Guidelines for the welfare and use of animals in cancer research

Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updat...

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Bibliographic Details
Published in:	British journal of cancer Vol. 102; no. 11; pp. 1555 - 1577
Main Authors:	Workman, P, Aboagye, E O, Balkwill, F, Balmain, A, Bruder, G, Chaplin, D J, Double, J A, Everitt, J, Farningham, D A H, Glennie, M J, Kelland, L R, Robinson, V, Stratford, I J, Tozer, G M, Watson, S, Wedge, S R, Eccles, S A
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 25.05.2010 Nature Publishing Group
Subjects:	631/1647/767/1424 631/92/436 692/699/67 Algorithms Animal Experimentation - ethics Animal Experimentation - standards Animal welfare Animal Welfare - ethics Animal Welfare - organization & administration Animal Welfare - standards Animals Best practice Biological and medical sciences Biomarkers, Pharmacological - analysis Biomedical and Life Sciences Biomedical Research - ethics Biomedical Research - legislation & jurisprudence Biomedical Research - organization & administration Biomedical Research - standards Biomedicine Cancer Research Cancer therapies Cell Line, Transformed Diagnostic Imaging Disease Models, Animal Drug Resistance Epidemiology Female guideline Guidelines Hospitals Humans Laboratory animals Male Medical research Medical sciences Medicine Metastasis Mice Molecular Medicine Neoplasm Transplantation - methods Neoplasm Transplantation - pathology Neoplasm Transplantation - standards Neoplasms - diagnosis Neoplasms - genetics Neoplasms - pathology Neoplasms - therapy Oncology Pharmaceuticals Pilot projects Practice Guidelines as Topic Radiation Treatment Outcome Tumors Xenograft Model Antitumor Assays United Kingdom > UK United States > US San Francisco California animal welfare drugs therapy orthotopic models fundamental and translational research tumour models imaging cancer research humane endpoints metastatic models restraint tumour burden imaging techniques pharmocokinetic, pharmacodynamic and efficacy studies pilot studies radiation therapy publication replacement, reduction and refinement (3Rs) genetically engineered mouse models human tumour xenografts clinical signs best practice anaesthesia Metastasis Heterotransplantation pharmocokinetic Surgery Graft Genetics pharmacodynamic and efficacy studies Human Pharmacodynamics Orthotopic Treatment efficiency Rodentia Radiotherapy Recommendation Vertebrata Animal Technique replacement Animal model Refinement Transplantation Prevention Cancerology Advanced stage Fundamental research Drug reduction and refinement (3Rs) Malignant tumor Mammalia Treatment Mouse Medical imagery Cancer
ISSN:	0007-0920, 1532-1827, 1532-1827
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Summary:	Animal experiments remain essential to understand the fundamental mechanisms underpinning malignancy and to discover improved methods to prevent, diagnose and treat cancer. Excellent standards of animal care are fully consistent with the conduct of high quality cancer research. Here we provide updated guidelines on the welfare and use of animals in cancer research. All experiments should incorporate the 3Rs: replacement, reduction and refinement. Focusing on animal welfare, we present recommendations on all aspects of cancer research, including: study design, statistics and pilot studies; choice of tumour models (e.g., genetically engineered, orthotopic and metastatic); therapy (including drugs and radiation); imaging (covering techniques, anaesthesia and restraint); humane endpoints (including tumour burden and site); and publication of best practice.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Instructional Material/Guideline-3 content type line 23 The National Cancer Research Institute (NCRI) is a partnership of 21 organisations from the government, charity and commercial sectors who support cancer research in the UK. Further information about NCRI can be found at http://www.ncri.org.uk Observers: V Navaratnam and S Ryder17
ISSN:	0007-0920 1532-1827 1532-1827
DOI:	10.1038/sj.bjc.6605642