Pharmacokinetics and Pharmacodynamics of Recombinant Human Angiotensin-Converting Enzyme 2 in Healthy Human Subjects

Background and Objectives Angiotensin-converting enzyme 2 (ACE2) converts angiotensin II (Ang1-8) to angiotensin 1-7 (Ang1-7), a functional antagonist of Ang1-8, with vasodilatory, antiproliferative, antiangiogenic, and anti-inflammatory properties. In conditions with an unbalanced renin–angiotensin...

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Bibliographic Details
Published in:	Clinical pharmacokinetics Vol. 52; no. 9; pp. 783 - 792
Main Authors:	Haschke, Manuel, Schuster, Manfred, Poglitsch, Marko, Loibner, Hans, Salzberg, Marc, Bruggisser, Marcel, Penninger, Joseph, Krähenbühl, Stephan
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01.09.2013 Adis International Springer Nature B.V
Subjects:	Angiotensin I - blood Angiotensin II - blood Angiotensin-Converting Enzyme 2 Biological and medical sciences Double-Blind Method Female General pharmacology Humans Internal Medicine Male Medical sciences Medicine Medicine & Public Health Original Research Article Peptide Fragments - blood Peptidyl-Dipeptidase A - administration & dosage Peptidyl-Dipeptidase A - pharmacokinetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacotherapy Recombinant Proteins - administration & dosage Recombinant Proteins - pharmacokinetics ACE2 Knockout Mouse Study Drug Administration Endogenous Peptide Signal Good Manufacture Practice Guideline Healthy Human Subject Human Pharmacokinetic pharmacodynamic relationship Recombinant protein Healthy subject
ISSN:	0312-5963, 1179-1926, 1179-1926
Online Access:	Get full text
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