Efficacy of commercial vaccines against newly emerging avian influenza H5N8 virus in Egypt

The newly emerging, highly pathogenic avian influenza (HPAI) H5N8 virus of clade 2.3.4.4 was recently detected in wild birds and domestic poultry in Egypt in the 2016/2017 winter season. Vaccination based on commercial H5 vaccines is used as an essential control strategy in Egyptian poultry. Here, w...

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Veröffentlicht in:Scientific reports Jg. 8; H. 1; S. 9697 - 6
Hauptverfasser: Kandeil, Ahmed, Sabir, Jamal S. M., Abdelaal, Ahmed, Mattar, Ehab H., El-Taweel, Ahmed N., Sabir, Mumdooh J., Khalil, Ahmed Aly, Webby, Richard, Kayali, Ghazi, Ali, Mohamed A.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 26.06.2018
Nature Publishing Group
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42/109
631/326/590/1883
631/326/596/1578
82/1
Animal vaccines
Animals
Avian flu
Chickens
Egypt
Genetics
Humanities and Social Sciences
Immunization
Influenza A Virus, H5N8 Subtype - pathogenicity
Influenza in Birds - prevention & control
Influenza in Birds - virology
Influenza Vaccines - therapeutic use
multidisciplinary
Poultry
Science
Science (multidisciplinary)
Vaccines
Viruses
Egypt
ISSN:2045-2322, 2045-2322
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Abstract The newly emerging, highly pathogenic avian influenza (HPAI) H5N8 virus of clade 2.3.4.4 was recently detected in wild birds and domestic poultry in Egypt in the 2016/2017 winter season. Vaccination based on commercial H5 vaccines is used as an essential control strategy in Egyptian poultry. Here, we studied the efficacy of the eight most common commercial H5 poultry vaccines in the Egyptian market and compared them with an experimental vaccine based on the Egyptian LPAI H5N8 virus that was prepared by using reverse genetics. The experimental vaccine and Re-5 commercial vaccine were able to completely protect chickens and significantly reduce virus shedding. Our results indicate that most of the commercial poultry H5 vaccines used in the present study were ineffective because the seed viruses in these vaccines are genetically distinct from the H5N8 viruses currently circulating in Egypt. Although some of the commercial vaccines protected chickens from mortality, they failed to prevent chickens from shedding the virus. Accordingly, we recommend updating and reinforcing the H5N8 prevention and control strategies in Egypt. The vaccination strategy should be reconsidered based on currently circulating viruses.
AbstractList The newly emerging, highly pathogenic avian influenza (HPAI) H5N8 virus of clade 2.3.4.4 was recently detected in wild birds and domestic poultry in Egypt in the 2016/2017 winter season. Vaccination based on commercial H5 vaccines is used as an essential control strategy in Egyptian poultry. Here, we studied the efficacy of the eight most common commercial H5 poultry vaccines in the Egyptian market and compared them with an experimental vaccine based on the Egyptian LPAI H5N8 virus that was prepared by using reverse genetics. The experimental vaccine and Re-5 commercial vaccine were able to completely protect chickens and significantly reduce virus shedding. Our results indicate that most of the commercial poultry H5 vaccines used in the present study were ineffective because the seed viruses in these vaccines are genetically distinct from the H5N8 viruses currently circulating in Egypt. Although some of the commercial vaccines protected chickens from mortality, they failed to prevent chickens from shedding the virus. Accordingly, we recommend updating and reinforcing the H5N8 prevention and control strategies in Egypt. The vaccination strategy should be reconsidered based on currently circulating viruses.
The newly emerging, highly pathogenic avian influenza (HPAI) H5N8 virus of clade 2.3.4.4 was recently detected in wild birds and domestic poultry in Egypt in the 2016/2017 winter season. Vaccination based on commercial H5 vaccines is used as an essential control strategy in Egyptian poultry. Here, we studied the efficacy of the eight most common commercial H5 poultry vaccines in the Egyptian market and compared them with an experimental vaccine based on the Egyptian LPAI H5N8 virus that was prepared by using reverse genetics. The experimental vaccine and Re-5 commercial vaccine were able to completely protect chickens and significantly reduce virus shedding. Our results indicate that most of the commercial poultry H5 vaccines used in the present study were ineffective because the seed viruses in these vaccines are genetically distinct from the H5N8 viruses currently circulating in Egypt. Although some of the commercial vaccines protected chickens from mortality, they failed to prevent chickens from shedding the virus. Accordingly, we recommend updating and reinforcing the H5N8 prevention and control strategies in Egypt. The vaccination strategy should be reconsidered based on currently circulating viruses.The newly emerging, highly pathogenic avian influenza (HPAI) H5N8 virus of clade 2.3.4.4 was recently detected in wild birds and domestic poultry in Egypt in the 2016/2017 winter season. Vaccination based on commercial H5 vaccines is used as an essential control strategy in Egyptian poultry. Here, we studied the efficacy of the eight most common commercial H5 poultry vaccines in the Egyptian market and compared them with an experimental vaccine based on the Egyptian LPAI H5N8 virus that was prepared by using reverse genetics. The experimental vaccine and Re-5 commercial vaccine were able to completely protect chickens and significantly reduce virus shedding. Our results indicate that most of the commercial poultry H5 vaccines used in the present study were ineffective because the seed viruses in these vaccines are genetically distinct from the H5N8 viruses currently circulating in Egypt. Although some of the commercial vaccines protected chickens from mortality, they failed to prevent chickens from shedding the virus. Accordingly, we recommend updating and reinforcing the H5N8 prevention and control strategies in Egypt. The vaccination strategy should be reconsidered based on currently circulating viruses.
ArticleNumber 9697
Author Sabir, Jamal S. M.
Kandeil, Ahmed
Sabir, Mumdooh J.
Ali, Mohamed A.
Webby, Richard
Khalil, Ahmed Aly
El-Taweel, Ahmed N.
Mattar, Ehab H.
Abdelaal, Ahmed
Kayali, Ghazi
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  surname: Kandeil
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  organization: Center of Scientific Excellence for Influenza Viruses, National Research Center
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  givenname: Jamal S. M.
  surname: Sabir
  fullname: Sabir, Jamal S. M.
  organization: Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University (KAU)
– sequence: 3
  givenname: Ahmed
  surname: Abdelaal
  fullname: Abdelaal, Ahmed
  organization: Faculty of Biotechnology, October University of Modern Sciences and Arts (MSA)
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  givenname: Ehab H.
  surname: Mattar
  fullname: Mattar, Ehab H.
  organization: Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University (KAU)
– sequence: 5
  givenname: Ahmed N.
  surname: El-Taweel
  fullname: El-Taweel, Ahmed N.
  organization: Center of Scientific Excellence for Influenza Viruses, National Research Center
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– sequence: 7
  givenname: Ahmed Aly
  surname: Khalil
  fullname: Khalil, Ahmed Aly
  organization: Veterinary Serum and Vaccine Research Institute
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  givenname: Richard
  surname: Webby
  fullname: Webby, Richard
  organization: Department of Infectious Diseases, St. Jude Children’s Research Hospital
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  givenname: Ghazi
  orcidid: 0000-0002-5387-1622
  surname: Kayali
  fullname: Kayali, Ghazi
  email: ghazi@human-link.org
  organization: Department of Epidemiology, Human Genetics, and Environmental Sciences, University of Texas Health Sciences Center, Human Link
– sequence: 10
  givenname: Mohamed A.
  surname: Ali
  fullname: Ali, Mohamed A.
  email: mohamedahmedali2004@yahoo.com
  organization: Center of Scientific Excellence for Influenza Viruses, National Research Center, Biotechnology Research Group, Department of Biological Sciences, Faculty of Science, King Abdulaziz University (KAU)
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29946159$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1186/1743-422X-9-294
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Snippet The newly emerging, highly pathogenic avian influenza (HPAI) H5N8 virus of clade 2.3.4.4 was recently detected in wild birds and domestic poultry in Egypt in...
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SubjectTerms 42/109
631/326/590/1883
631/326/596/1578
82/1
Animal vaccines
Animals
Avian flu
Chickens
Egypt
Genetics
Humanities and Social Sciences
Immunization
Influenza A Virus, H5N8 Subtype - pathogenicity
Influenza in Birds - prevention & control
Influenza in Birds - virology
Influenza Vaccines - therapeutic use
multidisciplinary
Poultry
Science
Science (multidisciplinary)
Vaccines
Viruses
Title Efficacy of commercial vaccines against newly emerging avian influenza H5N8 virus in Egypt
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Volume 8
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