Allosteric regulation of glutamate dehydrogenase deamination activity

Glutamate dehydrogenase (GDH) is a key enzyme interlinking carbon and nitrogen metabolism. Recent discoveries of the GDH specific role in breast cancer, hyperinsulinism/hyperammonemia (HI/HA) syndrome, and neurodegenerative diseases have reinvigorated interest on GDH regulation, which remains poorly...

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Bibliographic Details
Published in:	Scientific reports Vol. 10; no. 1; p. 16523
Main Authors:	Bera, Soumen, Rashid, Mubasher, Medvinsky, Alexander B., Sun, Gui-Quan, Li, Bai-Lian, Acquisti, Claudia, Sljoka, Adnan, Chakraborty, Amit
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 05.10.2020 Nature Publishing Group
Subjects:	631/114 631/57 631/57/2265 631/57/2266 631/57/2272 Active sites Adenosine Diphosphate - metabolism Allosteric properties Allosteric Regulation - physiology Biophysics - methods Breast cancer Computational Biology - methods Cryoelectron Microscopy - methods Deamination Dehydrogenase Dehydrogenases Electron microscopy Enzymatic activity Glutamate dehydrogenase Glutamate Dehydrogenase - metabolism Glutamate Dehydrogenase - ultrastructure Guanosine Triphosphate - metabolism Humanities and Social Sciences Hyperammonemia Hyperammonemia - genetics Models, Molecular Molecular Docking Simulation - methods multidisciplinary Mutagenesis Mutation - drug effects NAD - metabolism NADH Neurodegenerative diseases Protein Conformation Regulation Science Science (multidisciplinary) Structural analysis
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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