Impact of early-life bisphenol A exposure on behavior and executive function in children

To estimate the impact of gestational and childhood bisphenol A (BPA) exposures on behavior and executive function at 3 years of age and to determine whether child gender modified those associations. We used a prospective birth cohort of 244 mothers and their 3-year-old children from the greater Cin...

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Veröffentlicht in:	Pediatrics (Evanston) Jg. 128; H. 5; S. 873
Hauptverfasser:	Braun, Joe M, Kalkbrenner, Amy E, Calafat, Antonia M, Yolton, Kimberly, Ye, Xiaoyun, Dietrich, Kim N, Lanphear, Bruce P
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.11.2011
Schlagworte:	Age Factors Benzhydryl Compounds Child Behavior Disorders - chemically induced Child Behavior Disorders - epidemiology Child, Preschool Cohort Studies Environmental Exposure - adverse effects Executive Function Female Follow-Up Studies Humans Incidence Infant Male Maternal Exposure - adverse effects Phenols - adverse effects Pregnancy Prenatal Exposure Delayed Effects Prospective Studies Risk Assessment United States United States
ISSN:	1098-4275, 1098-4275
Online-Zugang:	Weitere Angaben
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Abstract	To estimate the impact of gestational and childhood bisphenol A (BPA) exposures on behavior and executive function at 3 years of age and to determine whether child gender modified those associations. We used a prospective birth cohort of 244 mothers and their 3-year-old children from the greater Cincinnati, Ohio, area. We characterized gestational and childhood BPA exposures by using the mean BPA concentrations in maternal (16 and 26 weeks of gestation and birth) and child (1, 2, and 3 years of age) urine samples, respectively. Behavior and executive function were measured by using the Behavior Assessment System for Children 2 (BASC-2) and the Behavior Rating Inventory of Executive Function-Preschool (BRIEF-P). BPA was detected in >97% of the gestational (median: 2.0 μg/L) and childhood (median: 4.1 μg/L) urine samples. With adjustment for confounders, each 10-fold increase in gestational BPA concentrations was associated with more anxious and depressed behavior on the BASC-2 and poorer emotional control and inhibition on the BRIEF-P. The magnitude of the gestational BPA associations differed according to child gender; BASC-2 and BRIEF-P scores increased 9 to 12 points among girls, but changes were null or negative among boys. Associations between childhood BPA exposure and neurobehavior were largely null and not modified by child gender. In this study, gestational BPA exposure affected behavioral and emotional regulation domains at 3 years of age, especially among girls. Clinicians may advise concerned patients to reduce their exposure to certain consumer products, but the benefits of such reductions are unclear.
AbstractList	To estimate the impact of gestational and childhood bisphenol A (BPA) exposures on behavior and executive function at 3 years of age and to determine whether child gender modified those associations.OBJECTIVESTo estimate the impact of gestational and childhood bisphenol A (BPA) exposures on behavior and executive function at 3 years of age and to determine whether child gender modified those associations.We used a prospective birth cohort of 244 mothers and their 3-year-old children from the greater Cincinnati, Ohio, area. We characterized gestational and childhood BPA exposures by using the mean BPA concentrations in maternal (16 and 26 weeks of gestation and birth) and child (1, 2, and 3 years of age) urine samples, respectively. Behavior and executive function were measured by using the Behavior Assessment System for Children 2 (BASC-2) and the Behavior Rating Inventory of Executive Function-Preschool (BRIEF-P).METHODSWe used a prospective birth cohort of 244 mothers and their 3-year-old children from the greater Cincinnati, Ohio, area. We characterized gestational and childhood BPA exposures by using the mean BPA concentrations in maternal (16 and 26 weeks of gestation and birth) and child (1, 2, and 3 years of age) urine samples, respectively. Behavior and executive function were measured by using the Behavior Assessment System for Children 2 (BASC-2) and the Behavior Rating Inventory of Executive Function-Preschool (BRIEF-P).BPA was detected in >97% of the gestational (median: 2.0 μg/L) and childhood (median: 4.1 μg/L) urine samples. With adjustment for confounders, each 10-fold increase in gestational BPA concentrations was associated with more anxious and depressed behavior on the BASC-2 and poorer emotional control and inhibition on the BRIEF-P. The magnitude of the gestational BPA associations differed according to child gender; BASC-2 and BRIEF-P scores increased 9 to 12 points among girls, but changes were null or negative among boys. Associations between childhood BPA exposure and neurobehavior were largely null and not modified by child gender.RESULTSBPA was detected in >97% of the gestational (median: 2.0 μg/L) and childhood (median: 4.1 μg/L) urine samples. With adjustment for confounders, each 10-fold increase in gestational BPA concentrations was associated with more anxious and depressed behavior on the BASC-2 and poorer emotional control and inhibition on the BRIEF-P. The magnitude of the gestational BPA associations differed according to child gender; BASC-2 and BRIEF-P scores increased 9 to 12 points among girls, but changes were null or negative among boys. Associations between childhood BPA exposure and neurobehavior were largely null and not modified by child gender.In this study, gestational BPA exposure affected behavioral and emotional regulation domains at 3 years of age, especially among girls. Clinicians may advise concerned patients to reduce their exposure to certain consumer products, but the benefits of such reductions are unclear.CONCLUSIONSIn this study, gestational BPA exposure affected behavioral and emotional regulation domains at 3 years of age, especially among girls. Clinicians may advise concerned patients to reduce their exposure to certain consumer products, but the benefits of such reductions are unclear. To estimate the impact of gestational and childhood bisphenol A (BPA) exposures on behavior and executive function at 3 years of age and to determine whether child gender modified those associations. We used a prospective birth cohort of 244 mothers and their 3-year-old children from the greater Cincinnati, Ohio, area. We characterized gestational and childhood BPA exposures by using the mean BPA concentrations in maternal (16 and 26 weeks of gestation and birth) and child (1, 2, and 3 years of age) urine samples, respectively. Behavior and executive function were measured by using the Behavior Assessment System for Children 2 (BASC-2) and the Behavior Rating Inventory of Executive Function-Preschool (BRIEF-P). BPA was detected in >97% of the gestational (median: 2.0 μg/L) and childhood (median: 4.1 μg/L) urine samples. With adjustment for confounders, each 10-fold increase in gestational BPA concentrations was associated with more anxious and depressed behavior on the BASC-2 and poorer emotional control and inhibition on the BRIEF-P. The magnitude of the gestational BPA associations differed according to child gender; BASC-2 and BRIEF-P scores increased 9 to 12 points among girls, but changes were null or negative among boys. Associations between childhood BPA exposure and neurobehavior were largely null and not modified by child gender. In this study, gestational BPA exposure affected behavioral and emotional regulation domains at 3 years of age, especially among girls. Clinicians may advise concerned patients to reduce their exposure to certain consumer products, but the benefits of such reductions are unclear.
Author	Dietrich, Kim N Yolton, Kimberly Ye, Xiaoyun Calafat, Antonia M Lanphear, Bruce P Braun, Joe M Kalkbrenner, Amy E
Author_xml	– sequence: 1 givenname: Joe M surname: Braun fullname: Braun, Joe M email: jbraun@hsph.harvard.edu organization: Department of Environmental Health, Harvard School of Public Health, Harvard University, Boston, MA 02130, USA. jbraun@hsph.harvard.edu – sequence: 2 givenname: Amy E surname: Kalkbrenner fullname: Kalkbrenner, Amy E – sequence: 3 givenname: Antonia M surname: Calafat fullname: Calafat, Antonia M – sequence: 4 givenname: Kimberly surname: Yolton fullname: Yolton, Kimberly – sequence: 5 givenname: Xiaoyun surname: Ye fullname: Ye, Xiaoyun – sequence: 6 givenname: Kim N surname: Dietrich fullname: Dietrich, Kim N – sequence: 7 givenname: Bruce P surname: Lanphear fullname: Lanphear, Bruce P
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/22025598$$D View this record in MEDLINE/PubMed
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References	17997365 - J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Dec 1;860(1):106-12 18184671 - Int J Epidemiol. 2008 Apr;37(2):382-5 17976571 - Environ Res. 2008 Feb;106(2):257-69 18338280 - J Toxicol Environ Health A. 2008;71(8):471-3 20955230 - Paediatr Perinat Epidemiol. 2010 Nov;24(6):524-34 12912767 - Arch Gen Psychiatry. 2003 Aug;60(8):837-44 20188014 - J Int Neuropsychol Soc. 2010 May;16(3):495-505 20087875 - Stat Med. 2010 Apr 30;29(9):1037-57 11196084 - Int Arch Occup Environ Health. 2001 Jan;74(1):63-7 18613034 - Birth Defects Res B Dev Reprod Toxicol. 2008 Jun;83(3):157-395 19933777 - Nicotine Tob Res. 2009 Dec;11(12):1458-66 21182865 - Neurotoxicology. 2011 Mar;32(2):261-7 7644606 - Psychol Bull. 1995 Jul;118(1):55-107 18803959 - Metabolism. 2008 Oct;57 Suppl 2:S16-21 18774129 - Environ Res. 2008 Oct;108(2):260-7 9256522 - Behav Res Ther. 1997 Aug;35(8):785-91 20678833 - Environ Pollut. 2010 Oct;158(10):3138-43 16097788 - Anal Chem. 2005 Aug 15;77(16):5407-13 20106747 - Environ Health Perspect. 2010 Apr;118(4):565-71 18949834 - Environ Res. 2008 Oct;108(2):150-7 18197297 - Environ Health Perspect. 2008 Jan;116(1):39-44 18502513 - Neurotoxicology. 2008 May;29(3):504-19 11337599 - Epidemiology. 2001 May;12(3):291-4 20829148 - Environ Health Perspect. 2010 Dec;118(12):1646-53 12435780 - Int J Epidemiol. 2002 Oct;31(5):1030-7 18288314 - Environ Health Perspect. 2008 Feb;116(2):173-8 21406337 - Environ Health Perspect. 2011 Jul;119(7):983-8 19750099 - Environ Health Perspect. 2009 Sep;117(9):1368-72 20955576 - Environ Health. 2010;9:62 20338858 - Environ Health Perspect. 2010 Aug;118(8):1055-70 16750524 - Environ Res. 2007 Jan;103(1):9-20 21524981 - Environ Health Perspect. 2011 Aug;119(8):1170-5 15220073 - Environ Res. 2004 Jul;95(3):394-405 19394271 - Int J Hyg Environ Health. 2009 Sep;212(5):481-91 12060833 - Environ Health Perspect. 2002 Jun;110 Suppl 3:387-91 16690810 - Endocrinology. 2006 Jun;147(6 Suppl):S56-69 20136739 - Risk Anal. 2010 Mar;30(3):473-87 12154363 - Nat Rev Neurosci. 2002 Aug;3(8):617-28 19906654 - Hum Reprod. 2010 Feb;25(2):519-27 17768031 - Reprod Toxicol. 2007 Aug-Sep;24(2):131-8 20049216 - Environ Health Perspect. 2009 Dec;117(12):1945-52 21450549 - Environ Health Perspect. 2011 Jul;119(7):914-20 18709157 - Environ Health Perspect. 2008 Aug;116(8):1092-7 19265696 - Horm Behav. 2009 Apr;55(4):465-79 20169576 - Synapse. 2010 Jun;64(6):432-9 21233055 - Environ Health Perspect. 2011 Jun;119(6):878-85 21205581 - Environ Health Perspect. 2011 Jan;119(1):131-7
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Snippet	To estimate the impact of gestational and childhood bisphenol A (BPA) exposures on behavior and executive function at 3 years of age and to determine whether...
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SubjectTerms	Age Factors Benzhydryl Compounds Child Behavior Disorders - chemically induced Child Behavior Disorders - epidemiology Child, Preschool Cohort Studies Environmental Exposure - adverse effects Executive Function Female Follow-Up Studies Humans Incidence Infant Male Maternal Exposure - adverse effects Phenols - adverse effects Pregnancy Prenatal Exposure Delayed Effects Prospective Studies Risk Assessment United States
Title	Impact of early-life bisphenol A exposure on behavior and executive function in children
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