41 start-page: 1350 year: 2009 end-page: 1353 ident: CR47 article-title: Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts publication-title: Nat. Genet. doi: 10.1038/ng.471 – volume: 14 start-page: R42 year: 2013 ident: CR33 article-title: Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance publication-title: Genome Biol. doi: 10.1186/gb-2013-14-5-r42 – volume: 38 start-page: 530 year: 2006 end-page: 544 ident: CR20 article-title: Complex disease, gender and epigenetics publication-title: Ann. Med. doi: 10.1080/07853890600989211 – volume: 102 start-page: 10604 year: 2005 end-page: 10609 ident: CR30 article-title: Epigenetic differences arise during the lifetime of monozygotic twins publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0500398102 – volume: 14 start-page: 49 year: 2015 end-page: 59 ident: CR34 article-title: Genetic variants modify the effect of age on APOE methylation in the Genetics of Lipid Lowering Drugs and Diet Network study publication-title: Aging Cell doi: 10.1111/acel.12293 – volume: 5 start-page: 347 year: 2014 end-page: 365 ident: CR57 article-title: Epigenetic variation in monozygotic twins: a genome-wide analysis of DNA methylation in buccal cells publication-title: Genes (Basel) doi: 10.3390/genes5020347 – volume: 31 start-page: 142 year: 2013 end-page: 147 ident: CR5 article-title: Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis publication-title: Nat. Biotechnol. doi: 10.1038/nbt.2487 – volume: 110 start-page: 9956 year: 2013 end-page: 9961 ident: CR29 article-title: Sex-specific epigenetic disruption and behavioral changes following low-dose in utero bisphenol A exposure publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1214056110 – volume: 27 start-page: 2104 year: 2011 end-page: 2111 ident: CR65 article-title: MixupMapper: correcting sample mix-ups in genome-wide datasets increases power to detect small genetic effects publication-title: Bioinformatics doi: 10.1093/bioinformatics/btr323 – volume: 6 start-page: 26 year: 2013 ident: CR41 article-title: Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array publication-title: Epigenetics Chromatin doi: 10.1186/1756-8935-6-26 – volume: 135 start-page: 1382 year: 2005 end-page: 1386 ident: CR27 article-title: Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring publication-title: J. Nutr. doi: 10.1093/jn/135.6.1382 – volume: 15 start-page: 503 year: 2014 ident: CR66 article-title: Functional normalization of 450k methylation array data improves replication in large cancer studies publication-title: Genome Biol. doi: 10.1186/s13059-014-0503-2 – volume: 44 start-page: 1388 year: 2015 end-page: 1396 ident: CR44 article-title: The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyu277 – volume: 6 start-page: e22 year: 2008 ident: CR46 article-title: A novel CpG island set identifies tissue-specific methylation at developmental gene loci publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0060022 – volume: 154 start-page: 888 year: 2013 end-page: 903 ident: CR68 article-title: Developmental fate and cellular maturity encoded in human regulatory DNA landscapes publication-title: Cell doi: 10.1016/j.cell.2013.07.020 – volume: 13 start-page: R97 year: 2012 ident: CR17 article-title: Aging effects on DNA methylation modules in human brain and blood tissue publication-title: Genome Biol. doi: 10.1186/gb-2012-13-10-r97 – volume: 500 start-page: 477 year: 2013 end-page: 481 ident: CR49 article-title: Charting a dynamic DNA methylation landscape of the human genome publication-title: Nature doi: 10.1038/nature12433 – volume: 16 start-page: 25 year: 2015 ident: CR43 article-title: DNA methylation age of blood predicts all-cause mortality in later life publication-title: Genome Biol. doi: 10.1186/s13059-015-0584-6 – volume: 16 start-page: 80 year: 2015 ident: CR55 article-title: Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin publication-title: Genome Biol. doi: 10.1186/s13059-015-0644-y – volume: 24 start-page: 1064 year: 2014 end-page: 1074 ident: CR50 article-title: The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes publication-title: Genome Res. doi: 10.1101/gr.171439.113 – volume: 8 start-page: 203 year: 2013 end-page: 209 ident: CR63 article-title: Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray publication-title: Epigenetics doi: 10.4161/epi.23470 – volume: 5 start-page: 554 year: 2002 end-page: 571 ident: CR71 article-title: Variance components models for gene-environment interaction in twin analysis publication-title: Twin. Res. doi: 10.1375/136905202762342026 – volume: 84 start-page: 58 year: 2013 end-page: 75 ident: CR54 article-title: Epigenetic vestiges of early developmental adversity: childhood stress exposure and DNA methylation in adolescence publication-title: Child Dev. doi: 10.1111/j.1467-8624.2011.01641.x – volume: 43 start-page: 519 year: 2011 end-page: 525 ident: CR37 article-title: Genome partitioning of genetic variation for complex traits using common SNPs publication-title: Nat. Genet. doi: 10.1038/ng.823 – volume: 8 start-page: 334 year: 2015 end-page: 342 ident: CR6 article-title: DNA methylation of lipid-related genes affects blood lipid levels publication-title: Circ. Cardiovasc. Genet. doi: 10.1161/CIRCGENETICS.114.000804 – volume: 38 start-page: 348 year: 2008 end-page: 360 ident: CR51 article-title: Gene-environment interaction in adults' IQ scores: measures of past and present environment publication-title: Behav. Genet. doi: 10.1007/s10519-008-9212-5 – volume: 8 start-page: e1002629 year: 2012 ident: BFncomms11115_CR16 publication-title: PLoS. Genet. doi: 10.1371/journal.pgen.1002629 – volume: 9 start-page: e1003520 year: 2013 ident: BFncomms11115_CR38 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1003520 – volume: 98 start-page: 288 year: 2011 ident: BFncomms11115_CR60 publication-title: Genomics doi: 10.1016/j.ygeno.2011.07.007 – volume: 23 start-page: 534 year: 2014 ident: BFncomms11115_CR42 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddt430 – volume: 8 start-page: 334 year: 2015 ident: BFncomms11115_CR6 publication-title: Circ. Cardiovasc. Genet. doi: 10.1161/CIRCGENETICS.114.000804 – volume: 5 start-page: 347 year: 2014 ident: BFncomms11115_CR57 publication-title: Genes (Basel) doi: 10.3390/genes5020347 – volume: 383 start-page: 1990 year: 2014 ident: BFncomms11115_CR3 publication-title: Lancet doi: 10.1016/S0140-6736(13)62674-4 – volume: 454 start-page: 766 year: 2008 ident: BFncomms11115_CR1 publication-title: Nature doi: 10.1038/nature07107 – volume: 5 start-page: 3365 year: 2014 ident: BFncomms11115_CR12 publication-title: Nat. Commun. doi: 10.1038/ncomms4365 – volume: 14 start-page: R115 year: 2013 ident: BFncomms11115_CR18 publication-title: Genome Biol. doi: 10.1186/gb-2013-14-10-r115 – volume: 13 start-page: 231 year: 2010 ident: BFncomms11115_CR56 publication-title: Twin Res. Hum. Genet. doi: 10.1375/twin.13.3.231 – volume: 63 start-page: 801 year: 2014 ident: BFncomms11115_CR4 publication-title: Diabetes doi: 10.2337/db13-1100 – ident: BFncomms11115_CR61 – volume: 93 start-page: 876 year: 2013 ident: BFncomms11115_CR9 publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2013.10.004 – volume: 38 start-page: 530 year: 2006 ident: BFncomms11115_CR20 publication-title: Ann. Med. doi: 10.1080/07853890600989211 – volume: 13 start-page: 640 year: 2012 ident: BFncomms11115_CR69 publication-title: Nat. Rev. Genet. doi: 10.1038/nrg3243 – volume: 293 start-page: 1093 year: 2001 ident: BFncomms11115_CR22 publication-title: Science doi: 10.1126/science.1063206 – volume: 24 start-page: 2349 year: 2015 ident: BFncomms11115_CR8 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddu751 – volume: 135 start-page: 1382 year: 2005 ident: BFncomms11115_CR27 publication-title: J. Nutr. doi: 10.1093/jn/135.6.1382 – volume: 5 start-page: 5592 year: 2014 ident: BFncomms11115_CR52 publication-title: Nat. Commun. doi: 10.1038/ncomms6592 – volume: 6 start-page: 26 year: 2013 ident: BFncomms11115_CR41 publication-title: Epigenetics Chromatin doi: 10.1186/1756-8935-6-26 – volume: 16 start-page: 80 year: 2015 ident: BFncomms11115_CR55 publication-title: Genome Biol. doi: 10.1186/s13059-015-0644-y – volume: 88 start-page: 76 year: 2011 ident: BFncomms11115_CR59 publication-title: Am. J. Hum. Genet. doi: 10.1016/j.ajhg.2010.11.011 – volume: 4 start-page: e6767 year: 2009 ident: BFncomms11115_CR13 publication-title: PLoS ONE doi: 10.1371/journal.pone.0006767 – volume: 14 start-page: 585 year: 2013 ident: BFncomms11115_CR2 publication-title: Nat. Rev. Genet. doi: 10.1038/nrg3405 – volume: 154 start-page: 888 year: 2013 ident: BFncomms11115_CR68 publication-title: Cell doi: 10.1016/j.cell.2013.07.020 – volume: 6 start-page: e22 year: 2008 ident: BFncomms11115_CR46 publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0060022 – volume: 27 start-page: 2104 year: 2011 ident: BFncomms11115_CR65 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btr323 – volume: 14 start-page: 49 year: 2015 ident: BFncomms11115_CR34 publication-title: Aging Cell doi: 10.1111/acel.12293 – volume: 28 start-page: 1045 year: 2010 ident: BFncomms11115_CR39 publication-title: Nat. Biotechnol. doi: 10.1038/nbt1010-1045 – volume: 22 start-page: 1395 year: 2012 ident: BFncomms11115_CR26 publication-title: Genome Res. doi: 10.1101/gr.136598.111 – volume: 12 start-page: 148 year: 2013 ident: BFncomms11115_CR14 publication-title: Aging Cell doi: 10.1111/acel.12030 – volume: 13 start-page: R97 year: 2012 ident: BFncomms11115_CR17 publication-title: Genome Biol. doi: 10.1186/gb-2012-13-10-r97 – volume: 16 start-page: 25 year: 2015 ident: BFncomms11115_CR43 publication-title: Genome Biol. doi: 10.1186/s13059-015-0584-6 – ident: BFncomms11115_CR70 – volume: 33 start-page: 1542 year: 2012 ident: BFncomms11115_CR35 publication-title: Carcinogenesis doi: 10.1093/carcin/bgs194 – volume: 24 start-page: 1064 year: 2014 ident: BFncomms11115_CR50 publication-title: Genome Res. doi: 10.1101/gr.171439.113 – volume: 27 start-page: 1496 year: 2011 ident: BFncomms11115_CR67 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btr171 – volume: 20 start-page: 350 year: 2004 ident: BFncomms11115_CR21 publication-title: Trends Genet. doi: 10.1016/j.tig.2004.06.009 – volume: 14 start-page: R42 year: 2013 ident: BFncomms11115_CR33 publication-title: Genome Biol. doi: 10.1186/gb-2013-14-5-r42 – volume: 6 start-page: e14821 year: 2011 ident: BFncomms11115_CR32 publication-title: PLoS ONE doi: 10.1371/journal.pone.0014821 – volume: 84 start-page: 58 year: 2013 ident: BFncomms11115_CR54 publication-title: Child Dev. doi: 10.1111/j.1467-8624.2011.01641.x – volume: 22 start-page: R7 year: 2013 ident: BFncomms11115_CR36 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddt375 – volume: 500 start-page: 477 year: 2013 ident: BFncomms11115_CR49 publication-title: Nature doi: 10.1038/nature12433 – volume: 20 start-page: 440 year: 2010 ident: BFncomms11115_CR19 publication-title: Genome Res. doi: 10.1101/gr.103606.109 – volume: 44 start-page: 1388 year: 2015 ident: BFncomms11115_CR44 publication-title: Int. J. Epidemiol. doi: 10.1093/ije/dyu277 – volume: 38 start-page: 348 year: 2008 ident: BFncomms11115_CR51 publication-title: Behav. Genet. doi: 10.1007/s10519-008-9212-5 – volume: 30 start-page: 3435 year: 2014 ident: BFncomms11115_CR62 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu566 – volume: 18 start-page: 340 year: 2013 ident: BFncomms11115_CR10 publication-title: Mol. Psychiatry doi: 10.1038/mp.2011.174 – volume: 102 start-page: 10604 year: 2005 ident: BFncomms11115_CR30 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0500398102 – volume: 27 start-page: 1401 year: 2012 ident: BFncomms11115_CR53 publication-title: Hum. Reprod. doi: 10.1093/humrep/des038 – volume: 21 start-page: 465 year: 2011 ident: BFncomms11115_CR45 publication-title: Genome Res. doi: 10.1101/gr.111922.110 – volume: 41 start-page: 1350 year: 2009 ident: BFncomms11115_CR47 publication-title: Nat. Genet. doi: 10.1038/ng.471 – volume: 49 start-page: 51 year: 2014 ident: BFncomms11115_CR7 publication-title: J. Psychiatr. Res. doi: 10.1016/j.jpsychires.2013.10.017 – volume: 11 start-page: 694 year: 2012 ident: BFncomms11115_CR31 publication-title: Aging Cell doi: 10.1111/j.1474-9726.2012.00835.x – volume: 30 start-page: 1363 year: 2014 ident: BFncomms11115_CR64 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu049 – volume: 343 start-page: 1145 year: 2014 ident: BFncomms11115_CR23 publication-title: Science doi: 10.1126/science.1248127 – volume: 8 start-page: 203 year: 2013 ident: BFncomms11115_CR63 publication-title: Epigenetics doi: 10.4161/epi.23470 – ident: BFncomms11115_CR58 doi: 10.1038/ng.3021 – volume: 15 start-page: 503 year: 2014 ident: BFncomms11115_CR66 publication-title: Genome Biol. doi: 10.1186/s13059-014-0503-2 – volume: 23 start-page: 314 year: 1999 ident: BFncomms11115_CR24 publication-title: Nat. Genet. doi: 10.1038/15490 – volume: 18 start-page: 4046 year: 2009 ident: BFncomms11115_CR28 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddp353 – volume: 43 start-page: 519 year: 2011 ident: BFncomms11115_CR37 publication-title: Nat. Genet. doi: 10.1038/ng.823 – volume: 41 start-page: 178 year: 2009 ident: BFncomms11115_CR48 publication-title: Nat. Genet. doi: 10.1038/ng.298 – volume: 24 start-page: 1725 year: 2014 ident: BFncomms11115_CR40 publication-title: Genome Res. doi: 10.1101/gr.176933.114 – volume: 5 start-page: 554 year: 2002 ident: BFncomms11115_CR71 publication-title: Twin. Res. doi: 10.1375/136905202762342026 – volume: 15 start-page: R73 year: 2014 ident: BFncomms11115_CR25 publication-title: Genome Biol. doi: 10.1186/gb-2014-15-5-r73 – volume: 5 start-page: e10028 year: 2010 ident: BFncomms11115_CR15 publication-title: PLoS ONE doi: 10.1371/journal.pone.0010028 – volume: 31 start-page: 142 year: 2013 ident: BFncomms11115_CR5 publication-title: Nat. Biotechnol. doi: 10.1038/nbt.2487 – volume: 23 start-page: 5893 year: 2014 ident: BFncomms11115_CR11 publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddu313 – volume: 110 start-page: 9956 year: 2013 ident: BFncomms11115_CR29 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1214056110 |
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| Title | Genetic and environmental influences interact with age and sex in shaping the human methylome |
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