Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination

Aging is associated with hyporesponse to vaccination, whose mechanisms remain unclear. In this study hepatitis B virus (HBV)-naive older adults received three vaccines, including one against HBV. Here we show, using transcriptional and cytometric profiling of whole blood collected before vaccination...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Nature communications Ročník 7; číslo 1; s. 10369
Hlavní autoři:	Fourati, Slim, Cristescu, Razvan, Loboda, Andrey, Talla, Aarthi, Filali, Ali, Railkar, Radha, Schaeffer, Andrea K., Favre, David, Gagnon, Dominic, Peretz, Yoav, Wang, I-Ming, Beals, Chan R., Casimiro, Danilo R., Carayannopoulos, Leonidas N., Sékaly, Rafick-Pierre
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 08.01.2016 Nature Publishing Group Nature Portfolio
Témata:	13 13/21 13/31 38/61 631/250/24/590 631/250/255/234/2513/1549 631/250/256 631/80/86 82/1 Adult Aged Aged, 80 and over Aging - immunology Aging - metabolism B-Lymphocytes - physiology Biomarkers Biomarkers - blood Cohort Studies Erythrocyte Count Female Flow Cytometry Hepatitis Hepatitis B Hepatitis B Surface Antigens - immunology Hepatitis B Vaccines - immunology Humanities and Social Sciences Humans Immunization Inflammation - metabolism Male Middle Aged multidisciplinary Older people Science Science (multidisciplinary) Transcriptome Vaccination Vaccines Florida United States > US
ISSN:	2041-1723, 2041-1723
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!