Retinal Capillary Plexus Pattern and Density from Fovea to Periphery Measured in Healthy Eyes with Swept-Source Optical Coherence Tomography Angiography

Optical coherence tomography angiography is evolving towards wider fields of view. As single widefield acquisitions have a lower resolution, preventing an accurate segmentation of vascular plexuses in the periphery, we examined the retinal vascularisation from the macula to the periphery in all reti...

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Bibliographic Details
Published in:Scientific reports Vol. 10; no. 1; p. 1474
Main Authors: Lavia, Carlo, Mecê, Pedro, Nassisi, Marco, Bonnin, Sophie, Marie-Louise, Jennifer, Couturier, Aude, Erginay, Ali, Tadayoni, Ramin, Gaudric, Alain
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 30.01.2020
Nature Publishing Group
Subjects:
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692/698
Adult
Angiography
Capillaries - anatomy & histology
Capillaries - diagnostic imaging
Cell density
Diabetes mellitus
Diabetic retinopathy
Eye
Female
Fovea Centralis - blood supply
Fovea Centralis - diagnostic imaging
Human health and pathology
Humanities and Social Sciences
Humans
Image processing
Life Sciences
Male
Medical imaging
multidisciplinary
Retina
Retina - diagnostic imaging
Retinal Vessels - anatomy & histology
Retinal Vessels - diagnostic imaging
Retinopathy
Science
Science (multidisciplinary)
Segmentation
Sensory Organs
Tomography
Tomography, Optical Coherence - methods
ISSN:2045-2322, 2045-2322
Online Access:Get full text
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Summary:Optical coherence tomography angiography is evolving towards wider fields of view. As single widefield acquisitions have a lower resolution, preventing an accurate segmentation of vascular plexuses in the periphery, we examined the retinal vascularisation from the macula to the periphery in all retinal quadrants, using 3 × 3-mm volume scans, to obtain montages with sufficient image resolution up to 11 mm from the foveal centre. Images were qualitatively and quantitatively analysed, using C- and B-scan approaches to calculate the capillary density (CD) and the interplexus distance (IPD). Three vascular plexuses ( i.e ., superficial vascular plexus: SVP, intermediate capillary plexus: ICP, and deep capillary plexus: DCP) were observed up to the mid-periphery in all sectors. The CD of the SVP decreased from about 5 mm of eccentricity, along with ganglion cell density decrease. The CD of the ICP progressively decreased from the fovea towards the periphery, along with the retinal thinning and then vanished from 8 to 9 mm of eccentricity, becoming undetectable beyond. This ICP disappearance resulted in an increased IPD between the SVP and the DCP in an area known to be frequently affected by capillary drop-out in diabetic retinopathy. The DCP only showed a slightly decreased CD towards the retinal periphery.
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PMCID: PMC6992636
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-58359-y