Line-Field Confocal Optical Coherence Tomography Evaluation of Eyelid Skin Lesions

Background: Periocular malignancies may be clinically different from the examples arising at other sites, with possible delayed diagnosis and greater challenges for treatment and repair. Line-field confocal optical coherence tomography (LC-OCT) is a recently developed technique characterized by an u...

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Veröffentlicht in:Diagnostics (Basel) Jg. 13; H. 23; S. 3590
Hauptverfasser: Di Stefani, Alessandro, Cappilli, Simone, Cuffaro, Giovanni, Fionda, Bruno, Pagliara, Monica Maria, Paradisi, Andrea, Ricci, Costantino, Rossi, Ernesto, Sammarco, Maria Grazia, Schinzari, Giovanni, Tagliaferri, Luca, Blasi, Maria Antonietta, Cinotti, Elisa, Moro, Alessandro, Savino, Gustavo, Suppa, Mariano, Peris, Ketty
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 01.12.2023
Schlagworte:
Cancer
Dermatology
epithelial carcinomas
eyelid
histology of the skin
Histopathology
line-field confocal optical coherence tomography
Medical research
Medicine, Experimental
melanoma
Microscopy
Morphology
non-invasive diagnosis
Skin
Software
Tomography
Tumors
line-field confocal optical coherence tomography
epithelial carcinomas
eyelid
melanoma
skin cancers
non-invasive diagnosis
histology of the skin
ISSN:2075-4418, 2075-4418
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Zusammenfassung:Background: Periocular malignancies may be clinically different from the examples arising at other sites, with possible delayed diagnosis and greater challenges for treatment and repair. Line-field confocal optical coherence tomography (LC-OCT) is a recently developed technique characterized by an unprecedented capacity to acquire high-definition images in vertical and horizontal modes. In this study, we aimed to investigate the LC-OCT morphological features of a series of eyelid skin lesions, correlating them to histopathological findings. Methods: Patients with biopsy-proven equivocal skin lesion in the eyelid area, previously investigated by means of LC-OCT, were included in the study. Percentage overall agreement was estimated for LC-OCT and histopathological diagnosis for study cases. Results: A total of 51 patients (28 women, 23 men; mean age 66.4 years old), for a total of 51 skin lesions, were assessed. The histopathological diagnosis consisted of 30 malignant and 21 benign tumors. Different entities were characterized by peculiar findings in LC-OCT, alike to histopathological features, allowing for an accurate “in vivo” classification in almost all cases, with a diagnostic concordance with histopathology of 92.1% (47/51). Conclusions: By integrating this new imaging technique into the assessment of suspicious tumors in this area, diagnostic accuracy may increase, improving strategies adopted in multidisciplinary meetings and patient-centered care.
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ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics13233590