A general functional response of cytotoxic T lymphocyte-mediated killing of target cells

Cytotoxic T lymphocytes (CTLs) kill virus-infected cells and tumor cells, and play a critical role in immune protection. Our knowledge of how the CTL killing efficiency varies with CTL and target cell numbers is limited. Here, we simulate a region of lymphoid tissue using a cellular Potts model to c...

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Veröffentlicht in:	Biophysical journal Jg. 106; H. 8; S. 1780
Hauptverfasser:	Gadhamsetty, Saikrishna, Marée, Athanasius F M, Beltman, Joost B, de Boer, Rob J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.04.2014
Schlagworte:	Computer Simulation Confidence Intervals Cytotoxicity, Immunologic Humans Immunological Synapses - metabolism Lymphocyte Count Models, Immunological Surface Tension T-Lymphocytes, Cytotoxic - immunology
ISSN:	1542-0086, 1542-0086
Online-Zugang:	Weitere Angaben
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