Human gut derived-organoids provide model to study gluten response and effects of microbiota-derived molecules in celiac disease

Celiac disease (CD) is an immune-mediated disorder triggered by gluten exposure. The contribution of the adaptive immune response to CD pathogenesis has been extensively studied, but the absence of valid experimental models has hampered our understanding of the early steps leading to loss of gluten...

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Bibliographic Details
Published in:	Scientific reports Vol. 9; no. 1; p. 7029
Main Authors:	Freire, Rachel, Ingano, Laura, Serena, Gloria, Cetinbas, Murat, Anselmo, Anthony, Sapone, Anna, Sadreyev, Ruslan I., Fasano, Alessio, Senger, Stefania
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 07.05.2019 Nature Publishing Group
Subjects:	13/1 13/100 13/106 13/2 13/21 13/31 13/51 14/19 38/22 38/39 38/91 631/532/2437 692/4020/1503/1702/1357 Adaptive immunity Adult Aged Autoimmune diseases Celiac disease Celiac Disease - genetics Celiac Disease - microbiology Celiac Disease - pathology Cell Proliferation Cytokines Cytokines - metabolism Digestive system Duodenum - cytology Duodenum - pathology Dysbiosis - metabolism Epithelium Gastrointestinal Microbiome - genetics Gastrointestinal Microbiome - physiology Gastrointestinal tract Gene Expression Gliadin Gliadin - metabolism Gliadin - pharmacology Gluten Glutens - metabolism Glutens - pharmacology Humanities and Social Sciences Humans Immune response Immunological tolerance Inflammation Innate immunity Intestinal Mucosa - cytology Intestinal Mucosa - drug effects Intestinal Mucosa - pathology Intestine Lactic acid Microbiota Middle Aged multidisciplinary Organoids Pathogenesis Permeability Polysaccharides Reproducibility of Results Ribonucleic acid RNA Science Science (multidisciplinary) Stem cells Stem Cells - pathology
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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