Applications for protein sequence–function evolution data: mRNA/protein expression analysis and coding SNP scoring tools

The vast amount of protein sequence data now available, together with accumulating experimental knowledge of protein function, enables modeling of protein sequence and function evolution. The PANTHER database was designed to model evolutionary sequence–function relationships on a large scale. There...

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Bibliographic Details
Published in:	Nucleic acids research Vol. 34; no. suppl-2; pp. W645 - W650
Main Authors:	Thomas, Paul D., Kejariwal, Anish, Guo, Nan, Mi, Huaiyu, Campbell, Michael J., Muruganujan, Anushya, Lazareva-Ulitsky, Betty
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01.07.2006
Subjects:	Amino Acid Substitution Animals Computer Graphics Data Interpretation, Statistical Databases, Protein Drosophila melanogaster - genetics Evolution, Molecular Genomics Humans Internet Markov Chains Mice Polymorphism, Single Nucleotide Proteins - classification Proteins - genetics Proteins - physiology Rats RNA, Messenger - metabolism Sequence Analysis, Protein Software User-Computer Interface
ISSN:	0305-1048, 1362-4962, 1362-4962
Online Access:	Get full text
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