Computational modeling of aberrant electrical activity following remuscularization with intramyocardially injected pluripotent stem cell-derived cardiomyocytes

Acute engraftment arrhythmias (EAs) remain a serious complication of remuscularization therapy. Preliminary evidence suggests that a focal source underlies these EAs stemming from the automaticity of immature pluripotent stem cell-derived cardiomyocytes (PSC-CMs) in nascent myocardial grafts. How th...

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Bibliographic Details
Published in:	Journal of molecular and cellular cardiology Vol. 162; pp. 97 - 109
Main Authors:	Yu, Joseph K., Liang, Jialiu A., Weinberg, Seth H., Trayanova, Natalia A.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.01.2022
Subjects:	Cardiac regeneration Cell Differentiation Cell therapy Computational modeling Computer Simulation Ephaptic coupling Heart failure Ischemic cardiomyopathy Myocardium Myocytes, Cardiac - transplantation Pluripotent Stem Cells Ventricular tachycardia Heart failure GJC Rgap Cell therapy PSC-CM Category Computational modeling Ischemic cardiomyopathy Ventricular tachycardia CM Cx43 Cardiac regeneration MDP Subject codes EpC EA MI Ephaptic coupling VT
ISSN:	0022-2828, 1095-8584, 1095-8584
Online Access:	Get full text
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