Cellular softening mediates leukocyte demargination and trafficking, thereby increasing clinical blood counts

Leukocytes normally marginate toward the vascular wall in large vessels and within the microvasculature. Reversal of this process, leukocyte demargination, leads to substantial increases in the clinical white blood cell and granulocyte count and is a well-documented effect of glucocorticoid and cate...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 8; p. 1987
Main Authors:	Fay, Meredith E, Myers, David R, Kumar, Amit, Turbyfield, Cory T, Byler, Rebecca, Crawford, Kaci, Mannino, Robert G, Laohapant, Alvin, Tyburski, Erika A, Sakurai, Yumiko, Rosenbluth, Michael J, Switz, Neil A, Sulchek, Todd A, Graham, Michael D, Lam, Wilbur A
Format:	Journal Article
Language:	English
Published:	United States 23.02.2016
Subjects:	Catecholamines - pharmacology Cell Movement - drug effects Cell Movement - physiology Female Glucocorticoids - pharmacology Granulocytes - cytology Granulocytes - metabolism Humans Lab-On-A-Chip Devices Leukocyte Count - instrumentation Leukocyte Count - methods Male Models, Cardiovascular cellular mechanics atomic force microscopy demargination microfluidics leukocyte deformability
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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