Flat clathrin lattices are dynamic actin-controlled hubs for clathrin-mediated endocytosis and signalling of specific receptors

Clathrin lattices at the plasma membrane coat both invaginated and flat regions forming clathrin-coated pits and clathrin plaques, respectively. The function and regulation of clathrin-coated pits in endocytosis are well understood but clathrin plaques remain enigmatic nanodomains. Here we use super...

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Bibliographic Details
Published in:	Nature communications Vol. 8; no. 1; pp. 16068 - 14
Main Authors:	Leyton-Puig, Daniela, Isogai, Tadamoto, Argenzio, Elisabetta, van den Broek, Bram, Klarenbeek, Jeffrey, Janssen, Hans, Jalink, Kees, Innocenti, Metello
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 13.07.2017 Nature Publishing Group Nature Portfolio
Subjects:	13 13/106 13/89 13/95 14 14/19 14/28 14/63 631/80/128/1276 631/80/313/1461 631/80/86/2368 96 96/10 96/34 96/35 Actin Actin Cytoskeleton - metabolism Actin-Related Protein 2-3 Complex - metabolism AKT protein Cell adhesion Cell adhesion & migration Cell migration Clathrin Clathrin - physiology Clathrin-Coated Vesicles - metabolism Coated pits Coating Control Dismantling Endocytosis Genetics HeLa Cells Hubs Humanities and Social Sciences Humans Lattices Machinery and equipment multidisciplinary Pits Plaques Polymerization Receptors Receptors, Lysophosphatidic Acid - metabolism Science Science (multidisciplinary) Signaling Wiskott-Aldrich Syndrome Protein, Neuronal - metabolism
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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