Epidemiology of Acute Kidney Injury in Critically Ill Children and Young Adults

Most children with serious acute illness do not have underlying chronic conditions. This prospective study involving patients in pediatric intensive care units showed that acute kidney injury is common and is associated with poor outcomes, including increased mortality. Epidemiologic studies involvi...

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Vydané v:The New England journal of medicine Ročník 376; číslo 1; s. 11 - 20
Hlavní autori: Kaddourah, Ahmad, Basu, Rajit K, Bagshaw, Sean M, Goldstein, Stuart L
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Massachusetts Medical Society 05.01.2017
Predmet:
Acute Kidney Injury - complications
Acute Kidney Injury - epidemiology
Acute Kidney Injury - mortality
Acute Kidney Injury - therapy
Adolescent
Adult
Body weight
Child
Child, Preschool
Children
Children & youth
Creatinine
Creatinine - blood
Critical care
Critical Illness
Death
Epidemiology
Female
Humans
Infant
Intensive care units
Intensive Care Units, Pediatric
Kidney diseases
Kidneys
Length of Stay
Male
Mechanical ventilation
Mortality
Nephrology
Pediatrics
Prospective Studies
Renal Replacement Therapy
Respiration, Artificial
Risk Factors
Severity of Illness Index
Treatment Outcome
Urine
Young Adult
Young adults
North America
ISSN:0028-4793, 1533-4406, 1533-4406
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Popis
Shrnutí:Most children with serious acute illness do not have underlying chronic conditions. This prospective study involving patients in pediatric intensive care units showed that acute kidney injury is common and is associated with poor outcomes, including increased mortality. Epidemiologic studies involving adults have shown that acute kidney injury is associated with increased mortality, prolonged mechanical ventilation, and prolonged length of stay in intensive care units (ICUs). 1 – 3 A multinational, prospective study involving 1802 adults 3 initiated the use of Kidney Disease: Improving Global Outcomes (KDIGO) guidelines to describe the epidemiology of acute kidney injury; the guidelines 4 define and stage acute kidney injury according to the plasma creatinine level and urine output (Table S1 in the Supplementary Appendix, available with the full text of this article at NEJM.org). That study showed graded associations between the severity of acute kidney injury and . . .
Bibliografia:ObjectType-Article-1
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1611391