Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial

The efficacy of α1 proteinase inhibitor (A1PI) augmentation treatment for α1 antitrypsin deficiency has not been substantiated by a randomised, placebo-controlled trial. CT-measured lung density is a more sensitive measure of disease progression in α1 antitrypsin deficiency emphysema than spirometry...

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Bibliographic Details
Published in:	The Lancet (British edition) Vol. 386; no. 9991; pp. 360 - 368
Main Authors:	Chapman, Kenneth R, Burdon, Jonathan G W, Piitulainen, Eeva, Sandhaus, Robert A, Seersholm, Niels, Stocks, James M, Stoel, Berend C, Huang, Liping, Yao, Zhenling, Edelman, Jonathan M, McElvaney, Noel G
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 25.07.2015
Subjects:	Adolescent Adult Aged alpha 1-Antitrypsin - administration & dosage alpha 1-Antitrypsin - therapeutic use alpha 1-Antitrypsin Deficiency - complications alpha 1-Antitrypsin Deficiency - diagnostic imaging alpha 1-Antitrypsin Deficiency - drug therapy alpha 1-Antitrypsin Deficiency - physiopathology Clinical Medicine Double-Blind Method Female Forced Expiratory Volume - drug effects Forced Expiratory Volume - physiology Functional Residual Capacity - drug effects Functional Residual Capacity - physiology Humans Infusions, Intravenous Internal Medicine Klinisk medicin Lung - diagnostic imaging Lung - physiopathology Lungmedicin och allergi Male Medical and Health Sciences Medicin och hälsovetenskap Middle Aged Pulmonary Emphysema - diagnostic imaging Pulmonary Emphysema - drug therapy Pulmonary Emphysema - etiology Pulmonary Emphysema - physiopathology Respiratory Medicine and Allergy Tomography, X-Ray Computed Total Lung Capacity - drug effects Total Lung Capacity - physiology Treatment Outcome Young Adult
ISSN:	0140-6736, 1474-547X, 1474-547X
Online Access:	Get full text
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