Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination

Aging is associated with hyporesponse to vaccination, whose mechanisms remain unclear. In this study hepatitis B virus (HBV)-naive older adults received three vaccines, including one against HBV. Here we show, using transcriptional and cytometric profiling of whole blood collected before vaccination...

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Vydáno v:Nature communications Ročník 7; číslo 1; s. 10369
Hlavní autoři: Fourati, Slim, Cristescu, Razvan, Loboda, Andrey, Talla, Aarthi, Filali, Ali, Railkar, Radha, Schaeffer, Andrea K., Favre, David, Gagnon, Dominic, Peretz, Yoav, Wang, I-Ming, Beals, Chan R., Casimiro, Danilo R., Carayannopoulos, Leonidas N., Sékaly, Rafick-Pierre
Médium: Journal Article
Jazyk:angličtina
Vydáno: London Nature Publishing Group UK 08.01.2016
Nature Publishing Group
Nature Portfolio
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Adult
Aged
Aged, 80 and over
Aging - immunology
Aging - metabolism
B-Lymphocytes - physiology
Biomarkers
Biomarkers - blood
Cohort Studies
Erythrocyte Count
Female
Flow Cytometry
Hepatitis
Hepatitis B
Hepatitis B Surface Antigens - immunology
Hepatitis B Vaccines - immunology
Humanities and Social Sciences
Humans
Immunization
Inflammation - metabolism
Male
Middle Aged
multidisciplinary
Older people
Science
Science (multidisciplinary)
Transcriptome
Vaccination
Vaccines
Florida
United States > US
ISSN:2041-1723, 2041-1723
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Popis
Shrnutí:Aging is associated with hyporesponse to vaccination, whose mechanisms remain unclear. In this study hepatitis B virus (HBV)-naive older adults received three vaccines, including one against HBV. Here we show, using transcriptional and cytometric profiling of whole blood collected before vaccination, that heightened expression of genes that augment B-cell responses and higher memory B-cell frequencies correlate with stronger responses to HBV vaccine. In contrast, higher levels of inflammatory response transcripts and increased frequencies of pro-inflammatory innate cells correlate with weaker responses to this vaccine. Increased numbers of erythrocytes and the haem-induced response also correlate with poor response to the HBV vaccine. A transcriptomics-based pre-vaccination predictor of response to HBV vaccine is built and validated in distinct sets of older adults. This moderately accurate (area under the curve≈65%) but robust signature is supported by flow cytometry and cytokine profiling. This study is the first that identifies baseline predictors and mechanisms of response to the HBV vaccine. Ageing is associated with poor responses to vaccines but the underlying mechanism remains unclear. Here the authors use a systems-based approach to define molecular signatures present before vaccination that correlate with non-responsiveness to hepatitis B vaccination in healthy, elderly adults.
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ISSN:2041-1723
2041-1723
DOI:10.1038/ncomms10369